JP2009529506A5 - - Google Patents
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- JP2009529506A5 JP2009529506A5 JP2008557619A JP2008557619A JP2009529506A5 JP 2009529506 A5 JP2009529506 A5 JP 2009529506A5 JP 2008557619 A JP2008557619 A JP 2008557619A JP 2008557619 A JP2008557619 A JP 2008557619A JP 2009529506 A5 JP2009529506 A5 JP 2009529506A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- phospholipid
- curcumin
- ratio
- alcohol solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Description
本発明によれば、該複合体は、プロトン性溶媒中に溶解させたクルクミンにリン脂質を加えることによって、より詳細には、ウコン根茎の水アルコール抽出物のエタノール溶液に、還流下で攪拌しながらリン脂質を加えることによって調製される。得られる懸濁液を、減圧下で濃縮して残留物とし、これを乾燥器内で乾燥させる。クルクミンに対するリン脂質の比は、１０から１ｗ／ｗの範囲内であり、より好ましいモル比は、５：１ｗ／ｗである。
Claims (9)
- クルクミンまたはそれを含有する抽出物のリン脂質複合体。
- 前記リン脂質がダイズリン脂質である、請求項１に記載の複合体。
- 前記リン脂質が、ホスファチジルコリン、ホスファチジルセリン、ホスファチジルエタノールアミンから選択される、請求項２に記載の複合体。
- 前記クルクミンに対する前記リン脂質の比が１０から１ｗ／ｗの範囲内である、請求項１に記載の複合体。
- 前記クルクミンに対する前記リン脂質の比が５から１ｗ／ｗ(from 5:1 w/w)である、請求項２に記載の複合体化合物。
- 請求項１から３に記載の複合体化合物を調製するための方法であって、ウコン根茎の水アルコール抽出物を、アルコール溶媒中でリン脂質と反応させ、次いで濃縮し、乾燥させることによって前記複合体化合物を単離する方法。
- 前記アルコール溶媒がエタノールである、請求項４に記載の方法。
- 適当な医薬担体と混合した、請求項１から５に記載の複合体を活性成分として含有する医薬組成物。
- 化学予防薬の調製のための、請求項１から５に記載の複合体の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06004820A EP1837030A1 (en) | 2006-03-09 | 2006-03-09 | Phospholipid complexes of curcumin having improved bioavailability |
| EP06004820.4 | 2006-03-09 | ||
| PCT/EP2007/001487 WO2007101551A2 (en) | 2006-03-09 | 2007-02-21 | Phospholipid complexes of curcumin having improved bioavailability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529506A JP2009529506A (ja) | 2009-08-20 |
| JP2009529506A5 true JP2009529506A5 (ja) | 2013-07-25 |
| JP5448462B2 JP5448462B2 (ja) | 2014-03-19 |
Family
ID=36677274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557619A Active JP5448462B2 (ja) | 2006-03-09 | 2007-02-21 | 改善されたバイオアベイラビリティーを有するクルクミンのリン脂質複合体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10603329B2 (ja) |
| EP (2) | EP1837030A1 (ja) |
| JP (1) | JP5448462B2 (ja) |
| KR (1) | KR101423269B1 (ja) |
| CN (1) | CN101400360A (ja) |
| AU (1) | AU2007222667B2 (ja) |
| CA (1) | CA2644017C (ja) |
| DK (1) | DK1991244T3 (ja) |
| ES (1) | ES2757580T3 (ja) |
| HU (1) | HUE046597T2 (ja) |
| IL (1) | IL193966A (ja) |
| NO (1) | NO344242B1 (ja) |
| PL (1) | PL1991244T3 (ja) |
| PT (1) | PT1991244T (ja) |
| RU (1) | RU2450818C2 (ja) |
| SI (1) | SI1991244T1 (ja) |
| WO (1) | WO2007101551A2 (ja) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007103435A2 (en) * | 2006-03-06 | 2007-09-13 | The Regents Of The University Of California | Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders |
| KR20100114498A (ko) | 2007-12-21 | 2010-10-25 | 아사끄 꼼빠니아 데 비오떼끄놀로히아 에 인베스띠가씨온 에쎄.아. | 쿠르쿠미노이드 및 유사체의 치료 효능을 증가시키는 방법 |
| US9700525B2 (en) | 2008-08-20 | 2017-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders |
| WO2010023128A1 (en) * | 2008-08-29 | 2010-03-04 | Chr. Hansen A/S | Turmeric curcumin compositions with low residual solvent |
| IT1395086B1 (it) * | 2009-03-11 | 2012-09-05 | Velleja Res Srl | Composizioni comprendenti curcumina in forma complessata con fosfolipidi e piperina ad azione chemio-sensibilizzante |
| ES2548867T3 (es) | 2009-03-20 | 2015-10-21 | Bioxtract S.A. | Composición farmacéutica que presenta propiedades antiinflamatorias y antihistamínicas |
| MA33220B1 (fr) | 2009-03-20 | 2012-04-02 | Bioxtract S A | Composition pharmaceutique a proprietes anti-inflammatoires |
| IT1395351B1 (it) | 2009-07-09 | 2012-09-14 | Axioma Srl | Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli |
| WO2011082290A2 (en) | 2009-12-31 | 2011-07-07 | Organomed Corporation | Formulations from natural products, turmeric, and aspirin |
| CN102068419A (zh) * | 2010-12-28 | 2011-05-25 | 神威药业有限公司 | 一种姜黄素组合物 |
| US8785380B2 (en) | 2011-02-01 | 2014-07-22 | M/S Akay Flavours & Aromatics Pvt Ltd. | Formulation containing curcuminoids exhibiting enhanced bioavailability |
| KR101614996B1 (ko) | 2011-05-16 | 2016-04-22 | 옴니액티브 헬스 테크놀로지스 리미티드 | 증가된 생체이용률을 갖는 커큐민을 포함하는 수용성 조성물 및 이의 방법 |
| ITTO20110901A1 (it) * | 2011-10-10 | 2013-04-11 | Medestea Biotech S P A | Composizione sinergica per la prevenzione ed il trattamento di disturbi connessi all'invecchiamento |
| ITPD20120021A1 (it) | 2012-01-26 | 2013-07-27 | Fidia Farmaceutici | "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina". |
| US20150110866A1 (en) * | 2012-05-22 | 2015-04-23 | Harold Gordon Cave | Complexes and compositions containing curcumin |
| US20150104503A1 (en) * | 2012-05-22 | 2015-04-16 | Harold Gordon Cave | Complexes and compositions containing curcumin |
| CN103120798A (zh) * | 2013-01-10 | 2013-05-29 | 施冬云 | 一种具有抗氧化应激作用的磷脂复合物制备方法及其应用 |
| US20160000714A1 (en) | 2013-03-06 | 2016-01-07 | Capsugel Belgium Nv | Curcumin solid lipid particles and methods for their preparation and use |
| PL2996704T3 (pl) * | 2013-05-14 | 2021-06-28 | Mars, Incorporated | Kompozycja do ochrony stawów |
| AU2015220913B2 (en) * | 2014-02-20 | 2020-04-09 | Indena S.P.A. | Compositions containing extracts of Curcuma Longa and Echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
| RU2571270C1 (ru) * | 2014-07-17 | 2015-12-20 | Открытое Акционерное Общество "Фаберлик" | Липосомальное наносредство на основе продуктов, полученных из корневищ куркумы |
| CA2963942A1 (en) | 2014-10-08 | 2016-04-14 | Boston Biopharm, Inc. | Compositions and methods for increasing the bioavailability of one or more compounds |
| EP3218006A4 (en) * | 2014-11-11 | 2018-08-15 | Verdure Sciences | Stable solid lipid particle composition for improved bioavailability of lipophilic compounds for age-related diseases |
| US11324699B2 (en) | 2014-12-04 | 2022-05-10 | Capsugel Belgium Nv | Lipid multiparticulate formulations |
| EP3150214A1 (en) | 2015-10-01 | 2017-04-05 | INDENA S.p.A. | Compositions containing extracts of curcuma spp and zingiber officinale which are useful to reduce peripheral inflammation and pain |
| WO2017095138A1 (en) * | 2015-11-30 | 2017-06-08 | Gil Medical Center | Curcumin-containing lipid nanoparticle complex comprising ginsenosides |
| AU2016373576B2 (en) * | 2015-12-16 | 2022-06-02 | Vivek Anand PARACHUR | Tri-molecular complex of natural compounds |
| CN105999290B (zh) * | 2016-04-21 | 2019-04-09 | 中国人民解放军第四军医大学 | 一种磷脂酰丝氨酸修饰的姜黄素纳米粒 |
| WO2018003857A1 (ja) * | 2016-06-29 | 2018-01-04 | 株式会社セラバイオファーマ | 非経口投与用医薬組成物 |
| US20170172921A1 (en) * | 2016-12-14 | 2017-06-22 | Mahmoud Reza Jaafari | Polyphenolic compounds encapsualated in long circulating liposomes and use thereof |
| KR101948407B1 (ko) | 2017-01-20 | 2019-02-14 | 가천대학교 산학협력단 | 커큐민이 포집된 진세노사이드 및 인지질 기반 지질나노입자를 유효성분으로 함유하는 헬리코박터 파이로리 감염의 예방 또는 치료용 조성물 |
| CN107213467A (zh) * | 2017-05-22 | 2017-09-29 | 江苏大学 | 一种姜黄素磷脂复合物的制备方法 |
| RU2684111C1 (ru) * | 2018-02-07 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ЮУГМУ Минздрава России) | Способ получения лекарственного средства с метионином и экстрактом куркумы в виде гранул с кишечнорастворимым покрытием системного действия |
| BE1026393B1 (fr) * | 2018-06-18 | 2020-01-28 | Normaphar | Composition pour utilisation dans le traitement de l'ostéopénie et/ou de l'ostéoporose |
| FR3082425B1 (fr) * | 2018-06-18 | 2020-09-11 | Normaphar | Composition pour utilisation dans le traitement de l'osteopenie et / ou de l'osteoporose |
| CN109589410B (zh) * | 2018-12-26 | 2022-02-01 | 晨光生物科技集团股份有限公司 | 一种姜黄素制剂及其制备方法 |
| CN109846865B (zh) * | 2018-12-26 | 2022-03-25 | 晨光生物科技集团股份有限公司 | 一种姜黄素制剂及其制备方法 |
| IT201900003907A1 (it) | 2019-03-18 | 2020-09-18 | Indena Spa | Composizioni comprendenti curcumina e coenzima q10 |
| CN114617968B (zh) | 2019-04-09 | 2023-10-03 | 北京五和博澳药业股份有限公司 | 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途 |
| GB202011069D0 (en) | 2020-07-17 | 2020-09-02 | Univ Of Lincoln | New curcumin products and uses |
| KR20220086467A (ko) | 2020-12-16 | 2022-06-23 | 가톨릭대학교 산학협력단 | 다당류를 이용하여 커큐민의 안정성 및 생체 이용률이 향상된 나노복합체 및 이의 제조방법 |
| KR20220086018A (ko) | 2020-12-16 | 2022-06-23 | 가톨릭대학교 산학협력단 | 셀룰로오스를 이용하여 커큐민의 안정성 및 생체 이용률이 향상된 나노복합체 및 이의 제조방법 |
| WO2023055005A1 (ko) | 2021-09-28 | 2023-04-06 | (주) 바이노텍 | 입자 표면이 개질된 커큐민 나노 입자 복합체 및 이의 제조 방법 |
| JP7321229B2 (ja) * | 2021-10-20 | 2023-08-04 | 義美食品股▲ふん▼有限公司 | ウコン根茎からクルクミノイドを分離する方法 |
| CN114557965B (zh) * | 2022-02-09 | 2023-06-09 | 汕头大学 | 一种提高姜黄素稳定性和生物可及性的磷脂复合物纳米粒及制备方法 |
| CN117582417A (zh) * | 2022-08-09 | 2024-02-23 | 湖南健瑞医药科技有限公司 | 药物-脂质颗粒及其制备方法和应用 |
| WO2024032507A1 (zh) * | 2022-08-09 | 2024-02-15 | 湖南健瑞医药科技有限公司 | 金属-磷脂复合物、金属-磷脂复合物颗粒和药物-脂质颗粒及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1215291B (it) | 1985-07-17 | 1990-01-31 | Inverni Della Beffa Spa | Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. |
| IT1201149B (it) | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| IT1203515B (it) | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| IT1296920B1 (it) | 1997-12-04 | 1999-08-03 | Indena Spa | Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici |
| IT1304183B1 (it) | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| EP1658061A2 (en) * | 2003-08-26 | 2006-05-24 | Research Development Foundation | Aerosol delivery of curcumin |
| CN1283237C (zh) * | 2004-11-22 | 2006-11-08 | 山东大学 | 姜黄素磷脂复合物及其制备方法 |
-
2006
- 2006-03-09 EP EP06004820A patent/EP1837030A1/en not_active Withdrawn
-
2007
- 2007-02-21 PT PT77035327T patent/PT1991244T/pt unknown
- 2007-02-21 EP EP07703532.7A patent/EP1991244B1/en active Active
- 2007-02-21 KR KR1020087021905A patent/KR101423269B1/ko active IP Right Grant
- 2007-02-21 RU RU2008136189/15A patent/RU2450818C2/ru active
- 2007-02-21 ES ES07703532T patent/ES2757580T3/es active Active
- 2007-02-21 DK DK07703532T patent/DK1991244T3/da active
- 2007-02-21 CN CNA2007800082936A patent/CN101400360A/zh active Pending
- 2007-02-21 HU HUE07703532A patent/HUE046597T2/hu unknown
- 2007-02-21 SI SI200732132T patent/SI1991244T1/sl unknown
- 2007-02-21 US US12/281,994 patent/US10603329B2/en active Active
- 2007-02-21 CA CA2644017A patent/CA2644017C/en active Active
- 2007-02-21 JP JP2008557619A patent/JP5448462B2/ja active Active
- 2007-02-21 AU AU2007222667A patent/AU2007222667B2/en active Active
- 2007-02-21 WO PCT/EP2007/001487 patent/WO2007101551A2/en active Application Filing
- 2007-02-21 PL PL07703532T patent/PL1991244T3/pl unknown
-
2008
- 2008-09-08 NO NO20083850A patent/NO344242B1/no unknown
- 2008-09-08 IL IL193966A patent/IL193966A/en active IP Right Grant
-
2019
- 2019-02-13 US US16/274,623 patent/US20190175628A1/en not_active Abandoned
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