ES2629766T3 - Reducción estereoselectiva de una morfinona - Google Patents

Reducción estereoselectiva de una morfinona Download PDF

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Publication number
ES2629766T3
ES2629766T3 ES07755867.4T ES07755867T ES2629766T3 ES 2629766 T3 ES2629766 T3 ES 2629766T3 ES 07755867 T ES07755867 T ES 07755867T ES 2629766 T3 ES2629766 T3 ES 2629766T3
Authority
ES
Spain
Prior art keywords
sodium
epimer
mem
butylborohydride
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07755867.4T
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English (en)
Spanish (es)
Inventor
Lin Cheng
Michael D. Bentley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38625648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2629766(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ES2629766T3 publication Critical patent/ES2629766T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
ES07755867.4T 2006-04-21 2007-04-19 Reducción estereoselectiva de una morfinona Active ES2629766T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74533606P 2006-04-21 2006-04-21
US745336P 2006-04-21
PCT/US2007/009761 WO2007124114A2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Publications (1)

Publication Number Publication Date
ES2629766T3 true ES2629766T3 (es) 2017-08-14

Family

ID=38625648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07755867.4T Active ES2629766T3 (es) 2006-04-21 2007-04-19 Reducción estereoselectiva de una morfinona

Country Status (13)

Country Link
US (2) US8183376B2 (https=)
EP (1) EP2010539B1 (https=)
JP (1) JP5586223B2 (https=)
KR (1) KR101421747B1 (https=)
CN (1) CN101466381B (https=)
AU (1) AU2007240680B2 (https=)
CA (1) CA2646313C (https=)
ES (1) ES2629766T3 (https=)
IL (1) IL194735A (https=)
MX (1) MX2008013594A (https=)
NZ (1) NZ572252A (https=)
WO (1) WO2007124114A2 (https=)
ZA (1) ZA200809258B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2654819T3 (es) * 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides
EP2905033B1 (en) * 2003-12-16 2020-09-02 Nektar Therapeutics Monodisperse PEGylated naloxol compositions
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
MX2010011727A (es) * 2008-05-07 2010-11-30 Nektar Therapeutics Administracion oral de antagonistas opioides que actuan perifericamente.
WO2009155259A1 (en) * 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
KR101660996B1 (ko) * 2008-09-16 2016-09-28 넥타르 테라퓨틱스 남용에 대한 낮은 잠재성을 갖는 페길화 오피오이드
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
AU2011307608B8 (en) 2010-09-30 2015-08-27 Grünenthal GmbH Crystalline naloxol-PEG conjugate
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
LT2914599T (lt) 2012-10-30 2018-02-12 Nektar Therapeutics Alfa-6-mpeg6-hidroksikodono, kaip opioidų agonistų, kieta druskos forma ir jos panaudojimas
LT3137081T (lt) 2014-04-28 2018-02-26 Orphomed, Inc. Buprenorfino dimeras ir jo naudojimas gydant virškinamojo trakto sutrikimus
WO2016028636A1 (en) * 2014-08-16 2016-02-25 Memorial Sloan Kettering Cancer Center Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
US11077103B2 (en) * 2016-11-23 2021-08-03 Aurobindo Pharma Ltd. Naloxegol oxalate and solid dispersion thereof
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US2654746A (en) 1952-02-13 1953-10-06 Lilly Co Eli 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US5208338A (en) 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
KR970011390B1 (ko) * 1992-01-23 1997-07-10 도레이 가부시키가이샤 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
ES2127532T3 (es) 1994-05-31 1999-04-16 Mallinckrodt Chemical Inc Preparacion de nalbufina con niveles bajos del epimero beta.
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
ES2654819T3 (es) 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides
EP2905033B1 (en) * 2003-12-16 2020-09-02 Nektar Therapeutics Monodisperse PEGylated naloxol compositions

Also Published As

Publication number Publication date
US8183376B2 (en) 2012-05-22
US8563726B2 (en) 2013-10-22
US20130018190A1 (en) 2013-01-17
US20090221766A1 (en) 2009-09-03
CA2646313C (en) 2014-05-20
EP2010539B1 (en) 2017-06-14
IL194735A0 (en) 2009-08-03
EP2010539A2 (en) 2009-01-07
CN101466381A (zh) 2009-06-24
IL194735A (en) 2015-09-24
NZ572252A (en) 2011-09-30
AU2007240680A1 (en) 2007-11-01
JP5586223B2 (ja) 2014-09-10
ZA200809258B (en) 2010-08-25
EP2010539A4 (en) 2010-06-02
JP2009534393A (ja) 2009-09-24
CA2646313A1 (en) 2007-11-01
KR101421747B1 (ko) 2014-07-30
AU2007240680B2 (en) 2013-05-02
WO2007124114A3 (en) 2008-11-27
KR20080110910A (ko) 2008-12-19
MX2008013594A (es) 2009-01-16
HK1134903A1 (en) 2010-05-20
WO2007124114A2 (en) 2007-11-01
CN101466381B (zh) 2012-11-14

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