KR20090109527A - Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 - Google Patents

Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 Download PDF

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Publication number
KR20090109527A
KR20090109527A KR1020097002141A KR20097002141A KR20090109527A KR 20090109527 A KR20090109527 A KR 20090109527A KR 1020097002141 A KR1020097002141 A KR 1020097002141A KR 20097002141 A KR20097002141 A KR 20097002141A KR 20090109527 A KR20090109527 A KR 20090109527A
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KR
South Korea
Prior art keywords
nc3c
group
ccc2c
amino
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020097002141A
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English (en)
Korean (ko)
Inventor
스티븐 피 고벡
앤드류 케이 쉬아우
스튜어트 에이 노블
데이비드 제이 토마스
Original Assignee
칼립시스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 칼립시스, 인코포레이티드 filed Critical 칼립시스, 인코포레이티드
Publication of KR20090109527A publication Critical patent/KR20090109527A/ko
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020097002141A 2006-07-07 2007-07-06 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 Abandoned KR20090109527A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81950906P 2006-07-07 2006-07-07
US60/819,509 2006-07-07
US88682507P 2007-01-26 2007-01-26
US60/886,825 2007-01-26
PCT/US2007/072919 WO2008006050A2 (en) 2006-07-07 2007-07-06 Bicyclic heteroaryl inhibitors of pde4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147036033A Division KR20150004441A (ko) 2006-07-07 2007-07-06 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제

Publications (1)

Publication Number Publication Date
KR20090109527A true KR20090109527A (ko) 2009-10-20

Family

ID=38739981

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097002141A Abandoned KR20090109527A (ko) 2006-07-07 2007-07-06 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제
KR1020147036033A Ceased KR20150004441A (ko) 2006-07-07 2007-07-06 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147036033A Ceased KR20150004441A (ko) 2006-07-07 2007-07-06 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제

Country Status (11)

Country Link
US (5) US8080563B2 (https=)
EP (1) EP2037924A2 (https=)
JP (2) JP5280357B2 (https=)
KR (2) KR20090109527A (https=)
CN (1) CN104606194A (https=)
AU (1) AU2007269070B2 (https=)
BR (1) BRPI0713253A2 (https=)
CA (1) CA2657093A1 (https=)
CO (1) CO6190532A2 (https=)
MX (1) MX2009000148A (https=)
WO (3) WO2008006052A2 (https=)

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Also Published As

Publication number Publication date
CO6190532A2 (es) 2010-08-19
EP2037924A2 (en) 2009-03-25
JP2009542815A (ja) 2009-12-03
WO2008006050A3 (en) 2008-06-26
WO2008006052A2 (en) 2008-01-10
WO2008006051A3 (en) 2008-06-26
US20100022586A1 (en) 2010-01-28
US9078887B2 (en) 2015-07-14
BRPI0713253A2 (pt) 2012-10-30
MX2009000148A (es) 2009-10-26
US7745646B2 (en) 2010-06-29
US8258154B2 (en) 2012-09-04
US20090291950A1 (en) 2009-11-26
WO2008006051A2 (en) 2008-01-10
AU2007269070B2 (en) 2013-03-21
CA2657093A1 (en) 2008-01-10
US20080027112A1 (en) 2008-01-31
US8080563B2 (en) 2011-12-20
JP5280357B2 (ja) 2013-09-04
KR20150004441A (ko) 2015-01-12
JP5705269B2 (ja) 2015-04-22
JP2013177421A (ja) 2013-09-09
US20130178498A1 (en) 2013-07-11
WO2008006050A2 (en) 2008-01-10
WO2008006052A3 (en) 2008-11-20
CN104606194A (zh) 2015-05-13
US20080027099A1 (en) 2008-01-31
AU2007269070A1 (en) 2008-01-10

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