JP5586223B2 - モルヒノンの立体選択的還元 - Google Patents

モルヒノンの立体選択的還元 Download PDF

Info

Publication number
JP5586223B2
JP5586223B2 JP2009506622A JP2009506622A JP5586223B2 JP 5586223 B2 JP5586223 B2 JP 5586223B2 JP 2009506622 A JP2009506622 A JP 2009506622A JP 2009506622 A JP2009506622 A JP 2009506622A JP 5586223 B2 JP5586223 B2 JP 5586223B2
Authority
JP
Japan
Prior art keywords
morphinone
group
daltons
mem
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009506622A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009534393A (ja
JP2009534393A5 (https=
Inventor
リン チェン，
マイケル ディー． ベントレー，
Original Assignee
ネクター セラピューティクス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38625648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5586223(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ネクター セラピューティクス filed Critical ネクター セラピューティクス
Publication of JP2009534393A publication Critical patent/JP2009534393A/ja
Publication of JP2009534393A5 publication Critical patent/JP2009534393A5/ja
Application granted granted Critical
Publication of JP5586223B2 publication Critical patent/JP5586223B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2009506622A 2006-04-21 2007-04-19 モルヒノンの立体選択的還元 Active JP5586223B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74533606P 2006-04-21 2006-04-21
US60/745,336 2006-04-21
PCT/US2007/009761 WO2007124114A2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Publications (3)

Publication Number Publication Date
JP2009534393A JP2009534393A (ja) 2009-09-24
JP2009534393A5 JP2009534393A5 (https=) 2010-06-03
JP5586223B2 true JP5586223B2 (ja) 2014-09-10

Family

ID=38625648

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506622A Active JP5586223B2 (ja) 2006-04-21 2007-04-19 モルヒノンの立体選択的還元

Country Status (13)

Country Link
US (2) US8183376B2 (https=)
EP (1) EP2010539B1 (https=)
JP (1) JP5586223B2 (https=)
KR (1) KR101421747B1 (https=)
CN (1) CN101466381B (https=)
AU (1) AU2007240680B2 (https=)
CA (1) CA2646313C (https=)
ES (1) ES2629766T3 (https=)
IL (1) IL194735A (https=)
MX (1) MX2008013594A (https=)
NZ (1) NZ572252A (https=)
WO (1) WO2007124114A2 (https=)
ZA (1) ZA200809258B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2654819T3 (es) * 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
JP2011519930A (ja) * 2008-05-07 2011-07-14 ネクター セラピューティクス 末梢性オピオイドアンタゴニストの経口投与
AU2009260303A1 (en) * 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
JP5827123B2 (ja) * 2008-09-16 2015-12-02 ウェルズ ファーゴ バンク ナショナル アソシエイション 乱用の可能性が低いｐｅｇ化オピオイド
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
PE20140636A1 (es) 2010-09-30 2014-06-18 Astrazeneca Ab Conjugado de naloxol-peg cristalino
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
CN104755481A (zh) 2012-10-30 2015-07-01 尼克塔治疗公司 作为阿片激动剂的α-6-mPEG6-O-羟基可酮的固体盐形式以及其用途
PL3137081T3 (pl) 2014-04-28 2018-06-29 Orphomed, Inc. Dimer buprenorfiny i jego zastosowanie w leczeniu chorób układu pokarmowego
US20160067362A1 (en) * 2014-08-16 2016-03-10 Memorial Sloan Kettering Cancer Center Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
US11077103B2 (en) * 2016-11-23 2021-08-03 Aurobindo Pharma Ltd. Naloxegol oxalate and solid dispersion thereof
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2715626A (en) 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US2654746A (en) 1952-02-13 1953-10-06 Lilly Co Eli 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US5208338A (en) 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
HU224914B1 (en) * 1994-05-31 2006-04-28 Mallinckrodt Chemical Inc Process for the preparation of nalbuphine having not more then 1% levels of beta-epimer
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
ES2654819T3 (es) * 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides
WO2005058367A2 (en) 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules

Also Published As

Publication number Publication date
CN101466381B (zh) 2012-11-14
IL194735A (en) 2015-09-24
EP2010539A4 (en) 2010-06-02
AU2007240680A1 (en) 2007-11-01
NZ572252A (en) 2011-09-30
US8183376B2 (en) 2012-05-22
IL194735A0 (en) 2009-08-03
ZA200809258B (en) 2010-08-25
CN101466381A (zh) 2009-06-24
US20130018190A1 (en) 2013-01-17
US20090221766A1 (en) 2009-09-03
EP2010539B1 (en) 2017-06-14
MX2008013594A (es) 2009-01-16
US8563726B2 (en) 2013-10-22
JP2009534393A (ja) 2009-09-24
AU2007240680B2 (en) 2013-05-02
HK1134903A1 (en) 2010-05-20
EP2010539A2 (en) 2009-01-07
ES2629766T3 (es) 2017-08-14
CA2646313C (en) 2014-05-20
CA2646313A1 (en) 2007-11-01
WO2007124114A2 (en) 2007-11-01
KR101421747B1 (ko) 2014-07-30
WO2007124114A3 (en) 2008-11-27
KR20080110910A (ko) 2008-12-19

Similar Documents

Publication Publication Date Title
JP5586223B2 (ja) モルヒノンの立体選択的還元
JP5877403B2 (ja) オリゴマー−オピオイドアゴニスト複合体
KR100974842B1 (ko) 아편양 길항제의 중합체 공액
AU2007317788B2 (en) Dosage forms and co-administration of an opioid agonist and an opioid antagonist
JP5837491B2 (ja) オリゴマー−オピオイドアゴニスト抱合体
US9126926B2 (en) Oligomer-anticholinergic agent conjugates
HK1134903B (en) Stereoselective reduction of a morphinone
HK1138501A (en) Oligomer-opioid agonist conjugates
HK1138501B (en) Oligomer-opioid agonist conjugates

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20100326

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100401

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100401

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110315

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130502

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20130502

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131028

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140127

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140228

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140625

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140722

R150 Certificate of patent or registration of utility model

Ref document number: 5586223

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250