JP2009542786A5 - - Google Patents
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- Publication number
- JP2009542786A5 JP2009542786A5 JP2009518955A JP2009518955A JP2009542786A5 JP 2009542786 A5 JP2009542786 A5 JP 2009542786A5 JP 2009518955 A JP2009518955 A JP 2009518955A JP 2009518955 A JP2009518955 A JP 2009518955A JP 2009542786 A5 JP2009542786 A5 JP 2009542786A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pur
- precursor
- dac
- arc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SVWZRGULYRDGJX-UHFFFAOYSA-N CN(C)c(cc1)cc2c1nc(ccc(N(C)C)c1)c1s2 Chemical compound CN(C)c(cc1)cc2c1nc(ccc(N(C)C)c1)c1s2 SVWZRGULYRDGJX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81962706P | 2006-07-11 | 2006-07-11 | |
| US60/819,627 | 2006-07-11 | ||
| PCT/GB2007/002570 WO2008007074A2 (en) | 2006-07-11 | 2007-07-10 | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013171087A Division JP6243659B2 (ja) | 2006-07-11 | 2013-08-21 | ジアミノフェノチアジニウム化合物の合成および/または精製の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542786A JP2009542786A (ja) | 2009-12-03 |
| JP2009542786A5 true JP2009542786A5 (cg-RX-API-DMAC10.html) | 2010-08-26 |
| JP5350237B2 JP5350237B2 (ja) | 2013-11-27 |
Family
ID=38669650
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518955A Active JP5350237B2 (ja) | 2006-07-11 | 2007-07-10 | ジアミノフェノチアジニウム化合物の合成および/または精製の方法 |
| JP2013171087A Active JP6243659B2 (ja) | 2006-07-11 | 2013-08-21 | ジアミノフェノチアジニウム化合物の合成および/または精製の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013171087A Active JP6243659B2 (ja) | 2006-07-11 | 2013-08-21 | ジアミノフェノチアジニウム化合物の合成および/または精製の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (10) | US7956183B2 (cg-RX-API-DMAC10.html) |
| EP (5) | EP4063354A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5350237B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN101511803B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007274057B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2657352C (cg-RX-API-DMAC10.html) |
| CY (1) | CY1118184T1 (cg-RX-API-DMAC10.html) |
| DK (4) | DK2057136T3 (cg-RX-API-DMAC10.html) |
| ES (4) | ES2421930T3 (cg-RX-API-DMAC10.html) |
| HU (1) | HUE030621T2 (cg-RX-API-DMAC10.html) |
| LT (1) | LT2457905T (cg-RX-API-DMAC10.html) |
| MY (2) | MY162313A (cg-RX-API-DMAC10.html) |
| PL (4) | PL2457904T3 (cg-RX-API-DMAC10.html) |
| PT (4) | PT2457905T (cg-RX-API-DMAC10.html) |
| SI (4) | SI2057136T1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008007074A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006032879A2 (en) | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| CN104119294B (zh) | 2006-03-29 | 2018-10-30 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
| MY162313A (en) | 2006-07-11 | 2017-05-31 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| FR2903696B1 (fr) * | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
| AU2008265045B2 (en) * | 2007-06-19 | 2014-02-27 | Taurx Therapeutics Management Ltd. | Phenothiazine compounds for treating Mild Cognitive Impairment |
| PT2954932T (pt) | 2007-10-03 | 2018-12-12 | Wista Lab Ltd | Utilização terapêutica de diaminofenotiazinas |
| MX2011005979A (es) * | 2008-12-09 | 2011-06-27 | Interquim Sa | Procedimiento de obtencion de (6s)-(-)-5,6,7,8-tetrahidro-6-[propi l-(2-tienil)etil]amino-1-naftol(rotigotina). |
| US8785434B2 (en) | 2010-04-30 | 2014-07-22 | Prosetta Antiviral Inc. | Antiviral compounds |
| US8828986B2 (en) | 2011-04-20 | 2014-09-09 | Prosetta Antiviral Inc. | Antiviral compounds |
| DE102010062810B4 (de) * | 2010-09-07 | 2014-03-13 | Immungenetics Ag | 2-(R2-Thio)-10-[3-(4-R1-piperazin-1-yl)propyl]-10H-phenothiazine zur Behandlung neurodegenerativer Erkrankungen ausgewählt aus beta-Amyloidopathien und alpha-Synucleinopathien |
| KR101888713B1 (ko) | 2011-02-11 | 2018-08-14 | 위스타 레보레이토리스 리미티드 | 페노티아진 디아미늄 염 및 이의 용도 |
| RU2535073C1 (ru) * | 2013-07-18 | 2014-12-10 | Федеральное государственное бюджетное учреждение науки "Научно-исследовательский институт общей реаниматологии имени В.А. Неговского" Российской академии медицинских наук | Способ лечения метгемоглобинемии |
| DK3033331T3 (da) * | 2013-08-15 | 2018-04-30 | Eupharma Pty Ltd | Fremgangsmåde til oprensning af diaminophenothiazinium forbindelser |
| GB201317702D0 (en) * | 2013-10-07 | 2013-11-20 | Wista Lab Ltd | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| FR3015481B1 (fr) * | 2013-12-20 | 2016-08-12 | Etat Francais Represente Par Le Delegue General Pour L'armement | Utilisation de composes de diaminophenothiazinium en tant qu'agents de prevention, reduction ou suppression d'une radiotoxicite |
| CN103864717B (zh) * | 2014-04-04 | 2015-11-11 | 山东理工大学 | 一种针状亚甲基白晶体的制备方法 |
| CA2976937C (en) | 2015-02-17 | 2023-04-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| CA2976776C (en) | 2015-02-17 | 2023-06-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
| GB201512678D0 (en) | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN105399703B (zh) * | 2015-12-15 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
| CN105541756B (zh) * | 2015-12-17 | 2018-02-09 | 陕西方舟制药有限公司 | 一种制备1‑(3,7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法 |
| ITUA20163526A1 (it) | 2016-05-17 | 2017-11-17 | Icrom Spa | Procedimento per la preparazione di composti diamminofenotiazinici ad elevato grado di purezza |
| PL3487505T3 (pl) | 2016-07-25 | 2023-10-09 | Wista Laboratories Ltd. | Podawanie i dawkowanie diaminofenotiazyn |
| WO2018039487A1 (en) * | 2016-08-25 | 2018-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US12570622B2 (en) | 2016-08-25 | 2026-03-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| US11390605B2 (en) | 2016-08-25 | 2022-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted pyrimidine compounds as multifunctional radical quenchers and their uses |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| WO2018126107A1 (en) | 2016-12-29 | 2018-07-05 | Board Of Regents, The University Of Texas System | Methylene blue solution for the treatment of oral lesions |
| US10584201B2 (en) * | 2017-01-10 | 2020-03-10 | The Texas A&M University System | Methanesulfonic acid mediated solvent free synthesis of conjugated porous polymer networks |
| FR3063495B1 (fr) * | 2017-03-02 | 2019-04-05 | Provepharm Life Solutions | Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium |
| EP3375777A1 (en) * | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
| BR112021000802A2 (pt) | 2018-07-26 | 2021-04-13 | Wista Laboratories Ltd. | Dosagem otimizada de diaminofenotiazinas em populações |
| US11350853B2 (en) | 2018-10-02 | 2022-06-07 | Under Armour, Inc. | Gait coaching in fitness tracking systems |
| CN109337681B (zh) * | 2018-11-22 | 2020-05-08 | 南京工业大学 | 一种硫氮共掺杂的碳量子点的制备方法和应用 |
| TR201818670A2 (tr) | 2018-12-05 | 2020-06-22 | Eti Gida Sanayi Ve Ticaret Anonim Sirketi | Sızıntı yapmayan gıda dolgu maddesi depozitör sistemi. |
| US12215234B2 (en) * | 2019-09-21 | 2025-02-04 | RK Pharma Solutions LLC | Process for the purification of methylene blue |
| US12441694B2 (en) * | 2020-02-28 | 2025-10-14 | Dishman Carbogen Amcis Ltd. | Process for the preparation of methylene blue |
| US12280062B2 (en) | 2021-02-24 | 2025-04-22 | Zydus Lifesciences Limited | Parenteral compositions comprising methylene blue |
| CN114656424B (zh) * | 2022-03-16 | 2023-06-27 | 深圳先进技术研究院 | 一种上转换长余辉化学发光成像纳米探针及其制备方法和应用 |
| CN114806211B (zh) * | 2022-03-16 | 2023-04-07 | 深圳先进技术研究院 | 一种疏水性亚甲蓝荧光染料及其制备方法和应用 |
| CN114507193B (zh) * | 2022-04-19 | 2022-06-24 | 英科隆生物技术(杭州)有限公司 | 电子媒介体天青c的提纯方法 |
| US20250270177A1 (en) * | 2022-04-19 | 2025-08-28 | Leadway (Hk) Limited | Purification method for electron mediator |
| CN116947783B (zh) * | 2022-04-19 | 2026-04-17 | 英科隆生物技术(杭州)有限公司 | 一种电子媒介体的提纯方法 |
| CA3257856A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | TREATMENT OF NEURODEGENERATIVE DISORDERS USING COMPOUNDS CONTAINING METHYLTHIONINIUM (MT) |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
| WO2024063700A1 (en) | 2022-09-21 | 2024-03-28 | Yin Sze Loh | Oral formulation of diaminophenothiazines and methods of making and using the same in the treatment and/or prevention of diseases |
| EP4342451A1 (en) | 2022-09-22 | 2024-03-27 | Galenicum Health SLU | Pharmaceutical compositions and manufacturing methods thereof |
| US20240115579A1 (en) | 2022-09-22 | 2024-04-11 | Galenicum Health S.L.U. | Pharmaceutical compositions and manufacturing methods thereof |
| CN117447421A (zh) * | 2023-10-30 | 2024-01-26 | 上海沃凯生物技术有限公司 | 一种3,7-双-(二甲胺基)-吩噻嗪的合成方法 |
| IT202400006715A1 (it) * | 2024-03-26 | 2025-09-26 | Icrom S R L | Blu di metilene a ridotto contenuto di impurità n-nitroso-azzurro b e processo per ottenerlo |
| GB202500018D0 (en) | 2025-01-02 | 2025-02-19 | Wista Lab Ltd | Long term dosing of neurodegenerative disorders utilising methylthioninium (mt) containing compounds |
| CN119823064B (zh) * | 2025-01-03 | 2025-12-30 | 仁合益康集团有限公司 | 一种亚甲蓝的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| DE103147C (de) | 1898-06-07 | 1899-04-05 | Cohn Georg | Verfahren zur darstellung von acetylleukomethylenblau und -äthylenblau. |
| DE113721C (de) * | 1899-06-01 | 1900-09-28 | Verfahren zur Darstellung von Acidylderivaten der Leukothioninfarbstoffe | |
| US3395018A (en) | 1964-04-29 | 1968-07-30 | Du Pont | Light-sensitive color-forming composition |
| US3641016A (en) * | 1968-02-16 | 1972-02-08 | Egyt Gyogyszervegyeszeti Gyar | Thionine derivatives |
| DE2515966C3 (de) | 1975-04-11 | 1979-11-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Vorgefärbte Objektträger für die Blutunte rsuchung |
| US4003892A (en) | 1975-04-17 | 1977-01-18 | Serva-Entwicklungslabor V. Grothe & Co. | Method of separating thionine and its N-methyl derivatives from each other |
| US4212971A (en) | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| JPS6385644A (ja) * | 1986-09-30 | 1988-04-16 | Ricoh Co Ltd | 電子写真現像剤用トナ− |
| US5344928A (en) | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| WO1998031219A1 (en) | 1997-01-21 | 1998-07-23 | The American National Red Cross | Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light |
| JP2000344685A (ja) | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | アズールa類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
| IT1307270B1 (it) | 1999-10-12 | 2001-10-30 | Dideco Spa | Procedimento e dispositivo per la determinazione della concentrazionedi eparina in un campione di fluido. |
| EP1263465B9 (en) * | 2000-02-26 | 2012-12-05 | Advanced Photodynamic Technologies, Inc. | Photodynamic cellular organism eradication using a photosensitive material and surfactant |
| FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
| GB0106953D0 (en) | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0113121D0 (en) | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
| US7176308B2 (en) * | 2002-06-17 | 2007-02-13 | Verification Technologies, Inc. | Processes for preparing novel methylene blue derivative |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| BRPI0416928A (pt) | 2003-11-28 | 2007-01-16 | Photopharmica Ltd | desenvolvimento de derivados biologicamente ativos de azul de metileno |
| WO2006032879A2 (en) | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| JP5186212B2 (ja) | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物(mtc)などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| CN104119294B (zh) | 2006-03-29 | 2018-10-30 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
| MY162313A (en) * | 2006-07-11 | 2017-05-31 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| FR2903696B1 (fr) | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
| KR101888713B1 (ko) | 2011-02-11 | 2018-08-14 | 위스타 레보레이토리스 리미티드 | 페노티아진 디아미늄 염 및 이의 용도 |
| PL3487505T3 (pl) | 2016-07-25 | 2023-10-09 | Wista Laboratories Ltd. | Podawanie i dawkowanie diaminofenotiazyn |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| BR112021000802A2 (pt) | 2018-07-26 | 2021-04-13 | Wista Laboratories Ltd. | Dosagem otimizada de diaminofenotiazinas em populações |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
-
2007
- 2007-07-10 MY MYPI2012001462A patent/MY162313A/en unknown
- 2007-07-10 MY MYPI20090099A patent/MY148145A/en unknown
- 2007-07-10 EP EP22153513.1A patent/EP4063354A1/en active Pending
- 2007-07-10 EP EP11173334.1A patent/EP2457904B1/en active Active
- 2007-07-10 SI SI200731284T patent/SI2057136T1/sl unknown
- 2007-07-10 CN CN2007800336078A patent/CN101511803B/zh active Active
- 2007-07-10 DK DK07733509.9T patent/DK2057136T3/da active
- 2007-07-10 EP EP07733509.9A patent/EP2057136B1/en active Active
- 2007-07-10 CA CA2657352A patent/CA2657352C/en active Active
- 2007-07-10 SI SI200731836A patent/SI2457905T1/sl unknown
- 2007-07-10 EP EP11173338.2A patent/EP2457905B1/en not_active Revoked
- 2007-07-10 LT LTEP11173338.2T patent/LT2457905T/lt unknown
- 2007-07-10 AU AU2007274057A patent/AU2007274057B2/en active Active
- 2007-07-10 EP EP16173815.8A patent/EP3121169B1/en active Active
- 2007-07-10 SI SI200731596T patent/SI2457904T1/sl unknown
- 2007-07-10 PL PL11173334T patent/PL2457904T3/pl unknown
- 2007-07-10 JP JP2009518955A patent/JP5350237B2/ja active Active
- 2007-07-10 ES ES07733509T patent/ES2421930T3/es active Active
- 2007-07-10 ES ES11173334.1T patent/ES2529714T3/es active Active
- 2007-07-10 SI SI200732186T patent/SI3121169T1/sl unknown
- 2007-07-10 CN CN201210195299.1A patent/CN102718730B/zh active Active
- 2007-07-10 ES ES16173815T patent/ES2912571T3/es active Active
- 2007-07-10 US US12/373,216 patent/US7956183B2/en active Active
- 2007-07-10 HU HUE11173338A patent/HUE030621T2/en unknown
- 2007-07-10 ES ES11173338.2T patent/ES2603783T3/es active Active
- 2007-07-10 DK DK16173815.8T patent/DK3121169T3/da active
- 2007-07-10 PT PT111733382T patent/PT2457905T/pt unknown
- 2007-07-10 PL PL11173338T patent/PL2457905T3/pl unknown
- 2007-07-10 WO PCT/GB2007/002570 patent/WO2008007074A2/en not_active Ceased
- 2007-07-10 PT PT161738158T patent/PT3121169T/pt unknown
- 2007-07-10 PL PL07733509T patent/PL2057136T3/pl unknown
- 2007-07-10 PT PT111733341T patent/PT2457904E/pt unknown
- 2007-07-10 DK DK11173334.1T patent/DK2457904T3/en active
- 2007-07-10 PL PL16173815T patent/PL3121169T3/pl unknown
- 2007-07-10 DK DK11173338.2T patent/DK2457905T3/en active
- 2007-07-10 PT PT77335099T patent/PT2057136E/pt unknown
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2011
- 2011-05-31 US US13/149,164 patent/US8440821B2/en active Active
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2013
- 2013-05-09 US US13/890,607 patent/US9382220B2/en active Active
- 2013-08-21 JP JP2013171087A patent/JP6243659B2/ja active Active
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2016
- 2016-06-17 US US15/185,803 patent/US9675621B2/en active Active
- 2016-11-03 CY CY20161101128T patent/CY1118184T1/el unknown
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2017
- 2017-06-09 US US15/619,199 patent/US9980971B2/en active Active
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2018
- 2018-05-23 US US15/987,354 patent/US10525061B2/en active Active
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2019
- 2019-11-15 US US16/685,420 patent/US11045477B2/en active Active
-
2021
- 2021-06-23 US US17/355,336 patent/US11878021B2/en active Active
-
2023
- 2023-12-08 US US18/533,515 patent/US20240115580A1/en not_active Abandoned
-
2025
- 2025-01-08 US US19/013,969 patent/US20250222006A1/en active Pending
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