JP2010180243A5 - - Google Patents
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- JP2010180243A5 JP2010180243A5 JP2010098845A JP2010098845A JP2010180243A5 JP 2010180243 A5 JP2010180243 A5 JP 2010180243A5 JP 2010098845 A JP2010098845 A JP 2010098845A JP 2010098845 A JP2010098845 A JP 2010098845A JP 2010180243 A5 JP2010180243 A5 JP 2010180243A5
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- JP
- Japan
- Prior art keywords
- compound
- acid
- formula
- chemical formula
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 31
- -1 ethyl carbonyloxy, isopropyl carbonyloxy, t- butyl carbonyloxy, cyclopropylcarbonyloxy, phenyl Chemical group 0.000 claims 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 150000007522 mineralic acids Chemical class 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 4
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 4
- 229910017604 nitric acid Inorganic materials 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000007868 Raney catalyst Substances 0.000 claims 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 claims 1
- 229910000564 Raney nickel Inorganic materials 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013590 bulk material Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19955190.1 | 1999-11-16 | ||
| DE19955190A DE19955190A1 (de) | 1999-11-16 | 1999-11-16 | Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007042774A Division JP2007137895A (ja) | 1999-11-16 | 2007-02-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013229622A Division JP5717824B2 (ja) | 1999-11-16 | 2013-11-05 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010180243A JP2010180243A (ja) | 2010-08-19 |
| JP2010180243A5 true JP2010180243A5 (cg-RX-API-DMAC7.html) | 2011-09-08 |
| JP5503393B2 JP5503393B2 (ja) | 2014-05-28 |
Family
ID=7929277
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537950A Expired - Lifetime JP4083431B2 (ja) | 1999-11-16 | 2000-11-15 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2007042774A Pending JP2007137895A (ja) | 1999-11-16 | 2007-02-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2010098844A Expired - Lifetime JP5650924B2 (ja) | 1999-11-16 | 2010-04-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2010098845A Expired - Lifetime JP5503393B2 (ja) | 1999-11-16 | 2010-04-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2011096911A Expired - Lifetime JP5290351B2 (ja) | 1999-11-16 | 2011-04-25 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2013229622A Expired - Lifetime JP5717824B2 (ja) | 1999-11-16 | 2013-11-05 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537950A Expired - Lifetime JP4083431B2 (ja) | 1999-11-16 | 2000-11-15 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2007042774A Pending JP2007137895A (ja) | 1999-11-16 | 2007-02-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2010098844A Expired - Lifetime JP5650924B2 (ja) | 1999-11-16 | 2010-04-22 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011096911A Expired - Lifetime JP5290351B2 (ja) | 1999-11-16 | 2011-04-25 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
| JP2013229622A Expired - Lifetime JP5717824B2 (ja) | 1999-11-16 | 2013-11-05 | ３，３−ジフェニルプロピルアミン類の新規誘導体の安定な塩 |
Country Status (30)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| DE29923134U1 (de) * | 1999-11-16 | 2000-06-29 | Schwarz Pharma Ag, 40789 Monheim | Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen |
| DE10028443C1 (de) * | 2000-06-14 | 2002-05-29 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen |
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| DE10315878B4 (de) * | 2003-04-08 | 2009-06-04 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Fesoterodin und Verwendung |
| WO2005012227A2 (en) * | 2003-08-05 | 2005-02-10 | Ranbaxy Laboratories Limited | Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine |
| ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| US8034823B2 (en) * | 2005-02-22 | 2011-10-11 | Savvipharm Inc | Method of increasing drug oral bioavailability and compositions of less toxic orotate salts |
| KR100647068B1 (ko) | 2005-09-15 | 2006-11-23 | 하나제약 주식회사 | 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법 |
| PL2029567T3 (pl) * | 2006-05-24 | 2011-01-31 | Pfizer Ltd | Sposób wytwarzania pochodnych benzopiran-2-olu |
| EP1862449A1 (en) * | 2006-05-31 | 2007-12-05 | Schwarz Pharma Ltd. | A shortened synthesis of substituted hydroxymethyl phenols |
| AU2007267371B2 (en) * | 2006-05-31 | 2012-09-20 | Schwarz Pharma Ltd. | New synthesis of substituted hydroxymethyl phenols |
| IES20060424A2 (en) * | 2006-06-08 | 2007-10-31 | Schwarz Pharma Ltd | Accelerated synthesis of (3-Diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol and its phenolic monoesters |
| BRPI0712865B1 (pt) | 2006-06-09 | 2021-08-17 | Schwarz Pharma Ag | Composição farmacêutica estabilizada compreendendo fesoterodina, método para preparação da mesma e uso de uma substância |
| US7807715B2 (en) | 2006-06-09 | 2010-10-05 | Ucb Pharma Gmbh | Pharmaceutical compositions comprising fesoterodine |
| EP2004592B1 (en) | 2006-06-09 | 2010-08-11 | Schwarz Pharma Ltd. | Synthesis of phenolic esters of hydroxymethyl phenols |
| IES20060435A2 (en) | 2006-06-12 | 2007-12-12 | Schwarz Pharma Ltd | Shortened synthesis using paraformaldehyde or trioxane |
| EA018376B1 (ru) | 2006-06-12 | 2013-07-30 | Шварц Фарма Аг | Новые хиральные промежуточные продукты, способ их получения и их применение в производстве толтеродина, фезотеродина или их активных метаболитов |
| WO2009037569A2 (en) * | 2007-09-21 | 2009-03-26 | Actavis Group Ptc Ehf | An improved process for the preparation of fesoterodine |
| US20100297241A1 (en) * | 2007-10-01 | 2010-11-25 | Actavis Group Ptc Ehf | Amorphous Fesoterodine Fumarate |
| EP2294047A2 (en) * | 2008-04-04 | 2011-03-16 | Actavis Group PTC EHF | Novel mandelate salt of fesoterodine |
| US20110171274A1 (en) * | 2008-07-21 | 2011-07-14 | Actavis Group Ptc Ehf | Fesoterodine Substantially Free of Dehydroxy Impurity |
| IT1392082B1 (it) * | 2008-12-10 | 2012-02-09 | Chemi Spa | Nuove forme solide della fesoterodina fumarato |
| KR20120014583A (ko) | 2009-05-11 | 2012-02-17 | 라티오팜 게엠베하 | 타르타르산 염 형태의 데스페소테로딘 |
| IT1394219B1 (it) | 2009-05-15 | 2012-06-01 | Chemi Spa | Metodo di preparazione di fesoterodina fumarato di elevata purezza. |
| IT1394217B1 (it) * | 2009-05-15 | 2012-06-01 | Chemi Spa | Metodo di preparazione di fesoterodina e/o fesoterodina fumarato. |
| WO2011029005A1 (en) | 2009-09-03 | 2011-03-10 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Crystalline forms of fesoterodine fumarate and fesoterodine base |
| IT1396373B1 (it) * | 2009-10-29 | 2012-11-19 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina. |
| EP2316432A1 (de) | 2009-10-30 | 2011-05-04 | ratiopharm GmbH | Zusammensetzung enthaltend Fesoterodin und Ballaststoffe |
| US20110124903A1 (en) * | 2009-11-20 | 2011-05-26 | Actavis Group Ptc Ehf | Solid state forms of fesoterodine intermediates |
| IT1397521B1 (it) * | 2009-12-21 | 2013-01-16 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina con un basso contenuto di impurezze. |
| IT1397920B1 (it) * | 2010-02-08 | 2013-02-04 | Dipharma Francis Srl | Forma cristallina di fesoterodina fumarato e procedimento per la sua preparazione |
| EP2549985A1 (en) | 2010-03-22 | 2013-01-30 | Cadila Healthcare Limited | Stable pharmaceutical compositions comprising fesoterodine |
| JP5812500B2 (ja) | 2010-04-30 | 2015-11-17 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規なβ３アドレナリン作動性受容体アゴニスト |
| US20110282094A1 (en) * | 2010-05-11 | 2011-11-17 | Intas Pharmaceuticals Limited | Process for preparation of phenolic monoesters of hydroxymethyl phenols |
| WO2011145019A1 (en) * | 2010-05-17 | 2011-11-24 | Orchid Chemicals And Pharmaceuticals Limited | Improved process for diphenylpropylamine derivatives |
| IT1401451B1 (it) | 2010-06-10 | 2013-07-26 | Chemi Spa | Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo. |
| WO2011158257A1 (en) | 2010-06-18 | 2011-12-22 | Panacea Biotec Ltd | Preparation process of fesoterodine and intermediates |
| WO2012025941A2 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Processes for the preparation of fesoterodine |
| IT1403094B1 (it) | 2010-12-09 | 2013-10-04 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina o un suo sale |
| WO2012098560A2 (en) * | 2011-01-17 | 2012-07-26 | Msn Laboratories Limited | Process for the preparation of muscarinic receptor antagonist |
| TWI590821B (zh) | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
| EP2508175A1 (en) | 2011-04-08 | 2012-10-10 | LEK Pharmaceuticals d.d. | Pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof |
| EP2508173A1 (en) | 2011-04-08 | 2012-10-10 | LEK Pharmaceuticals d.d. | Stabilized pharmaceutical composition comprising fesoterodine |
| WO2013113946A2 (en) | 2012-05-04 | 2013-08-08 | Crystal Pharma, S.A.U. | Process for the preparation of optically active 3,3-diphenylpropylamines |
| ITMI20121232A1 (it) | 2012-07-16 | 2014-01-17 | Cambrex Profarmaco Milano Srl | Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati |
| TR201721437A2 (tr) | 2017-12-25 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Fesoterodi̇ni̇n modi̇fi̇ye salim sağlayan formülasyonlari |
| WO2022090235A1 (en) * | 2020-10-27 | 2022-05-05 | Wella Germany Gmbh | 2-methoxymethyl-p-phenylenediamine in cosmetic grade quality |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL233786A1 (cg-RX-API-DMAC7.html) * | 1980-11-14 | 1982-05-24 | Lilly Co Eli | |
| IL66831A0 (en) * | 1981-10-05 | 1982-12-31 | Kefalas As | Indane derivatives |
| SE8800207D0 (sv) * | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
| IE910752A1 (en) * | 1990-03-08 | 1991-09-11 | Fujisawa Pharmaceutical Co | A novel substituted-amine compound and a process for the¹preparation thereof |
| JPH0483431A (ja) * | 1990-07-26 | 1992-03-17 | Seiko Epson Corp | 選択呼出受信機 |
| SE9203318D0 (sv) | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
| SE9701144D0 (sv) * | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| EP0957073A1 (en) | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| DE29923134U1 (de) * | 1999-11-16 | 2000-06-29 | Schwarz Pharma Ag, 40789 Monheim | Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen |
-
1999
- 1999-11-16 DE DE29923134U patent/DE29923134U1/de not_active Expired - Lifetime
- 1999-11-16 DE DE19955190A patent/DE19955190A1/de not_active Ceased
-
2000
- 2000-11-15 DK DK06011207T patent/DK1690536T3/da active
- 2000-11-15 SK SK657-2002A patent/SK287430B6/sk not_active IP Right Cessation
- 2000-11-15 HK HK02106545.5A patent/HK1045148B/zh not_active IP Right Cessation
- 2000-11-15 AT AT04018487T patent/ATE337293T1/de active
- 2000-11-15 CN CNB008157057A patent/CN1215045C/zh not_active Expired - Lifetime
- 2000-11-15 WO PCT/EP2000/011309 patent/WO2001035957A1/de not_active Ceased
- 2000-11-15 SI SI200030617T patent/SI1230209T1/xx unknown
- 2000-11-15 PT PT04018487T patent/PT1481964E/pt unknown
- 2000-11-15 SI SI200030890T patent/SI1481964T1/sl unknown
- 2000-11-15 AU AU26667/01A patent/AU778132B2/en not_active Expired
- 2000-11-15 PT PT00989857T patent/PT1230209E/pt unknown
- 2000-11-15 BR BRPI0015610A patent/BRPI0015610C1/pt not_active IP Right Cessation
- 2000-11-15 US US10/130,214 patent/US6858650B1/en not_active Expired - Lifetime
- 2000-11-15 HU HU0204034A patent/HU228197B1/hu unknown
- 2000-11-15 EP EP06011207A patent/EP1690536B1/de not_active Expired - Lifetime
- 2000-11-15 DE DE50013365T patent/DE50013365D1/de not_active Expired - Lifetime
- 2000-11-15 EP EP00989857A patent/EP1230209B3/de not_active Expired - Lifetime
- 2000-11-15 SK SK5027-2010A patent/SK288185B6/sk not_active IP Right Cessation
- 2000-11-15 EP EP04018487A patent/EP1481964B1/de not_active Expired - Lifetime
- 2000-11-15 DE DE50015163T patent/DE50015163D1/de not_active Expired - Lifetime
- 2000-11-15 ES ES00989857T patent/ES2236032T7/es active Active
- 2000-11-15 ES ES04018487T patent/ES2270240T3/es not_active Expired - Lifetime
- 2000-11-15 AT AT00989857T patent/ATE286872T1/de active
- 2000-11-15 DK DK00989857T patent/DK1230209T3/da active
- 2000-11-15 SK SK5024-2013A patent/SK288384B6/sk not_active IP Right Cessation
- 2000-11-15 DK DK04018487T patent/DK1481964T3/da active
- 2000-11-15 HU HU0900587A patent/HU227608B1/hu unknown
- 2000-11-15 UA UA2002043609A patent/UA73324C2/uk unknown
- 2000-11-15 DE DE50009239T patent/DE50009239D1/de not_active Expired - Lifetime
- 2000-11-15 EA EA200200511A patent/EA005588B1/ru not_active IP Right Cessation
- 2000-11-15 CA CA002389749A patent/CA2389749C/en not_active Expired - Lifetime
- 2000-11-15 KR KR10-2002-7006306A patent/KR100536095B1/ko not_active Expired - Fee Related
- 2000-11-15 KR KR1020057018318A patent/KR100563149B1/ko not_active Expired - Lifetime
- 2000-11-15 JP JP2001537950A patent/JP4083431B2/ja not_active Expired - Lifetime
- 2000-11-15 ES ES06011207T patent/ES2303708T3/es not_active Expired - Lifetime
- 2000-11-15 IL IL14956700A patent/IL149567A0/xx unknown
- 2000-11-15 SI SI200030998T patent/SI1690536T1/sl unknown
- 2000-11-15 NZ NZ519230A patent/NZ519230A/en not_active IP Right Cessation
- 2000-11-15 CZ CZ20021343A patent/CZ302967B6/cs not_active IP Right Cessation
- 2000-11-15 CZ CZ20060247A patent/CZ302497B6/cs not_active IP Right Cessation
- 2000-11-15 AT AT06011207T patent/ATE395056T1/de active
- 2000-11-15 MX MXPA02004603A patent/MXPA02004603A/es active IP Right Grant
- 2000-11-15 PT PT06011207T patent/PT1690536E/pt unknown
- 2000-11-15 PL PL356766A patent/PL201422B1/pl unknown
-
2002
- 2002-04-19 IS IS6351A patent/IS2124B/xx unknown
- 2002-04-25 ZA ZA200203315A patent/ZA200203315B/xx unknown
- 2002-05-09 IL IL149567A patent/IL149567A/en active IP Right Grant
- 2002-05-15 NO NO20022314A patent/NO323920B1/no not_active IP Right Cessation
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2005
- 2005-01-17 UA UAA200500434A patent/UA77322C2/uk unknown
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2006
- 2006-03-29 IS IS8382A patent/IS2673B/is unknown
- 2006-10-18 CY CY20061101493T patent/CY1106204T1/el unknown
- 2006-11-22 NO NO20065380A patent/NO332637B1/no not_active IP Right Cessation
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2007
- 2007-02-22 JP JP2007042774A patent/JP2007137895A/ja active Pending
- 2007-11-07 GE GEAP200710360A patent/GEP20084430B/en unknown
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2008
- 2008-07-08 CY CY20081100712T patent/CY1110389T1/el unknown
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2010
- 2010-04-22 JP JP2010098844A patent/JP5650924B2/ja not_active Expired - Lifetime
- 2010-04-22 JP JP2010098845A patent/JP5503393B2/ja not_active Expired - Lifetime
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2011
- 2011-04-25 JP JP2011096911A patent/JP5290351B2/ja not_active Expired - Lifetime
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2013
- 2013-11-05 JP JP2013229622A patent/JP5717824B2/ja not_active Expired - Lifetime