JP2010530223A5 - - Google Patents

Info

Publication number

JP2010530223A5

JP2010530223A5 JP2010511606A JP2010511606A JP2010530223A5 JP 2010530223 A5 JP2010530223 A5 JP 2010530223A5 JP 2010511606 A JP2010511606 A JP 2010511606A JP 2010511606 A JP2010511606 A JP 2010511606A JP 2010530223 A5 JP2010530223 A5 JP 2010530223A5

Authority

JP

Japan

Prior art keywords

microorganism

abc

negative regulatory

type transport

protein

Prior art date

2008-06-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 244000005700 microbiome Species 0.000 claims 24
• 108010078791 Carrier Proteins Proteins 0.000 claims 12
• 102000014914 Carrier Proteins Human genes 0.000 claims 11
• 102000034356 gene-regulatory proteins Human genes 0.000 claims 11
• 108091006104 gene-regulatory proteins Proteins 0.000 claims 11
• 230000035772 mutation Effects 0.000 claims 11
• 230000007614 genetic variation Effects 0.000 claims 9
• 230000000694 effects Effects 0.000 claims 8
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
• 229930003779 Vitamin B12 Natural products 0.000 claims 7
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 7
• 150000007523 nucleic acids Chemical group 0.000 claims 7
• 239000011715 vitamin B12 Substances 0.000 claims 7
• 235000019163 vitamin B12 Nutrition 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 239000012847 fine chemical Substances 0.000 claims 5
• 238000000034 method Methods 0.000 claims 4
• 238000012258 culturing Methods 0.000 claims 3
• 241000186226 Corynebacterium glutamicum Species 0.000 claims 2
• 230000002074 deregulated effect Effects 0.000 claims 2
• 241000606750 Actinobacillus Species 0.000 claims 1
• 241000186361 Actinobacteria <class> Species 0.000 claims 1
• OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
• 241000186216 Corynebacterium Species 0.000 claims 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
• QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 claims 1
• QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 claims 1
• 229960005305 adenosine Drugs 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 229930182817 methionine Natural products 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1