JP2010273685A5 - - Google Patents
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- Publication number
- JP2010273685A5 JP2010273685A5 JP2010166570A JP2010166570A JP2010273685A5 JP 2010273685 A5 JP2010273685 A5 JP 2010273685A5 JP 2010166570 A JP2010166570 A JP 2010166570A JP 2010166570 A JP2010166570 A JP 2010166570A JP 2010273685 A5 JP2010273685 A5 JP 2010273685A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- antibody
- seq
- vertebrate
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010036039 Serrate-Jagged Proteins Proteins 0.000 claims 17
- 102000011842 Serrate-Jagged Proteins Human genes 0.000 claims 17
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108700024228 Drosophila Ser Proteins 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/400,159 US5869282A (en) | 1991-12-11 | 1995-03-07 | Nucleotide and protein sequences of the serrate gene and methods based thereon |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007260391A Division JP2008099687A (ja) | 1995-03-07 | 2007-10-03 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023179A Division JP2013150605A (ja) | 1995-03-07 | 2013-02-08 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010273685A JP2010273685A (ja) | 2010-12-09 |
| JP2010273685A5 true JP2010273685A5 (cg-RX-API-DMAC7.html) | 2011-07-14 |
Family
ID=23582455
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8527061A Withdrawn JPH11507203A (ja) | 1995-03-07 | 1996-03-07 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
| JP2007260391A Withdrawn JP2008099687A (ja) | 1995-03-07 | 2007-10-03 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
| JP2010166570A Withdrawn JP2010273685A (ja) | 1995-03-07 | 2010-07-23 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
| JP2013023179A Withdrawn JP2013150605A (ja) | 1995-03-07 | 2013-02-08 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8527061A Withdrawn JPH11507203A (ja) | 1995-03-07 | 1996-03-07 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
| JP2007260391A Withdrawn JP2008099687A (ja) | 1995-03-07 | 2007-10-03 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023179A Withdrawn JP2013150605A (ja) | 1995-03-07 | 2013-02-08 | 脊椎動物Ｓｅｒｒａｔｅ遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5869282A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0813545B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JPH11507203A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE442381T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU718955B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2214830C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69638022D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0813545T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2333384T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT813545E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996027610A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US6004924A (en) | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| WO1997001571A1 (en) * | 1995-06-28 | 1997-01-16 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US6291210B1 (en) | 1996-07-16 | 2001-09-18 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitor |
| GB9623236D0 (en) * | 1996-11-07 | 1997-01-08 | Imperial College | Notch |
| AU773479B2 (en) * | 1996-11-07 | 2004-05-27 | Lorantis Limited | Notch |
| EP1616958A3 (en) * | 1996-11-07 | 2006-02-08 | Lorantis Limited | Notch-ligands for use in immunotherapy |
| US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
| JP4171528B2 (ja) * | 1997-05-14 | 2008-10-22 | 旭化成株式会社 | 新規な分化抑制剤 |
| US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
| US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
| WO2000025809A1 (en) * | 1998-10-30 | 2000-05-11 | Smith & Nephew Plc | Compositions comprising notch receptor manipulating agents |
| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
| GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
| US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| AU2001288628A1 (en) * | 2000-08-31 | 2002-03-13 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
| EP1350262B8 (en) * | 2000-12-08 | 2008-08-13 | Coley Pharmaceuticals GmbH | Cpg-like nucleic acids and methods of use thereof |
| JP2004537314A (ja) * | 2001-07-25 | 2004-12-16 | ロランティス リミテッド | ノッチシグナル伝達モジュレーターを検出する方法 |
| GB0118155D0 (en) | 2001-07-25 | 2001-09-19 | Lorantis Ltd | Superantigen |
| JP2005511754A (ja) * | 2001-12-07 | 2005-04-28 | リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 乳癌幹細胞の予測的同定および特徴づけ |
| US20030185829A1 (en) * | 2002-03-12 | 2003-10-02 | Erich Koller | Jagged 2 inhibitors for inducing apoptosis |
| US20040102401A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of jagged 1 expression |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
| GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
| WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| JP2007526455A (ja) * | 2004-02-03 | 2007-09-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法 |
| US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2006138275A2 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| AU2006308870B2 (en) | 2005-10-31 | 2012-08-16 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| AU2006308847C1 (en) * | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2008092002A2 (en) * | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| US8802103B2 (en) * | 2007-05-15 | 2014-08-12 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| US7982013B2 (en) | 2008-09-26 | 2011-07-19 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US8945569B2 (en) | 2009-11-19 | 2015-02-03 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US20130095079A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| EP3097916B1 (en) | 2010-04-09 | 2021-07-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
| AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| KR20150037857A (ko) | 2012-06-22 | 2015-04-08 | 싸이톰스 테라퓨틱스, 인크. | 항-jagged 1/jagged 2 교차-반응성 항체, 활성화가능한 항-jagged 항체 및 이의 제조 방법 |
| JP2015536933A (ja) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| CA2897499A1 (en) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| MX389160B (es) | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| WO2016118780A1 (en) | 2015-01-21 | 2016-07-28 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| JP2018537472A (ja) | 2015-12-04 | 2018-12-20 | フレッド ハッチンソン キャンサー リサーチ センター | 増殖造血幹細胞／前駆細胞集団の利用 |
| JP2021533788A (ja) * | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| CN112680471B (zh) * | 2019-10-17 | 2023-08-01 | 华南农业大学 | ZmSPL基因在调控玉米柱头乳突细胞发育中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| AU720890B2 (en) * | 1996-05-31 | 2000-06-15 | National American Red Cross, The | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| AU8003400A (en) * | 1999-10-06 | 2001-05-10 | Ansgar H. Santel | Mitofusins, fzo homologs and functional derivatives thereof |
| JP5890756B2 (ja) | 2012-06-28 | 2016-03-22 | 昭和電工株式会社 | 磁気記録媒体及び磁気記憶装置 |
-
1995
- 1995-03-07 US US08/400,159 patent/US5869282A/en not_active Expired - Lifetime
-
1996
- 1996-03-07 DE DE69638022T patent/DE69638022D1/de not_active Expired - Lifetime
- 1996-03-07 AT AT96911262T patent/ATE442381T1/de active
- 1996-03-07 EP EP96911262A patent/EP0813545B1/en not_active Expired - Lifetime
- 1996-03-07 PT PT96911262T patent/PT813545E/pt unknown
- 1996-03-07 DK DK96911262T patent/DK0813545T3/da active
- 1996-03-07 CA CA2214830A patent/CA2214830C/en not_active Expired - Lifetime
- 1996-03-07 WO PCT/US1996/003172 patent/WO1996027610A1/en not_active Ceased
- 1996-03-07 AU AU54202/96A patent/AU718955B2/en not_active Expired
- 1996-03-07 ES ES96911262T patent/ES2333384T3/es not_active Expired - Lifetime
- 1996-03-07 JP JP8527061A patent/JPH11507203A/ja not_active Withdrawn
-
2007
- 2007-10-03 JP JP2007260391A patent/JP2008099687A/ja not_active Withdrawn
-
2010
- 2010-07-23 JP JP2010166570A patent/JP2010273685A/ja not_active Withdrawn
-
2013
- 2013-02-08 JP JP2013023179A patent/JP2013150605A/ja not_active Withdrawn