JP2009537153A - ＡｈａのＲＮＡｉ調節およびその治療上の使用 - Google Patents

ＡｈａのＲＮＡｉ調節およびその治療上の使用 Download PDF

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JP2009537153A
JP2009537153A JP2009511246A JP2009511246A JP2009537153A JP 2009537153 A JP2009537153 A JP 2009537153A JP 2009511246 A JP2009511246 A JP 2009511246A JP 2009511246 A JP2009511246 A JP 2009511246A JP 2009537153 A JP2009537153 A JP 2009537153A
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seq
sequence number
dsrna
sequence
gene
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JP2009537153A5 (OSRAM
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ライナー コンシュタイン，
バージット ブラムラーゲ，
パメラ タン，
ハンス−ペーター フォルンロッヒャー，
ウィリアム ボールチ，
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アルニラム ファーマシューティカルズ， インコーポレイテッド
ザ スクリプス リサーチ インスティテュート
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Publication of JP2009537153A publication Critical patent/JP2009537153A/ja
Publication of JP2009537153A5 publication Critical patent/JP2009537153A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009511246A 2006-05-19 2007-05-18 ＡｈａのＲＮＡｉ調節およびその治療上の使用 Pending JP2009537153A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80184006P 2006-05-19 2006-05-19
PCT/US2007/069229 WO2007137156A2 (en) 2006-05-19 2007-05-18 Rnai modulation of aha and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
JP2009537153A true JP2009537153A (ja) 2009-10-29
JP2009537153A5 JP2009537153A5 (OSRAM) 2011-03-03

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JP2009511246A Pending JP2009537153A (ja) 2006-05-19 2007-05-18 ＡｈａのＲＮＡｉ調節およびその治療上の使用

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Country Link
US (3) US7812150B2 (OSRAM)
EP (2) EP2392583A1 (OSRAM)
JP (1) JP2009537153A (OSRAM)
CN (2) CN101489566B (OSRAM)
AT (1) ATE528008T1 (OSRAM)
AU (1) AU2007253803B2 (OSRAM)
BR (1) BRPI0712034A2 (OSRAM)
CA (1) CA2652770A1 (OSRAM)
WO (1) WO2007137156A2 (OSRAM)

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US8229398B2 (en) * 2006-01-30 2012-07-24 Qualcomm Incorporated GSM authentication in a CDMA network
ATE528008T1 (de) 2006-05-19 2011-10-15 Alnylam Pharmaceuticals Inc Rnai-modulation von aha und ihre therapeutische verwendung
US7910722B2 (en) * 2007-07-05 2011-03-22 Florida State University Research Foundation RNAi therapeutic for treatment of hepatitis C infection
ES2804764T3 (es) 2009-06-01 2021-02-09 Halo Bio Rnai Therapeutics Inc Polinucleótidos para la interferencia de ARN multivalente, composiciones y métodos de uso de los mismos
US20110152343A1 (en) * 2009-12-22 2011-06-23 Functional Genetics, Inc. Protease inhibitors and broad-spectrum antiviral
RU2631805C2 (ru) * 2011-06-21 2017-09-26 Элнилэм Фармасьютикалз, Инк. Композиции и способы ингибирования экспрессии генов аполипопротеина с-iii (арос3)
CN103902847B (zh) * 2012-12-26 2016-12-28 中国科学院深圳先进技术研究院 多聚谷氨酰胺致病机理的分析方法
JP6980953B2 (ja) * 2014-09-11 2021-12-15 ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ミスフォールディングタンパク質の検出
CN105018484B (zh) * 2015-07-31 2017-10-13 北京泱深生物信息技术有限公司 Crtap基因及其表达产物作为阿尔茨海默病的诊治靶标
CA2995995A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
WO2017147420A1 (en) * 2016-02-25 2017-08-31 The University Of Florida Research Foundation, Inc. Methods and compositions with vitamin d compounds for treatment of cystic fibrosis and respiratory disorders
EP3774850A1 (en) * 2018-03-29 2021-02-17 Kezar Life Sciences Cdp protein secretion inhibitors
CN112724236B (zh) * 2021-01-15 2022-03-04 武汉大学 一种两性蛋白1的抗原肽及其抗体与应用

Citations (3)

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