KR101390579B1 - 정량 흡입기를 사용한 트레프로스티닐 투여 - Google Patents

정량 흡입기를 사용한 트레프로스티닐 투여 Download PDF

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KR101390579B1
KR101390579B1 KR1020087030212A KR20087030212A KR101390579B1 KR 101390579 B1 KR101390579 B1 KR 101390579B1 KR 1020087030212 A KR1020087030212 A KR 1020087030212A KR 20087030212 A KR20087030212 A KR 20087030212A KR 101390579 B1 KR101390579 B1 KR 101390579B1
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treprostinil
acceptable salt
pharmaceutically acceptable
delete delete
inhalation
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KR20090007797A (ko
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호슈트 올슈스키
로버트 로스시그노
루이스 제이. 루빈
토마스 슈미흘
워너 시거
칼 스테릿트
로버트 보스빈켈
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유나이티드 세러퓨틱스 코오포레이션
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087030212A 2006-05-15 2007-05-14 정량 흡입기를 사용한 트레프로스티닐 투여 Active KR101390579B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80001606P 2006-05-15 2006-05-15
US60/800,016 2006-05-15
PCT/US2007/068884 WO2007134292A2 (en) 2006-05-15 2007-05-14 Treprostinil administration using a metered dose inhaler

Publications (2)

Publication Number Publication Date
KR20090007797A KR20090007797A (ko) 2009-01-20
KR101390579B1 true KR101390579B1 (ko) 2014-05-19

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KR1020087030212A Active KR101390579B1 (ko) 2006-05-15 2007-05-14 정량 흡입기를 사용한 트레프로스티닐 투여

Country Status (8)

Country Link
US (10) US20080200449A1 (enExample)
EP (1) EP2026816B1 (enExample)
JP (4) JP5797376B2 (enExample)
KR (1) KR101390579B1 (enExample)
CN (1) CN101495122B (enExample)
CA (1) CA2654492C (enExample)
ES (1) ES2707548T3 (enExample)
WO (1) WO2007134292A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020022546A1 (ko) * 2018-07-24 2020-01-30 주식회사 마더스제약 보센탄을 함유한 약학 제제

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462427T1 (de) * 2004-04-12 2010-04-15 United Therapeutics Corp Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
KR101390579B1 (ko) 2006-05-15 2014-05-19 유나이티드 세러퓨틱스 코오포레이션 정량 흡입기를 사용한 트레프로스티닐 투여
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
EP2120961A1 (en) * 2007-02-09 2009-11-25 United Therapeutics Corporation Treprostinil treatment for interstitial lung disease and asthma
KR20160048222A (ko) 2007-12-17 2016-05-03 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
WO2009115235A1 (en) * 2008-03-20 2009-09-24 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of pulmonary hypertension
ES2575565T3 (es) * 2008-05-08 2016-06-29 United Therapeutics Corporation Procedimiento para la preparación de monohidrato de treprostinilo y su utilización para el almacenamiento y el envío
WO2010036798A1 (en) * 2008-09-25 2010-04-01 Aradigm Corporation Deep lung pulmonary delivery of treprostinil
KR101544246B1 (ko) * 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP3108888B1 (en) * 2010-03-15 2020-02-12 United Therapeutics Corporation Treatment for pulmonary hypertension
CA2777070C (en) 2010-06-03 2019-11-05 United Therapeutics Corporation Treprostinil production
EP2681204B1 (en) 2011-03-02 2016-04-27 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
EP2701683B1 (en) * 2011-04-26 2017-03-08 Vectura GmbH Administration of iloprost as aerosol bolus
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
US9486427B2 (en) 2012-10-31 2016-11-08 Vectura Gmbh Administration of aerosolised iloprost
JP6357481B2 (ja) * 2012-11-30 2018-07-11 インスメッド, インコーポレイテッド プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
EP3712142B1 (en) 2013-01-11 2022-07-06 Corsair Pharma, Inc. Prodrugs of treprostinil
WO2014159050A1 (en) 2013-03-14 2014-10-02 United Therapeutics Corporation Solid forms of treprostinil
CN109608326A (zh) 2013-03-15 2019-04-12 联合治疗公司 曲前列环素的盐
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
WO2014160638A1 (en) 2013-03-25 2014-10-02 United Therapeutics Corporation Process of making prostacyclin compounds with linker thiol and pegylated forms
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3808731A1 (en) 2013-10-25 2021-04-21 Insmed Incorporated Prostacyclin compounds
WO2015089105A1 (en) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
US20170095432A1 (en) 2014-06-13 2017-04-06 United Therapeutics Corporation Treprostinil formulations
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
CA2967385C (en) 2014-11-18 2023-05-16 Insmed Incorporated Methods of manufacturing treprostinil and treprostinil derivative prodrugs
WO2016088119A1 (en) 2014-12-03 2016-06-09 Steadymed Ltd Preservative-free treprostinil formulations and methods and devices for use with same
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US20190321290A1 (en) * 2016-01-29 2019-10-24 Mannkind Corporation Composition and method for inhalation
AU2017211410B2 (en) * 2016-01-29 2022-10-13 Mannkind Corporation Dry powder inhaler
WO2017192993A1 (en) 2016-05-05 2017-11-09 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
JP7220650B2 (ja) 2016-09-26 2023-02-10 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
AU2017378409A1 (en) * 2016-12-14 2019-07-04 Respira Therapeutics, Inc. Methods and compositions for treatment of pulmonary hypertension and other lung disorders
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
US10702495B2 (en) 2017-02-20 2020-07-07 Nexien Biopharma, Inc. Method and compositions for treating dystrophies and myotonia
AU2019266171B2 (en) * 2018-05-07 2021-10-28 Pharmosa Biopharm Inc. Pharmaceutical composition for controlled release of treprostinil
CA3112986C (en) 2018-09-18 2024-06-18 Eli Lilly And Company Erbumine salt of treprostinil
US11458098B2 (en) 2019-04-29 2022-10-04 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof
EP3750528A1 (en) 2019-06-11 2020-12-16 Nexien Biopharma, Inc. Compositions for treating dystrophies and myotonia
US20210022994A1 (en) 2019-07-22 2021-01-28 Lupin Holdings, B.V. Sustained release trepostinil-compound microparticle compositions
CN114616225A (zh) 2019-08-23 2022-06-10 联合治疗公司 曲前列环素前药
CN112569210B (zh) * 2019-09-27 2023-09-15 盈科瑞(天津)创新医药研究有限公司 一种吸入用马昔腾坦溶液及其制备方法
CN115485000A (zh) 2020-03-31 2022-12-16 索芙特海尔公司 至少两种液体组合物的气溶胶递送
US11826327B2 (en) 2020-04-17 2023-11-28 United Therapeutics Corporation Treatment for interstitial lung disease
US11013688B1 (en) * 2020-05-28 2021-05-25 Softhale Nv Methods of treatment of viral diseases
WO2021252446A1 (en) 2020-06-09 2021-12-16 United Therapeutics Corporation Fumaryl diketopiperidine prodrugs of treprostinil
CA3199324A1 (en) 2020-11-17 2022-05-27 Adam Marc Silverstein Inhaled imatinib for pulmonary hypertension field
JP2023553989A (ja) 2020-12-14 2023-12-26 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグで疾患を治療する方法
AU2022229367A1 (en) 2021-03-03 2023-09-14 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
CN113876748A (zh) * 2021-11-22 2022-01-04 兆科药业(广州)有限公司 一种用于治疗肺动脉高压的曲前列尼尔气溶胶吸入剂的雾化方法
MX2024008941A (es) 2022-01-21 2024-09-23 Invox Belgium Nv Treprostinil para el tratamiento de la hipertension pulmonar.
KR20240141319A (ko) * 2022-02-08 2024-09-26 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 일로프로스트 조합 치료 요법
EP4516297A1 (en) * 2022-04-29 2025-03-05 Zhaoke Pharmaceutical (Guangzhou) Co., Ltd Treprostinil soft mist inhalant
KR20250139830A (ko) 2023-01-19 2025-09-23 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 유사체
US20250197338A1 (en) 2023-11-09 2025-06-19 United Therapeutics Corporation Syntheses of compounds useful for producing treprostinil

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539154A (ja) * 1999-03-18 2002-11-19 ユナイテッド セラピューティックス コーポレイション ベンゾインデンプロスタグランジンの吸入送達法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664337A (en) 1970-04-15 1972-05-23 Bio Logics Inc Respiration assembly and methods
US4001650A (en) 1975-09-02 1977-01-04 Puritan-Bennett Corporation Method and apparatus for ultrasonic transducer protection
US4007238A (en) 1976-02-25 1977-02-08 Glenn Joseph G Nebulizer for use with IPPB equipment
US4473296A (en) 1978-05-03 1984-09-25 Ppm, Inc. System and method and apparatus for a continuous aerosol monitor (CAM) using electro-optical weighing for general aerosols
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
US4281113A (en) * 1979-07-31 1981-07-28 The Upjohn Company 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6.beta.-5-iodo-PGF1 compounds
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4306076A (en) * 1980-04-23 1981-12-15 The Upjohn Company Inter-phenylene CBA compounds
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4349689A (en) * 1980-12-22 1982-09-14 The Upjohn Company Methano carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4495944A (en) 1983-02-07 1985-01-29 Trutek Research, Inc. Inhalation therapy apparatus
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4635647A (en) 1984-09-07 1987-01-13 Choksi Pradip V Incentive spirometer employing bellows air flow sensor
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4976259A (en) 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
US5080093A (en) 1987-07-08 1992-01-14 Vortran Medical Technology, Inc. Intermittant signal actuated nebulizer
US5322057A (en) 1987-07-08 1994-06-21 Vortran Medical Technology, Inc. Intermittent signal actuated nebulizer synchronized to operate in the exhalation phase, and its method of use
FI82808C (fi) 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfoerdelningsanordning.
GB8814438D0 (en) * 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
GB9011588D0 (en) * 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
EP0940154B1 (en) 1991-07-02 2007-04-18 Nektar Therapeutics Device for delivering aerosolized medicaments
GB2265845B (en) 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
FR2694215B1 (fr) 1992-07-30 1994-10-21 Dp Medical Appareil pour générer un brouillard à partir d'un liquide, notamment un médicament.
ES2145783T3 (es) 1992-10-16 2000-07-16 Sheiman Ultrasonic Research Fo Dispositivo nebulizador ultrasonico.
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5752502A (en) 1993-12-16 1998-05-19 King; Russell Wayne General purpose aerosol inhalation apparatus
AU735975B2 (en) 1995-02-27 2001-07-19 Toray Industries, Inc. Remedy for pulmonary heart
WO1997002857A1 (en) 1995-07-10 1997-01-30 A & D Company, Limited Atomizer
FR2746656B1 (fr) 1996-03-26 1999-05-28 System Assistance Medical Nebuliseur a capteur de pression
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
CN1142781C (zh) 1997-11-14 2004-03-24 联合治疗公司 9-脱氧-2′,9-α-亚甲基-3-氧杂-4,5,6-三去甲-3,7-(1′,3′-间亚苯基)-13,14-二氢-前列腺素F1在治疗外周血管疾病中的用途
DE19838711C1 (de) 1998-08-26 2000-06-21 Otto Schill Gmbh & Co Kg Inhalator zum Vernebeln von Flüssigkeiten
FR2783431B1 (fr) 1998-09-23 2001-02-02 System Assistance Medical Nebuliseur permettant de delivrer un brouillard a un patient et procede de fonctionnement d'un tel nebuliseur
SE9900369D0 (sv) * 1999-02-04 1999-02-04 Siemens Elema Ab Ultrasonic nebuliser
DE19934582C2 (de) 1999-07-23 2003-09-18 Otto Schill Gmbh & Co Kg Aerosolerzeuger
EP1292347B1 (en) 2000-02-11 2009-10-07 Respironics Respiratory Drug Delivery (UK) Ltd. Drug delivery apparatus
DE10022795B4 (de) 2000-05-10 2005-04-14 Pari GmbH Spezialisten für effektive Inhalation Atemgesteuertes Inhalationstherapiegerät
US6242482B1 (en) 2000-06-05 2001-06-05 United Therapeutics Corporation Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
JP2004512101A (ja) * 2000-10-20 2004-04-22 グラクソ グループ リミテッド 吸入器
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
WO2003026556A2 (en) 2001-09-12 2003-04-03 Ivax Corporation Breath-enhanced ultrasonic nebulizer and dedicated unit dose ampoule
US6626843B2 (en) 2001-09-28 2003-09-30 Deane Hillsman Respiratory timing and lung deflation method and device
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
US20040063912A1 (en) 2002-03-15 2004-04-01 The Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
US20030192532A1 (en) 2002-04-12 2003-10-16 Hopkins Andrew David Nebulizer
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040149282A1 (en) 2002-12-02 2004-08-05 Scott Laboratories, Inc. Respiratory monitoring systems and methods
US7726303B2 (en) 2003-02-25 2010-06-01 Hewlett-Packard Development Company, L.P. Controlled medicament ejection
CN101265226B (zh) 2003-05-22 2013-04-24 联合治疗公司 化合物和释放前列环素类似物的方法
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
JP4357230B2 (ja) * 2003-07-14 2009-11-04 帝人株式会社 酸素濃縮装置、在宅酸素療法システム
US7172557B1 (en) 2003-08-29 2007-02-06 Caldyne, Inc. Spirometer, display and method
DE602004022982D1 (de) 2003-12-16 2009-10-15 United Therapeutics Corp Verwendung von treprostinil zur verbesserung der nierenfunktion
CA2549724C (en) 2003-12-16 2014-02-11 United Therapeutics Corporation Use of treprostinil to treat and prevent ischemic lesions
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
DE102004009436A1 (de) 2004-02-24 2005-10-13 Boehringer Ingelheim International Gmbh Zerstäuber
US20060147520A1 (en) 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7721729B2 (en) 2005-03-09 2010-05-25 Ric Investments, Llc Nebulizing drug delivery device for ventilator
KR101390579B1 (ko) 2006-05-15 2014-05-19 유나이티드 세러퓨틱스 코오포레이션 정량 흡입기를 사용한 트레프로스티닐 투여
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
US20090036465A1 (en) 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
EP2120961A1 (en) 2007-02-09 2009-11-25 United Therapeutics Corporation Treprostinil treatment for interstitial lung disease and asthma
WO2010036798A1 (en) 2008-09-25 2010-04-01 Aradigm Corporation Deep lung pulmonary delivery of treprostinil
KR101544246B1 (ko) 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539154A (ja) * 1999-03-18 2002-11-19 ユナイテッド セラピューティックス コーポレイション ベンゾインデンプロスタグランジンの吸入送達法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020022546A1 (ko) * 2018-07-24 2020-01-30 주식회사 마더스제약 보센탄을 함유한 약학 제제

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