JP2009530353A5 - - Google Patents

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Publication number
JP2009530353A5
JP2009530353A5 JP2009500873A JP2009500873A JP2009530353A5 JP 2009530353 A5 JP2009530353 A5 JP 2009530353A5 JP 2009500873 A JP2009500873 A JP 2009500873A JP 2009500873 A JP2009500873 A JP 2009500873A JP 2009530353 A5 JP2009530353 A5 JP 2009530353A5
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JP
Japan
Prior art keywords
biphenyl
benzimidazole
benzimidazol
methoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009500873A
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English (en)
Japanese (ja)
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JP5260489B2 (ja
JP2009530353A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/052766 external-priority patent/WO2007110374A1/en
Publication of JP2009530353A publication Critical patent/JP2009530353A/ja
Publication of JP2009530353A5 publication Critical patent/JP2009530353A5/ja
Application granted granted Critical
Publication of JP5260489B2 publication Critical patent/JP5260489B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009500873A 2006-03-24 2007-03-22 ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用 Expired - Fee Related JP5260489B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US78527806P 2006-03-24 2006-03-24
DKPA200600426 2006-03-24
DKPA200600426 2006-03-24
US60/785,278 2006-03-24
DKPA200601327 2006-10-12
DKPA200601327 2006-10-12
US85128406P 2006-10-13 2006-10-13
US60/851,284 2006-10-13
PCT/EP2007/052766 WO2007110374A1 (en) 2006-03-24 2007-03-22 Benzimidazole derivatives and their use for modulating the gabaa receptor complex

Publications (3)

Publication Number Publication Date
JP2009530353A JP2009530353A (ja) 2009-08-27
JP2009530353A5 true JP2009530353A5 (enExample) 2010-05-13
JP5260489B2 JP5260489B2 (ja) 2013-08-14

Family

ID=39456294

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009500873A Expired - Fee Related JP5260489B2 (ja) 2006-03-24 2007-03-22 ベンズイミダゾール誘導体、及びｇａｂａａ受容体複合体をモジュレートするためのその使用

Country Status (26)

Country Link
US (2) US7902230B2 (enExample)
EP (2) EP2319837B1 (enExample)
JP (1) JP5260489B2 (enExample)
KR (1) KR20080111097A (enExample)
CN (1) CN101384559B (enExample)
AR (1) AR060084A1 (enExample)
AT (1) ATE486856T1 (enExample)
AU (1) AU2007229502B2 (enExample)
BR (1) BRPI0710203A2 (enExample)
CA (1) CA2647252A1 (enExample)
CY (1) CY1111603T1 (enExample)
DE (1) DE602007010261D1 (enExample)
DK (1) DK2001855T3 (enExample)
ES (1) ES2355163T3 (enExample)
HR (1) HRP20100616T1 (enExample)
IL (1) IL192297A (enExample)
MX (1) MX2008010885A (enExample)
MY (1) MY149855A (enExample)
NO (1) NO20084481L (enExample)
NZ (1) NZ569438A (enExample)
PL (1) PL2001855T3 (enExample)
PT (1) PT2001855E (enExample)
RU (1) RU2435759C2 (enExample)
SI (1) SI2001855T1 (enExample)
TW (1) TWI391381B (enExample)
WO (1) WO2007110374A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2604516A1 (en) 2005-04-13 2006-10-19 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US7923464B2 (en) 2005-12-05 2011-04-12 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
AU2008345696A1 (en) * 2007-12-21 2009-07-09 Wyeth Llc Benzimidazole compounds
WO2010055129A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029987A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2010055130A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055133A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029986A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
TW201029989A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
WO2014053409A1 (en) * 2012-10-01 2014-04-10 F. Hoffmann-La Roche Ag Benzimidazol.es as cns active agents
CN107445845A (zh) * 2017-08-24 2017-12-08 重庆沃肯精细化工有限公司 一种合成氯法齐明关键中间体n‑(4‑氯苯基)‑1，2‑苯二胺的方法
US12139508B2 (en) * 2018-02-11 2024-11-12 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Steroid derivative regulators, method for preparing the same, and uses thereof
HUE060943T2 (hu) * 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
KR102219563B1 (ko) * 2019-02-15 2021-02-24 에스티팜 주식회사 페나진 유도체 제조를 위한 중간체 및 그의 제조방법
CA3155618A1 (en) * 2019-10-23 2021-04-29 Jed Hubbs Treatment of epileptic conditions with gabaa receptor modulators
EP4359381A4 (en) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN116693555B (zh) * 2022-02-25 2025-07-04 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
AU2024411621A1 (en) 2023-12-27 2026-06-18 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK40192D0 (da) 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation
ES2150671T3 (es) * 1995-04-21 2000-12-01 Neurosearch As Compuesto de bencimidazol y su utilizacion como moduladores del complejo de receptores gaba-a.
CA2218493C (en) * 1995-04-21 2005-02-22 Neurosearch A/S Benzimidazole compounds and their use as modulators of the gabaa receptor complex
AU726447B2 (en) * 1996-10-21 2000-11-09 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
CN1275127A (zh) 1997-10-10 2000-11-29 神经研究公司 苯并咪唑化合物、含该化合物的药物组合物及其应用
BR0011823A (pt) * 1999-06-22 2002-03-19 Neurosearch As Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo
US7335777B2 (en) 2003-04-03 2008-02-26 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
MXPA05010449A (es) * 2003-04-03 2006-05-31 Neurosearch As Derivados del bencimidazol y su uso para modular el complejo del receptor de gabaa.
CA2589770A1 (en) * 2004-12-01 2006-06-08 Osi Pharmaceuticals, Inc. N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library
WO2006069381A2 (en) 2004-12-22 2006-06-29 Enterprise Integration Group Turn-taking confidence
CA2604516A1 (en) 2005-04-13 2006-10-19 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US7923464B2 (en) 2005-12-05 2011-04-12 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
WO2008008059A1 (en) 2006-07-12 2008-01-17 Locus Pharmaceuticals, Inc. Anti-cancer agents ans uses thereof

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