CN101466381B - 吗啡酮的立体选择性还原 - Google Patents

吗啡酮的立体选择性还原 Download PDF

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Publication number
CN101466381B
CN101466381B CN2007800215389A CN200780021538A CN101466381B CN 101466381 B CN101466381 B CN 101466381B CN 2007800215389 A CN2007800215389 A CN 2007800215389A CN 200780021538 A CN200780021538 A CN 200780021538A CN 101466381 B CN101466381 B CN 101466381B
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China
Prior art keywords
group
morphinone
daltons
sodium
peg
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Chinese (zh)
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CN101466381A (zh
Inventor
成林
M·D·本特利
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Nektar Therapeutics
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Nektar Therapeutics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CN2007800215389A 2006-04-21 2007-04-19 吗啡酮的立体选择性还原 Active CN101466381B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74533606P 2006-04-21 2006-04-21
US60/745,336 2006-04-21
PCT/US2007/009761 WO2007124114A2 (en) 2006-04-21 2007-04-19 Stereoselective reduction of a morphinone

Publications (2)

Publication Number Publication Date
CN101466381A CN101466381A (zh) 2009-06-24
CN101466381B true CN101466381B (zh) 2012-11-14

Family

ID=38625648

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800215389A Active CN101466381B (zh) 2006-04-21 2007-04-19 吗啡酮的立体选择性还原

Country Status (13)

Country Link
US (2) US8183376B2 (https=)
EP (1) EP2010539B1 (https=)
JP (1) JP5586223B2 (https=)
KR (1) KR101421747B1 (https=)
CN (1) CN101466381B (https=)
AU (1) AU2007240680B2 (https=)
CA (1) CA2646313C (https=)
ES (1) ES2629766T3 (https=)
IL (1) IL194735A (https=)
MX (1) MX2008013594A (https=)
NZ (1) NZ572252A (https=)
WO (1) WO2007124114A2 (https=)
ZA (1) ZA200809258B (https=)

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ES2654819T3 (es) * 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides
EP2905033B1 (en) * 2003-12-16 2020-09-02 Nektar Therapeutics Monodisperse PEGylated naloxol compositions
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
MX2010011727A (es) * 2008-05-07 2010-11-30 Nektar Therapeutics Administracion oral de antagonistas opioides que actuan perifericamente.
WO2009155259A1 (en) * 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
KR101660996B1 (ko) * 2008-09-16 2016-09-28 넥타르 테라퓨틱스 남용에 대한 낮은 잠재성을 갖는 페길화 오피오이드
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
AU2011307608B8 (en) 2010-09-30 2015-08-27 Grünenthal GmbH Crystalline naloxol-PEG conjugate
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
LT2914599T (lt) 2012-10-30 2018-02-12 Nektar Therapeutics Alfa-6-mpeg6-hidroksikodono, kaip opioidų agonistų, kieta druskos forma ir jos panaudojimas
LT3137081T (lt) 2014-04-28 2018-02-26 Orphomed, Inc. Buprenorfino dimeras ir jo naudojimas gydant virškinamojo trakto sutrikimus
WO2016028636A1 (en) * 2014-08-16 2016-02-25 Memorial Sloan Kettering Cancer Center Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
US11077103B2 (en) * 2016-11-23 2021-08-03 Aurobindo Pharma Ltd. Naloxegol oxalate and solid dispersion thereof
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules

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US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US2654746A (en) 1952-02-13 1953-10-06 Lilly Co Eli 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3254088A (en) 1961-03-14 1966-05-31 Lewenstein Morphine derivative
US3332950A (en) 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4451470A (en) * 1982-07-06 1984-05-29 E. I. Du Pont De Nemours And Company Analgesic, antagonist, and/or anorectic 14-fluoromorphinans
US5208338A (en) 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
KR970011390B1 (ko) * 1992-01-23 1997-07-10 도레이 가부시키가이샤 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물
US5428159A (en) 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
ES2127532T3 (es) 1994-05-31 1999-04-16 Mallinckrodt Chemical Inc Preparacion de nalbufina con niveles bajos del epimero beta.
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
ES2654819T3 (es) 2001-10-18 2018-02-15 Nektar Therapeutics Conjugados poliméricos de antagonistas de opioides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules

Also Published As

Publication number Publication date
US8183376B2 (en) 2012-05-22
US8563726B2 (en) 2013-10-22
US20130018190A1 (en) 2013-01-17
US20090221766A1 (en) 2009-09-03
CA2646313C (en) 2014-05-20
EP2010539B1 (en) 2017-06-14
IL194735A0 (en) 2009-08-03
EP2010539A2 (en) 2009-01-07
CN101466381A (zh) 2009-06-24
IL194735A (en) 2015-09-24
NZ572252A (en) 2011-09-30
AU2007240680A1 (en) 2007-11-01
JP5586223B2 (ja) 2014-09-10
ZA200809258B (en) 2010-08-25
EP2010539A4 (en) 2010-06-02
JP2009534393A (ja) 2009-09-24
CA2646313A1 (en) 2007-11-01
KR101421747B1 (ko) 2014-07-30
AU2007240680B2 (en) 2013-05-02
WO2007124114A3 (en) 2008-11-27
ES2629766T3 (es) 2017-08-14
KR20080110910A (ko) 2008-12-19
MX2008013594A (es) 2009-01-16
HK1134903A1 (en) 2010-05-20
WO2007124114A2 (en) 2007-11-01

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