|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE122009000019I1
(de)
|
1991-04-25 |
2009-07-16 |
Chugai Seiyaku K K 5 1 |
Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor
|
|
IE20030749A1
(en)
*
|
1991-05-03 |
2003-11-12 |
Indiana University Foundation |
Human notch and delta binding domains in torporythmic proteins, and methods based thereon
|
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
|
US20050112121A1
(en)
|
1992-04-30 |
2005-05-26 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
DE4425115A1
(de)
|
1994-07-15 |
1996-01-18 |
Boehringer Mannheim Gmbh |
Verfahren zur Modifizierung der Stabilität von Antikörpern
|
|
WO1996036361A1
(en)
|
1995-05-18 |
1996-11-21 |
The Regents Of The University Of Michigan |
Dna binding antibodies
|
|
CA2250394A1
(en)
|
1996-03-30 |
1997-10-09 |
Boehringer Mannheim Gmbh |
Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
|
|
JP2000512134A
(ja)
|
1996-05-31 |
2000-09-19 |
ザ ナショナル アメリカン レッド クロス |
Ｊａｇｇｅｄ／Ｎｏｔｃｈタンパク質および核酸に基づく治療および診断の方法および組成物
|
|
FR2751986B1
(fr)
*
|
1996-08-01 |
1998-12-31 |
Inst Nat Sante Rech Med |
Gene implique dans le cadasil, methode de diagnostic et application therapeutique
|
|
CA2271248C
(en)
|
1996-11-07 |
2009-08-11 |
Jonathan Robert Lamb |
Use of a notch ligand in immunotherapy
|
|
AU751659B2
(en)
|
1997-05-02 |
2002-08-22 |
Genentech Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US6379925B1
(en)
|
1997-06-18 |
2002-04-30 |
The Trustees Of Columbia University In The City Of New York |
Angiogenic modulation by notch signal transduction
|
|
WO1998057621A1
(en)
|
1997-06-18 |
1998-12-23 |
The Trustees Of Columbia University In The City Ofnew York |
Angiogenic modulation by notch signal transduction
|
|
US6692919B1
(en)
*
|
1997-07-23 |
2004-02-17 |
Yale University |
Activated forms of notch and methods based thereon
|
|
US6004528A
(en)
*
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
|
US7361336B1
(en)
*
|
1997-09-18 |
2008-04-22 |
Ivan Bergstein |
Methods of cancer therapy targeted against a cancer stem line
|
|
AU768269B2
(en)
|
1998-10-02 |
2003-12-04 |
Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The |
Apoptosis inducing agents and methods
|
|
US20030003572A1
(en)
|
1999-03-05 |
2003-01-02 |
David J. Anderson |
Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression
|
|
US20020010320A1
(en)
|
1999-04-05 |
2002-01-24 |
James W. Fett |
Chemeric and humanized antibodies to angiogenin
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
US20030031670A1
(en)
*
|
1999-11-08 |
2003-02-13 |
Jack R. Wands |
Diagnosis and treatment of malignant neoplasms
|
|
DE10031380A1
(de)
|
2000-06-28 |
2002-01-10 |
Merck Patent Gmbh |
Verfahren zur Übertragung von Alkyliden-Gruppen auf organischen Verbindungen
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
US20080194022A1
(en)
|
2000-08-03 |
2008-08-14 |
Clarke Michael F |
Isolation and use of solid tumor stem cells
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
AU2001288628A1
(en)
|
2000-08-31 |
2002-03-13 |
Loyola University Chicago |
Method and reagents for treatment of skin disorders by modulating the notch pathway
|
|
US6689744B2
(en)
*
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
|
EP1322761A4
(en)
|
2000-10-02 |
2005-03-23 |
Korea Res Inst Of Bioscience |
HUMANIZED ANTIBODY AGAINST THE HEPATITE B VIRUS SURFACE ANTIGEN AND METHOD OF PREPARING THE SAME
|
|
ATE484522T1
(de)
|
2001-04-24 |
2010-10-15 |
Bayer Corp |
Menschliche antikörper gegen timp-1
|
|
US7356224B2
(en)
*
|
2001-07-03 |
2008-04-08 |
Brown University Research Foundation |
Method and apparatus for detecting multiple optical wave lengths
|
|
EP1415342B1
(de)
*
|
2001-07-30 |
2006-06-07 |
BISTEKOS, Michael-Georg |
Einrichtung zur kühlung von gehausen, raumen, bauteilen, medien u. dgl
|
|
WO2003042246A2
(en)
|
2001-11-14 |
2003-05-22 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
|
CA2469204A1
(en)
|
2001-12-07 |
2003-06-19 |
Regents Of The University Of Michigan |
Prospective identification and characterization of breast cancer stem cells
|
|
GB0201674D0
(en)
|
2002-01-25 |
2002-03-13 |
Lorantis Ltd |
Medical treatment
|
|
JP2005530856A
(ja)
|
2002-06-21 |
2005-10-13 |
ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン |
膜関連腫瘍内皮マーカー
|
|
JP2006515747A
(ja)
*
|
2002-11-01 |
2006-06-08 |
ジェネンテック・インコーポレーテッド |
免疫関連疾患の治療のための組成物と方法
|
|
WO2004052389A2
(en)
*
|
2002-12-06 |
2004-06-24 |
Singapore General Hospital Pte Ltd. |
Nogo, caspr, f3 nb-3 useful in the treatment of injury and disease to the central nervous system
|
|
EP2060918A3
(en)
|
2003-04-01 |
2009-08-26 |
The Johns Hopkins University |
Breast endothelial cell expression patterns
|
|
US7425328B2
(en)
|
2003-04-22 |
2008-09-16 |
Purdue Pharma L.P. |
Tissue factor antibodies and uses thereof
|
|
GB0321805D0
(en)
|
2003-09-18 |
2003-10-15 |
Univ Wales Medicine |
Human tumour growth patterns
|
|
WO2005054434A2
(en)
*
|
2003-11-26 |
2005-06-16 |
Health Research, Inc. |
Use of notch pathway interfering agents for treatment of plasma cell disorders
|
|
EP1718767B1
(en)
|
2004-02-03 |
2012-04-11 |
The Regents Of The University Of Michigan |
Compositions for treating breast and pancreatic cancer
|
|
WO2005090981A2
(en)
|
2004-03-24 |
2005-09-29 |
Technion Research & Development Foundation Ltd. |
Electrode
|
|
WO2005111072A2
(en)
|
2004-04-29 |
2005-11-24 |
The Trustees Of Columbia University In The City Of New York |
Notch-based fusion proteins and uses thereof
|
|
US20070077245A1
(en)
|
2004-08-04 |
2007-04-05 |
The Brigham And Women's Hospital, Inc. |
NOTCH mutations leading to increased receptor signaling
|
|
GB0421838D0
(en)
*
|
2004-09-30 |
2004-11-03 |
Congenia S R L |
Cancer markers
|
|
WO2006053063A2
(en)
|
2004-11-05 |
2006-05-18 |
The Regents Of The University Of California |
Notch-1 assay to detect neurodegenerative diseases
|
|
US20070265246A1
(en)
*
|
2004-11-10 |
2007-11-15 |
Clevers Johannes C |
Treatment of an Intestinal Adenoma and/or Adenocarcinoma by Inhibition of Notch Pathway Activation
|
|
US10538742B2
(en)
*
|
2004-11-12 |
2020-01-21 |
Cambridge Enterprise Limited |
Methods and means related to cancer stem cells
|
|
EP2083088A3
(en)
|
2005-04-07 |
2009-10-14 |
Novartis Vaccines and Diagnostics, Inc. |
Cancer-related genes
|
|
WO2007061988A2
(en)
|
2005-11-22 |
2007-05-31 |
University Of Vermont And State Agricultural College |
Methods for determining notch signaling and uses thereof
|
|
WO2007075915A2
(en)
|
2005-12-22 |
2007-07-05 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Monoclonal antibodies against orthopoxviruses
|
|
AR059922A1
(es)
|
2006-04-01 |
2008-05-07 |
Galaxy Biotech Llc |
Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
|
|
WO2008057144A2
(en)
|
2006-05-15 |
2008-05-15 |
The Brigham And Women's Hospital, Inc. |
Functional negative regulatory domain sequences from human notch1 and 2 and isolated lnr domains from human notch1
|
|
CA2655362A1
(en)
|
2006-06-13 |
2007-12-21 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
HUE028379T2
(en)
|
2006-09-29 |
2016-12-28 |
Oncomed Pharm Inc |
Preparations and procedures for the diagnosis and treatment of cancer
|
|
CA2666672A1
(en)
*
|
2006-10-19 |
2008-05-02 |
Genentech, Inc. |
Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases
|
|
CA2666179A1
(en)
|
2006-10-19 |
2008-11-13 |
Genentech, Inc. |
Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
|
|
US7700113B2
(en)
*
|
2006-10-19 |
2010-04-20 |
Maine Medical Research Institute, A Division Of Maine Medical Center |
Inhibiting breast cancer cell growth by administering an intracellular domain of NOTCH2
|
|
WO2008057114A1
(en)
|
2006-11-06 |
2008-05-15 |
Howard Shapiro |
Management of teaching processes for individualized instruction in a multi-student environment
|
|
TWI419904B
(zh)
*
|
2006-12-18 |
2013-12-21 |
Genentech Inc |
拮抗劑抗-ｎｏｔｃｈ３抗體及其用於預防及治療ｎｏｔｃｈ３相關疾病之用途
|
|
AU2008209482B2
(en)
|
2007-01-24 |
2014-05-01 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
US20090208491A1
(en)
|
2007-02-14 |
2009-08-20 |
Austin Gurney |
Compositions and Methods for Diagnosing and Treating Cancer
|
|
JP2010520280A
(ja)
|
2007-03-05 |
2010-06-10 |
ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム |
ＮｏｔｃｈまたはＮｕｍｂ特異的免疫療法との相乗効果を有する、癌細胞の再生のネガティブな遺伝的制御
|
|
WO2008109075A2
(en)
|
2007-03-05 |
2008-09-12 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to ctla-4 antagonists
|
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
CN106432496B
(zh)
|
2007-07-16 |
2020-02-07 |
健泰科生物技术公司 |
抗cd79b抗体和免疫偶联物及使用方法
|
|
BRPI0815291A2
(pt)
|
2007-08-23 |
2015-02-03 |
Univ Columbia |
"proteina de fusão, metodo de tratamento de pacientes que possuem um tumor, método de inibição da angiogênese em pacientes, método de tratamento de pacientes que possuem câncer do ovário, método de tratamento de pacientes que possuem um distúrbio metábolico, uso de proteína de fusão, método de inibição de linfoangiogênese patológica em pacientes, método de inibição da metástase de tumores em pacientes, método de inibição do crescimento de tumores secundários em pacientes, métodos de inibição da cooptação de vasos sanguineos por um tumor em pacientes, método de tratamento de cancer em pacientes e método de tratamento da retinopatia proliferativa vascular"
|
|
CA2697106A1
(en)
|
2007-08-28 |
2009-03-12 |
Donald Bergstrom |
Expression profiles of biomarker genes in notch mediated cancers
|
|
WO2009035522A1
(en)
|
2007-09-14 |
2009-03-19 |
Albert Einstein College Of Medicine Of Yeshiva University |
Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
|
|
US7807630B2
(en)
|
2007-09-14 |
2010-10-05 |
Vanderbilt University |
Targeting of Notch3 receptor function for cancer therapy
|
|
US20120082659A1
(en)
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
|
US8119366B2
(en)
|
2007-10-05 |
2012-02-21 |
Trojan Technologies, Ltd. |
Antennapedia-dominant negative mastermind-like construct
|
|
AU2009235467A1
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Single variable domains against the Notch pathways
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
US8834875B2
(en)
|
2010-01-13 |
2014-09-16 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
NZ590127A
(en)
|
2008-07-08 |
2012-11-30 |
Oncomed Pharm Inc |
Notch1 receptor binding agents and methods of use thereof
|
|
PE20120080A1
(es)
|
2008-10-01 |
2012-02-17 |
Genentech Inc |
Anticuerpos anti-notch2 y metodos de uso
|
|
JP2012520325A
(ja)
|
2009-03-13 |
2012-09-06 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
プレバイオティックオリゴ糖
|
|
RU2012117619A
(ru)
|
2009-09-30 |
2013-11-10 |
Дженентек, Инк. |
ЛЕЧЕНИЕ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ, УСТОЙЧИВЫХ К ДЕЙСТВИЮ АНТАГОНИСТА Notch1, С ПОМОЩЬЮ АНТАГОНИСТА Notch3
|
|
DE102009047243A1
(de)
|
2009-11-27 |
2011-06-01 |
Orgentec Diagnostika Gmbh |
Monospezifische Polypeptidreagenzien
|
|
WO2011100566A2
(en)
|
2010-02-12 |
2011-08-18 |
Oncomed Pharmaceuticals, Inc. |
Methods for identifying and isolating cells expressing a polypeptide
|
|
JP5450221B2
(ja)
|
2010-04-14 |
2014-03-26 |
株式会社神戸製鋼所 |
高電流密度ガスシールドアーク溶接方法
|
|
KR20200044999A
(ko)
|
2010-05-04 |
2020-04-29 |
파이브 프라임 테라퓨틱스, 인크. |
Ｃｓｆ1ｒ에 결합하는 항체들
|
|
WO2012003472A1
(en)
|
2010-07-02 |
2012-01-05 |
Aveo Pharmaceuticals, Inc. |
Anti-notch1 antibodies
|
|
WO2012080926A2
(en)
|
2010-12-15 |
2012-06-21 |
Wyeth Llc |
Anti-notch1 antibodies
|
|
PL2683406T3
(pl)
|
2011-03-11 |
2019-11-29 |
Beth Israel Deaconess Medical Ct Inc |
Przeciwciała anty-cd40 i ich zastosowania
|
|
CN104105702B
(zh)
|
2011-11-16 |
2016-11-23 |
昂考梅德药品有限公司 |
人notch受体突变及其应用
|
|
WO2013173542A1
(en)
|
2012-05-16 |
2013-11-21 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating cancer with notch2/3 antibodies
|
|
WO2014039533A2
(en)
|
2012-09-04 |
2014-03-13 |
Eleison Pharmaceuticals, Llc |
Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
|
|
AU2013317886A1
(en)
|
2012-09-21 |
2015-04-09 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating hematological malignancies with NOTCH1 antibodies
|
|
BR112015010436A2
(pt)
*
|
2012-11-07 |
2017-08-22 |
Pfizer |
Anticorpos anti-notch3 e conjugados anticorpo-fármaco
|
|
WO2014151606A2
(en)
|
2013-03-15 |
2014-09-25 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating pancreatic cancer
|
|
WO2015134627A1
(en)
|
2014-03-07 |
2015-09-11 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating cancer with notch1 antibodies
|
|
WO2015153997A2
(en)
|
2014-04-04 |
2015-10-08 |
Oncomed Pharmaceuticals, Inc. |
Notch3 antibodies and uses thereof
|