JP2009538614A - プロバイオティクス菌株及びこれに由来する抗菌性ペプチド - Google Patents
プロバイオティクス菌株及びこれに由来する抗菌性ペプチド Download PDFInfo
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5881017B2 (ja) * | 2010-11-05 | 2016-03-09 | 国立大学法人広島大学 | 籾殻または玄米から単離された植物乳酸菌およびその利用 |
| JP2018537126A (ja) * | 2015-11-17 | 2018-12-20 | プレミア リサーチ ラボズ, リミテッドパートナーPremier Research Labs, LP | ジヒドロリポ酸の生成・抽出プロセス |
| WO2019151371A1 (ja) * | 2018-01-31 | 2019-08-08 | ニュートリー株式会社 | 肺炎球菌感染症の予防及び／又は治療剤 |
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| EA017558B1 (ru) * | 2006-05-28 | 2013-01-30 | Сипла Медпро Ресеч Энд Девелопмент (Пти) Лтд. | ШТАММ БАКТЕРИЙ Е.Mundtii ST4SA, СПОСОБНЫЙ ПРОДУЦИРОВАТЬ АНТИБАКТЕРИАЛЬНЫЙ ПЕПТИД ST4SA, СПОСОБ ПОЛУЧЕНИЯ ПЕПТИДА ST4SA И ПРИМЕНЕНИЕ ШТАММА БАКТЕРИЙ Е.Mundtii ST4SA И ПЕПТИДА |
| US8357519B2 (en) * | 2008-11-19 | 2013-01-22 | The Ohio State University | Methods and processes for producing esters |
| WO2011045764A1 (en) * | 2009-10-15 | 2011-04-21 | Cipla Medpro Research And Development (Pty) Ltd | A product for delivering antimicrobially active substances to an infected site |
| WO2012148891A1 (en) * | 2011-04-29 | 2012-11-01 | Evonik Degussa Corporation | Peptide-lipid conjugates and uses thereof |
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| RU2599430C1 (ru) * | 2015-07-23 | 2016-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет" | ШТАММ ЛАКТОБАКТЕРИЙ Enterococcus mundtii - ПРОДУЦЕНТ МОЛОЧНОЙ КИСЛОТЫ И АНТИБИОТИЧЕСКИХ ВЕЩЕСТВ |
| CN105385636A (zh) * | 2015-12-07 | 2016-03-09 | 江南大学 | 一株产细菌素的肠膜明串珠菌及其应用 |
| EP3436156A1 (en) | 2016-03-31 | 2019-02-06 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| AU2017240069B2 (en) | 2016-03-31 | 2024-03-07 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
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| US11179339B2 (en) * | 2017-09-19 | 2021-11-23 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or listeria strains |
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| CN109456911B (zh) * | 2018-10-10 | 2019-10-18 | 南京林业大学 | 一株蒙氏肠球菌HcM7及其应用 |
| CN110846260B (zh) * | 2019-12-18 | 2021-03-02 | 江南大学 | 一株降低生物胺的肉葡萄球菌及其应用 |
| KR20240115407A (ko) * | 2023-01-18 | 2024-07-26 | 조선대학교산학협력단 | 오리 유래 항균 펩타이드로부터 설계된 신규 항균 펩타이드 및 이의 용도 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002238465A (ja) * | 2001-02-05 | 2002-08-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | 農業家畜飼育用飼料への添加物としてのプロバイオテックス含有ソルビン酸調製物 |
| JP2003339377A (ja) * | 2002-05-23 | 2003-12-02 | Prima Meat Packers Ltd | 新規バクテリオシン |
| WO2004005492A2 (fr) * | 2002-07-03 | 2004-01-15 | Galina Gennadievna Alekhina | Composition probiotique a base d'une souche d'enterocoques pour moyens de traitement et de prevention et procede de fabrication correspondant |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1084969A (ja) | 1996-09-19 | 1998-04-07 | Chemo Sero Therapeut Res Inst | ヘモフィルス・パラガリナルム由来新規ポリペプチド及びその製法 |
| US7655775B2 (en) * | 1997-09-05 | 2010-02-02 | Canbiocin, Inc. | Expression vectors for treating bacterial infections |
| WO2001030818A1 (fr) | 1999-10-22 | 2001-05-03 | Shanghai Bio Road Gene Development Ltd. | Nouveau polypeptide, proteine de liaison 33 a l'arn, et polynucleotide codant pour ce polypeptide |
| GB0027761D0 (en) | 2000-11-14 | 2000-12-27 | Nestle Sa | Nutritional composition for an immune condition |
| GB0125535D0 (en) | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
| US6878373B2 (en) | 2001-12-03 | 2005-04-12 | Micropure Technologies, Inc. | Probiotic composition containing Bacillus cereus RRRL B-30535 |
| EP1384483A1 (en) | 2002-07-23 | 2004-01-28 | Nestec S.A. | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
| ITBO20020564A1 (it) | 2002-09-06 | 2004-03-07 | Alfa Wassermann Spa | Bifidobatteri e preparazioni che li contengono. |
| EA017558B1 (ru) * | 2006-05-28 | 2013-01-30 | Сипла Медпро Ресеч Энд Девелопмент (Пти) Лтд. | ШТАММ БАКТЕРИЙ Е.Mundtii ST4SA, СПОСОБНЫЙ ПРОДУЦИРОВАТЬ АНТИБАКТЕРИАЛЬНЫЙ ПЕПТИД ST4SA, СПОСОБ ПОЛУЧЕНИЯ ПЕПТИДА ST4SA И ПРИМЕНЕНИЕ ШТАММА БАКТЕРИЙ Е.Mundtii ST4SA И ПЕПТИДА |
-
2007
- 2007-05-25 EA EA200802409A patent/EA017558B1/ru not_active IP Right Cessation
- 2007-05-25 KR KR1020087031307A patent/KR101521123B1/ko not_active Expired - Fee Related
- 2007-05-25 CN CN2007800198580A patent/CN101454440B/zh not_active Expired - Fee Related
- 2007-05-25 AP AP2008004626A patent/AP2841A/xx active
- 2007-05-25 AU AU2007266675A patent/AU2007266675B2/en not_active Ceased
- 2007-05-25 US US12/302,067 patent/US7951385B2/en active Active
- 2007-05-25 JP JP2009512739A patent/JP2009538614A/ja active Pending
- 2007-05-25 CA CA002647161A patent/CA2647161A1/en not_active Abandoned
- 2007-05-25 WO PCT/IB2007/051982 patent/WO2007138538A2/en not_active Ceased
- 2007-05-25 EP EP07736018.8A patent/EP2021457B1/en active Active
- 2007-05-25 NZ NZ571619A patent/NZ571619A/en not_active IP Right Cessation
-
2008
- 2008-11-03 NO NO20084577A patent/NO20084577L/no not_active Application Discontinuation
- 2008-11-26 IL IL195520A patent/IL195520A0/en unknown
-
2011
- 2011-04-26 US US13/094,155 patent/US8444998B2/en not_active Expired - Fee Related
-
2017
- 2017-02-16 IL IL250634A patent/IL250634A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002238465A (ja) * | 2001-02-05 | 2002-08-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | 農業家畜飼育用飼料への添加物としてのプロバイオテックス含有ソルビン酸調製物 |
| JP2003339377A (ja) * | 2002-05-23 | 2003-12-02 | Prima Meat Packers Ltd | 新規バクテリオシン |
| WO2004005492A2 (fr) * | 2002-07-03 | 2004-01-15 | Galina Gennadievna Alekhina | Composition probiotique a base d'une souche d'enterocoques pour moyens de traitement et de prevention et procede de fabrication correspondant |
Non-Patent Citations (7)
| Title |
|---|
| JPN6012026131; Ａｐｐｌ Ｅｎｖｉｒｏｎ Ｍｉｃｒｏｂｉｏｌ．， ２００２年， 第６８巻， ３８３０-３８４０ページ * |
| JPN6012026132; Ａｎｔｉｍｉｃｒｏｂ Ａｇｅｎｔｓ Ｃｈｅｍｏｔｈｅｒ．， ２００４年， 第４８巻， ２７７８-２７８１ページ * |
| JPN6012026135; Ｉｎｔ Ｊ Ａｎｔｉｍｉｃｒｏｂ Ａｇｅｎｔｓ．， １９９９年， 第１２巻， ２９３-２９９ページ * |
| JPN6013036188; Ｆｅｅｄ Ｍｉｘ Ｓｐｅｃｉａｌ， ２０００年， ２８-３０ページ * |
| JPN6013036189; Ｉｎｔ Ｊ Ｆｏｏｄ Ｍｉｃｒｏｂｉｏｌ．， １９９９年， 第４７巻， １-２４ページ * |
| JPN6013036190; Ａｎａｅｒｏｂｅ， １９９７年， 第３巻， ７３-７８ページ * |
| JPN6013036191; Ｉｎｔ Ｊ Ｆｏｏｄ Ｍｉｃｒｏｂｉｏｌ．， ２００６年１月， 第１０６巻， １-２４ページ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5881017B2 (ja) * | 2010-11-05 | 2016-03-09 | 国立大学法人広島大学 | 籾殻または玄米から単離された植物乳酸菌およびその利用 |
| JP2018537126A (ja) * | 2015-11-17 | 2018-12-20 | プレミア リサーチ ラボズ, リミテッドパートナーPremier Research Labs, LP | ジヒドロリポ酸の生成・抽出プロセス |
| WO2019151371A1 (ja) * | 2018-01-31 | 2019-08-08 | ニュートリー株式会社 | 肺炎球菌感染症の予防及び／又は治療剤 |
| JPWO2019151371A1 (ja) * | 2018-01-31 | 2021-01-07 | ニュートリー株式会社 | 肺炎球菌感染症の予防及び／又は治療剤 |
| JP7289798B2 (ja) | 2018-01-31 | 2023-06-12 | ニュートリー株式会社 | 肺炎球菌感染症の予防及び／又は治療剤 |
| US11911420B2 (en) | 2018-01-31 | 2024-02-27 | Nutri Co., Ltd. | Prophylactic and/or therapeutic agents for Streptococcus pneumoniae infection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101454440B (zh) | 2013-05-29 |
| KR101521123B1 (ko) | 2015-05-19 |
| NO20084577L (no) | 2008-12-19 |
| EA017558B1 (ru) | 2013-01-30 |
| US7951385B2 (en) | 2011-05-31 |
| WO2007138538A2 (en) | 2007-12-06 |
| IL250634A0 (en) | 2017-03-30 |
| AU2007266675B2 (en) | 2012-09-06 |
| US20110268703A1 (en) | 2011-11-03 |
| EP2021457B1 (en) | 2015-02-11 |
| AU2007266675A1 (en) | 2007-12-06 |
| WO2007138538A3 (en) | 2008-04-17 |
| US8444998B2 (en) | 2013-05-21 |
| KR20090023626A (ko) | 2009-03-05 |
| AP2008004626A0 (en) | 2008-10-31 |
| CA2647161A1 (en) | 2007-12-06 |
| EP2021457A2 (en) | 2009-02-11 |
| EA200802409A1 (ru) | 2009-10-30 |
| NZ571619A (en) | 2011-10-28 |
| US20090297482A1 (en) | 2009-12-03 |
| CN101454440A (zh) | 2009-06-10 |
| IL195520A0 (en) | 2011-08-01 |
| AP2841A (en) | 2014-02-28 |
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