KR101390579B1 - 정량 흡입기를 사용한 트레프로스티닐 투여 - Google Patents
정량 흡입기를 사용한 트레프로스티닐 투여 Download PDFInfo
- Publication number
- KR101390579B1 KR101390579B1 KR1020087030212A KR20087030212A KR101390579B1 KR 101390579 B1 KR101390579 B1 KR 101390579B1 KR 1020087030212 A KR1020087030212 A KR 1020087030212A KR 20087030212 A KR20087030212 A KR 20087030212A KR 101390579 B1 KR101390579 B1 KR 101390579B1
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- South Korea
- Prior art keywords
- treprostinil
- acceptable salt
- pharmaceutically acceptable
- delete delete
- inhalation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80001606P | 2006-05-15 | 2006-05-15 | |
| US60/800,016 | 2006-05-15 | ||
| PCT/US2007/068884 WO2007134292A2 (en) | 2006-05-15 | 2007-05-14 | Treprostinil administration using a metered dose inhaler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090007797A KR20090007797A (ko) | 2009-01-20 |
| KR101390579B1 true KR101390579B1 (ko) | 2014-05-19 |
Family
ID=38544006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087030212A Active KR101390579B1 (ko) | 2006-05-15 | 2007-05-14 | 정량 흡입기를 사용한 트레프로스티닐 투여 |
Country Status (8)
| Country | Link |
|---|---|
| US (10) | US20080200449A1 (enExample) |
| EP (1) | EP2026816B1 (enExample) |
| JP (4) | JP5797376B2 (enExample) |
| KR (1) | KR101390579B1 (enExample) |
| CN (1) | CN101495122B (enExample) |
| CA (1) | CA2654492C (enExample) |
| ES (1) | ES2707548T3 (enExample) |
| WO (1) | WO2007134292A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020022546A1 (ko) * | 2018-07-24 | 2020-01-30 | 주식회사 마더스제약 | 보센탄을 함유한 약학 제제 |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE462427T1 (de) * | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| KR101390579B1 (ko) | 2006-05-15 | 2014-05-19 | 유나이티드 세러퓨틱스 코오포레이션 | 정량 흡입기를 사용한 트레프로스티닐 투여 |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| EP2120961A1 (en) * | 2007-02-09 | 2009-11-25 | United Therapeutics Corporation | Treprostinil treatment for interstitial lung disease and asthma |
| KR20160048222A (ko) | 2007-12-17 | 2016-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법 |
| WO2009115235A1 (en) * | 2008-03-20 | 2009-09-24 | Bayer Schering Pharma Aktiengesellschaft | Pde inhibitors for the treatment of pulmonary hypertension |
| ES2575565T3 (es) * | 2008-05-08 | 2016-06-29 | United Therapeutics Corporation | Procedimiento para la preparación de monohidrato de treprostinilo y su utilización para el almacenamiento y el envío |
| WO2010036798A1 (en) * | 2008-09-25 | 2010-04-01 | Aradigm Corporation | Deep lung pulmonary delivery of treprostinil |
| KR101544246B1 (ko) * | 2009-05-07 | 2015-08-12 | 유나이티드 세러퓨틱스 코오포레이션 | 프로스타시클린 유사체의 고체 제제 |
| MY186975A (en) | 2009-06-12 | 2021-08-26 | Mannkind Corp | Diketopiperazine microparticles with defined specific surface areas |
| EP3108888B1 (en) * | 2010-03-15 | 2020-02-12 | United Therapeutics Corporation | Treatment for pulmonary hypertension |
| CA2777070C (en) | 2010-06-03 | 2019-11-05 | United Therapeutics Corporation | Treprostinil production |
| EP2681204B1 (en) | 2011-03-02 | 2016-04-27 | United Therapeutics Corporation | Synthesis of intermediate for treprostinil production |
| EP2701683B1 (en) * | 2011-04-26 | 2017-03-08 | Vectura GmbH | Administration of iloprost as aerosol bolus |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| US9387214B2 (en) | 2012-01-13 | 2016-07-12 | United Therapeutics Corporation | Method of identifying therapies for pulmonary hypertension |
| US9486427B2 (en) | 2012-10-31 | 2016-11-08 | Vectura Gmbh | Administration of aerosolised iloprost |
| JP6357481B2 (ja) * | 2012-11-30 | 2018-07-11 | インスメッド, インコーポレイテッド | プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| WO2014159050A1 (en) | 2013-03-14 | 2014-10-02 | United Therapeutics Corporation | Solid forms of treprostinil |
| CN109608326A (zh) | 2013-03-15 | 2019-04-12 | 联合治疗公司 | 曲前列环素的盐 |
| EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
| WO2014160638A1 (en) | 2013-03-25 | 2014-10-02 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| EP3808731A1 (en) | 2013-10-25 | 2021-04-21 | Insmed Incorporated | Prostacyclin compounds |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| US20170095432A1 (en) | 2014-06-13 | 2017-04-06 | United Therapeutics Corporation | Treprostinil formulations |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| CA2967385C (en) | 2014-11-18 | 2023-05-16 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
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| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US20190321290A1 (en) * | 2016-01-29 | 2019-10-24 | Mannkind Corporation | Composition and method for inhalation |
| AU2017211410B2 (en) * | 2016-01-29 | 2022-10-13 | Mannkind Corporation | Dry powder inhaler |
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| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| AU2017378409A1 (en) * | 2016-12-14 | 2019-07-04 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
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| AU2019266171B2 (en) * | 2018-05-07 | 2021-10-28 | Pharmosa Biopharm Inc. | Pharmaceutical composition for controlled release of treprostinil |
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| KR20240141319A (ko) * | 2022-02-08 | 2024-09-26 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 일로프로스트 조합 치료 요법 |
| EP4516297A1 (en) * | 2022-04-29 | 2025-03-05 | Zhaoke Pharmaceutical (Guangzhou) Co., Ltd | Treprostinil soft mist inhalant |
| KR20250139830A (ko) | 2023-01-19 | 2025-09-23 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 유사체 |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
Citations (1)
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| JP2002539154A (ja) * | 1999-03-18 | 2002-11-19 | ユナイテッド セラピューティックス コーポレイション | ベンゾインデンプロスタグランジンの吸入送達法 |
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| US20100076083A1 (en) | 2010-03-25 |
| EP2026816A2 (en) | 2009-02-25 |
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| CN101495122A (zh) | 2009-07-29 |
| WO2007134292A2 (en) | 2007-11-22 |
| US10376525B2 (en) | 2019-08-13 |
| WO2007134292A3 (en) | 2008-01-10 |
| US20160143868A1 (en) | 2016-05-26 |
| JP5797376B2 (ja) | 2015-10-21 |
| EP2026816B1 (en) | 2018-10-24 |
| JP2014114269A (ja) | 2014-06-26 |
| JP2009537246A (ja) | 2009-10-29 |
| US20200171044A1 (en) | 2020-06-04 |
| CA2654492C (en) | 2017-06-27 |
| JP2016006066A (ja) | 2016-01-14 |
| US10716793B2 (en) | 2020-07-21 |
| US9339507B2 (en) | 2016-05-17 |
| US20220218720A1 (en) | 2022-07-14 |
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