JP2009528369A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009528369A5 JP2009528369A5 JP2008557383A JP2008557383A JP2009528369A5 JP 2009528369 A5 JP2009528369 A5 JP 2009528369A5 JP 2008557383 A JP2008557383 A JP 2008557383A JP 2008557383 A JP2008557383 A JP 2008557383A JP 2009528369 A5 JP2009528369 A5 JP 2009528369A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- drug
- mammal
- allograft
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 89
- 241000124008 Mammalia Species 0.000 claims 26
- 239000003814 drug Substances 0.000 claims 25
- 239000003018 immunosuppressive agent Substances 0.000 claims 25
- 229940079593 drug Drugs 0.000 claims 23
- 229940124589 immunosuppressive drug Drugs 0.000 claims 23
- 230000024203 complement activation Effects 0.000 claims 16
- 230000001684 chronic effect Effects 0.000 claims 13
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 12
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 12
- 102100031506 Complement C5 Human genes 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 8
- 229930105110 Cyclosporin A Natural products 0.000 claims 7
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 7
- 108010036949 Cyclosporine Proteins 0.000 claims 7
- 229960001265 ciclosporin Drugs 0.000 claims 7
- -1 OKT3 Substances 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 229960002224 eculizumab Drugs 0.000 claims 4
- 230000002519 immonomodulatory effect Effects 0.000 claims 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- IDINUJSAMVOPCM-UHFFFAOYSA-N 15-Deoxyspergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-UHFFFAOYSA-N 0.000 claims 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 2
- 108010028773 Complement C5 Proteins 0.000 claims 2
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- ZSNYYEIGOZADKA-UHFFFAOYSA-N Cyclosporin L Natural products CCC1NC(=O)C(C(O)C(C)CC=CC)NC(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZSNYYEIGOZADKA-UHFFFAOYSA-N 0.000 claims 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 2
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims 2
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 102100039373 Membrane cofactor protein Human genes 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 229960004669 basiliximab Drugs 0.000 claims 2
- 229950010231 brequinar Drugs 0.000 claims 2
- PHEZJEYUWHETKO-UHFFFAOYSA-N brequinar Chemical compound N1=C2C=CC(F)=CC2=C(C(O)=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PHEZJEYUWHETKO-UHFFFAOYSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 108010047295 complement receptors Proteins 0.000 claims 2
- 102000006834 complement receptors Human genes 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229960002806 daclizumab Drugs 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960000681 leflunomide Drugs 0.000 claims 2
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001428 mercaptopurine Drugs 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
- BLUYEPLOXLPVCJ-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxyethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC[C@H](O)NC(=O)CCCCCCNC(N)=N BLUYEPLOXLPVCJ-INIZCTEOSA-N 0.000 claims 2
- 229950003203 pexelizumab Drugs 0.000 claims 2
- 150000003212 purines Chemical class 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 238000010911 splenectomy Methods 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 229960001967 tacrolimus Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 229940045686 antimetabolites antineoplastic purine analogs Drugs 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77885906P | 2006-03-02 | 2006-03-02 | |
| US60/778,859 | 2006-03-02 | ||
| PCT/US2007/005290 WO2007103134A2 (en) | 2006-03-02 | 2007-03-02 | Prolongation of survival of an allograft by inhibiting complement activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013105946A Division JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528369A JP2009528369A (ja) | 2009-08-06 |
| JP2009528369A5 true JP2009528369A5 (enExample) | 2011-02-24 |
| JP5722524B2 JP5722524B2 (ja) | 2015-05-20 |
Family
ID=38475394
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557383A Expired - Fee Related JP5722524B2 (ja) | 2006-03-02 | 2007-03-02 | 補体活性を抑制することによる同種移植片の生存の延長 |
| JP2013105946A Withdrawn JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013105946A Withdrawn JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20100135992A1 (enExample) |
| EP (2) | EP1988882B1 (enExample) |
| JP (2) | JP5722524B2 (enExample) |
| KR (2) | KR101650264B1 (enExample) |
| CN (1) | CN101437501B (enExample) |
| AU (1) | AU2007224250B2 (enExample) |
| BR (1) | BRPI0708424A2 (enExample) |
| CA (1) | CA2644020C (enExample) |
| DK (1) | DK1988882T3 (enExample) |
| ES (1) | ES2530637T3 (enExample) |
| HR (1) | HRP20150182T1 (enExample) |
| IL (1) | IL193623A0 (enExample) |
| MX (1) | MX2008011054A (enExample) |
| NZ (1) | NZ570802A (enExample) |
| PL (1) | PL1988882T3 (enExample) |
| PT (1) | PT1988882E (enExample) |
| RS (1) | RS53864B1 (enExample) |
| RU (1) | RU2445975C2 (enExample) |
| SG (1) | SG171578A1 (enExample) |
| SI (1) | SI1988882T1 (enExample) |
| WO (1) | WO2007103134A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| EP2380907B1 (en) | 2006-09-05 | 2016-11-30 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
| EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| RS64039B1 (sr) * | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| WO2010126898A1 (en) * | 2009-04-27 | 2010-11-04 | The Trustees Of The University Of Pennsylvania | Methods for reducing the level of alloantibodies in a subject |
| NZ597259A (en) * | 2009-06-23 | 2014-04-30 | Alexion Pharma Inc | Bispecific antibodies that bind to complement proteins |
| AU2010266127B2 (en) * | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| CN101621801B (zh) * | 2009-08-11 | 2012-11-28 | 华为终端有限公司 | 无线局域网的认证方法、系统及服务器、终端 |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| CA2835819A1 (en) * | 2011-05-16 | 2012-11-22 | Genzyme Corporation | Induction of immune tolerance using methotrexate |
| CN102585016B (zh) * | 2012-03-06 | 2014-06-04 | 江苏健德生物药业有限公司 | 一种可同时抑制t、b淋巴细胞功能的免疫融合蛋白、其制备方法及其应用 |
| CN103232542B (zh) * | 2013-02-01 | 2015-05-13 | 殷勇 | 一种双靶标嵌合蛋白 |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| EP3033093A1 (en) * | 2013-08-16 | 2016-06-22 | Alexion Pharmaceuticals, Inc. | Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant |
| HUE041809T2 (hu) * | 2013-11-22 | 2019-05-28 | Shire Viropharma Inc | Eljárások antitest által közvetített kilökõdés kezelésére szervbeültetéses páciensekben C1-észteráz inhibitorral |
| NZ631007A (en) * | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| HUE056489T2 (hu) | 2014-12-19 | 2022-02-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| HK1254190A1 (zh) | 2015-05-08 | 2019-07-12 | President And Fellows Of Harvard College | 通用供体干细胞和相关方法 |
| ES2986888T3 (es) * | 2015-10-30 | 2024-11-13 | Alexion Pharma Inc | Un método para inhibir las exacerbaciones de la vasculopatía del aloinjerto mediada por células T |
| DK3390442T5 (da) * | 2015-12-18 | 2024-09-23 | Chugai Pharmaceutical Co Ltd | Anti-C5 antistoffer og fremgangsmåde til anvendelse deraf |
| JP2019517473A (ja) | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 難治性全身型重症筋無力症の処置のための方法 |
| EP3463460A1 (en) * | 2016-06-07 | 2019-04-10 | Novartis AG | An anti-c5 antibody dosing regimen |
| CN109310759A (zh) * | 2016-06-07 | 2019-02-05 | 诺华股份有限公司 | 用于在移植排斥治疗中使用的特斯多鲁单抗 |
| MY191668A (en) | 2016-06-14 | 2022-07-06 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| ES2965486T3 (es) | 2017-07-27 | 2024-04-15 | Alexion Pharma Inc | Formulaciones de anticuerpos anti-C5 de alta concentración |
| KR20200070355A (ko) | 2017-10-26 | 2020-06-17 | 알렉시온 파마슈티칼스, 인코포레이티드 | 발작성 야간 혈색소뇨 (pnh) 및 비정형 용혈성 요독 증후군 (ahus)의 치료를 위한 항-c5 항체의 투여량 및 투여 |
| JP2021506241A (ja) | 2017-12-13 | 2021-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗ｃ５抗体組み合わせ物およびその使用 |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| ES2996257T3 (en) | 2018-05-31 | 2025-02-12 | Alexion Pharma Inc | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| EP3802603A1 (en) | 2018-06-04 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) in pediatric patients |
| WO2020006266A1 (en) | 2018-06-28 | 2020-01-02 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-c5 antibodies |
| US12240893B2 (en) | 2018-10-30 | 2025-03-04 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技（上海）有限公司 | 环孢菌素类似物及其用途 |
| SG11202112506SA (en) | 2019-05-10 | 2021-12-30 | Univ California | Modified pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| CN114401733A (zh) | 2019-10-12 | 2022-04-26 | 睿诺医疗科技（上海）有限公司 | 肾毒素诱发的肾损伤的治疗和预防 |
| US20230058557A1 (en) * | 2020-01-15 | 2023-02-23 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| EP4135743A4 (en) | 2020-04-15 | 2024-05-22 | Farsight Medical Technology (Shanghai) Co., Ltd. | Prevention and treatment of organ injuries |
| CN114532982A (zh) * | 2022-01-12 | 2022-05-27 | 高谋 | 评价干细胞系统移植调控补体活化作用的体系 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2588579B2 (ja) | 1988-04-21 | 1997-03-05 | 株式会社クラレ | 耐熱水性にすぐれたポリビニルアルコール系繊維およびその製造法 |
| US5705732A (en) | 1989-06-12 | 1998-01-06 | Oklahoma Medical Research Foundation | Universal donor cells |
| US5573940A (en) | 1989-06-12 | 1996-11-12 | Oklahoma Medical Research Foundation | Cells expressing high levels of CD59 |
| US5135916A (en) | 1989-06-12 | 1992-08-04 | Oklahoma Medical Research Foundation | Inhibition of complement mediated inflammatory response |
| US20010018051A1 (en) * | 1990-04-09 | 2001-08-30 | White David James Graham | Inhibition of allograft and concordant xenograft rejection |
| EP0560929A1 (en) * | 1990-12-06 | 1993-09-22 | T Cell Sciences, Inc. | Synergistic compositions of soluble complement receptors and compounds that inhibit complement and/or suppress immune activity |
| US5456909A (en) | 1992-08-07 | 1995-10-10 | T Cell Sciences, Inc. | Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo |
| US5308341A (en) | 1993-09-28 | 1994-05-03 | Becton, Dickinson And Company | Method of testing the dose accuracy of a medication delivery device |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5679345A (en) * | 1994-06-02 | 1997-10-21 | The Johns Hopkins University | Method for preventing complement-dependent rejection of organ or tissue transplants |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US6355242B1 (en) * | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
| ATE265220T1 (de) * | 1998-02-04 | 2004-05-15 | Gen Hospital Corp | Kostimulatorische blockade und gemischter chimerismus in allotransplantationen |
| US6302855B1 (en) * | 1998-05-20 | 2001-10-16 | Novo Nordisk A/S | Medical apparatus for use by a patient for medical self treatment of diabetes |
| WO2000027421A2 (en) | 1998-11-06 | 2000-05-18 | The Schepens Eye Research Institute, Inc. | LOCAL USE OF SOLUBLE TUMOR NECROSIS RECEPTOR I (sTNFRI) FOR PROPHYLAXIS AND TREATMENT OF CORNEAL TRANSPLANT REJECTION AND OTHER DISORDERS OF THE EYE |
| US6192891B1 (en) | 1999-04-26 | 2001-02-27 | Becton Dickinson And Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
| AUPQ431299A0 (en) | 1999-11-26 | 1999-12-23 | Unisearch Limited | Method of inducing immune tolerance |
| US6538028B1 (en) * | 2000-02-01 | 2003-03-25 | Vanderbilt University | Method for inhibiting complement activation |
| AU2001296594A1 (en) * | 2000-10-10 | 2002-04-22 | Tanox, Inc. | Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
| PL364359A1 (en) * | 2001-06-08 | 2004-12-13 | Novartis Ag | Treatment or prophylaxis of insulin-producing cell graft rejection |
| US7432356B2 (en) | 2001-08-17 | 2008-10-07 | Genentech, Inc. | Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b |
| EP1478354A4 (en) | 2002-01-22 | 2008-09-24 | Genzyme Corp | USE OF TGF-BETA ANTAGONISTS IN THE TREATMENT OR PREVENTION OF CHRONIC RELEASE OF TRANSPLANT |
| AU2003263043A1 (en) * | 2002-08-28 | 2004-03-19 | Sangstat Medical Corporation | Methods and compostions for immune tolerance |
| US7923010B2 (en) * | 2003-09-11 | 2011-04-12 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune diseases and conditions |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| EP3056218A1 (en) * | 2004-05-14 | 2016-08-17 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| CA2566861A1 (en) * | 2004-05-17 | 2005-12-08 | Combinatorx, Incorporated | Methods and reagents for the treatment of immunoinflammatory disorders |
-
2007
- 2007-03-02 EP EP07752018.7A patent/EP1988882B1/en not_active Revoked
- 2007-03-02 HR HRP20150182TT patent/HRP20150182T1/hr unknown
- 2007-03-02 JP JP2008557383A patent/JP5722524B2/ja not_active Expired - Fee Related
- 2007-03-02 MX MX2008011054A patent/MX2008011054A/es active IP Right Grant
- 2007-03-02 DK DK07752018.7T patent/DK1988882T3/en active
- 2007-03-02 PL PL07752018T patent/PL1988882T3/pl unknown
- 2007-03-02 RU RU2008139118/15A patent/RU2445975C2/ru not_active IP Right Cessation
- 2007-03-02 EP EP14198274.4A patent/EP2918269A1/en not_active Withdrawn
- 2007-03-02 BR BRPI0708424-2A patent/BRPI0708424A2/pt not_active IP Right Cessation
- 2007-03-02 CA CA2644020A patent/CA2644020C/en not_active Expired - Fee Related
- 2007-03-02 PT PT77520187T patent/PT1988882E/pt unknown
- 2007-03-02 RS RS20150109A patent/RS53864B1/sr unknown
- 2007-03-02 CN CN200780015830XA patent/CN101437501B/zh active Active
- 2007-03-02 KR KR1020147028450A patent/KR101650264B1/ko not_active Expired - Fee Related
- 2007-03-02 SI SI200731610T patent/SI1988882T1/sl unknown
- 2007-03-02 ES ES07752018T patent/ES2530637T3/es active Active
- 2007-03-02 KR KR1020087023398A patent/KR101527225B1/ko not_active Expired - Fee Related
- 2007-03-02 NZ NZ570802A patent/NZ570802A/en not_active IP Right Cessation
- 2007-03-02 SG SG201102357-9A patent/SG171578A1/en unknown
- 2007-03-02 AU AU2007224250A patent/AU2007224250B2/en active Active
- 2007-03-02 WO PCT/US2007/005290 patent/WO2007103134A2/en not_active Ceased
- 2007-03-02 US US12/224,567 patent/US20100135992A1/en not_active Abandoned
-
2008
- 2008-08-21 IL IL193623A patent/IL193623A0/en unknown
-
2013
- 2013-05-20 JP JP2013105946A patent/JP2013155202A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009528369A5 (enExample) | ||
| RU2008139118A (ru) | Продление срока выживаемости аллотрансплантата путем ингибирования активности комплемента | |
| CN105073110B (zh) | 通过诱导分化成调节性t细胞和促进调节性t细胞增殖来抑制免疫应答的药物组合物 | |
| JP2007537299A5 (enExample) | ||
| Post et al. | Immunosuppression in liver transplantation | |
| JP2010534243A5 (enExample) | ||
| CA2801241C (en) | Methods for treating bipolar disorder | |
| JP2013501056A5 (enExample) | ||
| RU2625222C2 (ru) | Комбинированная терапия антителом к cd19 и азотистым ипритом | |
| CN103561744A (zh) | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮在治疗免疫相关性和炎症性疾病中的用途 | |
| JP2014080438A (ja) | 補体活性を阻害することによる同種移植片の生存の延長 | |
| JP6129155B2 (ja) | 同種移植片拒絶反応を抑制する方法 | |
| US9156912B2 (en) | Immunological reconstitution promoter or prophylactic agent for infections each of which maintains graft-versus-tumor effect | |
| JP2014505056A5 (enExample) | ||
| US20110142953A1 (en) | Combinations of immunosuppressive agents for the treatment or prevention of graft rejections | |
| JP2016050181A (ja) | 血管炎治療剤 | |
| US20240197816A1 (en) | Composition and method for prolong survival of transplant and recipient | |
| JP2007510661A5 (enExample) | ||
| Okamoto et al. | Clinicopathological evaluation of renal allograft treated with anti‐CD25 monoclonal antibody | |
| JP2025540339A (ja) | 移植物およびレシピエントの生存を延長するための組成物および方法 | |
| JP2023500352A (ja) | 移植片対宿主病を予防又は治療するための化合物 | |
| Cantarovich et al. | Improvement of acute renal dysfunction (ARD) in heart transplant (TX) patients (PTS) during calcineurin inhibitor (CNI)‘holiday’without rejection under anti-CD25 monoclonal antibody (MAB) coverage | |
| Tack et al. | Humoral and echo-Doppler parameters in predicting the benefits of betablockers in patients with dilated cardiomyopathy |