RU2010101001A - Микроорганизмы с дерегулированной системой витамина в12 - Google Patents
Микроорганизмы с дерегулированной системой витамина в12 Download PDFInfo
- Publication number
- RU2010101001A RU2010101001A RU2010101001/10A RU2010101001A RU2010101001A RU 2010101001 A RU2010101001 A RU 2010101001A RU 2010101001/10 A RU2010101001/10 A RU 2010101001/10A RU 2010101001 A RU2010101001 A RU 2010101001A RU 2010101001 A RU2010101001 A RU 2010101001A
- Authority
- RU
- Russia
- Prior art keywords
- microorganism
- abc
- protein
- genetic change
- seq
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title claims abstract 26
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 230000002068 genetic effect Effects 0.000 claims abstract 23
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract 15
- 102000004169 proteins and genes Human genes 0.000 claims abstract 15
- 230000000694 effects Effects 0.000 claims abstract 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 9
- 229930003779 Vitamin B12 Natural products 0.000 claims abstract 9
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract 9
- 239000011715 vitamin B12 Substances 0.000 claims abstract 9
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract 9
- 230000001105 regulatory effect Effects 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 230000002222 downregulating effect Effects 0.000 claims abstract 4
- 230000002074 deregulated effect Effects 0.000 claims abstract 3
- 238000010521 absorption reaction Methods 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000003828 downregulation Effects 0.000 claims 3
- 101100130094 Bacillus subtilis (strain 168) metK gene Proteins 0.000 claims 2
- 101100023016 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) mat gene Proteins 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 101150063051 hom gene Proteins 0.000 claims 2
- 101150108178 metE gene Proteins 0.000 claims 2
- 101150051471 metF gene Proteins 0.000 claims 2
- 101150042623 metH gene Proteins 0.000 claims 2
- 101150095438 metK gene Proteins 0.000 claims 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 2
- 101150014006 thrA gene Proteins 0.000 claims 2
- 101150072448 thrB gene Proteins 0.000 claims 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 1
- 241000186361 Actinobacteria <class> Species 0.000 claims 1
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 claims 1
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07110382.4 | 2007-06-15 | ||
| EP07110382 | 2007-06-15 | ||
| EP08157115 | 2008-05-28 | ||
| EP08157115.0 | 2008-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010101001A true RU2010101001A (ru) | 2011-07-20 |
Family
ID=39769554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010101001/10A RU2010101001A (ru) | 2007-06-15 | 2008-06-09 | Микроорганизмы с дерегулированной системой витамина в12 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100047881A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2158324A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010530223A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100049012A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101849017A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0812515A2 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2010101001A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008152016A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| US8906653B2 (en) | 2008-01-23 | 2014-12-09 | Basf Se | Method for fermentatively producing 1,5-diaminopentane |
| BRPI0909690A2 (pt) | 2008-03-05 | 2019-02-26 | Genomatica Inc | organismos produtores de alcoóis primários |
| AU2009242615A1 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| JP2012511928A (ja) | 2008-12-16 | 2012-05-31 | ゲノマチカ， インク． | 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法 |
| AU2010242849A1 (en) | 2009-04-30 | 2011-11-24 | Genomatica, Inc. | Organisms for the production of isopropanol, n-butanol, and isobutanol |
| ES2593117T3 (es) | 2009-04-30 | 2016-12-05 | Genomatica, Inc. | Organismos para la producción de 1,3-butanodiol |
| EP2462221B1 (en) | 2009-08-05 | 2017-02-22 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
| BR112012009332A2 (pt) | 2009-10-23 | 2015-09-15 | Genomatica Inc | micro-organismo para a produção de anilina |
| KR20120120493A (ko) | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
| MX2012008738A (es) | 2010-01-29 | 2012-08-31 | Genomatica Inc | Microorganismos y metodos para la biosintesis de p-toluato y tereftalato. |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| BR112013001635A2 (pt) | 2010-07-26 | 2016-05-24 | Genomatica Inc | micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno |
| CN113025729B (zh) * | 2020-12-24 | 2022-11-04 | 复旦大学 | 结核分枝杆菌对氨基水杨酸耐药相关的基因突变位点及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432686B1 (en) * | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| DE10239308A1 (de) * | 2002-08-27 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung von schwefelhaltigen Feinchemikalien |
| US20070026505A1 (en) * | 2005-06-17 | 2007-02-01 | Madden Kevin T | Amino acid and metabolite biosynthesis |
-
2008
- 2008-06-09 BR BRPI0812515-5A2A patent/BRPI0812515A2/pt not_active IP Right Cessation
- 2008-06-09 WO PCT/EP2008/057158 patent/WO2008152016A1/en not_active Ceased
- 2008-06-09 CN CN200880020285A patent/CN101849017A/zh active Pending
- 2008-06-09 JP JP2010511606A patent/JP2010530223A/ja not_active Withdrawn
- 2008-06-09 RU RU2010101001/10A patent/RU2010101001A/ru not_active Application Discontinuation
- 2008-06-09 EP EP08760723A patent/EP2158324A1/en not_active Withdrawn
- 2008-06-09 KR KR1020107000839A patent/KR20100049012A/ko not_active Withdrawn
- 2008-06-09 US US12/518,531 patent/US20100047881A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100047881A1 (en) | 2010-02-25 |
| KR20100049012A (ko) | 2010-05-11 |
| EP2158324A1 (en) | 2010-03-03 |
| BRPI0812515A2 (pt) | 2014-12-30 |
| JP2010530223A (ja) | 2010-09-09 |
| WO2008152016A9 (en) | 2009-05-07 |
| WO2008152016A1 (en) | 2008-12-18 |
| CN101849017A (zh) | 2010-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130304 |