AU718955B2 - Nucleotide and protein sequences of vertebrate serrate genes and methods based thereon - Google Patents
Nucleotide and protein sequences of vertebrate serrate genes and methods based thereon Download PDFInfo
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- AU718955B2 AU718955B2 AU54202/96A AU5420296A AU718955B2 AU 718955 B2 AU718955 B2 AU 718955B2 AU 54202/96 A AU54202/96 A AU 54202/96A AU 5420296 A AU5420296 A AU 5420296A AU 718955 B2 AU718955 B2 AU 718955B2
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Applications Claiming Priority (3)
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| US08/400,159 US5869282A (en) | 1991-12-11 | 1995-03-07 | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| PCT/US1996/003172 WO1996027610A1 (en) | 1995-03-07 | 1996-03-07 | Nucleotide and protein sequences of vertebrate serrate genes and methods based thereon |
| US400159 | 1999-09-21 |
Publications (2)
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| AU5420296A AU5420296A (en) | 1996-09-23 |
| AU718955B2 true AU718955B2 (en) | 2000-05-04 |
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| AU54202/96A Expired AU718955B2 (en) | 1995-03-07 | 1996-03-07 | Nucleotide and protein sequences of vertebrate serrate genes and methods based thereon |
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| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US6004924A (en) | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| WO1997001571A1 (en) * | 1995-06-28 | 1997-01-16 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
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| GB9623236D0 (en) * | 1996-11-07 | 1997-01-08 | Imperial College | Notch |
| AU773479B2 (en) * | 1996-11-07 | 2004-05-27 | Lorantis Limited | Notch |
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| US6887475B1 (en) | 1996-11-07 | 2005-05-03 | Lorantis Limited | Notch |
| JP4171528B2 (ja) * | 1997-05-14 | 2008-10-22 | 旭化成株式会社 | 新規な分化抑制剤 |
| US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
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| US6436650B1 (en) | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
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| US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
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| US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
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| JP2005511754A (ja) * | 2001-12-07 | 2005-04-28 | リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 乳癌幹細胞の予測的同定および特徴づけ |
| US20030185829A1 (en) * | 2002-03-12 | 2003-10-02 | Erich Koller | Jagged 2 inhibitors for inducing apoptosis |
| US20040102401A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of jagged 1 expression |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
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| WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| JP2007526455A (ja) * | 2004-02-03 | 2007-09-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法 |
| US20060252073A1 (en) * | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
| WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2006138275A2 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| AU2006308870B2 (en) | 2005-10-31 | 2012-08-16 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| AU2006308847C1 (en) * | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2008092002A2 (en) * | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| US8802103B2 (en) * | 2007-05-15 | 2014-08-12 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| US7982013B2 (en) | 2008-09-26 | 2011-07-19 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US8945569B2 (en) | 2009-11-19 | 2015-02-03 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US20130095079A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| EP3097916B1 (en) | 2010-04-09 | 2021-07-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
| AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| KR20150037857A (ko) | 2012-06-22 | 2015-04-08 | 싸이톰스 테라퓨틱스, 인크. | 항-jagged 1/jagged 2 교차-반응성 항체, 활성화가능한 항-jagged 항체 및 이의 제조 방법 |
| JP2015536933A (ja) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| CA2897499A1 (en) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| MX389160B (es) | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| WO2016118780A1 (en) | 2015-01-21 | 2016-07-28 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| JP2018537472A (ja) | 2015-12-04 | 2018-12-20 | フレッド ハッチンソン キャンサー リサーチ センター | 増殖造血幹細胞／前駆細胞集団の利用 |
| JP2021533788A (ja) * | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| CN112680471B (zh) * | 2019-10-17 | 2023-08-01 | 华南农业大学 | ZmSPL基因在调控玉米柱头乳突细胞发育中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| IL101728A (en) * | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| AU720890B2 (en) * | 1996-05-31 | 2000-06-15 | National American Red Cross, The | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| AU8003400A (en) * | 1999-10-06 | 2001-05-10 | Ansgar H. Santel | Mitofusins, fzo homologs and functional derivatives thereof |
| JP5890756B2 (ja) | 2012-06-28 | 2016-03-22 | 昭和電工株式会社 | 磁気記録媒体及び磁気記憶装置 |
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1995
- 1995-03-07 US US08/400,159 patent/US5869282A/en not_active Expired - Lifetime
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1996
- 1996-03-07 DE DE69638022T patent/DE69638022D1/de not_active Expired - Lifetime
- 1996-03-07 AT AT96911262T patent/ATE442381T1/de active
- 1996-03-07 EP EP96911262A patent/EP0813545B1/en not_active Expired - Lifetime
- 1996-03-07 PT PT96911262T patent/PT813545E/pt unknown
- 1996-03-07 DK DK96911262T patent/DK0813545T3/da active
- 1996-03-07 CA CA2214830A patent/CA2214830C/en not_active Expired - Lifetime
- 1996-03-07 WO PCT/US1996/003172 patent/WO1996027610A1/en not_active Ceased
- 1996-03-07 AU AU54202/96A patent/AU718955B2/en not_active Expired
- 1996-03-07 ES ES96911262T patent/ES2333384T3/es not_active Expired - Lifetime
- 1996-03-07 JP JP8527061A patent/JPH11507203A/ja not_active Withdrawn
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2007
- 2007-10-03 JP JP2007260391A patent/JP2008099687A/ja not_active Withdrawn
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2010
- 2010-07-23 JP JP2010166570A patent/JP2010273685A/ja not_active Withdrawn
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2013
- 2013-02-08 JP JP2013023179A patent/JP2013150605A/ja not_active Withdrawn
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| ATE442381T1 (de) | 2009-09-15 |
| EP0813545B1 (en) | 2009-09-09 |
| AU5420296A (en) | 1996-09-23 |
| EP0813545A1 (en) | 1997-12-29 |
| EP0813545A4 (en) | 2002-04-24 |
| CA2214830C (en) | 2012-06-12 |
| ES2333384T3 (es) | 2010-02-19 |
| US5869282A (en) | 1999-02-09 |
| DE69638022D1 (de) | 2009-10-22 |
| JPH11507203A (ja) | 1999-06-29 |
| DK0813545T3 (da) | 2009-12-14 |
| CA2214830A1 (en) | 1996-09-12 |
| PT813545E (pt) | 2009-12-16 |
| JP2013150605A (ja) | 2013-08-08 |
| JP2008099687A (ja) | 2008-05-01 |
| WO1996027610A1 (en) | 1996-09-12 |
| JP2010273685A (ja) | 2010-12-09 |
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