JP2010193788A5 - - Google Patents
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- Publication number
- JP2010193788A5 JP2010193788A5 JP2009042561A JP2009042561A JP2010193788A5 JP 2010193788 A5 JP2010193788 A5 JP 2010193788A5 JP 2009042561 A JP2009042561 A JP 2009042561A JP 2009042561 A JP2009042561 A JP 2009042561A JP 2010193788 A5 JP2010193788 A5 JP 2010193788A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- bacterium according
- bacterium
- protein
- increased
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims 14
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 101150009558 dsbA gene Proteins 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 235000013878 L-cysteine Nutrition 0.000 claims 5
- 239000004201 L-cysteine Substances 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims 2
- 235000019393 L-cystine Nutrition 0.000 claims 2
- 239000004158 L-cystine Substances 0.000 claims 2
- 229960003067 cystine Drugs 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 101150005558 ydeD gene Proteins 0.000 claims 2
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 150000008538 L-cysteines Chemical class 0.000 claims 1
- JJIHLJJYMXLCOY-BYPYZUCNSA-N N-acetyl-L-serine Chemical compound CC(=O)N[C@@H](CO)C(O)=O JJIHLJJYMXLCOY-BYPYZUCNSA-N 0.000 claims 1
- VZXPDPZARILFQX-BYPYZUCNSA-N O-acetyl-L-serine Chemical group CC(=O)OC[C@H]([NH3+])C([O-])=O VZXPDPZARILFQX-BYPYZUCNSA-N 0.000 claims 1
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108091022908 Serine O-acetyltransferase Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 150000003548 thiazolidines Chemical class 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009042561A JP5463528B2 (ja) | 2009-02-25 | 2009-02-25 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US12/711,299 US8293506B2 (en) | 2009-02-25 | 2010-02-24 | L-cysteine-producing bacterium and a method for producing L-cysteine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009042561A JP5463528B2 (ja) | 2009-02-25 | 2009-02-25 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010193788A JP2010193788A (ja) | 2010-09-09 |
| JP2010193788A5 true JP2010193788A5 (enExample) | 2012-04-05 |
| JP5463528B2 JP5463528B2 (ja) | 2014-04-09 |
Family
ID=42631316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009042561A Expired - Fee Related JP5463528B2 (ja) | 2009-02-25 | 2009-02-25 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US8293506B2 (enExample) |
| JP (1) | JP5463528B2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2624913T3 (es) * | 2008-09-08 | 2017-07-18 | Ajinomoto Co., Inc. | Microorganismo que produce un L-aminoácido y procedimiento para producir un L-aminoácido |
| EP2508594B1 (en) | 2009-11-30 | 2017-08-16 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium, and process for production of l-cysteine |
| RU2460793C2 (ru) * | 2010-01-15 | 2012-09-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
| CN103119154B (zh) | 2010-09-14 | 2015-11-25 | 味之素株式会社 | 含硫氨基酸生产菌以及含硫氨基酸的制造方法 |
| JP2014087259A (ja) * | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| BR112013023465B1 (pt) * | 2011-04-01 | 2020-10-27 | Ajinomoto Co., Inc | método para produzir l-cisteína |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| US9611461B2 (en) | 2013-03-19 | 2017-04-04 | National University Corporation NARA Institute of Science and Technology | Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability |
| WO2015033849A1 (ja) * | 2013-09-04 | 2015-03-12 | 国立大学法人奈良先端科学技術大学院大学 | Ｌ―システインの製造方法 |
| JP2019129708A (ja) * | 2016-06-07 | 2019-08-08 | 味の素株式会社 | ヒポタウリンまたはタウリンの製造法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05336986A (ja) | 1992-06-05 | 1993-12-21 | Takara Shuzo Co Ltd | タンパク質の再賦活化剤 |
| DE19539952A1 (de) | 1995-10-26 | 1997-04-30 | Consortium Elektrochem Ind | Verfahren zur Herstellung von O-Acetylserin, L-Cystein und L-Cystein-verwandten Produkten |
| DE19726083A1 (de) | 1997-06-19 | 1998-12-24 | Consortium Elektrochem Ind | Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten |
| JP4151094B2 (ja) | 1997-11-25 | 2008-09-17 | 味の素株式会社 | Ｌ−システインの製造法 |
| JP2000083670A (ja) | 1998-09-09 | 2000-03-28 | Hsp Kenkyusho:Kk | ＤｓｂＡ／ＤｓｂＢ／ＤｓｂＣ／ＤｓｂＤ発現プラスミド |
| DE19949579C1 (de) | 1999-10-14 | 2000-11-16 | Consortium Elektrochem Ind | Verfahren zur fermentativen Herstellung von L-Cystein oder L-Cystein-Derivaten |
| JP4622111B2 (ja) | 2001-02-09 | 2011-02-02 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP4461210B2 (ja) * | 2001-08-27 | 2010-05-12 | ジェネンテック， インコーポレイテッド | 抗体発現系とその構築法 |
| JP4186564B2 (ja) | 2001-09-28 | 2008-11-26 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP4923573B2 (ja) | 2003-07-16 | 2012-04-25 | 味の素株式会社 | 変異型セリンアセチルトランスフェラーゼ及びｌ−システインの製造法 |
| JP4479283B2 (ja) | 2004-03-04 | 2010-06-09 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| JP4604537B2 (ja) | 2004-03-31 | 2011-01-05 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| WO2007055789A2 (en) * | 2005-10-31 | 2007-05-18 | Neose Technologies, Inc. | Expression of soluble therapeutic proteins |
| JP5332237B2 (ja) | 2008-03-06 | 2013-11-06 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US8383372B2 (en) | 2008-03-06 | 2013-02-26 | Ajinomoto Co., Inc. | L-cysteine producing bacterium and a method for producing L-cysteine |
-
2009
- 2009-02-25 JP JP2009042561A patent/JP5463528B2/ja not_active Expired - Fee Related
-
2010
- 2010-02-24 US US12/711,299 patent/US8293506B2/en not_active Expired - Fee Related
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