JP2009535329A5 - - Google Patents

Info

Publication number

JP2009535329A5

JP2009535329A5 JP2009507632A JP2009507632A JP2009535329A5 JP 2009535329 A5 JP2009535329 A5 JP 2009535329A5 JP 2009507632 A JP2009507632 A JP 2009507632A JP 2009507632 A JP2009507632 A JP 2009507632A JP 2009535329 A5 JP2009535329 A5 JP 2009535329A5

Authority

JP

Japan

Prior art keywords

use according

seq

pharmaceutical composition

antisecretory

protein

Prior art date

2007-04-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 206010020772 Hypertension Diseases 0.000 claims description 6
• 230000002159 abnormal effect Effects 0.000 claims description 3
• 230000001262 anti-secretory effect Effects 0.000 claims 13
• 108090000623 proteins and genes Proteins 0.000 claims 12
• 102000004169 proteins and genes Human genes 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 239000012634 fragment Substances 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 3
• 210000001742 aqueous humor Anatomy 0.000 claims 3
• 230000004410 intraocular pressure Effects 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 102000002322 Egg Proteins Human genes 0.000 claims 2
• 108010000912 Egg Proteins Proteins 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 210000002159 anterior chamber Anatomy 0.000 claims 2
• 235000013345 egg yolk Nutrition 0.000 claims 2
• 210000002969 egg yolk Anatomy 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 230000002500 effect on skin Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000006199 nebulizer Substances 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 238000007910 systemic administration Methods 0.000 claims 1
• 238000011200 topical administration Methods 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 210000001585 trabecular meshwork Anatomy 0.000 claims 1
• 208000010412 Glaucoma Diseases 0.000 description 6
• 230000006866 deterioration Effects 0.000 description 2
• 230000000007 visual effect Effects 0.000 description 2
• 201000004569 Blindness Diseases 0.000 description 1
• 206010056677 Nerve degeneration Diseases 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 210000001328 optic nerve Anatomy 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 210000001116 retinal neuron Anatomy 0.000 description 1