JP2009542815A5 - - Google Patents

Download PDF

Info

Publication number
JP2009542815A5
JP2009542815A5 JP2009519604A JP2009519604A JP2009542815A5 JP 2009542815 A5 JP2009542815 A5 JP 2009542815A5 JP 2009519604 A JP2009519604 A JP 2009519604A JP 2009519604 A JP2009519604 A JP 2009519604A JP 2009542815 A5 JP2009542815 A5 JP 2009542815A5
Authority
JP
Japan
Prior art keywords
ylamino
methoxyquinolin
group
dichloropyridin
cyclopentyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009519604A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009542815A (ja
JP5280357B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/072919 external-priority patent/WO2008006050A2/en
Publication of JP2009542815A publication Critical patent/JP2009542815A/ja
Publication of JP2009542815A5 publication Critical patent/JP2009542815A5/ja
Application granted granted Critical
Publication of JP5280357B2 publication Critical patent/JP5280357B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009519604A 2006-07-07 2007-07-06 Ｐｄｅ４の二環式ヘテロアリール阻害剤 Expired - Fee Related JP5280357B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81950906P 2006-07-07 2006-07-07
US60/819,509 2006-07-07
US88682507P 2007-01-26 2007-01-26
US60/886,825 2007-01-26
PCT/US2007/072919 WO2008006050A2 (en) 2006-07-07 2007-07-06 Bicyclic heteroaryl inhibitors of pde4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013107844A Division JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Publications (3)

Publication Number Publication Date
JP2009542815A JP2009542815A (ja) 2009-12-03
JP2009542815A5 true JP2009542815A5 (https=) 2010-08-26
JP5280357B2 JP5280357B2 (ja) 2013-09-04

Family

ID=38739981

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009519604A Expired - Fee Related JP5280357B2 (ja) 2006-07-07 2007-07-06 Ｐｄｅ４の二環式ヘテロアリール阻害剤
JP2013107844A Expired - Fee Related JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013107844A Expired - Fee Related JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Country Status (11)

Country Link
US (5) US20090291950A1 (https=)
EP (1) EP2037924A2 (https=)
JP (2) JP5280357B2 (https=)
KR (2) KR20150004441A (https=)
CN (1) CN104606194A (https=)
AU (1) AU2007269070B2 (https=)
BR (1) BRPI0713253A2 (https=)
CA (1) CA2657093A1 (https=)
CO (1) CO6190532A2 (https=)
MX (1) MX2009000148A (https=)
WO (3) WO2008006052A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2006084033A1 (en) * 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
US8138205B2 (en) * 2006-07-07 2012-03-20 Kalypsys, Inc. Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
EP2037924A2 (en) 2006-07-07 2009-03-25 Steven P. Govek Bicyclic heteroaryl inhibitors of pde4
JP5607025B2 (ja) 2008-04-21 2014-10-15 シグナム バイオサイエンシーズ， インコーポレイテッド 化合物、組成物およびそれらを作製する方法
CN101353338B (zh) * 2008-07-10 2011-05-04 上海交通大学 糖胺改性的水溶性香豆素酮衍生物及其制备方法
US20110082145A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2569285A1 (en) 2010-05-10 2013-03-20 Gilead Sciences, Inc. Bifunctional quinoline derivatives
US20130116279A1 (en) * 2011-11-07 2013-05-09 Kalypsys, Inc. Bicyclic heteroaryl inhibitors of pde4
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
JP2016510000A (ja) 2013-02-20 2016-04-04 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物およびその使用
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
NZ719185A (en) 2013-11-01 2017-11-24 Kala Pharmaceuticals Inc Crystalline forms of therapeutic compounds and uses thereof
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
PL3177624T3 (pl) 2014-08-06 2019-09-30 Pfizer Inc. Związki imidazopirydazynowe
KR20180086187A (ko) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
AU2016379444B2 (en) * 2015-12-24 2021-04-29 The Regents Of The University Of California CFTR regulators and methods of use thereof
KR20190051010A (ko) 2016-09-08 2019-05-14 칼라 파마슈티컬스, 인크. 치료 화합물의 결정형 및 그의 용도
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
CN106916104B (zh) * 2017-02-28 2019-08-27 牡丹江医学院 用于治疗结肠炎的药物
JP7217259B2 (ja) * 2017-07-26 2023-02-02 エイチジーアンドエイチ ファーマスーティカルズ（ピーティワイ）リミテッド てんかん及び関連疾患を患う患者の予防及び治療のためのメセンブレノール及び／又はメセンブラノール
JP2020531511A (ja) 2017-08-24 2020-11-05 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 眼球用医薬組成物
EP3914701B1 (en) * 2019-01-23 2025-12-03 Path Therapeutics Inc. Methods of treating epilepsy via phosphodiesterase 4 b (pde4) inhibition
WO2021044430A1 (en) * 2019-09-08 2021-03-11 Hadasit Medical Research Services And Development Ltd. Anti-fibrotic compounds and use thereof
JP7826294B2 (ja) * 2020-09-10 2026-03-09 バンダ・ファーマシューティカルズ・インコーポレイテッド Ｐｄｅｉｖ媒介性の疾患又は状態を処置する方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US542104A (en) * 1895-07-02 Nut-sheller
AU639529B2 (en) 1987-03-04 1993-07-29 Higuchi, Yoshinari Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
EP0325964A1 (en) * 1988-01-15 1989-08-02 Abbott Laboratories Aminomethyl-chroman and -thiochroman compounds
AU8665991A (en) 1990-09-07 1992-03-30 Schering Corporation Antiviral compounds and antihypertensive compounds
US5430153A (en) 1991-04-03 1995-07-04 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives
WO1994012488A1 (de) 1992-11-27 1994-06-09 Byk Nederland Bv Nitroxyverbindungen mit pharmazeutischen eigenschaften
FR2703683B1 (fr) 1993-04-08 1995-07-07 Seractec Dérivés d'aminocoumarines hydrophobes, et leur utilisation comme substrats d'enzymes protéolytiques ou pour la préparation de tels substrats.
FR2711992A1 (fr) 1993-11-03 1995-05-12 Lipha Nouveaux dérivé hétérocycliques, procédé de préparation et composition pharmaceutique les contenant.
DE4337906A1 (de) 1993-11-08 1995-05-11 Cassella Ag Verwendung von Cumarinderivaten
US5563280A (en) 1994-07-25 1996-10-08 American Cyanamid Co. 4-Phenoxycoumarins as herbicidal agents
DK0861242T3 (da) 1995-10-13 2001-08-06 Aventis Cropscience Uk Ltd Hetorocycliske fungicider
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
US20040081959A9 (en) 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
MY134008A (en) * 1999-12-22 2007-11-30 Merck Frosst Canada Inc Subtituted 8-arylquinoline phospohodiestrase-4 inhibitors
US6436971B2 (en) * 2000-02-09 2002-08-20 Smithkline Beecham Corporation Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection
DE10021256A1 (de) * 2000-04-20 2001-10-31 Forschungsverbund Berlin Ev Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung
US20030028018A1 (en) 2000-09-11 2003-02-06 Chiron Coporation Quinolinone derivatives
CZ304344B6 (cs) 2000-09-11 2014-03-19 Novartis Vaccines & Diagnostics, Inc. Chinolinonový derivát a jeho použití a farmaceutický prostředek s obsahem tohoto derivátu
US6740666B2 (en) * 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
JP2002371078A (ja) 2001-06-12 2002-12-26 Sankyo Co Ltd キノリン誘導体及びキノロン誘導体
JP2003146972A (ja) * 2001-11-14 2003-05-21 Teikoku Hormone Mfg Co Ltd カルボスチリル誘導体
US6822097B1 (en) 2002-02-07 2004-11-23 Amgen, Inc. Compounds and methods of uses
AU2003241429A1 (en) 2002-05-14 2003-12-02 Vivoquest, Inc. 4-thio coumarins
US7148253B2 (en) 2002-05-14 2006-12-12 Xtl Biopharmaceuticals Ltd. 4-thio coumarins
WO2004011446A1 (en) * 2002-07-26 2004-02-05 Bayer Pharmaceuticals Corporation Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics
CA2496164C (en) 2002-08-23 2010-11-09 Chiron Corporation Benzimidazole quinolinones and uses thereof
CN1506359A (zh) 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
ITMI20022739A1 (it) * 2002-12-23 2004-06-24 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4.
CA2538874A1 (en) 2003-09-15 2005-03-31 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods of treatment therewith
US7875624B2 (en) 2004-02-20 2011-01-25 Novartis Vaccines And Diagnostics, Inc. Modulating and measuring cellular adhesion
ATE531705T1 (de) * 2004-05-18 2011-11-15 Schering Corp Substituierte 2-chinolyloxazole geeignet als pde4 inhibitoren
ATE474833T1 (de) 2004-09-22 2010-08-15 Janssen Pharmaceutica Nv Inhibitoren der wechselwirkung zwischen mdm2 und p53
WO2006083692A2 (en) * 2005-01-28 2006-08-10 Mount Sinai Schoool Of Medicine Methods of identifying modulators of bromodomains
NL1028569C2 (nl) 2005-03-18 2006-09-20 Rademaker Holding B V Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, alsmede kattenvoer.
US8048889B2 (en) 2005-03-29 2011-11-01 Xtl Biopharmaceuticals Ltd. 3,4-disubstituted coumarin and quinolone compounds
EA015358B1 (ru) 2005-09-30 2011-06-30 Пульмаджен Терапьютикс (Эсме) Лимитед Хинолины и их терапевтическое применение
US8138205B2 (en) 2006-07-07 2012-03-20 Kalypsys, Inc. Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
EP2037924A2 (en) 2006-07-07 2009-03-25 Steven P. Govek Bicyclic heteroaryl inhibitors of pde4
US20130116279A1 (en) * 2011-11-07 2013-05-09 Kalypsys, Inc. Bicyclic heteroaryl inhibitors of pde4

Similar Documents

Publication Publication Date Title
JP2009542815A5 (https=)
ES2683355T3 (es) Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades
JP2014525427A5 (https=)
HRP20200836T1 (hr) Liječenje bolesti povezanih s imunitetom i upalnih bolesti
JP2014525426A5 (https=)
JP2009515949A5 (https=)
JP2015025011A5 (https=)
JP2017528494A (ja) ｓＧＣ刺激剤
NZ600136A (en) Pyrazine derivatives and their use in the treatment of neurological disorders
WO2006105063A1 (en) Heterobicylic inhibitors of tgfbeta
RU2011153772A (ru) Фторированные аминотриазольные производные
JP2017043614A5 (https=)
JP2014518853A5 (https=)
RU2016121150A (ru) Терапевтическое средство против заболеваний, связанных с гибелью клеток эндотелия роговицы, обусловленной состоянием эндоплазматического ретикулума
JP2013538811A5 (https=)
JP2019521958A5 (https=)
RU2013153140A (ru) Новая ассоциация между 4-{3-[цис-гексагидроциклопента[c] пиррол-2 (1н )- ил] пропокси} бензамидом и ингибитором ацетилхолинэстеразы и фармацевтические композиции, которые ее содержат
JP2014526508A5 (https=)
RU2011112684A (ru) АГЕНТ, СПОСОБСТВУЮЩИЙ РОСТУ ВОЛОС, СОДЕРЖАЩИЙ В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА ПРОИЗВОДНОЕ 15,15-ДИФТОРПРОСТАГЛАНДИНА F2α
JP2013515040A5 (https=)
RU2006120486A (ru) Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны
RU2016106641A (ru) Терапевтические средства, направленные на ecm эндотелия роговицы
HRP20140326T1 (hr) Derivat aromatiäśnog 6-äślanog prstena koji sadrži dušik i farmaceutsko sredstvo koje sadrži taj derivat
RU2012131276A (ru) Карбоксамидные соединения и их применение в качестве ингибиторов кальпаина
JP2007527417A5 (https=)