JP2009529891A - 多価不飽和脂肪酸を含む植物種子油 - Google Patents

多価不飽和脂肪酸を含む植物種子油 Download PDF

Info

Publication number
JP2009529891A
JP2009529891A JP2009500612A JP2009500612A JP2009529891A JP 2009529891 A JP2009529891 A JP 2009529891A JP 2009500612 A JP2009500612 A JP 2009500612A JP 2009500612 A JP2009500612 A JP 2009500612A JP 2009529891 A JP2009529891 A JP 2009529891A
Authority
JP
Japan
Prior art keywords
plant
pufa
domain
carbon
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009500612A
Other languages
English (en)
Japanese (ja)
Inventor
ジェイムズ ジー． メッズ
Original Assignee
マーテック バイオサイエンシーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マーテック バイオサイエンシーズ コーポレーション filed Critical マーテック バイオサイエンシーズ コーポレーション
Publication of JP2009529891A publication Critical patent/JP2009529891A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
JP2009500612A 2006-03-15 2007-03-15 多価不飽和脂肪酸を含む植物種子油 Pending JP2009529891A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78320506P 2006-03-15 2006-03-15
US78461606P 2006-03-21 2006-03-21
PCT/US2007/064105 WO2007106904A2 (en) 2006-03-15 2007-03-15 Plant seed oils containing polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
JP2009529891A true JP2009529891A (ja) 2009-08-27

Family

ID=38510298

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009500612A Pending JP2009529891A (ja) 2006-03-15 2007-03-15 多価不飽和脂肪酸を含む植物種子油
JP2009500611A Expired - Fee Related JP5227302B2 (ja) 2006-03-15 2007-03-15 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2012259228A Pending JP2013116104A (ja) 2006-03-15 2012-11-28 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2013219079A Withdrawn JP2014087338A (ja) 2006-03-15 2013-10-22 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009500611A Expired - Fee Related JP5227302B2 (ja) 2006-03-15 2007-03-15 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2012259228A Pending JP2013116104A (ja) 2006-03-15 2012-11-28 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2013219079A Withdrawn JP2014087338A (ja) 2006-03-15 2013-10-22 Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法

Country Status (13)

Country Link
US (5) US7759548B2 (enExample)
EP (3) EP2001277B9 (enExample)
JP (4) JP2009529891A (enExample)
KR (3) KR101517243B1 (enExample)
CN (1) CN104073505A (enExample)
AU (2) AU2007226510B2 (enExample)
BR (1) BRPI0709317A2 (enExample)
CA (2) CA2646317A1 (enExample)
ES (1) ES2527875T3 (enExample)
IL (2) IL194077A (enExample)
MX (3) MX339812B (enExample)
TW (2) TWI504748B (enExample)
WO (3) WO2007106905A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516193A (ja) * 2010-01-07 2013-05-13 ビーエーエスエフ アグロ ベー．ブイ．，アーンヘム（エヌエル），ツヴァイクニーデルラースウンク ヴェーデンスヴィル 除草剤耐性植物
JP2016508156A (ja) * 2013-01-09 2016-03-17 バスフ ファーマ（カラニッシュ）リミテッド 多重ステップ分離法
US9695382B2 (en) 2011-07-06 2017-07-04 Basf Pharma (Callanish) Limited SMB process for producing highly pure EPA from fish oil
US9771542B2 (en) 2011-07-06 2017-09-26 Basf Pharma Callanish Ltd. Heated chromatographic separation process
US9790162B2 (en) 2009-12-30 2017-10-17 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
JP2019068806A (ja) * 2011-07-26 2019-05-09 ダウ アグロサイエンシィズ エルエルシー 植物におけるｄｈａおよび他のｌｃ−ｐｕｆａの生成

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
US7834250B2 (en) 2004-04-22 2010-11-16 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
EP2001277B9 (en) * 2006-03-15 2014-11-26 DSM IP Assets B.V. Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
AU2007291937B2 (en) 2006-08-29 2014-05-15 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
JP2010515465A (ja) * 2007-01-12 2010-05-13 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド，ア ボディー コーポレート 微生物によって生成される有機化学物質の生成に対する耐性を高めるための組成物および方法
US20090004715A1 (en) 2007-06-01 2009-01-01 Solazyme, Inc. Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8021874B2 (en) * 2008-01-28 2011-09-20 The Board Of Regents Of The University Of Oklahoma Very long chain polyunsaturated fatty acids, methods of production, and uses
WO2010019813A2 (en) * 2008-08-13 2010-02-18 Sapphire Energy, Inc. Production of fatty actds by genetically modified photosynthetic organisms
WO2010033921A2 (en) * 2008-09-19 2010-03-25 President And Fellows Of Harvard College Photoautotrophic adipogenesis technology (phat)
JP6068800B2 (ja) 2008-11-18 2017-01-25 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション オメガ−３脂肪酸を産生するための酵素および方法
EP2370555B1 (en) * 2008-11-28 2016-04-20 Solazyme, Inc. Production of tailored oils in heterotrophic microorganisms
MX2011006619A (es) * 2008-12-19 2011-11-29 Alpha J Res Ltd Partnership Optimizacion de la produccion de productos de algas mediante el desacoplamiento de la proliferacion celular y produccion del producto de algas.
TW201028472A (en) * 2009-01-13 2010-08-01 Alpha J Res Ltd Partnership Use of plant growth regulators to enhance algae growth for the production of added value products
ES2752196T3 (es) * 2009-03-16 2020-04-03 Dsm Ip Assets Bv Producción de proteínas en microorganismos del filo Labyrinthulomycota
ES2623610T3 (es) 2009-03-19 2017-07-11 Dsm Ip Assets B.V. Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
US8993841B2 (en) 2009-06-08 2015-03-31 Basf Plant Science Company Gmbh Fatty acid elongation components and uses thereof
MX2011013447A (es) * 2009-06-30 2012-02-13 Solae Llc Composiciones de alimentos horneados y barras enriquecidos con acidos grasos omega-3.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CA2775390C (en) * 2009-09-27 2021-06-29 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
CA2785867C (en) * 2009-12-28 2018-03-27 Dsm Ip Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae
EP4130273B1 (en) * 2009-12-28 2024-06-12 Sanofi Vaccine Technologies, S.A.S. Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof
AU2011210852B2 (en) * 2010-01-27 2015-12-24 Opx Biotechnologies, Inc. Microorganism production of high-value chemical products, and related compositions, methods and systems
CN104388439B (zh) * 2010-02-01 2018-02-23 三得利控股株式会社 编码酰基‑CoA合成酶同源物的多核苷酸及其用途
US8372465B2 (en) 2010-02-17 2013-02-12 Bunge Oils, Inc. Oil compositions of stearidonic acid
US11236351B2 (en) * 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
TW201144442A (en) * 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
MX352746B (es) 2010-05-28 2017-12-06 Terravia Holdings Inc Aceites específicos producidos a partir de microorganismos heterótrofos recombinantes.
AU2013202057B2 (en) * 2010-06-25 2016-01-28 Basf Plant Science Company Gmbh Acyltransferases and uses therof in fatty acid production
US9388437B2 (en) 2010-06-25 2016-07-12 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
SG10201509035WA (en) 2010-11-03 2015-12-30 Solazyme Inc Microbial Oils With Lowered Pour Points, Dielectric Fluids Produced Therefrom, And Related Methods
CN110066836A (zh) 2011-02-02 2019-07-30 柯碧恩生物技术公司 产自重组产油微生物的定制油
CN102250864B (zh) * 2011-05-03 2013-03-20 中国农业大学 亚油酸异构酶在脱氢和异构方面的双重用途
EP2705138B1 (en) 2011-05-06 2017-03-22 TerraVia Holdings, Inc. Genetically engineered microorganisms that metabolize xylose
US8980591B2 (en) * 2011-08-04 2015-03-17 Suntory Holdings Limited Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof
JPWO2013077420A1 (ja) * 2011-11-25 2015-04-27 独立行政法人農業生物資源研究所 植物の形質転換体、植物の形質転換方法、並びに該方法に用いられるベクター
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
SG10201702442RA (en) 2012-04-18 2017-05-30 Terravia Holdings Inc Tailored oils
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
CN104853596B (zh) 2012-06-15 2018-10-09 联邦科学技术研究组织 在植物细胞中产生长链多不饱和脂肪酸
KR20150040359A (ko) 2012-08-10 2015-04-14 오피엑스 바이오테크놀로지스, 인크. 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법
US9809804B2 (en) 2013-01-23 2017-11-07 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using KASIII for production of bi-functional fatty acids
US10184140B2 (en) 2013-01-23 2019-01-22 Iowa State University Research Foundation, Inc. Materials and methods for production of bi-functional fatty acids in recombinant bacteria
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
EP2976141A4 (en) 2013-03-15 2016-10-05 Cargill Inc FLASHING FOR PRODUCTION CLEANING AND RECOVERY
US10047383B2 (en) 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10337038B2 (en) 2013-07-19 2019-07-02 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
BR112016006839A8 (pt) 2013-10-04 2017-10-03 Solazyme Inc Óleos customizados
CN105916991A (zh) * 2013-11-01 2016-08-31 康纳根有限公司 使用酰基-CoA合成酶生物合成生成酰基-CoA的方法
TW201525136A (zh) * 2013-11-26 2015-07-01 Dow Agrosciences Llc 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸
AU2014360086B2 (en) 2013-12-05 2018-04-19 Genomatica, Inc. Microbial production of fatty amines
CN111154724B (zh) 2013-12-18 2024-02-06 联邦科学技术研究组织 包含二十二碳六烯酸的提取的植物脂质
EP3099782B1 (en) * 2014-01-28 2019-03-20 DSM IP Assets B.V. Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질
ES2764273T3 (es) 2014-07-10 2020-06-02 Corbion Biotech Inc Nuevos genes de cetoacil ACP sintasa y uso de los mismos
CN107087416A (zh) 2014-07-24 2017-08-22 泰拉瑞亚控股公司 变体硫酯酶及使用方法
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
US10125382B2 (en) 2014-09-18 2018-11-13 Corbion Biotech, Inc. Acyl-ACP thioesterases and mutants thereof
US10570427B2 (en) * 2014-10-31 2020-02-25 Lanzatech New Zealand Limited Fermentation process for the production of lipids
WO2016137897A1 (en) * 2015-02-24 2016-09-01 William Marsh Rice University Kasiii-free fa synthesis
ES2906721T3 (es) 2015-06-06 2022-04-20 Dsm Ip Assets Bv Producción de ácidos grasos poliinsaturados (PUFA) utilizando una nueva sintasa modular de ácido docosahexaenoico (DHA)
US20170191094A1 (en) * 2015-12-31 2017-07-06 Synthetic Genomics, Inc. Expression of type i fatty acid synthase genes in eukaryotic algae
WO2017120473A1 (en) 2016-01-07 2017-07-13 Conagen Inc. Methods of making capsinoids by biosynthetic processes
JP7053565B2 (ja) 2016-07-19 2022-04-12 コナジェン・インコーポレイテッド 特定の天然カプサイシノイドの微生物生成のための方法
JP2020506702A (ja) 2017-02-02 2020-03-05 カーギル インコーポレイテッド Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞
US11352601B2 (en) 2017-07-27 2022-06-07 University Of Florida Research Foundation, Incorporated Cyanobacterial hosts and methods for producing chemicals
KR102318983B1 (ko) * 2018-02-21 2021-11-01 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
WO2019164294A1 (ko) * 2018-02-21 2019-08-29 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
CN112661821B (zh) * 2021-01-21 2022-04-12 江南大学 一种柠檬酸转运蛋白及其在脂质合成中的应用
WO2023076901A2 (en) * 2021-10-25 2023-05-04 Purdue Research Foundation Heterodimeric benzaldehyde synthase, methods of producing, and uses thereof
CA3249246A1 (en) 2022-01-25 2023-08-03 Dsm Ip Assets Bv REFINEMENT OF MEDIA AND NUTRITION SUPPLY APPROACHES TO INCREASE POLYUNSATURATED FATTY ACID PRODUCTION
WO2025238190A1 (en) 2024-05-15 2025-11-20 Dsm Ip Assets B.V. Spray-dried powders having high pufa content
CN119193346A (zh) * 2024-11-26 2024-12-27 南京师范大学 一种过表达溶血磷脂酸酰基转移酶基因的裂殖壶菌基因工程菌株及其构建方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020194641A1 (en) * 1999-01-14 2002-12-19 Metz James G. PUFA polyketide synthase systems and uses thereof
US20050100995A1 (en) * 1999-01-14 2005-05-12 Weaver Craig A. PUFA polyketide synthase systems and uses thereof

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317248D0 (en) * 1983-06-24 1983-07-27 Wyeth John & Brother Ltd Fat compositions
US5246841A (en) * 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5601860A (en) * 1990-11-30 1997-02-11 American Home Products Corporation Corandomized fat compositions for infant formulas
US5639790A (en) * 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
EP0616644B1 (en) * 1991-12-04 2003-07-02 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
US5683898A (en) * 1992-05-15 1997-11-04 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
WO1993023545A1 (fr) 1992-05-15 1993-11-25 Sagami Chemical Research Center Gene qui code pour le groupe de l'acide eicosapentaenoique synthetase et procede pour produire de l'acide eicosapentaenoique
US5798259A (en) * 1992-05-15 1998-08-25 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US5310242A (en) * 1992-09-28 1994-05-10 Golder Kimberly A Portable infant seat
US6372965B1 (en) * 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
DE4323727A1 (de) * 1993-07-15 1995-03-09 Boehringer Mannheim Gmbh Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
CA2209987A1 (en) 1995-01-13 1996-07-18 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US6582941B1 (en) 1995-04-17 2003-06-24 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
AR006830A1 (es) * 1996-04-26 1999-09-29 Du Pont Aceite de soja con alta estabilidad oxidativa
EP0913473A4 (en) 1996-07-10 2000-12-06 Sagami Chem Res METHOD FOR PRODUCING EICOSAPENTIC ACID BY GENETIC RECOMBINATION
US6033883A (en) * 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
SA98190002B1 (ar) * 1997-03-28 2006-06-20 ذي يونيفيرسيتي اوف تننيسي ريسيرش كوربوريشن استخدام أحماض دهنية تحتوي على عدة روابط غير مشبعة polyunsaturated fatty acids لتقليل حدوث الالتهاب المعوي القولوني الناخر incidence of necrotizing enterocolitis
US6051754A (en) * 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
BR9808506A (pt) 1997-04-11 2000-05-23 Calgene Llc Métodos e composições para sìntese de ácidos graxos poliinsaturados de cadeia longa em plantas
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
IL133272A0 (en) 1997-06-04 2001-04-30 Calgene Llc Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7271315B2 (en) * 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
WO2001094565A2 (en) * 2000-06-08 2001-12-13 Miami University FATTY ACID ELONGASE 3-KETOACYL CoA SYNTHASE POLYPEPTIDES
US20040010817A1 (en) * 2000-07-21 2004-01-15 Washington State University Research Foundation Plant acyl-CoA synthetases
CN105483142A (zh) * 2000-09-28 2016-04-13 生物源食物及科学公司 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用
US6912470B2 (en) 2001-05-21 2005-06-28 Ecopia Biosciences, Inc. Genes and proteins involved in the biosynthesis of enediyne ring structures
TWI324181B (en) * 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
TWI426126B (zh) 2001-04-16 2014-02-11 Dsm Ip Assets Bv 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二）
US20040005672A1 (en) * 2002-02-22 2004-01-08 Santi Daniel V. Heterologous production of polyketides
GB2385852A (en) * 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
WO2003078639A2 (en) * 2002-03-16 2003-09-25 The University Of York Transgenic plants expressing enzymes involved in fatty acid biosynthesis
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
WO2004087879A2 (en) 2003-03-26 2004-10-14 Martek Biosciences Corporation Pufa polyketide synthase systems and uses thereof
EP3121269A1 (de) 2003-03-31 2017-01-25 University Of Bristol Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7208590B2 (en) * 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
DE102004017370A1 (de) * 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
AU2005286889B2 (en) 2004-09-20 2011-12-08 Michigan State University Arabidopsis genes encoding proteins involved in sugar and lipid metabolism and methods of use
GB0421937D0 (en) * 2004-10-02 2004-11-03 Univ York Acyl CoA synthetases
WO2006135866A2 (en) * 2005-06-10 2006-12-21 Martek Biosciences Corporation Pufa polyketide synthase systems and uses thereof
EP2001277B9 (en) * 2006-03-15 2014-11-26 DSM IP Assets B.V. Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
FR2904328B1 (fr) * 2006-07-27 2008-10-24 St Microelectronics Sa Depot par adsorption sous un champ electrique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020194641A1 (en) * 1999-01-14 2002-12-19 Metz James G. PUFA polyketide synthase systems and uses thereof
US20050100995A1 (en) * 1999-01-14 2005-05-12 Weaver Craig A. PUFA polyketide synthase systems and uses thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9790162B2 (en) 2009-12-30 2017-10-17 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
JP2013516193A (ja) * 2010-01-07 2013-05-13 ビーエーエスエフ アグロ ベー．ブイ．，アーンヘム（エヌエル），ツヴァイクニーデルラースウンク ヴェーデンスヴィル 除草剤耐性植物
US10174336B2 (en) 2010-01-07 2019-01-08 Basf Agrochemical Products B.V. Herbicide-tolerant plants
US9695382B2 (en) 2011-07-06 2017-07-04 Basf Pharma (Callanish) Limited SMB process for producing highly pure EPA from fish oil
US9771542B2 (en) 2011-07-06 2017-09-26 Basf Pharma Callanish Ltd. Heated chromatographic separation process
JP2019068806A (ja) * 2011-07-26 2019-05-09 ダウ アグロサイエンシィズ エルエルシー 植物におけるｄｈａおよび他のｌｃ−ｐｕｆａの生成
JP2016508156A (ja) * 2013-01-09 2016-03-17 バスフ ファーマ（カラニッシュ）リミテッド 多重ステップ分離法
US9694302B2 (en) 2013-01-09 2017-07-04 Basf Pharma (Callanish) Limited Multi-step separation process
US10179759B2 (en) 2013-01-09 2019-01-15 Basf Pharma (Callanish) Limited Multi-step separation process
US10214475B2 (en) 2013-01-09 2019-02-26 Basf Pharma (Callanish) Limited Multi-step separation process
US10723973B2 (en) 2013-01-09 2020-07-28 Basf Pharma (Callanish) Limited Multi-step separation process

Also Published As

Publication number Publication date
CA2647150A1 (en) 2007-09-20
EP2004835A4 (en) 2011-02-23
CA2646317A1 (en) 2007-09-20
AU2007226511A1 (en) 2007-09-20
TW200813222A (en) 2008-03-16
WO2007106905A3 (en) 2008-11-27
MX2008011783A (es) 2009-03-20
WO2007106904A2 (en) 2007-09-20
US9382521B2 (en) 2016-07-05
IL194078A0 (en) 2011-08-01
EP2001277B9 (en) 2014-11-26
KR101506347B1 (ko) 2015-03-26
US20070270494A1 (en) 2007-11-22
IL194077A0 (en) 2011-08-01
KR20080104374A (ko) 2008-12-02
US20100313309A1 (en) 2010-12-09
KR101517243B1 (ko) 2015-05-28
US7759548B2 (en) 2010-07-20
CN104073505A (zh) 2014-10-01
JP5227302B2 (ja) 2013-07-03
AU2007226510B2 (en) 2013-09-19
HK1126253A1 (en) 2009-08-28
EP2653557A1 (en) 2013-10-23
US20070220634A1 (en) 2007-09-20
EP2001277A2 (en) 2008-12-17
TW200806792A (en) 2008-02-01
EP2001277A4 (en) 2011-06-22
US20140289904A1 (en) 2014-09-25
BRPI0709317A2 (pt) 2013-09-24
KR101524398B1 (ko) 2015-06-04
US20070245431A1 (en) 2007-10-18
MX340759B (es) 2015-03-11
EP2004835A2 (en) 2008-12-24
KR20130103832A (ko) 2013-09-24
WO2007106903A2 (en) 2007-09-20
AU2007226510A1 (en) 2007-09-20
TWI504748B (zh) 2015-10-21
MX339812B (es) 2016-06-08
WO2007106905A2 (en) 2007-09-20
EP2001277B1 (en) 2014-10-15
JP2014087338A (ja) 2014-05-15
IL194077A (en) 2016-02-29
WO2007106904A3 (en) 2008-01-24
WO2007106903A3 (en) 2009-04-09
KR20090004971A (ko) 2009-01-12
IL194078A (en) 2015-10-29
MX2008011784A (es) 2008-11-27
US8426686B2 (en) 2013-04-23
JP2013116104A (ja) 2013-06-13
JP2009529890A (ja) 2009-08-27
ES2527875T3 (es) 2015-02-02

Similar Documents

Publication Publication Date Title
JP5227302B2 (ja) Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP5551584B2 (ja) キメラｐｕｆａポリケチドシンターゼシステムおよびその使用
US7897844B2 (en) PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) Plant seed oils containing polyunsaturated fatty acids
CN101573451B (zh) 利用pufa聚酮化合物合成酶系统在异源的生物体中产生多不饱和脂肪酸的方法
JP5460232B2 (ja) Ｐｕｆａポリケチドシンターゼ系およびそれらの使用方法
US20080005811A1 (en) Pufa polyketide synthase systems and uses thereof
US7271315B2 (en) PUFA polyketide synthase systems and uses thereof
JP2008515461A (ja) Ｐｕｆａポリケチドシンターゼ系およびその使用法
AU2013251201A1 (en) Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
HK1126253B (en) Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120530

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120815

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120822

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121127

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20121126

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130304

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130702

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130806

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130809

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20130830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140822

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140827