JP2010017185A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010017185A5 JP2010017185A5 JP2009192598A JP2009192598A JP2010017185A5 JP 2010017185 A5 JP2010017185 A5 JP 2010017185A5 JP 2009192598 A JP2009192598 A JP 2009192598A JP 2009192598 A JP2009192598 A JP 2009192598A JP 2010017185 A5 JP2010017185 A5 JP 2010017185A5
- Authority
- JP
- Japan
- Prior art keywords
- flavivirus
- virus
- antigen
- subviral particle
- particle according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 22
- 241000710831 Flavivirus Species 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 241000700605 Viruses Species 0.000 claims 12
- 208000001490 Dengue Diseases 0.000 claims 8
- 206010012310 Dengue fever Diseases 0.000 claims 8
- 208000025729 dengue disease Diseases 0.000 claims 8
- 101710204837 Envelope small membrane protein Proteins 0.000 claims 7
- 101710145006 Lysis protein Proteins 0.000 claims 7
- 238000013518 transcription Methods 0.000 claims 6
- 230000035897 transcription Effects 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 241000710842 Japanese encephalitis virus Species 0.000 claims 3
- 241000710888 St. Louis encephalitis virus Species 0.000 claims 3
- 101710085938 Matrix protein Proteins 0.000 claims 2
- 101710127721 Membrane protein Proteins 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/826,115 | 2001-04-04 | ||
| US09/826,115 US7227011B2 (en) | 1998-06-04 | 2001-04-04 | Nucleic acid vaccines for prevention of flavivirus infection |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579516A Division JP4448281B2 (ja) | 2001-04-04 | 2002-04-04 | フラビウイルス感染症の予防のための核酸ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010017185A JP2010017185A (ja) | 2010-01-28 |
| JP2010017185A5 true JP2010017185A5 (enExample) | 2010-10-14 |
| JP5236597B2 JP5236597B2 (ja) | 2013-07-17 |
Family
ID=25245753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579516A Expired - Lifetime JP4448281B2 (ja) | 2001-04-04 | 2002-04-04 | フラビウイルス感染症の予防のための核酸ワクチン |
| JP2009192598A Expired - Fee Related JP5236597B2 (ja) | 2001-04-04 | 2009-08-21 | フラビウイルス感染症の予防のための核酸ワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579516A Expired - Lifetime JP4448281B2 (ja) | 2001-04-04 | 2002-04-04 | フラビウイルス感染症の予防のための核酸ワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US7227011B2 (enExample) |
| EP (3) | EP1383931A4 (enExample) |
| JP (2) | JP4448281B2 (enExample) |
| KR (1) | KR100913984B1 (enExample) |
| CN (2) | CN1304575C (enExample) |
| BR (1) | BRPI0208301B8 (enExample) |
| CA (1) | CA2443323C (enExample) |
| MX (1) | MXPA03008838A (enExample) |
| NZ (1) | NZ529106A (enExample) |
| WO (1) | WO2002081754A1 (enExample) |
| ZA (1) | ZA200307580B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7227011B2 (en) * | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| EP1322655B1 (en) | 2000-01-14 | 2007-11-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US20050031641A1 (en) * | 2001-04-06 | 2005-02-10 | Loosmore Sheena May | Recombinant vaccine against West Nile Virus |
| US7740863B2 (en) * | 2001-04-06 | 2010-06-22 | Merial | Recombinant vaccine against West Nile Virus |
| FR2823222B1 (fr) * | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
| US20040037848A1 (en) * | 2001-04-06 | 2004-02-26 | Audonnet Jean-Christophe Francis | Recombinant vaccine against West Nile Virus |
| KR20090053967A (ko) * | 2001-07-27 | 2009-05-28 | 와이어쓰 | 웨스트 나일 백신 |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| US7351547B2 (en) * | 2002-10-31 | 2008-04-01 | Health Research, Inc. | Diagnostic test for West Nile virus |
| US7785799B2 (en) * | 2002-08-16 | 2010-08-31 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to flavivirus envelope protein domain III antigens |
| US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| JP5250179B2 (ja) | 2002-11-08 | 2013-07-31 | ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド | フラビウイルス融合インヒビター |
| CA2432738A1 (en) * | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
| US8475808B2 (en) | 2003-05-23 | 2013-07-02 | Novartis Vaccines And Diagnostics, Inc. | Immunogenic reagents from west nile virus |
| US7060280B2 (en) * | 2003-06-11 | 2006-06-13 | Academia Sinica | Immunization against flavivirus |
| EP1664786B1 (en) | 2003-09-09 | 2014-11-12 | Idexx Laboratories, Inc. | Detection of west nile virus infection and vaccination |
| US7074555B2 (en) | 2004-04-28 | 2006-07-11 | Idexx Laboratories, Inc. | Detection of West Nile Virus |
| US20080118528A1 (en) * | 2004-05-04 | 2008-05-22 | Tsanyang Jake Liang | Synthesis and Purification of West Nile Virus Virus-Like Particles |
| CN103088038B (zh) * | 2004-07-12 | 2015-06-24 | 美国天甲生物医药有限公司 | 黄病毒疫苗 |
| ATE521627T1 (de) | 2004-07-27 | 2011-09-15 | Us Gov Health & Human Serv | Identifikation kreuzreaktiver epitope des flavivirus-hüllglykoproteins |
| WO2006029300A2 (en) * | 2004-09-09 | 2006-03-16 | Research Development Foundation | Flavivirus variants having phenotypic variation and immunogenic compositions thereof |
| JP4993301B2 (ja) * | 2004-10-20 | 2012-08-08 | サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー | 日本脳炎ウイルスおよび西ナイルウイルスに対するワクチン |
| AU2006232865A1 (en) * | 2005-04-01 | 2006-10-12 | Wyeth | Use of WNV DNA vaccine in combination with a conventional vaccine to overcome immunogen interference |
| KR102017842B1 (ko) | 2005-04-08 | 2019-09-03 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP1896069B1 (en) * | 2005-06-24 | 2013-03-13 | Intervet International BV | Inactivated chimeric vaccines and related methods of use |
| US7455842B2 (en) * | 2005-12-05 | 2008-11-25 | University Of Kansas | Chimeric West Nile viruses and uses thereof |
| US20070190617A1 (en) * | 2006-02-13 | 2007-08-16 | Chang-Jer Wu | DNA vaccine for Japanese encephalitis virus |
| US20080044808A1 (en) * | 2006-08-15 | 2008-02-21 | Qian-Li Song | West nile virus antigen and assay |
| EP2086526B1 (en) * | 2006-11-09 | 2014-07-23 | The United States Of America As Represented By The Secretary of the Navy | Induction of an immune response against Dengue virus using prime-boost approach |
| SI2308514T1 (sl) | 2007-03-23 | 2013-09-30 | To-Bbb Holding B.V. | Konjugati za prenos zdravila preko krvno-moĹľganske pregrade |
| JP2008263964A (ja) * | 2007-03-29 | 2008-11-06 | Yamaguchi Univ | コウモリ由来細胞株 |
| EP2003144A1 (en) * | 2007-06-15 | 2008-12-17 | Institut Pasteur | Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications |
| WO2009024534A2 (en) * | 2007-08-17 | 2009-02-26 | Intercell Ag | Japanese encephalitis virus (jev) and tick-borne encephalitis virus (tbev) peptides stimulating human t cell responses |
| US8138318B2 (en) * | 2007-09-13 | 2012-03-20 | Abbott Laboratories | Hepatitis B pre-S2 nucleic acid |
| KR101686942B1 (ko) * | 2008-01-11 | 2016-12-28 | 이노비오 파마수티컬즈, 인크. | 뎅기 바이러스 다중 서브타입에 대항하는 신규한 백신 |
| WO2009098277A1 (en) * | 2008-02-08 | 2009-08-13 | Intercell Ag | Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines |
| MX2010011373A (es) * | 2008-04-22 | 2010-11-12 | Cytos Biotechnology Ag | Composiciones de vacuna para el tratamiento de la fiebre del dengue y uso de las mismas. |
| CN101333246B (zh) * | 2008-07-30 | 2011-04-13 | 中国农业科学院哈尔滨兽医研究所 | 乙型脑炎病毒e蛋白中和性b细胞抗原表位多肽及其应用 |
| MX2011002071A (es) | 2008-08-29 | 2011-04-05 | Boehringer Ingelheim Vetmed | Vacuna para el virus del nilo occidental. |
| CN101607983B (zh) * | 2009-07-29 | 2012-06-13 | 中国农业科学院哈尔滨兽医研究所 | 乙型脑炎病毒PrM/M蛋白B细胞抗原表位多肽及应用 |
| ES2524975T3 (es) | 2009-07-31 | 2014-12-16 | Ge Healthcare Bio-Sciences Corp. | Cepa del virus de la fiebre amarilla de alto rendimiento con mayor propagación en células |
| US20110182976A1 (en) * | 2010-01-28 | 2011-07-28 | National Taiwan Ocean University | Lipoplex-patch based dna vaccine |
| CN102906266A (zh) | 2010-05-21 | 2013-01-30 | 高等教育联邦系统-匹兹堡大学 | 登革病毒通用序列及其使用方法 |
| AR079970A1 (es) * | 2010-07-23 | 2012-02-29 | Xcellerex Inc | Cepas de alto rendimiento del virus de la fiebre amarilla con una propagacion incrementada en las celulas |
| WO2012065105A2 (en) * | 2010-11-12 | 2012-05-18 | Thomas Monath | Chimeric flavivirus vaccines |
| EP2772266B1 (en) | 2011-03-14 | 2019-07-31 | Boehringer Ingelheim Animal Health USA Inc. | Equine Rhinitis vaccine |
| EP3269728B1 (en) | 2011-10-20 | 2020-12-16 | The Government of The United States of America as represented by The Secretary, Department of Health and Human Services | Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes |
| US8920804B2 (en) | 2011-12-22 | 2014-12-30 | Inbios International, Inc. | Methods and materials for the detection of dengue virus infection |
| US20150265695A1 (en) * | 2012-07-24 | 2015-09-24 | Sanofi Pasteur | Vaccine compositions for prevention against dengue virus infection |
| TWI852899B (zh) | 2014-09-02 | 2024-08-21 | 法商賽諾菲巴斯德公司 | 疫苗組合物 |
| EP3031923A1 (en) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| CN104630160B (zh) * | 2015-01-23 | 2018-04-27 | 中国农业科学院哈尔滨兽医研究所 | 表达西尼罗热病毒PrM/E蛋白的重组新城疫LaSota疫苗株 |
| EP3316905A1 (en) | 2015-07-03 | 2018-05-09 | Sanofi Pasteur | Concomitant dengue and yellow fever vaccination |
| US11007260B2 (en) * | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
| US10947277B2 (en) | 2016-06-13 | 2021-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding zika virus-like particles and their use in zika virus vaccines and diagnostic assays |
| US20180028643A1 (en) * | 2016-06-21 | 2018-02-01 | Brock Adam Kingstad-Bakke | Zika virus vaccines using virus-like particles |
| US10898566B2 (en) | 2016-09-19 | 2021-01-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Zika virus vaccines |
| EP4043031A3 (en) * | 2016-11-17 | 2022-11-23 | GlaxoSmithKline Biologicals SA | Zika viral antigen constructs |
| WO2018152526A1 (en) | 2017-02-20 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Zika virus vaccines |
| US11690903B2 (en) | 2017-10-05 | 2023-07-04 | Sanofi Pasteur | Compositions for booster vaccination against dengue |
| WO2019162454A1 (en) * | 2018-02-22 | 2019-08-29 | Euroimmun Medizinische Labordiagnostika Ag | Assay for the diagnosis of viral infections |
| EP3530668A1 (en) * | 2018-02-22 | 2019-08-28 | Euroimmun Medizinische Labordiagnostika AG | A novel assay for the diagnosis of viral infections |
| CN113372441B (zh) * | 2018-04-04 | 2023-03-10 | 中国科学院微生物研究所 | 一种高灵敏度的黄热病毒人源单克隆抗体及其应用 |
| CN108904793B (zh) * | 2018-07-29 | 2021-03-30 | 首都医科大学附属北京友谊医院 | 预防流行性乙型脑炎的dna疫苗及其构建方法 |
| CA3124373A1 (en) * | 2018-12-20 | 2020-06-25 | The Wistar Institute Of Anatomy And Biology | Vaccines against powassan virus, and methods of using same |
| US20250276051A1 (en) * | 2019-12-18 | 2025-09-04 | Geneone Life Science, Inc. | Powassan viral antigens and related compositions, and uses thereof to vaccinate and treat patients |
| KR102216078B1 (ko) * | 2020-04-22 | 2021-02-16 | 국방과학연구소 | 유전자 백신으로 사용하기 위한 항원 유전자 전달용 발현 벡터 및 이를 포함하는 유전자 백신 |
| WO2021262659A1 (en) * | 2020-06-22 | 2021-12-30 | University Of Connecticut | Flavivirus signal peptides, vaccine constructs, and methods therefor |
| WO2024097725A1 (en) * | 2022-11-02 | 2024-05-10 | Takeda Vaccines, Inc. | A method for determining the infectivity of a virus |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1601438A (enExample) | 1968-10-17 | 1970-08-24 | ||
| JPS53133627A (en) | 1977-04-25 | 1978-11-21 | Nippon Seibutsu Kagaku Kenkiyu | High purity deactivated vaccine for japanese encephalitis |
| JPH0768267B2 (ja) * | 1986-06-05 | 1995-07-26 | 財団法人阪大微生物病研究会 | フラビウイルス抗原 |
| JPS634895A (ja) | 1986-06-24 | 1988-01-09 | Mitsubishi Electric Corp | オゾン精製水供給装置 |
| JPS63105682A (ja) | 1986-10-23 | 1988-05-10 | Mitsubishi Kasei Corp | デングウイルス３型由来のｃＤＮＡ |
| FR2614219B1 (fr) | 1987-04-23 | 1993-07-09 | Materiels Annexes Dialyse | Procede de fabrication de granules destines a la preparation de solutions de dialyse et installation pour sa mise en oeuvre. |
| JPH084508B2 (ja) | 1987-09-16 | 1996-01-24 | 国立予防衛生研究所長 | 組み換えワクチニアウイルス |
| US4783502A (en) | 1987-12-03 | 1988-11-08 | Ppg Industries, Inc. | Stable nonaqueous polyurethane microparticle dispersion |
| JP2511494B2 (ja) | 1988-05-12 | 1996-06-26 | 善治 松浦 | 日本脳炎ウイルス表面抗原蛋白質の製造法 |
| IL91304A0 (en) | 1988-08-20 | 1990-03-19 | Us Health | Recombinant vaccinia virus for prevention of disease caused by flavivirus |
| JPH0425408A (ja) | 1990-05-21 | 1992-01-29 | Hitachi Ltd | ペレタイジングシステムの自動連続運転制御方法 |
| FR2665710A1 (fr) | 1990-08-10 | 1992-02-14 | Pasteur Institut | Baculovirus recombinant exprimant les proteines e et ns1 de virus appartenant aux flaviviridae ou de virus apparentes aux flaviviridae, applications diagnostiques et therapeutiques. |
| US5514375A (en) | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| MY109299A (en) | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| US5494671A (en) | 1990-08-27 | 1996-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | C-terminally truncated dengue and Japanese encephalitis virus envelope proteins |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2140418T3 (es) * | 1991-09-19 | 2000-03-01 | Us Health | Flavivirus quimericos y/o flavivirus de crecimiento restringido. |
| JPH05276941A (ja) | 1992-02-28 | 1993-10-26 | Nippon Zeon Co Ltd | フラビウイルス科に属するウイルスの表面抗原タンパク質を含む非感染性の構造物粒子の製造方法 |
| JPH07265093A (ja) | 1994-03-30 | 1995-10-17 | Chemo Sero Therapeut Res Inst | 哺乳動物細胞を用いる日本脳炎ウイルス表面抗原蛋白質の製法 |
| US6136561A (en) * | 1995-05-24 | 2000-10-24 | Hawaii Biotechnology Group, Inc. | Methods of preparing carboxy-terminally truncated recombinant flavivirus envelope glycoproteins employing drosophila melanogaster expression systems |
| ATE227584T1 (de) | 1995-05-24 | 2002-11-15 | Hawaii Biotech Group | Untereinheitsimpfstoff gegen flavivirus infektion |
| US6074865A (en) * | 1995-07-20 | 2000-06-13 | The United States Of America As Represented By The Secretary Of The Army | Recombinant dengue virus DNA fragment |
| US6455509B1 (en) * | 1996-06-04 | 2002-09-24 | The United States Of America As Represented By The Secretary Of The Navy | Dengue nucleic acid vaccines that induce neutralizing antibodies |
| US6962708B1 (en) * | 1997-02-28 | 2005-11-08 | Acambis, Inc. | Chimeric flavivirus vaccines |
| DE69830579T2 (de) * | 1997-02-28 | 2006-05-04 | Acambis, Inc., Cambridge | Chimäre impfstoffe gegen flaviviren |
| EP1005363B1 (en) | 1997-07-31 | 2006-03-29 | Hawaii Biotech, Inc. | Recombinant dimeric envelope vaccine against flaviviral infection |
| EP1047448B1 (en) | 1997-11-20 | 2006-02-01 | United States Army Medical Research and Materiel Command | Dna vaccines against tick-borne flaviviruses |
| IL139844A0 (en) | 1998-06-04 | 2002-02-10 | Us Gov Health & Human Serv | Nucleic acid vaccines for prevention of flavivirus infection |
| US7227011B2 (en) * | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
| WO2002083903A2 (en) | 2001-02-28 | 2002-10-24 | Brown University Research Foundation | West nile virus epitopes and uses thereof |
| AU2002309508A1 (en) | 2001-03-12 | 2002-09-24 | L2 Diagnostics, Llc | Compositions and methods comprising west nile virus polypeptides |
-
2001
- 2001-04-04 US US09/826,115 patent/US7227011B2/en not_active Expired - Lifetime
-
2002
- 2002-04-04 BR BRPI0208301-9 patent/BRPI0208301B8/pt not_active IP Right Cessation
- 2002-04-04 EP EP02763960A patent/EP1383931A4/en not_active Withdrawn
- 2002-04-04 EP EP10177282.0A patent/EP2332572B1/en not_active Expired - Lifetime
- 2002-04-04 KR KR1020037013021A patent/KR100913984B1/ko not_active Expired - Lifetime
- 2002-04-04 CN CNB02807758XA patent/CN1304575C/zh not_active Expired - Lifetime
- 2002-04-04 CA CA2443323A patent/CA2443323C/en not_active Expired - Lifetime
- 2002-04-04 NZ NZ529106A patent/NZ529106A/en not_active IP Right Cessation
- 2002-04-04 US US10/500,796 patent/US7662394B2/en not_active Expired - Lifetime
- 2002-04-04 CN CNA2007100020999A patent/CN101002936A/zh active Pending
- 2002-04-04 MX MXPA03008838A patent/MXPA03008838A/es active IP Right Grant
- 2002-04-04 WO PCT/US2002/010764 patent/WO2002081754A1/en not_active Ceased
- 2002-04-04 JP JP2002579516A patent/JP4448281B2/ja not_active Expired - Lifetime
- 2002-04-04 EP EP08004141A patent/EP1935991B1/en not_active Expired - Lifetime
-
2003
- 2003-09-29 ZA ZA2003/07580A patent/ZA200307580B/en unknown
-
2006
- 2006-06-14 US US11/424,127 patent/US7521177B2/en not_active Expired - Fee Related
- 2006-06-14 US US11/424,138 patent/US7632510B2/en not_active Expired - Lifetime
-
2009
- 2009-07-24 US US12/508,946 patent/US8232379B2/en not_active Expired - Fee Related
- 2009-08-21 JP JP2009192598A patent/JP5236597B2/ja not_active Expired - Fee Related
- 2009-10-15 US US12/580,080 patent/US8221768B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010017185A5 (enExample) | ||
| Martinez-Flores et al. | SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants | |
| Yong et al. | Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus | |
| US11826416B2 (en) | Induce and enhance immune responses using recombinant replicon systems | |
| Boyoglu-Barnum et al. | Biology of infection and disease pathogenesis to guide RSV vaccine development | |
| JP6797275B2 (ja) | フラビウイルスワクチン接種のための組成物及び方法 | |
| JP2004532023A5 (enExample) | ||
| JP2016501015A5 (ja) | デングウイルス血清型４（ｄｅｎ−４）構築物に関する組成物、方法および使用 | |
| JP2008529558A5 (enExample) | ||
| JP2008508859A5 (enExample) | ||
| JP2013542224A5 (enExample) | ||
| JP2019151636A5 (enExample) | ||
| JP2010522540A5 (enExample) | ||
| JP2015524422A5 (enExample) | ||
| HUP0002139A2 (hu) | Kiméra flavivírus-vakcinák | |
| FI3539565T3 (fi) | Koostumuksia ja menetelmiä dengue-viruksen kimeerisille rakenteille rokotteissa | |
| JP2014529399A5 (enExample) | ||
| JP2014513952A5 (enExample) | ||
| JP2009504654A5 (enExample) | ||
| WO2004085633A8 (en) | A novel human virus causing severe acute respiratory syndrome (sars) and uses thereof | |
| JP2019511221A (ja) | 弱毒化された生ジカウイルスワクチン | |
| JP2016504315A5 (enExample) | ||
| JP2005510244A5 (enExample) | ||
| ES2637629T3 (es) | Inducción de una respuesta inmunitaria frente al virus del dengue usando un enfoque de sensibilización-refuerzo | |
| JP2019535291A5 (enExample) |