JP2009531031A5 - - Google Patents
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- JP2009531031A5 JP2009531031A5 JP2009501604A JP2009501604A JP2009531031A5 JP 2009531031 A5 JP2009531031 A5 JP 2009531031A5 JP 2009501604 A JP2009501604 A JP 2009501604A JP 2009501604 A JP2009501604 A JP 2009501604A JP 2009531031 A5 JP2009531031 A5 JP 2009531031A5
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- Prior art keywords
- antibody
- composition
- fragment
- tumor cell
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 47
- 239000012634 fragment Substances 0.000 claims 33
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 241000124008 Mammalia Species 0.000 claims 15
- 238000001514 detection method Methods 0.000 claims 11
- 210000004881 tumor cell Anatomy 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- 229940127121 immunoconjugate Drugs 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 230000000259 anti-tumor effect Effects 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 102100030377 Endoplasmic reticulum metallopeptidase 1 Human genes 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102100021613 Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase Human genes 0.000 claims 6
- 101001063315 Homo sapiens Endoplasmic reticulum metallopeptidase 1 Proteins 0.000 claims 6
- 101001044070 Homo sapiens Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase Proteins 0.000 claims 6
- 101000638481 Homo sapiens Protein THEM6 Proteins 0.000 claims 6
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 claims 6
- -1 LOC157378 Proteins 0.000 claims 6
- 102100031255 Protein THEM6 Human genes 0.000 claims 6
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 101000857740 Homo sapiens Probable G-protein coupled receptor 160 Proteins 0.000 claims 5
- 102100025346 Probable G-protein coupled receptor 160 Human genes 0.000 claims 5
- 102000012987 SLC1A5 Human genes 0.000 claims 5
- 108060002241 SLC1A5 Proteins 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002254 cytotoxic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- WOWDZACBATWTAU-FEFUEGSOSA-N (2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-n-[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 WOWDZACBATWTAU-FEFUEGSOSA-N 0.000 claims 2
- 102100032528 C-type lectin domain family 11 member A Human genes 0.000 claims 2
- 101710167766 C-type lectin domain family 11 member A Proteins 0.000 claims 2
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 102000009133 Arylsulfatases Human genes 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 1
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims 1
- 229930126263 Maytansine Natural products 0.000 claims 1
- 231100000757 Microbial toxin Toxicity 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 108010073038 Penicillin Amidase Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 231100000742 Plant toxin Toxicity 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 150000001224 Uranium Chemical group 0.000 claims 1
- 229910052770 Uranium Inorganic materials 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 231100000659 animal toxin Toxicity 0.000 claims 1
- 102000005936 beta-Galactosidase Human genes 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 102000006635 beta-lactamase Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001839 endoscopy Methods 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- GMBVGUFXJFKNMR-UHFFFAOYSA-N gadolinium Chemical compound [Gd].[Gd].[Gd] GMBVGUFXJFKNMR-UHFFFAOYSA-N 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 239000003667 hormone antagonist Substances 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 108060007951 sulfatase Proteins 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78570406P | 2006-03-23 | 2006-03-23 | |
| PCT/US2007/007382 WO2007109376A2 (en) | 2006-03-23 | 2007-03-22 | Anti-tumor cell antigen antibody therapeutics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531031A JP2009531031A (ja) | 2009-09-03 |
| JP2009531031A5 true JP2009531031A5 (enExample) | 2011-03-17 |
Family
ID=38523127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501604A Pending JP2009531031A (ja) | 2006-03-23 | 2007-03-22 | 抗−腫瘍細胞抗原抗体療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110135570A1 (enExample) |
| EP (7) | EP2389947A1 (enExample) |
| JP (1) | JP2009531031A (enExample) |
| KR (1) | KR20080110810A (enExample) |
| CN (1) | CN101437536A (enExample) |
| AU (1) | AU2007227224A1 (enExample) |
| CA (1) | CA2647107A1 (enExample) |
| IL (1) | IL194137A0 (enExample) |
| MA (1) | MA30346B1 (enExample) |
| MX (1) | MX2008012013A (enExample) |
| NO (1) | NO20084479L (enExample) |
| RU (1) | RU2008141912A (enExample) |
| SG (1) | SG170728A1 (enExample) |
| WO (1) | WO2007109376A2 (enExample) |
| ZA (1) | ZA200808128B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110031469A (ko) * | 2008-07-17 | 2011-03-28 | 교와 핫꼬 기린 가부시키가이샤 | 항시스템 ａｓｃ 아미노산 트랜스포터 2(ａｓｃｔ2) 항체 |
| WO2011063127A1 (en) * | 2009-11-18 | 2011-05-26 | University Of Medicine And Dentistry Of New Jersey | Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies |
| EP2494361B2 (en) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Ovary tumor markers and methods of use thereof |
| US8921058B2 (en) | 2009-10-26 | 2014-12-30 | Externautics Spa | Prostate tumor markers and methods of use thereof |
| EP3345920A1 (en) * | 2009-10-26 | 2018-07-11 | Externautics S.p.A. | Breast tumor markers and methods of use thereof |
| US9849192B2 (en) | 2009-11-18 | 2017-12-26 | Rutgers, The State University Of New Jersey | Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies |
| WO2011087091A1 (ja) * | 2010-01-15 | 2011-07-21 | 協和発酵キリン株式会社 | 抗システムａｓｃアミノ酸トランスポーター２（ａｓｃｔ２）抗体 |
| ES2555864T3 (es) * | 2010-08-19 | 2016-01-11 | F. Hoffmann-La Roche Ag | Ensayo para la medición de anticuerpos de unión a un anticuerpo monoclonal terapéutico |
| WO2013151649A1 (en) | 2012-04-04 | 2013-10-10 | Sialix Inc | Glycan-interacting compounds |
| US10093736B2 (en) * | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| JP2016029335A (ja) * | 2012-12-17 | 2016-03-03 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 大腸がんの判定方法 |
| AU2014262843B2 (en) | 2013-05-06 | 2017-06-22 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
| SI3218005T1 (sl) | 2014-11-12 | 2023-06-30 | Seagen Inc. | Z glikanom delujoče spojine, in postopki uporabe |
| US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| JP6990650B2 (ja) * | 2015-09-17 | 2022-03-04 | ザ スクリプス リサーチ インスティテュート | 二重可変ドメインイムノコンジュゲートおよびその用途 |
| CN106554962B (zh) * | 2015-09-30 | 2021-06-04 | 中国科学院上海药物研究所 | 过表达gpr160的癌症的预防、诊断和治疗 |
| PT3374398T (pt) * | 2015-11-10 | 2020-06-16 | Medimmune Llc | Moléculas de ligação específicas para asct2 e suas utilizações |
| CA3002097A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| IL261757B2 (en) | 2016-03-18 | 2023-09-01 | Univ Rutgers | Treatment of stem cells with chemotherapeutic agents conjugated to anti-matriptase antibodies using connecting parts that can be broken down in the living body |
| IL263617B2 (en) * | 2016-07-01 | 2024-02-01 | Univ Leland Stanford Junior | conjugates for editing cell surface area is intended |
| KR20190083654A (ko) * | 2016-11-10 | 2019-07-12 | 메디뮨 엘엘씨 | Asct2에 특이적인 결합 분자 및 이의 용도 |
| EP3541847A4 (en) | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE |
| GB201701332D0 (en) * | 2017-01-26 | 2017-03-15 | Tc Biopharm Ltd | Immune cells with modified metabolism and their use thereof |
| EP3589319A4 (en) | 2017-03-03 | 2021-07-14 | Seagen Inc. | COMPOUNDS INTERACTING WITH GLYCAN AND METHODS OF USE |
| KR101899426B1 (ko) * | 2017-05-25 | 2018-09-17 | (주)큐브바이오 | 종양 진단을 위한 퓨린 대사체 하이포잔틴 및 잔틴 농도 분석용 효소 조성물 |
| WO2019005902A1 (en) * | 2017-06-27 | 2019-01-03 | Qcdx, Llc | SYSTEM AND METHODS FOR DIAGNOSING QUANTITATIVE LIQUID BIOPSY |
| CA3087529A1 (en) | 2018-01-03 | 2019-07-11 | Palleon Pharmaceuticals Inc. | Recombinant human sialidases, sialidase fusion proteins, and methods of using the same |
| CN111712494A (zh) | 2018-02-13 | 2020-09-25 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN111366547A (zh) * | 2018-12-26 | 2020-07-03 | 贵州中烟工业有限责任公司 | 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法 |
| CN110055249B (zh) * | 2019-03-19 | 2021-10-15 | 江苏医药职业学院 | 降低THEM6基因表达的siRNA、重组载体及其应用 |
| KR102242900B1 (ko) * | 2019-08-07 | 2021-04-22 | 연세대학교 산학협력단 | Slc1a5 전사물 변이체를 이용한 항암용 조성물, 항암제 스크리닝 방법 및 암 진단 방법 |
| CN115372604B (zh) * | 2022-07-07 | 2023-03-28 | 山东第一医科大学附属省立医院(山东省立医院) | 一种用于预测肿瘤患者免疫治疗疗效的标志物及其应用 |
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2007
- 2007-03-22 WO PCT/US2007/007382 patent/WO2007109376A2/en not_active Ceased
- 2007-03-22 EP EP11167328A patent/EP2389947A1/en not_active Withdrawn
- 2007-03-22 JP JP2009501604A patent/JP2009531031A/ja active Pending
- 2007-03-22 EP EP11167316A patent/EP2389946A1/en not_active Withdrawn
- 2007-03-22 MX MX2008012013A patent/MX2008012013A/es unknown
- 2007-03-22 RU RU2008141912/13A patent/RU2008141912A/ru not_active Application Discontinuation
- 2007-03-22 SG SG201101875-1A patent/SG170728A1/en unknown
- 2007-03-22 EP EP11167460A patent/EP2389951A1/en not_active Withdrawn
- 2007-03-22 EP EP11167456A patent/EP2389949A1/en not_active Withdrawn
- 2007-03-22 EP EP11167459A patent/EP2389950A1/en not_active Withdrawn
- 2007-03-22 EP EP11167453A patent/EP2389948A1/en not_active Withdrawn
- 2007-03-22 US US12/225,353 patent/US20110135570A1/en not_active Abandoned
- 2007-03-22 CN CNA2007800161919A patent/CN101437536A/zh active Pending
- 2007-03-22 CA CA002647107A patent/CA2647107A1/en not_active Abandoned
- 2007-03-22 KR KR1020087025032A patent/KR20080110810A/ko not_active Abandoned
- 2007-03-22 AU AU2007227224A patent/AU2007227224A1/en not_active Abandoned
- 2007-03-22 EP EP07773740A patent/EP2004221A2/en not_active Withdrawn
-
2008
- 2008-09-16 IL IL194137A patent/IL194137A0/en unknown
- 2008-09-22 ZA ZA200808128A patent/ZA200808128B/xx unknown
- 2008-10-20 MA MA31311A patent/MA30346B1/fr unknown
- 2008-10-23 NO NO20084479A patent/NO20084479L/no not_active Application Discontinuation
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