|
CA2264819C
(en)
*
|
1996-09-04 |
2010-03-23 |
Intertrust Technologies Corp. |
Trusted infrastructure support systems, methods and techniques for secure electronic commerce, electronic transactions, commerce process control and automation, distributed computing, and rights management
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
KR20090021155A
(ko)
|
2006-04-26 |
2009-02-27 |
에프. 호프만-라 로슈 아게 |
Pi3k 억제제로서의 피리미딘 유도체
|
|
TWI498332B
(zh)
|
2006-04-26 |
2015-09-01 |
Hoffmann La Roche |
作為pi3k抑制劑之嘧啶衍生物及相關製備方法、醫藥組合物、用途、套組及產物
|
|
RU2470936C2
(ru)
*
|
2006-12-07 |
2012-12-27 |
Дженентек, Инк. |
Соединения-ингибиторы фосфоинозитид 3-киназы и способы применения
|
|
MX2009005950A
(es)
*
|
2006-12-07 |
2009-10-12 |
Genentech Inc |
Compuestos inhibidores de fosfoinositido 3-quinasas y metodos de uso.
|
|
US7893060B2
(en)
*
|
2007-06-12 |
2011-02-22 |
F. Hoffmann-La Roche Ag |
Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
|
EP2205242B1
(en)
*
|
2007-09-12 |
2015-04-15 |
Genentech, Inc. |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
CA2704711C
(en)
|
2007-09-24 |
2016-07-05 |
Genentech, Inc. |
Thiazolopyrimidine p13k inhibitor compounds and methods of use
|
|
JP5348725B2
(ja)
*
|
2007-10-25 |
2013-11-20 |
ジェネンテック, インコーポレイテッド |
チエノピリミジン化合物の製造方法
|
|
GB0721095D0
(en)
*
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US20110230464A1
(en)
*
|
2007-10-26 |
2011-09-22 |
Paul Goldsmith |
Purine derivatives useful as p13 kinase inhibitors
|
|
GB0723748D0
(en)
*
|
2007-12-04 |
2008-01-16 |
Ucb Pharma Sa |
Therapeutic agents
|
|
DK2644194T3
(en)
*
|
2008-03-18 |
2017-07-03 |
Genentech Inc |
Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
|
|
JP2011515462A
(ja)
*
|
2008-03-27 |
2011-05-19 |
アウククランド ウニセルビセス リミテッド |
置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
|
|
WO2010002954A1
(en)
*
|
2008-07-02 |
2010-01-07 |
Wyeth |
(2-aryl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
|
|
CA2729045A1
(en)
*
|
2008-07-31 |
2010-02-04 |
Philippe Bergeron |
Pyrimidine compounds, compositions and methods of use
|
|
TWI378933B
(en)
|
2008-10-14 |
2012-12-11 |
Daiichi Sankyo Co Ltd |
Morpholinopurine derivatives
|
|
GB2465405A
(en)
*
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
WO2010059788A1
(en)
*
|
2008-11-20 |
2010-05-27 |
Genentech, Inc. |
Pyrazolopyridine pi3k inhibitor compounds and methods of use
|
|
EA024252B1
(ru)
|
2009-01-08 |
2016-08-31 |
Кьюрис, Инк. |
Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой
|
|
JP5709766B2
(ja)
*
|
2009-03-12 |
2015-04-30 |
ジェネンテック, インコーポレイテッド |
造血器腫瘍の治療のためのホスホイノシチド3キナーゼ阻害剤化合物と化学療法剤の併用
|
|
CN102361878A
(zh)
|
2009-03-24 |
2012-02-22 |
住友化学株式会社 |
用于制备硼酸酯化合物的方法
|
|
TW201038567A
(en)
|
2009-03-27 |
2010-11-01 |
Pathway Therapeutics Ltd |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
BRPI1014572B8
(pt)
|
2009-04-16 |
2022-07-19 |
Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii |
Imidazopirazinas para uso como inibidores de cinase
|
|
BRPI1009022A2
(pt)
*
|
2009-05-27 |
2016-03-08 |
Hoffmann La Roche |
"composto, composição farmacêutica, processo para produzir uma composição farmacêutica, uso de um composto, método para tratamento de uma doença ou transtorno e kit"
|
|
US8158625B2
(en)
*
|
2009-05-27 |
2012-04-17 |
Genentech, Inc. |
Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
|
|
US20100331305A1
(en)
*
|
2009-06-24 |
2010-12-30 |
Genentech, Inc. |
Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use
|
|
CA2767008C
(en)
*
|
2009-07-07 |
2018-01-30 |
Pathway Therapeutics, Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
CA2768843A1
(en)
|
2009-07-21 |
2011-01-27 |
Gilead Calistoga Llc |
Treatment of liver disorders with pi3k inhibitors
|
|
NZ598220A
(en)
|
2009-08-17 |
2014-02-28 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
JP2013504325A
(ja)
*
|
2009-09-09 |
2013-02-07 |
アビラ セラピューティクス, インコーポレイテッド |
Pi3キナーゼインヒビターおよびその使用
|
|
JP2013505965A
(ja)
*
|
2009-09-29 |
2013-02-21 |
エックスカバリー ホールディング カンパニー エルエルシー |
Pi3k(デルタ)選択的阻害剤
|
|
EP2499143B1
(en)
*
|
2009-11-12 |
2016-03-16 |
F.Hoffmann-La Roche Ag |
N7-substituted purine and pyrazolopyrimidine compounds, compositions and methods of use
|
|
JP5579864B2
(ja)
*
|
2009-11-12 |
2014-08-27 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
N−9−置換プリン化合物、組成物及び使用の方法
|
|
US9073927B2
(en)
|
2010-01-22 |
2015-07-07 |
Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii |
Inhibitors of PI3 kinase
|
|
EP2539337A1
(en)
|
2010-02-22 |
2013-01-02 |
F. Hoffmann-La Roche AG |
Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
|
|
WO2011141713A1
(en)
|
2010-05-13 |
2011-11-17 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
New bicyclic compounds as pi3-k and mtor inhibitors
|
|
ES2536780T3
(es)
|
2010-07-14 |
2015-05-28 |
F. Hoffmann-La Roche Ag |
Compuestos de purina selectivos para I3 p110 delta, y métodos de uso
|
|
RU2013120966A
(ru)
*
|
2010-10-08 |
2014-11-20 |
Эббви Инк. |
ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
|
|
EP2444084A1
(en)
|
2010-10-21 |
2012-04-25 |
Centro Nacional de Investigaciones Oncológicas (CNIO) |
Use of PI3K inibitors for the treatment of obesity
|
|
TW201500358A
(zh)
|
2010-12-16 |
2015-01-01 |
赫夫門羅氏藥廠股份有限公司 |
三環pi3k抑制劑化合物及其使用方法
|
|
EP2667874A4
(en)
*
|
2011-01-27 |
2014-07-30 |
Univ Princeton |
MTOR KINASE HEMMER AS ANTIVIRUS AGENT
|
|
RU2013138835A
(ru)
|
2011-02-09 |
2015-03-20 |
Ф. Хоффманн-Ля Рош Аг |
Гетероциклические соединения в качестве ингибиторов pi3 киназы
|
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
US9090628B2
(en)
|
2011-03-21 |
2015-07-28 |
Genentech, Inc. |
Benzoxazepin compounds selective for PI3K P110 delta and methods of use
|
|
TWI572599B
(zh)
*
|
2011-03-28 |
2017-03-01 |
Mei製藥公司 |
(α-經取代之芳烷胺基及雜芳烷胺基)嘧啶基及1,3,5-三基苯并咪唑,其醫藥組合物及其在治療增生性疾病之用途
|
|
WO2012135571A1
(en)
|
2011-04-01 |
2012-10-04 |
Curis, Inc. |
Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
|
|
US20140298493A1
(en)
|
2011-07-28 |
2014-10-02 |
Somasekar Seshagiri |
PIK3CA H1047R Knock-In Non-Human Animal Breast Cancer Model
|
|
WO2013078126A1
(en)
|
2011-11-23 |
2013-05-30 |
Cancer Research Technology Limited |
Thienopyrimidine inhibitors of atypical protein kinase c
|
|
CN102643272B
(zh)
*
|
2011-12-30 |
2015-03-11 |
沈阳药科大学 |
新的噻吩并[3,2-d]嘧啶类化合物
|
|
KR20160027219A
(ko)
|
2012-05-23 |
2016-03-09 |
에프. 호프만-라 로슈 아게 |
내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
|
|
BR112014028376A2
(pt)
|
2012-06-08 |
2018-04-24 |
Hoffmann La Roche |
métodos para o tratamento de um distúrbio hiperproliferativo, para a determinação dos compostos, para monitorar, para optimizar a eficácia terapêutica e de identificação de um biomarcador; formulação farmacêutica; utilização de uma combinação terapêutica e de gdc-0032, artigo de manufatura, produto e invenção
|
|
ES2595240T3
(es)
|
2012-07-09 |
2016-12-28 |
Lupin Limited |
Derivados de tetrahidroquinazolinona como inhibidores de PARP
|
|
BR112015002493A8
(pt)
*
|
2012-08-30 |
2019-07-30 |
Hoffmann La Roche |
composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, kit e uso de um composto”
|
|
US8895729B2
(en)
|
2012-10-10 |
2014-11-25 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
EP3053926B1
(en)
*
|
2013-09-30 |
2018-08-08 |
Shanghai Yingli Pharmaceutical Co. Ltd. |
Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
|
|
TWI648281B
(zh)
|
2013-10-17 |
2019-01-21 |
日商安斯泰來製藥股份有限公司 |
含硫二環式化合物
|
|
JP6618901B2
(ja)
|
2013-11-13 |
2019-12-11 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
AR104068A1
(es)
|
2015-03-26 |
2017-06-21 |
Hoffmann La Roche |
Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
|
|
HK1250161B
(en)
|
2015-03-30 |
2020-05-15 |
Daiichi Sankyo Company, Limited |
6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
HK1249866A1
(zh)
|
2015-06-29 |
2018-11-16 |
豪夫迈‧罗氏有限公司 |
用他塞利昔布进行治疗的方法
|
|
MX2018006856A
(es)
*
|
2015-12-07 |
2018-08-01 |
Plexxikon Inc |
Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos.
|
|
PL3458067T3
(pl)
|
2016-05-18 |
2021-12-13 |
Torqur Ag |
Leczenie chorób neurologicznych
|
|
KR20190049691A
(ko)
|
2016-07-07 |
2019-05-09 |
카듀리온 파마슈티칼스, 엘엘씨 |
심부전의 치료 방법
|
|
TW201815787A
(zh)
|
2016-09-23 |
2018-05-01 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
TW201813963A
(zh)
|
2016-09-23 |
2018-04-16 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
TW201825465A
(zh)
|
2016-09-23 |
2018-07-16 |
美商基利科學股份有限公司 |
磷脂醯肌醇3-激酶抑制劑
|
|
US11304953B2
(en)
|
2017-05-23 |
2022-04-19 |
Mei Pharma, Inc. |
Combination therapy
|
|
WO2018226846A1
(en)
|
2017-06-07 |
2018-12-13 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
KR20200041358A
(ko)
|
2017-08-14 |
2020-04-21 |
메이 파마, 아이엔씨. |
병용 요법
|
|
EP3774742A1
(en)
|
2018-04-06 |
2021-02-17 |
H. Lundbeck A/S |
Process for the preparation of 2,2-dimethylpiperazine
|
|
MX2020010884A
(es)
|
2018-04-17 |
2021-02-26 |
Cardurion Pharmaceuticals Llc |
Sales de meglumina de tienopirimidinas.
|
|
CA3102279A1
(en)
|
2018-06-01 |
2019-12-05 |
Cornell University |
Combination therapy for pi3k-associated disease or disorder
|
|
MX2021002385A
(es)
*
|
2018-08-31 |
2021-04-29 |
Astellas Pharma Inc |
Composicion farmaceutica para administracion oral.
|
|
CN113164466B
(zh)
|
2018-09-11 |
2025-07-08 |
柯瑞斯公司 |
使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗
|
|
CN111205310B
(zh)
*
|
2018-11-22 |
2023-12-19 |
上海迪诺医药科技有限公司 |
杂环稠合嘧啶衍生物、其药物组合物及应用
|
|
CN112920199B
(zh)
*
|
2020-06-02 |
2023-02-03 |
四川大学 |
一种哌嗪酮取代物或其衍生物及其制备方法和应用、药物组合物
|
|
US20240150358A1
(en)
*
|
2020-06-03 |
2024-05-09 |
Kineta, Inc. |
Purines and methods of their use
|
|
CN113045582B
(zh)
*
|
2021-02-05 |
2022-12-23 |
中国药科大学 |
Parp-1/pi3k双靶点抑制剂或其药学上可接受的盐及其制备方法与用途
|
|
EP4410795A4
(en)
*
|
2021-09-30 |
2025-10-01 |
Hanmi Pharmaceutical Co Ltd |
PIKFYVE KINASE INHIBITOR
|
|
WO2023058003A1
(en)
*
|
2021-10-07 |
2023-04-13 |
Tme Therapeutics Llc |
Novel inhibitors of pikfyve and methods using same
|