JP2009534393A5 - - Google Patents
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- Publication number
- JP2009534393A5 JP2009534393A5 JP2009506622A JP2009506622A JP2009534393A5 JP 2009534393 A5 JP2009534393 A5 JP 2009534393A5 JP 2009506622 A JP2009506622 A JP 2009506622A JP 2009506622 A JP2009506622 A JP 2009506622A JP 2009534393 A5 JP2009534393 A5 JP 2009534393A5
- Authority
- JP
- Japan
- Prior art keywords
- organic radical
- morphinone
- borohydride
- item
- following structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74533606P | 2006-04-21 | 2006-04-21 | |
| US60/745,336 | 2006-04-21 | ||
| PCT/US2007/009761 WO2007124114A2 (en) | 2006-04-21 | 2007-04-19 | Stereoselective reduction of a morphinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534393A JP2009534393A (ja) | 2009-09-24 |
| JP2009534393A5 true JP2009534393A5 (https=) | 2010-06-03 |
| JP5586223B2 JP5586223B2 (ja) | 2014-09-10 |
Family
ID=38625648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506622A Active JP5586223B2 (ja) | 2006-04-21 | 2007-04-19 | モルヒノンの立体選択的還元 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8183376B2 (https=) |
| EP (1) | EP2010539B1 (https=) |
| JP (1) | JP5586223B2 (https=) |
| KR (1) | KR101421747B1 (https=) |
| CN (1) | CN101466381B (https=) |
| AU (1) | AU2007240680B2 (https=) |
| CA (1) | CA2646313C (https=) |
| ES (1) | ES2629766T3 (https=) |
| IL (1) | IL194735A (https=) |
| MX (1) | MX2008013594A (https=) |
| NZ (1) | NZ572252A (https=) |
| WO (1) | WO2007124114A2 (https=) |
| ZA (1) | ZA200809258B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| WO2005058367A2 (en) * | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| JP2011519930A (ja) * | 2008-05-07 | 2011-07-14 | ネクター セラピューティクス | 末梢性オピオイドアンタゴニストの経口投与 |
| AU2009260303A1 (en) * | 2008-06-17 | 2009-12-23 | Mallinckrodt Inc. | Processes for the preparation of 6- beta-hydroxy morphinan compounds |
| JP5827123B2 (ja) * | 2008-09-16 | 2015-12-02 | ウェルズ ファーゴ バンク ナショナル アソシエイション | 乱用の可能性が低いｐｅｇ化オピオイド |
| WO2010121369A1 (en) | 2009-04-24 | 2010-10-28 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
| CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| EP2580201B1 (en) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| PE20140636A1 (es) | 2010-09-30 | 2014-06-18 | Astrazeneca Ab | Conjugado de naloxol-peg cristalino |
| CN103289075B (zh) * | 2012-02-22 | 2016-01-20 | 天津键凯科技有限公司 | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 |
| CN104755481A (zh) | 2012-10-30 | 2015-07-01 | 尼克塔治疗公司 | 作为阿片激动剂的α-6-mPEG6-O-羟基可酮的固体盐形式以及其用途 |
| PL3137081T3 (pl) | 2014-04-28 | 2018-06-29 | Orphomed, Inc. | Dimer buprenorfiny i jego zastosowanie w leczeniu chorób układu pokarmowego |
| US20160067362A1 (en) * | 2014-08-16 | 2016-03-10 | Memorial Sloan Kettering Cancer Center | Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods |
| CN107033155B (zh) * | 2016-02-04 | 2019-04-26 | 国药集团国瑞药业有限公司 | 一种吗啡酮类化合物的立体选择性还原方法 |
| US11077103B2 (en) * | 2016-11-23 | 2021-08-03 | Aurobindo Pharma Ltd. | Naloxegol oxalate and solid dispersion thereof |
| CN110305142B (zh) * | 2019-07-12 | 2021-11-16 | 宜昌人福药业有限责任公司 | 一种6β-羟基吗啡衍生物的立体选择性合成方法 |
| CN110330500B (zh) * | 2019-07-12 | 2021-11-23 | 宜昌人福药业有限责任公司 | 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
| US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US2715626A (en) | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
| US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
| US2654746A (en) | 1952-02-13 | 1953-10-06 | Lilly Co Eli | 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin |
| US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
| US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
| DE2538075A1 (de) * | 1975-08-27 | 1977-03-17 | Boehringer Sohn Ingelheim | N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
| US4089855A (en) * | 1976-04-23 | 1978-05-16 | Cornell Research Foundation, Inc. | Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby |
| GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| US4451470A (en) * | 1982-07-06 | 1984-05-29 | E. I. Du Pont De Nemours And Company | Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
| US5208338A (en) | 1991-06-14 | 1993-05-04 | The United States Of America As Represented By The Department Of Health & Human Services. | Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans |
| DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| ES2121988T3 (es) * | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| US5428159A (en) | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
| HU224914B1 (en) * | 1994-05-31 | 2006-04-28 | Mallinckrodt Chemical Inc | Process for the preparation of nalbuphine having not more then 1% levels of beta-epimer |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| WO2005058367A2 (en) | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
-
2007
- 2007-04-19 ES ES07755867.4T patent/ES2629766T3/es active Active
- 2007-04-19 US US12/297,632 patent/US8183376B2/en active Active
- 2007-04-19 AU AU2007240680A patent/AU2007240680B2/en active Active
- 2007-04-19 WO PCT/US2007/009761 patent/WO2007124114A2/en not_active Ceased
- 2007-04-19 KR KR1020087028010A patent/KR101421747B1/ko active Active
- 2007-04-19 EP EP07755867.4A patent/EP2010539B1/en active Active
- 2007-04-19 CA CA2646313A patent/CA2646313C/en active Active
- 2007-04-19 NZ NZ572252A patent/NZ572252A/en unknown
- 2007-04-19 CN CN2007800215389A patent/CN101466381B/zh active Active
- 2007-04-19 MX MX2008013594A patent/MX2008013594A/es active IP Right Grant
- 2007-04-19 JP JP2009506622A patent/JP5586223B2/ja active Active
-
2008
- 2008-10-22 IL IL194735A patent/IL194735A/en active IP Right Grant
- 2008-10-28 ZA ZA200809258A patent/ZA200809258B/xx unknown
-
2012
- 2012-04-13 US US13/447,131 patent/US8563726B2/en active Active
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