JP2009542815A5 - - Google Patents
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- Publication number
- JP2009542815A5 JP2009542815A5 JP2009519604A JP2009519604A JP2009542815A5 JP 2009542815 A5 JP2009542815 A5 JP 2009542815A5 JP 2009519604 A JP2009519604 A JP 2009519604A JP 2009519604 A JP2009519604 A JP 2009519604A JP 2009542815 A5 JP2009542815 A5 JP 2009542815A5
- Authority
- JP
- Japan
- Prior art keywords
- ylamino
- methoxyquinolin
- group
- dichloropyridin
- cyclopentyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81950906P | 2006-07-07 | 2006-07-07 | |
| US60/819,509 | 2006-07-07 | ||
| US88682507P | 2007-01-26 | 2007-01-26 | |
| US60/886,825 | 2007-01-26 | ||
| PCT/US2007/072919 WO2008006050A2 (en) | 2006-07-07 | 2007-07-06 | Bicyclic heteroaryl inhibitors of pde4 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013107844A Division JP5705269B2 (ja) | 2006-07-07 | 2013-05-22 | Pde4の二環式ヘテロアリール阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542815A JP2009542815A (ja) | 2009-12-03 |
| JP2009542815A5 true JP2009542815A5 (https=) | 2010-08-26 |
| JP5280357B2 JP5280357B2 (ja) | 2013-09-04 |
Family
ID=38739981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519604A Expired - Fee Related JP5280357B2 (ja) | 2006-07-07 | 2007-07-06 | Pde4の二環式ヘテロアリール阻害剤 |
| JP2013107844A Expired - Fee Related JP5705269B2 (ja) | 2006-07-07 | 2013-05-22 | Pde4の二環式ヘテロアリール阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013107844A Expired - Fee Related JP5705269B2 (ja) | 2006-07-07 | 2013-05-22 | Pde4の二環式ヘテロアリール阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8080563B2 (https=) |
| EP (1) | EP2037924A2 (https=) |
| JP (2) | JP5280357B2 (https=) |
| KR (2) | KR20090109527A (https=) |
| CN (1) | CN104606194A (https=) |
| AU (1) | AU2007269070B2 (https=) |
| BR (1) | BRPI0713253A2 (https=) |
| CA (1) | CA2657093A1 (https=) |
| CO (1) | CO6190532A2 (https=) |
| MX (1) | MX2009000148A (https=) |
| WO (3) | WO2008006052A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| CA2601777A1 (en) * | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| AU2009239430B2 (en) | 2008-04-21 | 2015-01-22 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| CN101353338B (zh) * | 2008-07-10 | 2011-05-04 | 上海交通大学 | 糖胺改性的水溶性香豆素酮衍生物及其制备方法 |
| CN102548536A (zh) * | 2009-10-01 | 2012-07-04 | 爱尔康研究有限公司 | 奥洛他定组合物及其用途 |
| CA2796826A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bifunctional quinoline derivatives |
| UY33373A (es) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?. |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
| EP2956138B1 (en) | 2013-02-15 | 2022-06-22 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| MX368903B (es) | 2013-02-20 | 2019-10-21 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos en el tratamiento de enfermedades proliferativas. |
| US9458169B2 (en) | 2013-11-01 | 2016-10-04 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| WO2016012896A1 (en) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| MD20170011A2 (ro) | 2014-08-06 | 2017-08-31 | Pfizer Inc. | Compuşi imidazopiridazinici |
| JP6740354B2 (ja) | 2015-10-05 | 2020-08-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | オートファジーの流れ及びホスホリパーゼd及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法 |
| MX383072B (es) | 2015-12-24 | 2025-03-13 | Univ California | Reguladores del cftr y métodos para su uso |
| US10336767B2 (en) | 2016-09-08 | 2019-07-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| AU2017324713B2 (en) | 2016-09-08 | 2020-08-13 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| CN106916104B (zh) * | 2017-02-28 | 2019-08-27 | 牡丹江医学院 | 用于治疗结肠炎的药物 |
| AU2018307730B9 (en) | 2017-07-26 | 2024-02-15 | Hg&H Pharmaceuticals (Pty) Ltd | Mesembrenol and/or mesembranol for prophylaxis and treatment of patients suffering from epilepsy and associated diseases |
| JP2020531511A (ja) | 2017-08-24 | 2020-11-05 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 眼球用医薬組成物 |
| CA3127357A1 (en) * | 2019-01-23 | 2020-07-30 | Path Therapeutics, Inc. | Methods of treating epilepsy via phosphodiesterase 4 (pde4) inhibition |
| US20220371990A1 (en) * | 2019-09-08 | 2022-11-24 | Hadasit Medical Research Services And Developmect Ltd. | Anti-fibrotic compounds and use thereof |
| IL300628A (en) * | 2020-09-10 | 2023-04-01 | Vanda Pharmaceuticals Inc | Methods for the treatment of cyclic diseases or conditions-PDE IV |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US542104A (en) * | 1895-07-02 | Nut-sheller | ||
| AU639529B2 (en) | 1987-03-04 | 1993-07-29 | Higuchi, Yoshinari | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
| ES2059828T3 (es) * | 1988-01-15 | 1994-11-16 | Abbott Lab | Un procedimiento para la preparacion de un compuesto. |
| EP0549729B1 (en) * | 1990-09-07 | 1997-12-17 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
| US5430153A (en) | 1991-04-03 | 1995-07-04 | Korea Research Institute Of Chemical Technology | 2-quinolinone derivatives |
| AU5626494A (en) | 1992-11-27 | 1994-06-22 | Byk Nederland Bv | Nitroxy compounds with pharmaceutical properties |
| FR2703683B1 (fr) | 1993-04-08 | 1995-07-07 | Seractec | Dérivés d'aminocoumarines hydrophobes, et leur utilisation comme substrats d'enzymes protéolytiques ou pour la préparation de tels substrats. |
| FR2711992A1 (fr) | 1993-11-03 | 1995-05-12 | Lipha | Nouveaux dérivé hétérocycliques, procédé de préparation et composition pharmaceutique les contenant. |
| DE4337906A1 (de) | 1993-11-08 | 1995-05-11 | Cassella Ag | Verwendung von Cumarinderivaten |
| US5563280A (en) * | 1994-07-25 | 1996-10-08 | American Cyanamid Co. | 4-Phenoxycoumarins as herbicidal agents |
| EP0861242B1 (en) * | 1995-10-13 | 2001-05-30 | Aventis CropScience UK Limited | Heterocyclic fungicides |
| IT1296985B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| US20040081959A9 (en) * | 1999-12-08 | 2004-04-29 | Epoch Biosciences, Inc. | Fluorescent quenching detection reagents and methods |
| MY134008A (en) * | 1999-12-22 | 2007-11-30 | Merck Frosst Canada Inc | Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors |
| US6436971B2 (en) * | 2000-02-09 | 2002-08-20 | Smithkline Beecham Corporation | Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection |
| DE10021256A1 (de) * | 2000-04-20 | 2001-10-31 | Forschungsverbund Berlin Ev | Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
| DE60115069T2 (de) | 2000-09-11 | 2006-08-03 | Chiron Corp., Emeryville | Chinolinonderivate als tyrosin-kinase inhibitoren |
| US6740666B2 (en) * | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
| JP2002371078A (ja) | 2001-06-12 | 2002-12-26 | Sankyo Co Ltd | キノリン誘導体及びキノロン誘導体 |
| JP2003146972A (ja) * | 2001-11-14 | 2003-05-21 | Teikoku Hormone Mfg Co Ltd | カルボスチリル誘導体 |
| US6822097B1 (en) | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| US7148253B2 (en) * | 2002-05-14 | 2006-12-12 | Xtl Biopharmaceuticals Ltd. | 4-thio coumarins |
| EP1504000A4 (en) | 2002-05-14 | 2006-08-23 | Vivoquest Inc | 4-THIO COUMARINES |
| WO2004011446A1 (en) * | 2002-07-26 | 2004-02-05 | Bayer Pharmaceuticals Corporation | Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics |
| EP1539754A4 (en) | 2002-08-23 | 2009-02-25 | Novartis Vaccines & Diagnostic | BENZIMIDAZOCHINOLINONE AND ITS USE |
| CN1506359A (zh) * | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
| ITMI20022739A1 (it) * | 2002-12-23 | 2004-06-24 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4. |
| MXPA06002876A (es) * | 2003-09-15 | 2006-06-05 | Signal Pharm Llc | Compuestos de benzopiranona, composiciones de los mismos y metodos de tratamiento que los utilizan. |
| EP1718306A2 (en) | 2004-02-20 | 2006-11-08 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
| CA2565599C (en) * | 2004-05-18 | 2012-07-31 | Schering Corporation | Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors |
| ATE474833T1 (de) | 2004-09-22 | 2010-08-15 | Janssen Pharmaceutica Nv | Inhibitoren der wechselwirkung zwischen mdm2 und p53 |
| WO2006083692A2 (en) | 2005-01-28 | 2006-08-10 | Mount Sinai Schoool Of Medicine | Methods of identifying modulators of bromodomains |
| NL1028569C2 (nl) | 2005-03-18 | 2006-09-20 | Rademaker Holding B V | Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, alsmede kattenvoer. |
| US8048889B2 (en) * | 2005-03-29 | 2011-11-01 | Xtl Biopharmaceuticals Ltd. | 3,4-disubstituted coumarin and quinolone compounds |
| DK1928457T3 (da) | 2005-09-30 | 2013-02-04 | Pulmagen Therapeutics Asthma Ltd | Quinoliner og deres terapeutiske anvendelse |
| US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
-
2007
- 2007-07-06 CA CA002657093A patent/CA2657093A1/en not_active Abandoned
- 2007-07-06 EP EP07812666A patent/EP2037924A2/en not_active Withdrawn
- 2007-07-06 WO PCT/US2007/072924 patent/WO2008006052A2/en not_active Ceased
- 2007-07-06 AU AU2007269070A patent/AU2007269070B2/en not_active Ceased
- 2007-07-06 WO PCT/US2007/072920 patent/WO2008006051A2/en not_active Ceased
- 2007-07-06 US US12/307,730 patent/US8080563B2/en not_active Expired - Fee Related
- 2007-07-06 MX MX2009000148A patent/MX2009000148A/es active IP Right Grant
- 2007-07-06 WO PCT/US2007/072919 patent/WO2008006050A2/en not_active Ceased
- 2007-07-06 BR BRPI0713253-0A patent/BRPI0713253A2/pt not_active IP Right Cessation
- 2007-07-06 KR KR1020097002141A patent/KR20090109527A/ko not_active Abandoned
- 2007-07-06 US US12/307,738 patent/US20090291950A1/en not_active Abandoned
- 2007-07-06 JP JP2009519604A patent/JP5280357B2/ja not_active Expired - Fee Related
- 2007-07-06 KR KR1020147036033A patent/KR20150004441A/ko not_active Ceased
- 2007-07-06 US US11/774,058 patent/US7745646B2/en not_active Expired - Fee Related
- 2007-07-06 CN CN201410768897.2A patent/CN104606194A/zh active Pending
- 2007-07-06 US US11/774,053 patent/US8258154B2/en not_active Expired - Fee Related
-
2009
- 2009-02-04 CO CO09010461A patent/CO6190532A2/es active IP Right Grant
-
2012
- 2012-06-28 US US13/536,716 patent/US9078887B2/en not_active Expired - Fee Related
-
2013
- 2013-05-22 JP JP2013107844A patent/JP5705269B2/ja not_active Expired - Fee Related
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