JP2009537246A5 - - Google Patents
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- Publication number
- JP2009537246A5 JP2009537246A5 JP2009511194A JP2009511194A JP2009537246A5 JP 2009537246 A5 JP2009537246 A5 JP 2009537246A5 JP 2009511194 A JP2009511194 A JP 2009511194A JP 2009511194 A JP2009511194 A JP 2009511194A JP 2009537246 A5 JP2009537246 A5 JP 2009537246A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- treprostinil
- metered dose
- kit
- dose inhaler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 25
- 229940071648 metered dose inhaler Drugs 0.000 claims 22
- 229960005032 treprostinil Drugs 0.000 claims 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 230000009885 systemic effect Effects 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 229940112141 dry powder inhaler Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 4
- 229940124818 soft mist inhaler Drugs 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 208000002815 pulmonary hypertension Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- -1 ambrisenatn Chemical compound 0.000 claims 2
- 229960000528 amlodipine Drugs 0.000 claims 2
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 2
- 230000004872 arterial blood pressure Effects 0.000 claims 2
- 229960002890 beraprost Drugs 0.000 claims 2
- CTPOHARTNNSRSR-APJZLKAGSA-N beraprost Chemical compound O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC(O)=O CTPOHARTNNSRSR-APJZLKAGSA-N 0.000 claims 2
- 229960003065 bosentan Drugs 0.000 claims 2
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 claims 2
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 2
- 229960004166 diltiazem Drugs 0.000 claims 2
- 208000002173 dizziness Diseases 0.000 claims 2
- 229960001123 epoprostenol Drugs 0.000 claims 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 2
- 238000011010 flushing procedure Methods 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 229960002240 iloprost Drugs 0.000 claims 2
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 229960001597 nifedipine Drugs 0.000 claims 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 2
- 229960003310 sildenafil Drugs 0.000 claims 2
- 229960002578 sitaxentan Drugs 0.000 claims 2
- PHWXUGHIIBDVKD-UHFFFAOYSA-N sitaxentan Chemical compound CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl PHWXUGHIIBDVKD-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229960000835 tadalafil Drugs 0.000 claims 2
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 2
- 229960002381 vardenafil Drugs 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80001606P | 2006-05-15 | 2006-05-15 | |
| US60/800,016 | 2006-05-15 | ||
| PCT/US2007/068884 WO2007134292A2 (en) | 2006-05-15 | 2007-05-14 | Treprostinil administration using a metered dose inhaler |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013185229A Division JP2014114269A (ja) | 2006-05-15 | 2013-09-06 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2015142794A Division JP2016006066A (ja) | 2006-05-15 | 2015-07-17 | 定量吸入器を用いたトレプロスチニル投与 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537246A JP2009537246A (ja) | 2009-10-29 |
| JP2009537246A5 true JP2009537246A5 (enExample) | 2010-06-17 |
| JP5797376B2 JP5797376B2 (ja) | 2015-10-21 |
Family
ID=38544006
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511194A Active JP5797376B2 (ja) | 2006-05-15 | 2007-05-14 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2013185229A Withdrawn JP2014114269A (ja) | 2006-05-15 | 2013-09-06 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2015142794A Withdrawn JP2016006066A (ja) | 2006-05-15 | 2015-07-17 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2019038370A Pending JP2019112434A (ja) | 2006-05-15 | 2019-03-04 | 定量吸入器を用いたトレプロスチニル投与 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013185229A Withdrawn JP2014114269A (ja) | 2006-05-15 | 2013-09-06 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2015142794A Withdrawn JP2016006066A (ja) | 2006-05-15 | 2015-07-17 | 定量吸入器を用いたトレプロスチニル投与 |
| JP2019038370A Pending JP2019112434A (ja) | 2006-05-15 | 2019-03-04 | 定量吸入器を用いたトレプロスチニル投与 |
Country Status (8)
| Country | Link |
|---|---|
| US (10) | US20080200449A1 (enExample) |
| EP (1) | EP2026816B1 (enExample) |
| JP (4) | JP5797376B2 (enExample) |
| KR (1) | KR101390579B1 (enExample) |
| CN (1) | CN101495122B (enExample) |
| CA (1) | CA2654492C (enExample) |
| ES (1) | ES2707548T3 (enExample) |
| WO (1) | WO2007134292A2 (enExample) |
Families Citing this family (63)
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| CN101287457B (zh) * | 2004-04-12 | 2011-11-16 | 联合治疗公司 | Treprostinil用于治疗神经性糖尿病的足部溃疡的用途 |
| WO2007134292A2 (en) * | 2006-05-15 | 2007-11-22 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| CN101678033A (zh) * | 2007-02-09 | 2010-03-24 | 联合治疗公司 | 用于间质性肺病和哮喘的曲前列尼治疗 |
| EP2252570B1 (en) | 2007-12-17 | 2017-04-05 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin ® |
| WO2009115235A1 (en) * | 2008-03-20 | 2009-09-24 | Bayer Schering Pharma Aktiengesellschaft | Pde inhibitors for the treatment of pulmonary hypertension |
| WO2009137066A1 (en) * | 2008-05-08 | 2009-11-12 | United Therapeutics Corporation | Treprostinil monohydrate |
| EP2330893A4 (en) * | 2008-09-25 | 2013-01-09 | Aradigm Corp | DEEP PULMONARY ADMINISTRATION OF TREPROSTINIL |
| CN102421288B (zh) * | 2009-05-07 | 2015-04-22 | 联合治疗公司 | 前列环素类似物的固体剂型 |
| MY157166A (en) | 2009-06-12 | 2016-05-13 | Mankind Corp | Diketopiperazine microparticles with defined specific surface areas |
| ES2611187T3 (es) * | 2010-03-15 | 2017-05-05 | United Therapeutics Corporation | Tratamiento para hipertensión pulmonar |
| EP2576492B1 (en) | 2010-06-03 | 2017-09-20 | United Therapeutics Corporation | Treprostinil production |
| EP2681204B1 (en) | 2011-03-02 | 2016-04-27 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| RU2605849C2 (ru) * | 2011-04-26 | 2016-12-27 | Фектура Гмбх | Введение илопроста в виде аэрозольных болюсов |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
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| CN104822372A (zh) * | 2012-11-30 | 2015-08-05 | 英斯梅德股份有限公司 | 前列环素组合物及其使用方法 |
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-
2007
- 2007-05-14 WO PCT/US2007/068884 patent/WO2007134292A2/en not_active Ceased
- 2007-05-14 CN CN2007800239379A patent/CN101495122B/zh active Active
- 2007-05-14 KR KR1020087030212A patent/KR101390579B1/ko active Active
- 2007-05-14 JP JP2009511194A patent/JP5797376B2/ja active Active
- 2007-05-14 ES ES07783735T patent/ES2707548T3/es active Active
- 2007-05-14 US US11/748,205 patent/US20080200449A1/en not_active Abandoned
- 2007-05-14 CA CA2654492A patent/CA2654492C/en active Active
- 2007-05-14 EP EP07783735.9A patent/EP2026816B1/en active Active
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2009
- 2009-11-12 US US12/591,200 patent/US9358240B2/en active Active
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2012
- 2012-05-11 US US13/469,854 patent/US9339507B2/en active Active
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2013
- 2013-09-06 JP JP2013185229A patent/JP2014114269A/ja not_active Withdrawn
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2015
- 2015-07-17 JP JP2015142794A patent/JP2016006066A/ja not_active Withdrawn
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2016
- 2016-02-01 US US15/011,999 patent/US10376525B2/en active Active
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2019
- 2019-03-04 JP JP2019038370A patent/JP2019112434A/ja active Pending
- 2019-08-09 US US16/536,954 patent/US20190365778A1/en not_active Abandoned
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2020
- 2020-01-31 US US16/778,662 patent/US10716793B2/en active Active
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2021
- 2021-09-27 US US17/486,721 patent/US11357782B2/en active Active
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2022
- 2022-03-29 US US17/707,651 patent/US20220218720A1/en active Pending
- 2022-05-16 US US17/745,333 patent/US20220323459A1/en active Pending
- 2022-10-17 US US17/967,255 patent/US20230062605A1/en active Pending
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