JP5280357B2 - Ｐｄｅ４の二環式ヘテロアリール阻害剤 - Google Patents

Ｐｄｅ４の二環式ヘテロアリール阻害剤 Download PDF

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Publication number
JP5280357B2
JP5280357B2 JP2009519604A JP2009519604A JP5280357B2 JP 5280357 B2 JP5280357 B2 JP 5280357B2 JP 2009519604 A JP2009519604 A JP 2009519604A JP 2009519604 A JP2009519604 A JP 2009519604A JP 5280357 B2 JP5280357 B2 JP 5280357B2
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nc3c
ccc2c
coc1ccc2c
ccc23
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Expired - Fee Related
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JP2009519604A
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English (en)
Japanese (ja)
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JP2009542815A (ja
JP2009542815A5 (https=
Inventor
スティーブン・ピー・ガベック
アンドリュー・ケイ・シャウ
スチュアート・エイ・ノーブル
デイビッド・ジェイ・トーマス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Andrew K Shiau
David J Thomas
Steven P Govek
Stewart A Noble
Original Assignee
Andrew K Shiau
David J Thomas
Steven P Govek
Stewart A Noble
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Application filed by Andrew K Shiau, David J Thomas, Steven P Govek, Stewart A Noble filed Critical Andrew K Shiau
Publication of JP2009542815A publication Critical patent/JP2009542815A/ja
Publication of JP2009542815A5 publication Critical patent/JP2009542815A5/ja
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Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009519604A 2006-07-07 2007-07-06 Ｐｄｅ４の二環式ヘテロアリール阻害剤 Expired - Fee Related JP5280357B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81950906P 2006-07-07 2006-07-07
US60/819,509 2006-07-07
US88682507P 2007-01-26 2007-01-26
US60/886,825 2007-01-26
PCT/US2007/072919 WO2008006050A2 (en) 2006-07-07 2007-07-06 Bicyclic heteroaryl inhibitors of pde4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013107844A Division JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Publications (3)

Publication Number Publication Date
JP2009542815A JP2009542815A (ja) 2009-12-03
JP2009542815A5 JP2009542815A5 (https=) 2010-08-26
JP5280357B2 true JP5280357B2 (ja) 2013-09-04

Family

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Family Applications (2)

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JP2009519604A Expired - Fee Related JP5280357B2 (ja) 2006-07-07 2007-07-06 Ｐｄｅ４の二環式ヘテロアリール阻害剤
JP2013107844A Expired - Fee Related JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Family Applications After (1)

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JP2013107844A Expired - Fee Related JP5705269B2 (ja) 2006-07-07 2013-05-22 Ｐｄｅ４の二環式ヘテロアリール阻害剤

Country Status (11)

Country Link
US (5) US20090291950A1 (https=)
EP (1) EP2037924A2 (https=)
JP (2) JP5280357B2 (https=)
KR (2) KR20150004441A (https=)
CN (1) CN104606194A (https=)
AU (1) AU2007269070B2 (https=)
BR (1) BRPI0713253A2 (https=)
CA (1) CA2657093A1 (https=)
CO (1) CO6190532A2 (https=)
MX (1) MX2009000148A (https=)
WO (3) WO2008006052A2 (https=)

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US8138205B2 (en) * 2006-07-07 2012-03-20 Kalypsys, Inc. Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
EP2037924A2 (en) 2006-07-07 2009-03-25 Steven P. Govek Bicyclic heteroaryl inhibitors of pde4
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US20130116279A1 (en) * 2011-11-07 2013-05-09 Kalypsys, Inc. Bicyclic heteroaryl inhibitors of pde4
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Also Published As

Publication number Publication date
AU2007269070B2 (en) 2013-03-21
EP2037924A2 (en) 2009-03-25
JP2009542815A (ja) 2009-12-03
CO6190532A2 (es) 2010-08-19
US8080563B2 (en) 2011-12-20
CN104606194A (zh) 2015-05-13
WO2008006050A3 (en) 2008-06-26
CA2657093A1 (en) 2008-01-10
US20080027099A1 (en) 2008-01-31
US7745646B2 (en) 2010-06-29
WO2008006050A2 (en) 2008-01-10
BRPI0713253A2 (pt) 2012-10-30
WO2008006051A2 (en) 2008-01-10
US9078887B2 (en) 2015-07-14
KR20090109527A (ko) 2009-10-20
JP2013177421A (ja) 2013-09-09
AU2007269070A1 (en) 2008-01-10
US20100022586A1 (en) 2010-01-28
US8258154B2 (en) 2012-09-04
WO2008006052A2 (en) 2008-01-10
WO2008006051A3 (en) 2008-06-26
KR20150004441A (ko) 2015-01-12
WO2008006052A3 (en) 2008-11-20
MX2009000148A (es) 2009-10-26
US20130178498A1 (en) 2013-07-11
JP5705269B2 (ja) 2015-04-22
US20090291950A1 (en) 2009-11-26
US20080027112A1 (en) 2008-01-31

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