JP2010017189A5 - - Google Patents
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- JP2010017189A5 JP2010017189A5 JP2009214994A JP2009214994A JP2010017189A5 JP 2010017189 A5 JP2010017189 A5 JP 2010017189A5 JP 2009214994 A JP2009214994 A JP 2009214994A JP 2009214994 A JP2009214994 A JP 2009214994A JP 2010017189 A5 JP2010017189 A5 JP 2010017189A5
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- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- pharmaceutical composition
- psma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 28
- 239000000427 antigen Substances 0.000 claims 24
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- 108091007433 antigens Proteins 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 17
- 230000005855 radiation Effects 0.000 claims 9
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- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 231100000433 cytotoxic Toxicity 0.000 claims 7
- 230000001472 cytotoxic effect Effects 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
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- 229910052765 Lutetium Inorganic materials 0.000 claims 6
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 claims 6
- OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical compound [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 claims 6
- 238000011277 treatment modality Methods 0.000 claims 6
- 231100000599 cytotoxic agent Toxicity 0.000 claims 5
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 claims 4
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- NKIJBSVPDYIEAT-UHFFFAOYSA-N 1,4,7,10-tetrazacyclododec-10-ene Chemical group C1CNCCN=CCNCCN1 NKIJBSVPDYIEAT-UHFFFAOYSA-N 0.000 claims 2
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- 102000008070 Interferon-gamma Human genes 0.000 claims 1
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- 108010002352 Interleukin-1 Proteins 0.000 claims 1
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- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
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- 2002-05-30 IL IL15896902A patent/IL158969A0/xx unknown
- 2002-05-30 JP JP2003502017A patent/JP4619651B2/ja not_active Expired - Lifetime
- 2002-05-30 CA CA2447695A patent/CA2447695C/en not_active Expired - Lifetime
- 2002-05-30 EP EP10181902.7A patent/EP2277542B1/en not_active Expired - Lifetime
- 2002-05-30 MX MXPA03010804A patent/MXPA03010804A/es active IP Right Grant
- 2002-05-30 US US10/160,505 patent/US7045605B2/en not_active Expired - Lifetime
- 2002-05-30 AU AU2002318169A patent/AU2002318169B2/en not_active Expired
- 2002-05-30 EP EP02747873A patent/EP1392360B1/en not_active Expired - Lifetime
- 2002-05-30 AT AT02747873T patent/ATE535258T1/de active
-
2003
- 2003-11-20 IL IL158969A patent/IL158969A/en unknown
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2009
- 2009-09-16 JP JP2009214994A patent/JP2010017189A/ja active Pending
- 2009-10-01 IL IL201274A patent/IL201274A/en active IP Right Grant
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