TWI391381B - 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 - Google Patents

新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 Download PDF

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TWI391381B
TWI391381B TW096106596A TW96106596A TWI391381B TW I391381 B TWI391381 B TW I391381B TW 096106596 A TW096106596 A TW 096106596A TW 96106596 A TW96106596 A TW 96106596A TW I391381 B TWI391381 B TW I391381B
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Taiwan
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biphenyl
benzimidazole
benzimidazol
phenyl
methoxy
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TW096106596A
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Chinese (zh)
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TW200811113A (en
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Janus S Larsen
Lene Teuber
Philip K Ahring
Naheed Mirza
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Neurosearch As
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    • C07—ORGANIC CHEMISTRY
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW096106596A 2006-03-24 2007-02-27 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 TWI391381B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600426 2006-03-24
DKPA200601327 2006-10-12

Publications (2)

Publication Number Publication Date
TW200811113A TW200811113A (en) 2008-03-01
TWI391381B true TWI391381B (zh) 2013-04-01

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TW096106596A TWI391381B (zh) 2006-03-24 2007-02-27 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途

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US (2) US7902230B2 (enExample)
EP (2) EP2319837B1 (enExample)
JP (1) JP5260489B2 (enExample)
KR (1) KR20080111097A (enExample)
CN (1) CN101384559B (enExample)
AR (1) AR060084A1 (enExample)
AT (1) ATE486856T1 (enExample)
AU (1) AU2007229502B2 (enExample)
BR (1) BRPI0710203A2 (enExample)
CA (1) CA2647252A1 (enExample)
CY (1) CY1111603T1 (enExample)
DE (1) DE602007010261D1 (enExample)
DK (1) DK2001855T3 (enExample)
ES (1) ES2355163T3 (enExample)
HR (1) HRP20100616T1 (enExample)
IL (1) IL192297A (enExample)
MX (1) MX2008010885A (enExample)
MY (1) MY149855A (enExample)
NO (1) NO20084481L (enExample)
NZ (1) NZ569438A (enExample)
PL (1) PL2001855T3 (enExample)
PT (1) PT2001855E (enExample)
RU (1) RU2435759C2 (enExample)
SI (1) SI2001855T1 (enExample)
TW (1) TWI391381B (enExample)
WO (1) WO2007110374A1 (enExample)

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CA2604516A1 (en) 2005-04-13 2006-10-19 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US7923464B2 (en) 2005-12-05 2011-04-12 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
AU2008345696A1 (en) * 2007-12-21 2009-07-09 Wyeth Llc Benzimidazole compounds
WO2010055129A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029987A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2010055130A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055133A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
TW201029986A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
TW201029989A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
WO2014053409A1 (en) * 2012-10-01 2014-04-10 F. Hoffmann-La Roche Ag Benzimidazol.es as cns active agents
CN107445845A (zh) * 2017-08-24 2017-12-08 重庆沃肯精细化工有限公司 一种合成氯法齐明关键中间体n‑(4‑氯苯基)‑1，2‑苯二胺的方法
US12139508B2 (en) * 2018-02-11 2024-11-12 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Steroid derivative regulators, method for preparing the same, and uses thereof
HUE060943T2 (hu) * 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
KR102219563B1 (ko) * 2019-02-15 2021-02-24 에스티팜 주식회사 페나진 유도체 제조를 위한 중간체 및 그의 제조방법
CA3155618A1 (en) * 2019-10-23 2021-04-29 Jed Hubbs Treatment of epileptic conditions with gabaa receptor modulators
EP4359381A4 (en) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN116693555B (zh) * 2022-02-25 2025-07-04 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
AU2024411621A1 (en) 2023-12-27 2026-06-18 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

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US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
WO1996033191A1 (en) * 1995-04-21 1996-10-24 Neurosearch A/S Benzimidazole compounds and their use as modulators of the gabaa receptor complex

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TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
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US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
WO1996033191A1 (en) * 1995-04-21 1996-10-24 Neurosearch A/S Benzimidazole compounds and their use as modulators of the gabaa receptor complex

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CN101384559B (zh) 2012-03-14
NZ569438A (en) 2011-05-27
ATE486856T1 (de) 2010-11-15
EP2001855B1 (en) 2010-11-03
DK2001855T3 (da) 2011-02-07
WO2007110374A1 (en) 2007-10-04
PL2001855T3 (pl) 2011-04-29
MX2008010885A (es) 2008-09-08
CN101384559A (zh) 2009-03-11
US8288418B2 (en) 2012-10-16
KR20080111097A (ko) 2008-12-22
HK1132257A1 (en) 2010-02-19
IL192297A (en) 2013-11-28
JP5260489B2 (ja) 2013-08-14
DE602007010261D1 (de) 2010-12-16
PT2001855E (pt) 2011-01-17
EP2319837A1 (en) 2011-05-11
RU2008129868A (ru) 2010-04-27
CA2647252A1 (en) 2007-10-04
EP2001855A1 (en) 2008-12-17
AU2007229502A1 (en) 2007-10-04
US20090036476A1 (en) 2009-02-05
AU2007229502B2 (en) 2012-09-20
JP2009530353A (ja) 2009-08-27
BRPI0710203A2 (pt) 2011-05-24
TW200811113A (en) 2008-03-01
SI2001855T1 (sl) 2011-03-31
US20110118259A1 (en) 2011-05-19
ES2355163T3 (es) 2011-03-23
CY1111603T1 (el) 2015-10-07
NO20084481L (no) 2008-12-18
RU2435759C2 (ru) 2011-12-10
IL192297A0 (en) 2009-09-22
MY149855A (en) 2013-10-31
AR060084A1 (es) 2008-05-21
EP2319837B1 (en) 2012-10-31
US7902230B2 (en) 2011-03-08
HRP20100616T1 (hr) 2011-02-28

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