JP2009538386A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009538386A5 JP2009538386A5 JP2009512295A JP2009512295A JP2009538386A5 JP 2009538386 A5 JP2009538386 A5 JP 2009538386A5 JP 2009512295 A JP2009512295 A JP 2009512295A JP 2009512295 A JP2009512295 A JP 2009512295A JP 2009538386 A5 JP2009538386 A5 JP 2009538386A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- lmwh
- composition according
- activity
- surgical intervention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 122
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 113
- 230000000694 effects Effects 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 20
- 238000011477 surgical intervention Methods 0.000 claims description 19
- 230000001858 anti-Xa Effects 0.000 claims description 16
- 229920000669 heparin Polymers 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 208000035475 disorder Diseases 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 239000003495 polar organic solvent Substances 0.000 claims description 10
- 102000007327 Protamines Human genes 0.000 claims description 9
- 108010007568 Protamines Proteins 0.000 claims description 9
- 150000002016 disaccharides Chemical class 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000002244 precipitate Substances 0.000 claims description 8
- 238000001556 precipitation Methods 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 206010053567 Coagulopathies Diseases 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 230000035602 clotting Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229950008679 protamine sulfate Drugs 0.000 claims description 5
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 238000013146 percutaneous coronary intervention Methods 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims description 3
- 102000002262 Thromboplastin Human genes 0.000 claims description 3
- 108010000499 Thromboplastin Proteins 0.000 claims description 3
- 208000007536 Thrombosis Diseases 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 206010002388 Angina unstable Diseases 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108010022901 Heparin Lyase Proteins 0.000 claims description 2
- 208000000770 Non-ST Elevated Myocardial Infarction Diseases 0.000 claims description 2
- 208000006117 ST-elevation myocardial infarction Diseases 0.000 claims description 2
- 208000007718 Stable Angina Diseases 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 208000007814 Unstable Angina Diseases 0.000 claims description 2
- 238000002399 angioplasty Methods 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 230000003381 solubilizing effect Effects 0.000 claims description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 2
- 150000002482 oligosaccharides Polymers 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 241000287463 Phalacrocorax Species 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000007820 coagulation assay Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003055 low molecular weight heparin Substances 0.000 claims 1
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 26
- 238000012544 monitoring process Methods 0.000 description 5
- 229940048914 protamine Drugs 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 3
- 229960000610 enoxaparin Drugs 0.000 description 2
- 150000002118 epoxides Chemical class 0.000 description 2
- 150000008273 hexosamines Chemical class 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000005084 2D-nuclear magnetic resonance Methods 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical class OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960004969 dalteparin Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- CENHPXAQKISCGD-UHFFFAOYSA-N trioxathietane 4,4-dioxide Chemical compound O=S1(=O)OOO1 CENHPXAQKISCGD-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80913606P | 2006-05-25 | 2006-05-25 | |
| US84957806P | 2006-10-04 | 2006-10-04 | |
| US84962806P | 2006-10-05 | 2006-10-05 | |
| PCT/US2007/069626 WO2007140231A2 (en) | 2006-05-25 | 2007-05-24 | Low molecular weight heparin composition and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538386A JP2009538386A (ja) | 2009-11-05 |
| JP2009538386A5 true JP2009538386A5 (https=) | 2010-06-17 |
Family
ID=38722686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512295A Pending JP2009538386A (ja) | 2006-05-25 | 2007-05-24 | 低分子量ヘパリン組成物およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8609632B2 (https=) |
| EP (3) | EP2447285A3 (https=) |
| JP (1) | JP2009538386A (https=) |
| CN (1) | CN101495517B (https=) |
| AU (1) | AU2007267561B2 (https=) |
| CA (1) | CA2652205A1 (https=) |
| WO (1) | WO2007140231A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575886B2 (en) | 2002-03-11 | 2009-08-18 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
| CN101495517B (zh) | 2006-05-25 | 2012-10-10 | 莫曼塔医药品有限公司 | 低分子量肝素及其用途 |
| US7968082B1 (en) | 2007-01-26 | 2011-06-28 | Momenta Pharmaceuticals, Inc. | Evaluating mixtures of low molecular weight heparins by NMR |
| US7790466B1 (en) * | 2007-01-26 | 2010-09-07 | Momenta Pharmaceuticals, Inc. | Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping |
| US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
| US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| US8592393B2 (en) | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| ES2567079T3 (es) | 2007-11-02 | 2016-04-19 | Momenta Pharmaceuticals, Inc. | Composiciones de polisacáridos que no son anticoagulantes |
| WO2009105522A1 (en) * | 2008-02-20 | 2009-08-27 | Momenta Pharmaceuticals, Inc. | Methods of making low molecular weight heparin compositions |
| US20100036310A1 (en) * | 2008-08-05 | 2010-02-11 | Hillman Robert S | Integrated patient management and control system for medication delivery |
| CN101711771B (zh) * | 2008-10-07 | 2015-12-09 | 上海喜恩医药科技发展有限公司 | 一种肝素衍生的多糖混合物及其制法和药物组合物 |
| EP2256138A1 (en) * | 2009-05-05 | 2010-12-01 | Sanofi-Aventis | Novel acylated 1,6-anhhydro decasaccharide and its use as antithrombotic agent |
| EP2256137A1 (en) * | 2009-05-05 | 2010-12-01 | Sanofi-Aventis | Novel sulfated octasaccharide and its use as antithrombotic agent |
| EP2256136A1 (en) * | 2009-05-05 | 2010-12-01 | Sanofi-Aventis | Novel acylated decasaccharides and their use as antithrombotic agents |
| EP2256139A1 (en) * | 2009-05-05 | 2010-12-01 | Sanofi-Aventis | Novel sulfated heptasaccharide and its use as antithrombotic agent |
| US8834807B2 (en) * | 2009-08-12 | 2014-09-16 | Caliper Life Sciences, Inc. | Device and method for improving sample injection and stacking |
| FR2949114B1 (fr) * | 2009-08-14 | 2011-08-26 | Sanofi Aventis | OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| WO2011031299A1 (en) * | 2009-08-28 | 2011-03-17 | Mount Sinai School Of Medicine Of New York University | Intrapericardial injections |
| EP2480237A1 (en) * | 2009-09-23 | 2012-08-01 | Momenta Pharmaceuticals, Inc. | Methods of treatment with a low molecular weight heparin composition |
| CN102711463B (zh) | 2009-12-03 | 2015-05-13 | Opko健康公司 | 超硫酸化双糖制剂 |
| US8435795B2 (en) * | 2010-01-19 | 2013-05-07 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| BR112012026542A2 (pt) | 2010-04-16 | 2016-07-12 | Momenta Pharmaceuticals Inc | abordagem seletiva de tecido |
| CA2795868A1 (en) | 2010-06-17 | 2011-12-22 | Momenta Pharmaceuticals, Inc. | Methods and compositions for modulating hair growth |
| US11203772B2 (en) | 2010-12-23 | 2021-12-21 | The University Of North Carolina At Chapel Hill | Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins |
| UA112070C2 (uk) * | 2011-01-28 | 2016-07-25 | Хангжоу Джіуюан Джін Енджініерінг Ко., Лтд | Спосіб капілярного електрофорезу для аналізу тонкої структури еноксапарину натрію |
| US9068957B2 (en) | 2011-02-21 | 2015-06-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| WO2013095215A1 (en) * | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| CN104144950B (zh) * | 2011-12-19 | 2017-09-05 | 迪乐方有限责任公司 | 含有重复的二糖单元的非抗凝的葡糖胺聚糖及其医药用途 |
| CN103059165B (zh) * | 2012-12-26 | 2015-04-29 | 安徽丰原药业股份有限公司 | 一种多糖酰化物及其制备方法 |
| CN103204958B (zh) * | 2013-04-24 | 2015-04-01 | 深圳赛保尔生物药业有限公司 | 一种低乙醇残留的那曲肝素钙生产工艺 |
| JP2016520613A (ja) | 2013-05-28 | 2016-07-14 | モメンタ ファーマシューティカルズ インコーポレイテッド | 薬学的組成物 |
| ES2924830T3 (es) * | 2013-06-17 | 2022-10-11 | Univ North Carolina Chapel Hill | Moléculas de heparina reversibles |
| CN103788232A (zh) * | 2013-12-23 | 2014-05-14 | 深圳市海普瑞药业股份有限公司 | 一种硫酸乙酰肝素十糖及其制备方法和应用 |
| CN104193849B (zh) * | 2014-08-13 | 2016-08-17 | 南京健友生化制药股份有限公司 | 一种依诺肝素钠的生产方法 |
| US10688249B2 (en) * | 2015-06-11 | 2020-06-23 | Virchow Biotech Pvt. Ltd. | Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same |
| CN105504097B (zh) * | 2015-12-30 | 2018-07-03 | 深圳市海普瑞药业集团股份有限公司 | 一种硫酸化肝素寡糖及其制备方法和应用 |
| JP6741277B2 (ja) * | 2015-12-30 | 2020-08-19 | シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドＳｈｅｎｚｈｅｎ Ｈｅｐａｌｉｎｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． | 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用 |
| JP6844890B2 (ja) * | 2016-01-07 | 2021-03-17 | 藤森工業株式会社 | 採血管、試薬及びそれらを利用した血液性状分析方法 |
| CN105461831A (zh) * | 2016-01-08 | 2016-04-06 | 东营天东制药有限公司 | 一种快速分离快速移动肝素与硫酸皮肤素的方法 |
| RU2641058C1 (ru) * | 2016-11-17 | 2018-01-15 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Способ профилактики венозной тромбоэмболии у больных раком шейки матки |
| CN108117614B (zh) * | 2016-11-29 | 2020-09-04 | 北京碧澄生物科技有限公司 | 低分子量肝素 |
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| WO2019010216A1 (en) | 2017-07-03 | 2019-01-10 | The University Of North Carolina At Chapel Hill | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES |
| JP7495061B2 (ja) | 2017-11-03 | 2024-06-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗炎症作用を有する硫酸化オリゴ糖 |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| WO2020010273A1 (en) | 2018-07-03 | 2020-01-09 | University Of Miami | Compositions and methods for treating inflammasome related diseases or conditions |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| CA3144968A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| WO2021097345A1 (en) | 2019-11-13 | 2021-05-20 | The University Of North Carolina At Chapel Hill | Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury |
| WO2021253008A1 (en) * | 2020-06-12 | 2021-12-16 | Ihp Therapeutics Inc. | Partially desulfated heparin for treating coronaviral infections |
| IL308411A (en) * | 2021-05-12 | 2024-01-01 | Nexeos Diagnostics Inc | Methods for the production of the high molecular weight heparin (HMWH) compound |
| KR20250063537A (ko) * | 2023-11-01 | 2025-05-08 | 건국대학교 글로컬산학협력단 | 저분자량 헤파린 및 지질이 결합되어 자가 조립된 나노 입자, 이의 제조방법 및 이의 용도 |
| WO2026057759A1 (en) * | 2024-09-13 | 2026-03-19 | Sanofi | Novel bioengineered heparins, low molecular weight heparins derived thereof, and their method of production |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK196986D0 (da) * | 1986-04-30 | 1986-04-30 | Novo Industri As | Fremstilling af polysaccharider |
| FR2663639B1 (fr) | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
| US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
| US5849721A (en) * | 1992-02-07 | 1998-12-15 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof |
| FR2687158B1 (fr) | 1992-02-07 | 1995-06-30 | Rhone Poulenc Rorer Sa | Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation. |
| US5681733A (en) | 1994-06-10 | 1997-10-28 | Ibex Technologies | Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum |
| FR2723847A1 (fr) * | 1994-08-29 | 1996-03-01 | Debiopharm Sa | Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques. |
| US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| CA2293595A1 (en) * | 1997-06-06 | 1998-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Modified low molecular weight heparin that inhibits clot associated coagulation factors |
| US20010046974A1 (en) * | 1997-06-06 | 2001-11-29 | Hamilton Civic Hospitals Res Dev., Inc. | Modified low molecular weight heparin that inhibits clot associated coagulation factors |
| US5896789A (en) | 1997-10-09 | 1999-04-27 | Chicago Pneumatic Tool Company | Ratchet wrench head |
| JP4226101B2 (ja) | 1998-05-12 | 2009-02-18 | 株式会社アルバック | 静電チャックプレート表面からの基板離脱方法 |
| US20020009782A1 (en) * | 1999-06-03 | 2002-01-24 | Daphna Miron | Heparin and heparan sulfate derived oligosaccharides and a method for their manufacture |
| CA2377734A1 (en) * | 1999-06-30 | 2001-01-11 | Hamilton Civic Hospitals Research Development, Inc. | Heparin compositions that inhibit clot associated coagulation factors |
| RU2322245C2 (ru) | 2000-01-10 | 2008-04-20 | Дитер ВЕЛЬЦЕЛЬ | Гепарин со средней молекулярной массой |
| CA2402160C (en) * | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| US6608042B2 (en) * | 2000-03-28 | 2003-08-19 | Aventis Pharma, S.A. | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof |
| FR2811992B1 (fr) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| US6969705B2 (en) * | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| DE60138115D1 (de) | 2000-09-12 | 2009-05-07 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2002224408B2 (en) | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| US20030050799A1 (en) * | 2001-04-03 | 2003-03-13 | Richard Jay | Permission based marketing for use with medical prescriptions |
| JP2005505537A (ja) * | 2001-08-28 | 2005-02-24 | レオ・ファーマ・アクティーゼルスカブ | 低分子量ヘパリンと低分子量デルマタン硫酸とを含む抗血栓組成物 |
| US7084118B2 (en) * | 2002-02-22 | 2006-08-01 | Genentech, Inc. | Combination treatment with t-PA variant and low molecular weight heparin |
| US7575886B2 (en) | 2002-03-11 | 2009-08-18 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR2857971B1 (fr) * | 2003-07-24 | 2005-08-26 | Aventis Pharma Sa | Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| US7662928B2 (en) * | 2003-08-08 | 2010-02-16 | The Research Foundation Of State University Of New York | Anti-FcRn antibodies for treatment of auto/allo immune conditions |
| CN1268650C (zh) * | 2003-12-24 | 2006-08-09 | 兆科药业（合肥）有限公司 | 一种低亚硝酸盐含量的低分子肝素钙的制备方法 |
| RU2295538C2 (ru) | 2005-03-01 | 2007-03-20 | Гематологический научный центр РАМН | Способ получения гепаринов с низкой молекулярной массой |
| AU2007244927B2 (en) * | 2006-04-24 | 2012-01-12 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| CN101495517B (zh) | 2006-05-25 | 2012-10-10 | 莫曼塔医药品有限公司 | 低分子量肝素及其用途 |
-
2007
- 2007-05-24 CN CN2007800280960A patent/CN101495517B/zh not_active Expired - Fee Related
- 2007-05-24 AU AU2007267561A patent/AU2007267561B2/en not_active Ceased
- 2007-05-24 EP EP11172772A patent/EP2447285A3/en not_active Withdrawn
- 2007-05-24 JP JP2009512295A patent/JP2009538386A/ja active Pending
- 2007-05-24 EP EP07797722A patent/EP2019843A2/en not_active Withdrawn
- 2007-05-24 CA CA002652205A patent/CA2652205A1/en not_active Abandoned
- 2007-05-24 EP EP11172771A patent/EP2404939A3/en not_active Withdrawn
- 2007-05-24 US US11/805,829 patent/US8609632B2/en not_active Expired - Fee Related
- 2007-05-24 WO PCT/US2007/069626 patent/WO2007140231A2/en not_active Ceased
-
2010
- 2010-05-26 US US12/788,264 patent/US20100305022A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009538386A5 (https=) | ||
| US8609632B2 (en) | Low molecular weight heparin composition and uses thereof | |
| Casu et al. | Re-visiting the structure of heparin | |
| EP2205642B1 (en) | Non-anticoagulant polysaccharide compositions | |
| EP2794666B1 (en) | Use of chemically modified heparin derivates in sickle cell disease | |
| US8592393B2 (en) | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization | |
| EP1070503B1 (en) | Compositions comprising low molecular weight Heparin | |
| JPH0629282B2 (ja) | 解重合及び超硫酸化ヘパリン、その製造方法並びに製薬組成物 | |
| RU2010122324A (ru) | Полисахаридные композиции, не обладающие антикоагулянтными свойствами | |
| Fu et al. | Structure and activity of a new low-molecular-weight heparin produced by enzymatic ultrafiltration | |
| Fareed et al. | Biochemical and pharmacologic heterogeneity in low molecular weight heparins. Impact on the therapeutic profile | |
| BR112014014454B1 (pt) | glicosaminoglicanos não anti-coagulativos compreendendo unidade de dissacarìdo repetida e seus usos médicos | |
| US20110076729A1 (en) | Methods of making low molecular weight heparin compositions | |
| US20120322760A1 (en) | Methods of treatment with a low molecular weight heparin composition | |
| JPH10218902A (ja) | 低分子化硫酸化多糖、その製造法及び医薬組成物 | |
| JP4897991B2 (ja) | 超低分子量ヘパリン組成物 | |
| US7812151B2 (en) | Low molecular weight polysaccharides having antithrombotic activity | |
| JPH10218902A5 (https=) | ||
| JP2010518251A (ja) | ビオチンまたはビオチン誘導体との少なくとも１つの共有結合を含むヘパリン、これらの調製方法およびこれらの使用 | |
| US7618652B2 (en) | Glycosaminoglycan anticoagulants derived from fish | |
| RU2008151420A (ru) | Композиции гепарина низкой молекулярной массы и их применение | |
| Messmore et al. | Studies comparing low molecular weight heparin with heparin for the treatment of thromboembolism: a literature review | |
| Mousa | Heparin and low molecular weight heparin in thrombosis, cancer, and inflammatory diseases | |
| Bisio et al. | Carbohydrate‐Based Antithrombotics | |
| THABETHE | THE HEPARINS |