JP2009544969A - 検体を捕捉することが可能なキャピラリー用コーティング - Google Patents
検体を捕捉することが可能なキャピラリー用コーティング Download PDFInfo
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- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
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- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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| PCT/US2007/016626 WO2008013801A2 (en) | 2006-07-24 | 2007-07-23 | Coatings for capillaries capable of capturing analytes |
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Cited By (2)
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Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7846676B2 (en) * | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US8945361B2 (en) | 2005-09-20 | 2015-02-03 | ProteinSimple | Electrophoresis standards, methods and kits |
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| US9182411B2 (en) * | 2009-07-14 | 2015-11-10 | Colen Innovations, L.L.C. | Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample |
| DE102009047802B4 (de) * | 2009-09-30 | 2012-07-05 | Siemens Aktiengesellschaft | Vorrichtung zum Filtern eines oder mehrerer nachzuweisender Partikel aus einem Fluid |
| US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
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| JP5701894B2 (ja) | 2009-11-23 | 2015-04-15 | サイヴェク・インコーポレイテッド | アッセイを行う方法及び装置 |
| US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
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| US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
| CN106552682B (zh) | 2011-03-22 | 2020-06-19 | 西维克公司 | 微流体装置以及制造方法和用途 |
| EP2724163B1 (en) * | 2011-06-24 | 2017-08-09 | The Regents of The University of California | Microfluidic devices and methods for separating and detecting constituents in a fluid sample |
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| US9804079B2 (en) | 2012-04-19 | 2017-10-31 | ProteinSimple | Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates |
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| US9303239B2 (en) | 2013-02-27 | 2016-04-05 | Shimadzu Corporation | Method for cleaning microfluidic device and cleaning liquid |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523499A (ja) * | 1999-01-12 | 2003-08-05 | スペクトラメディックス コーポレイション | キャピラリーゲル電気泳動のためのコポリマー |
| JP2004501994A (ja) * | 2000-06-30 | 2004-01-22 | アンスティテュ キュリィ | 吸着及び／又は電気浸透現象を最小限化する表面処理溶液 |
| WO2005033158A2 (en) * | 2003-10-01 | 2005-04-14 | Surmodics, Inc. | Attachment of molecules to surfaces |
| JP2005534749A (ja) * | 2002-07-29 | 2005-11-17 | アプレラ コーポレイション | グラフト共重合体、それらの調製、およびキャピラリー電気泳動での使用 |
| WO2006014680A1 (en) * | 2004-07-19 | 2006-02-09 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US514753A (en) | 1894-02-13 | Horseshoe | ||
| US309593A (en) * | 1884-12-23 | Refrigerator | ||
| CH594444A5 (https=) * | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
| US4843010A (en) * | 1983-11-10 | 1989-06-27 | Genetic Systems Corporation | Polymerization-induced separation immunoassays |
| US4921790A (en) * | 1987-04-24 | 1990-05-01 | Research Corporation | Tumor specific assay for CA125 ovarian cancer antigen |
| US4788138A (en) * | 1987-04-30 | 1988-11-29 | Beckman Instruments, Inc. | Method to achieve a linear standard curve in a sandwich immunoassay |
| US4870003A (en) * | 1987-06-15 | 1989-09-26 | Coulter Corporation | Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans |
| US6300101B1 (en) * | 1988-10-24 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions including a 13kD B. burgdorferi protein |
| US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5858188A (en) * | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5143753A (en) | 1990-10-26 | 1992-09-01 | Indiana University Foundation | Suppression of electroosmosis with hydrolytically stable coatings |
| US5074982A (en) | 1990-10-26 | 1991-12-24 | Indiana University Foundation | Suppression of electroosmosis with hydrolytically stable coatings |
| US5110434A (en) * | 1990-12-20 | 1992-05-05 | Bio-Rad Laboratories, Inc. | Use of zwitterions to mobilize isoelectrically focused ampholyte zones |
| US5244813A (en) * | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
| AU658257B2 (en) * | 1991-10-31 | 1995-04-06 | Matritech, Inc. | Nuclear matrix protein fluid assay |
| US5213669A (en) | 1992-01-31 | 1993-05-25 | Beckman Instruments, Inc. | Capillary column containing a dynamically cross-linked composition and method of use |
| US5759369A (en) | 1992-09-24 | 1998-06-02 | The Perkin-Elmer Corporation | Viscous electrophoresis polymer medium and method |
| US5290418A (en) | 1992-09-24 | 1994-03-01 | Applied Biosystems, Inc. | Viscous electrophoresis polymer medium and method |
| DK0591914T4 (da) * | 1992-10-06 | 2010-05-25 | Siemens Healthcare Diagnostics | Retrovirus fra HIV-gruppen og dets anvendelse |
| US5376249A (en) * | 1992-11-25 | 1994-12-27 | Perseptive Biosystems, Inc. | Analysis utilizing isoelectric focusing |
| AU1254295A (en) | 1993-12-17 | 1995-07-03 | Perkin-Elmer Corporation, The | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
| US6358385B1 (en) * | 1993-12-17 | 2002-03-19 | The Perkin-Elmer Corporation | Polymers for separation of biomolecules by capillary electrophoresis |
| US6355709B1 (en) | 1993-12-17 | 2002-03-12 | The Perkin-Elmer Corporation | Polymers for separation of biomolecules by capillary electrophoresis |
| US5976896A (en) * | 1994-06-06 | 1999-11-02 | Idexx Laboratories, Inc. | Immunoassays in capillary tubes |
| DE69633962T2 (de) * | 1995-01-27 | 2005-12-01 | Northeastern University, Boston | Verfahren zum Bilden einer kovalent gebundenen hydrophilen Schicht auf Basis von Polyvinyl-Alkohol für die Kapillarelektrophorese |
| WO1997017384A1 (en) * | 1995-11-08 | 1997-05-15 | Kirkpatrick Francis H | Methods and reagents for gel electrophoresis |
| US5830539A (en) * | 1995-11-17 | 1998-11-03 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for functionalizing and coating substrates and devices made according to the methods |
| US5798035A (en) * | 1996-10-03 | 1998-08-25 | Pharmacopeia, Inc. | High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay |
| US5804384A (en) * | 1996-12-06 | 1998-09-08 | Vysis, Inc. | Devices and methods for detecting multiple analytes in samples |
| US6100045A (en) * | 1997-02-10 | 2000-08-08 | Dsm N.V. | Detection of analytes using electrochemistry |
| EP0898162A1 (en) * | 1997-08-20 | 1999-02-24 | Suzuki Motor Corporation | Immunoassay apparatus |
| US6054032A (en) * | 1998-01-27 | 2000-04-25 | 3M Innovative Properties Company | Capillary electrophoresis array |
| CA2306752C (en) * | 1998-08-14 | 2008-11-18 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Chemiluminescent reagent and chemiluminescent analysis using the same |
| EP1006355A3 (en) * | 1998-11-30 | 2000-11-08 | The Institute of Physical and Chemical Research | Capillary electrophoretic apparatus |
| EP1159605B1 (en) * | 1999-02-02 | 2012-07-11 | Caliper Life Sciences, Inc. | Methods for characterizing proteins |
| DE60044491D1 (de) * | 1999-02-12 | 2010-07-15 | Univ Louisville Res Found | Dihydroouabain-ähnlicher faktor, diagnostische und therapeutische verbindungen und methoden |
| US6326083B1 (en) * | 1999-03-08 | 2001-12-04 | Calipher Technologies Corp. | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety |
| US6375817B1 (en) * | 1999-04-16 | 2002-04-23 | Perseptive Biosystems, Inc. | Apparatus and methods for sample analysis |
| US6423536B1 (en) * | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
| US6716629B2 (en) * | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| WO2002052045A1 (en) * | 2000-12-26 | 2002-07-04 | Aviva Biosciences | Active and biocompatible platforms prepared by polymerization of surface coating films |
| US7083987B2 (en) * | 2001-02-05 | 2006-08-01 | Activx Biosciences, Inc. | Activity based probe analysis |
| US6878256B2 (en) * | 2001-04-02 | 2005-04-12 | Hitachi, Ltd. | Capillary array device |
| US20050176070A1 (en) * | 2001-04-05 | 2005-08-11 | Auton Kevin A. | Protein analysis |
| WO2002089972A1 (en) | 2001-05-03 | 2002-11-14 | Commissariat A L'energie Atomique | Microfluidic device for analyzing nucleic acids and/or proteins, methods of preparation and uses thereof |
| US7374724B2 (en) * | 2001-05-29 | 2008-05-20 | Tecan Trading Ag | Device for processing samples, use of the device, and method for producing the device |
| JP3935487B2 (ja) * | 2001-07-16 | 2007-06-20 | フーベルト・ケスター | 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法 |
| US20030181826A1 (en) * | 2001-12-04 | 2003-09-25 | Dave Smith | Hydrophobic/hydrophilic sample collection tip |
| US6864480B2 (en) * | 2001-12-19 | 2005-03-08 | Sau Lan Tang Staats | Interface members and holders for microfluidic array devices |
| EP1487568A4 (en) * | 2002-03-12 | 2005-10-05 | Syngenta Participations Ag | Microcapillaries Hybridization Chamber |
| US7010964B2 (en) * | 2002-10-31 | 2006-03-14 | Nanostream, Inc. | Pressurized microfluidic devices with optical detection regions |
| EP2259068B1 (en) * | 2003-01-16 | 2013-08-14 | caprotec bioanalytics GmbH | Capture compounds and methods for analyzing the proteome |
| US20040181443A1 (en) * | 2003-03-10 | 2004-09-16 | Horton Carl A. | Method and apparatus for the management of infrastructure assets, work orders,service requests, and work flows, utilizing an integrated call center, database, GIS system, and wireless handheld device |
| US7635734B2 (en) * | 2004-02-17 | 2009-12-22 | The Children's Hospital Of Philadelphia | Photochemical activation of surfaces for attaching biomaterial |
| WO2004099378A2 (en) * | 2003-04-30 | 2004-11-18 | Aurora Discovery, Inc. | Automated laboratory for high-throughput biological assays and rna interference |
| DE10343900A1 (de) * | 2003-09-19 | 2005-04-21 | Basf Ag | Verwendung von N-Vinyllactam enthaltenden Copolymeren zur Herstellung von funktionalisierten Membranen |
| CN101189271A (zh) * | 2004-02-13 | 2008-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 制造微流体设备的功能材料和新型方法 |
| US7382258B2 (en) * | 2004-03-19 | 2008-06-03 | Applera Corporation | Sample carrier device incorporating radio frequency identification, and method |
| US7846676B2 (en) * | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US20060292558A1 (en) * | 2004-07-19 | 2006-12-28 | Cell Biosciences Inc. | Methods and apparatus for protein assay diagnostics |
| US20060292649A1 (en) * | 2004-07-19 | 2006-12-28 | Cell Biosciences Inc. | Methods and apparatus for reference lab diagnostics |
| US7807750B2 (en) * | 2004-08-06 | 2010-10-05 | Surmodics, Inc. | Thermally-reactive polymers |
| JP2008530540A (ja) * | 2005-02-10 | 2008-08-07 | コミサリア ア レネルジィ アトミーク | 支持体への生体分子の光化学的結合のための方法 |
| US8945361B2 (en) * | 2005-09-20 | 2015-02-03 | ProteinSimple | Electrophoresis standards, methods and kits |
| US7640078B2 (en) * | 2006-07-05 | 2009-12-29 | Advanced Energy Industries, Inc. | Multi-mode control algorithm |
| US20090023156A1 (en) * | 2007-07-20 | 2009-01-22 | Voss Karl O | Methods and reagents for quantifying analytes |
-
2007
- 2007-01-16 US US11/654,143 patent/US20080017512A1/en not_active Abandoned
- 2007-07-23 EP EP07836214A patent/EP2049652A4/en not_active Withdrawn
- 2007-07-23 EP EP13183395.6A patent/EP2713158A1/en not_active Withdrawn
- 2007-07-23 JP JP2009521800A patent/JP2009544969A/ja active Pending
- 2007-07-23 WO PCT/US2007/016626 patent/WO2008013801A2/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523499A (ja) * | 1999-01-12 | 2003-08-05 | スペクトラメディックス コーポレイション | キャピラリーゲル電気泳動のためのコポリマー |
| JP2004501994A (ja) * | 2000-06-30 | 2004-01-22 | アンスティテュ キュリィ | 吸着及び／又は電気浸透現象を最小限化する表面処理溶液 |
| JP2005534749A (ja) * | 2002-07-29 | 2005-11-17 | アプレラ コーポレイション | グラフト共重合体、それらの調製、およびキャピラリー電気泳動での使用 |
| WO2005033158A2 (en) * | 2003-10-01 | 2005-04-14 | Surmodics, Inc. | Attachment of molecules to surfaces |
| WO2006014680A1 (en) * | 2004-07-19 | 2006-02-09 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
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| JP2016517509A (ja) * | 2013-03-07 | 2016-06-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 電気泳動分離装置およびそれを使用するための方法 |
| JP2021123712A (ja) * | 2020-01-31 | 2021-08-30 | 国立研究開発法人物質・材料研究機構 | 組成物、硬化膜、積層体、船舶、水中構造物、医療デバイス、及び、マイクロ流路チップ |
| JP7656895B2 (ja) | 2020-01-31 | 2025-04-04 | 国立研究開発法人物質・材料研究機構 | 組成物、硬化膜、積層体、船舶、水中構造物、医療デバイス、及び、マイクロ流路チップ |
| JP2025063156A (ja) * | 2020-01-31 | 2025-04-15 | 国立研究開発法人物質・材料研究機構 | 高分子化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2713158A1 (en) | 2014-04-02 |
| EP2049652A2 (en) | 2009-04-22 |
| WO2008013801A3 (en) | 2008-06-26 |
| WO2008013801A2 (en) | 2008-01-31 |
| EP2049652A4 (en) | 2010-07-21 |
| US20080017512A1 (en) | 2008-01-24 |
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