CO6190532A2 - Inhibidores heteroaril biciclicos de pde4, metodos para su sintesis y metodos para inhibir pde4 - Google Patents
Inhibidores heteroaril biciclicos de pde4, metodos para su sintesis y metodos para inhibir pde4Info
- Publication number
- CO6190532A2 CO6190532A2 CO09010461A CO09010461A CO6190532A2 CO 6190532 A2 CO6190532 A2 CO 6190532A2 CO 09010461 A CO09010461 A CO 09010461A CO 09010461 A CO09010461 A CO 09010461A CO 6190532 A2 CO6190532 A2 CO 6190532A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- amino
- pde4
- alkoxy
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
1.- Un método de inhibición de PDE4 que comprende poner en contacto PDE4 con un compuesto de Fórmula estructural IVo una de sus sales, ésteres o profármacos, en donde: X3 es (CR18 R19); R1 y R2 se seleccionan de modo independiente del grupo que consiste en -(CH2)sG1G2G3, acilo, acilalquilo, carboxialquilo, cianoalquilo, alcoxi, alcoxialquilo, amidoalquilo, amino, alquilo, alquilalcoxi, aminoalquilo, alquenilo, alquinilo, carboxilo, carboxialquilo, éter, heteroalquilo, haloalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquilalquilo, aralquilo, arilo, guanidina, heteroarilo, heteroaralquilo, hidrógeno y hidroxialquilo, alguno de los cuales puede estar opcionalmente sustituido; s es 1-8; G1 se selecciona del grupo que consiste en alcoxi, amino, amido, carbonilo, hidroxi, éter, un aminoácido, y nulo; G2 se selecciona del grupo que consiste en alquilo, alcoxi, amino, arilo, halo, haloalquilo, heterocicloalquilo, heteroarilo, carboxilalquilamino, guanidina, un aminoácido, y nulo, alguno de los cuales puede estar opcionalmente sustituido;G3 se selecciona del grupo que consiste en alquilo, alcoxi, amino, hidroxi, éter, carboxilo, ácido hidroxámico, un aminoácido, fosfonato, fosfoamida, y nulo, alguno de los cuales puede estar opcionalmente sustituido; R3 y R4 se seleccionan de modo independiente del grupo que consiste en hidrógeno, halógeno, alcoxi y alquilo inferior;R5 se selecciona del grupo que consiste en (CR8R9)mW(CR10R11)n- y -(CR12R13)p-; W se selecciona del grupo que consiste en O, N(R7), C(O)N(R7), y SOq; m, n, y q son de modo independiente 0, 1 o 2; p es 1 o 2; R6 se selecciona del grupo que consiste en carboxilo, alquilcarboxi, amido, arilo, heteroarilo, cicloalquilo, ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81950906P | 2006-07-07 | 2006-07-07 | |
US88682507P | 2007-01-26 | 2007-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6190532A2 true CO6190532A2 (es) | 2010-08-19 |
Family
ID=38739981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09010461A CO6190532A2 (es) | 2006-07-07 | 2009-02-04 | Inhibidores heteroaril biciclicos de pde4, metodos para su sintesis y metodos para inhibir pde4 |
Country Status (11)
Country | Link |
---|---|
US (5) | US20090291950A1 (es) |
EP (1) | EP2037924A2 (es) |
JP (2) | JP5280357B2 (es) |
KR (2) | KR20150004441A (es) |
CN (1) | CN104606194A (es) |
AU (1) | AU2007269070B2 (es) |
BR (1) | BRPI0713253A2 (es) |
CA (1) | CA2657093A1 (es) |
CO (1) | CO6190532A2 (es) |
MX (1) | MX2009000148A (es) |
WO (3) | WO2008006052A2 (es) |
Families Citing this family (32)
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MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
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DK1606261T3 (da) | 2003-03-10 | 2010-01-18 | Nycomed Gmbh | Hidtil ukendt fremgangsmåde til fremstilling af roflumilast |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
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DK1861074T3 (da) * | 2005-03-16 | 2013-07-29 | Takeda Gmbh | Smagsmaskeret doseringsform indeholdende roflumilast |
US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
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US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
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BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
BR112018012949B1 (pt) | 2015-12-24 | 2023-11-14 | The Regents Of The University Of California | Reguladores cftr e métodos de uso dos mesmos |
EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
WO2018048747A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
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CN106916104B (zh) * | 2017-02-28 | 2019-08-27 | 牡丹江医学院 | 用于治疗结肠炎的药物 |
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-
2007
- 2007-07-06 KR KR1020147036033A patent/KR20150004441A/ko not_active Application Discontinuation
- 2007-07-06 BR BRPI0713253-0A patent/BRPI0713253A2/pt not_active IP Right Cessation
- 2007-07-06 WO PCT/US2007/072924 patent/WO2008006052A2/en active Application Filing
- 2007-07-06 AU AU2007269070A patent/AU2007269070B2/en not_active Ceased
- 2007-07-06 US US12/307,738 patent/US20090291950A1/en not_active Abandoned
- 2007-07-06 MX MX2009000148A patent/MX2009000148A/es active IP Right Grant
- 2007-07-06 WO PCT/US2007/072920 patent/WO2008006051A2/en active Application Filing
- 2007-07-06 KR KR1020097002141A patent/KR20090109527A/ko active IP Right Grant
- 2007-07-06 CA CA002657093A patent/CA2657093A1/en not_active Abandoned
- 2007-07-06 US US12/307,730 patent/US8080563B2/en not_active Expired - Fee Related
- 2007-07-06 JP JP2009519604A patent/JP5280357B2/ja not_active Expired - Fee Related
- 2007-07-06 US US11/774,053 patent/US8258154B2/en not_active Expired - Fee Related
- 2007-07-06 US US11/774,058 patent/US7745646B2/en not_active Expired - Fee Related
- 2007-07-06 CN CN201410768897.2A patent/CN104606194A/zh active Pending
- 2007-07-06 WO PCT/US2007/072919 patent/WO2008006050A2/en active Application Filing
- 2007-07-06 EP EP07812666A patent/EP2037924A2/en not_active Withdrawn
-
2009
- 2009-02-04 CO CO09010461A patent/CO6190532A2/es active IP Right Grant
-
2012
- 2012-06-28 US US13/536,716 patent/US9078887B2/en not_active Expired - Fee Related
-
2013
- 2013-05-22 JP JP2013107844A patent/JP5705269B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20150004441A (ko) | 2015-01-12 |
WO2008006051A3 (en) | 2008-06-26 |
WO2008006051A2 (en) | 2008-01-10 |
US20080027112A1 (en) | 2008-01-31 |
WO2008006050A2 (en) | 2008-01-10 |
US20080027099A1 (en) | 2008-01-31 |
MX2009000148A (es) | 2009-10-26 |
WO2008006052A3 (en) | 2008-11-20 |
JP2013177421A (ja) | 2013-09-09 |
KR20090109527A (ko) | 2009-10-20 |
WO2008006052A2 (en) | 2008-01-10 |
CA2657093A1 (en) | 2008-01-10 |
BRPI0713253A2 (pt) | 2012-10-30 |
WO2008006050A3 (en) | 2008-06-26 |
US20090291950A1 (en) | 2009-11-26 |
EP2037924A2 (en) | 2009-03-25 |
US8080563B2 (en) | 2011-12-20 |
CN104606194A (zh) | 2015-05-13 |
JP5705269B2 (ja) | 2015-04-22 |
US20130178498A1 (en) | 2013-07-11 |
AU2007269070A1 (en) | 2008-01-10 |
US9078887B2 (en) | 2015-07-14 |
JP2009542815A (ja) | 2009-12-03 |
JP5280357B2 (ja) | 2013-09-04 |
US7745646B2 (en) | 2010-06-29 |
US8258154B2 (en) | 2012-09-04 |
US20100022586A1 (en) | 2010-01-28 |
AU2007269070B2 (en) | 2013-03-21 |
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