JP2009527518A5 - - Google Patents
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- Publication number
- JP2009527518A5 JP2009527518A5 JP2008555694A JP2008555694A JP2009527518A5 JP 2009527518 A5 JP2009527518 A5 JP 2009527518A5 JP 2008555694 A JP2008555694 A JP 2008555694A JP 2008555694 A JP2008555694 A JP 2008555694A JP 2009527518 A5 JP2009527518 A5 JP 2009527518A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- thia
- aza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 15
- 150000002148 esters Chemical class 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- UXNUAPAXTLFKIZ-UHFFFAOYSA-N 2-(2,7-dichloro-4-methoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound COC1=NC2=CC(Cl)=CC=C2C(=CC(O)=O)C2=C1C=C(Cl)S2 UXNUAPAXTLFKIZ-UHFFFAOYSA-N 0.000 claims 1
- WBLRAUZCGTWGTP-UHFFFAOYSA-N 2-(2,7-dichloro-4-oxo-5h-thieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound O=C1NC2=CC(Cl)=CC=C2C(=CC(=O)O)C2=C1C=C(Cl)S2 WBLRAUZCGTWGTP-UHFFFAOYSA-N 0.000 claims 1
- ASEWOQKMDZAFII-UHFFFAOYSA-N 2-(2,7-difluoro-4-methoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound COC1=NC2=CC(F)=CC=C2C(=CC(O)=O)C2=C1C=C(F)S2 ASEWOQKMDZAFII-UHFFFAOYSA-N 0.000 claims 1
- VQROHRUWTICCSC-UHFFFAOYSA-N 2-(2,7-difluoro-4-oxo-5h-thieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound O=C1NC2=CC(F)=CC=C2C(=CC(=O)O)C2=C1C=C(F)S2 VQROHRUWTICCSC-UHFFFAOYSA-N 0.000 claims 1
- OXERCZMJFFKEGU-UHFFFAOYSA-N 2-(2-chloro-4-ethoxy-7-fluorothieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound CCOC1=NC2=CC(F)=CC=C2C(=CC(O)=O)C2=C1C=C(Cl)S2 OXERCZMJFFKEGU-UHFFFAOYSA-N 0.000 claims 1
- YQPVGONBHYUGEJ-UHFFFAOYSA-N 2-(2-chloro-4-ethoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound CCOC1=NC2=CC=CC=C2C(=CC(O)=O)C2=C1C=C(Cl)S2 YQPVGONBHYUGEJ-UHFFFAOYSA-N 0.000 claims 1
- UHQGCNJXTQOKLU-UHFFFAOYSA-N 2-(2-chloro-4-methoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound COC1=NC2=CC=CC=C2C(=CC(O)=O)C2=C1C=C(Cl)S2 UHQGCNJXTQOKLU-UHFFFAOYSA-N 0.000 claims 1
- WTLOBSBAQGENTG-UHFFFAOYSA-N 2-(2-chloro-4-oxo-5h-thieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound O=C1NC2=CC=CC=C2C(=CC(=O)O)C2=C1C=C(Cl)S2 WTLOBSBAQGENTG-UHFFFAOYSA-N 0.000 claims 1
- HIOVITYFVAJSEY-UHFFFAOYSA-N 2-(2-chloro-7-fluoro-4-methoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound COC1=NC2=CC(F)=CC=C2C(=CC(O)=O)C2=C1C=C(Cl)S2 HIOVITYFVAJSEY-UHFFFAOYSA-N 0.000 claims 1
- VUHGDQUSRVEKSR-UHFFFAOYSA-N 2-(4-ethoxy-2,7-difluorothieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound CCOC1=NC2=CC(F)=CC=C2C(=CC(O)=O)C2=C1C=C(F)S2 VUHGDQUSRVEKSR-UHFFFAOYSA-N 0.000 claims 1
- YBHBZMCZDWWULG-UHFFFAOYSA-N 2-(7-chloro-4-ethoxythieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound CCOC1=NC2=CC(Cl)=CC=C2C(=CC(O)=O)C2=C1C=CS2 YBHBZMCZDWWULG-UHFFFAOYSA-N 0.000 claims 1
- UYENDJRGLPJPMO-UHFFFAOYSA-N 2-(7-chloro-4-oxo-5h-thieno[3,2-c][1]benzazepin-10-ylidene)acetic acid Chemical compound O=C1NC2=CC(Cl)=CC=C2C(=CC(=O)O)C2=C1C=CS2 UYENDJRGLPJPMO-UHFFFAOYSA-N 0.000 claims 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 1
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- -1 amino, amino Chemical group 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000001754 anti-pyretic effect Effects 0.000 claims 1
- 239000002221 antipyretic Substances 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000006211 transdermal dosage form Substances 0.000 claims 1
- 0 *CCC[I-][N+]=C Chemical compound *CCC[I-][N+]=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06003702 | 2006-02-23 | ||
| EP06003702.5 | 2006-02-23 | ||
| PCT/EP2007/001507 WO2007096150A2 (en) | 2006-02-23 | 2007-02-21 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009527518A JP2009527518A (ja) | 2009-07-30 |
| JP2009527518A5 true JP2009527518A5 (enExample) | 2010-04-15 |
| JP5135233B2 JP5135233B2 (ja) | 2013-02-06 |
Family
ID=36282923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555694A Expired - Fee Related JP5135233B2 (ja) | 2006-02-23 | 2007-02-21 | 有機化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8258128B2 (enExample) |
| EP (1) | EP1989209B1 (enExample) |
| JP (1) | JP5135233B2 (enExample) |
| KR (1) | KR20080106525A (enExample) |
| CN (1) | CN101389633B (enExample) |
| AR (1) | AR059597A1 (enExample) |
| AU (1) | AU2007218166B9 (enExample) |
| BR (1) | BRPI0708251A2 (enExample) |
| CA (1) | CA2640488C (enExample) |
| ES (1) | ES2540089T3 (enExample) |
| IL (1) | IL192928A0 (enExample) |
| MX (1) | MX2008010834A (enExample) |
| NO (1) | NO20083558L (enExample) |
| NZ (1) | NZ569551A (enExample) |
| RU (1) | RU2430921C2 (enExample) |
| TW (1) | TW200808810A (enExample) |
| WO (1) | WO2007096150A2 (enExample) |
| ZA (1) | ZA200805331B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200808810A (en) | 2006-02-23 | 2008-02-16 | Novartis Ag | Organic compounds |
| IT1391792B1 (it) * | 2008-11-21 | 2012-01-27 | Forem Pharma S R L | Composizione per un integratore naturale alimentare, particolarmente per favorire la fisiologica funzionalita' delle cartilagini. |
| CN105727249A (zh) * | 2016-03-24 | 2016-07-06 | 河南牧业经济学院 | 治疗猫、犬关节病症的外用膏剂及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2128029B1 (enExample) * | 1971-03-01 | 1974-08-02 | Roussel Uclaf | |
| BE791902A (fr) | 1971-11-26 | 1973-05-24 | Wander Ag Dr A | Nouveaux derives de la thieno (3,2-c) (1)benzazepine, leur preparation et leur application comme medicaments |
| DE2918778A1 (de) * | 1979-05-10 | 1980-11-20 | Basf Ag | 6-substituierte 11-alkylen-morphantridine |
| DE2918832A1 (de) * | 1979-05-10 | 1980-11-20 | Basf Ag | 5,6-dihydro-11-alkylen-morphantridin- 6-one |
| HU195800B (en) * | 1983-10-13 | 1988-07-28 | Sandoz Ltd | Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them |
| DE3524744A1 (de) * | 1985-07-11 | 1987-01-15 | Basf Ag | 4-substituierte 10-cyanmethylen-thieno (4,3-e)-benzo-azepine |
| JP2766266B2 (ja) * | 1988-06-20 | 1998-06-18 | 協和醗酵工業株式会社 | ピリジン誘導体およびその中間体 |
| SE9901530D0 (sv) | 1999-04-28 | 1999-04-28 | Astra Pharma Prod | Novel compounds |
| SE9901901D0 (sv) | 1999-05-26 | 1999-05-26 | Astra Ab | Compounds |
| TW200808810A (en) | 2006-02-23 | 2008-02-16 | Novartis Ag | Organic compounds |
-
2007
- 2007-02-16 TW TW096106330A patent/TW200808810A/zh unknown
- 2007-02-21 US US12/224,734 patent/US8258128B2/en not_active Expired - Fee Related
- 2007-02-21 BR BRPI0708251-7A patent/BRPI0708251A2/pt not_active IP Right Cessation
- 2007-02-21 NZ NZ569551A patent/NZ569551A/en not_active IP Right Cessation
- 2007-02-21 EP EP07722883.1A patent/EP1989209B1/en not_active Not-in-force
- 2007-02-21 AU AU2007218166A patent/AU2007218166B9/en not_active Ceased
- 2007-02-21 MX MX2008010834A patent/MX2008010834A/es active IP Right Grant
- 2007-02-21 KR KR1020087020597A patent/KR20080106525A/ko not_active Withdrawn
- 2007-02-21 CA CA2640488A patent/CA2640488C/en not_active Expired - Fee Related
- 2007-02-21 WO PCT/EP2007/001507 patent/WO2007096150A2/en not_active Ceased
- 2007-02-21 RU RU2008137533/04A patent/RU2430921C2/ru not_active IP Right Cessation
- 2007-02-21 JP JP2008555694A patent/JP5135233B2/ja not_active Expired - Fee Related
- 2007-02-21 AR ARP070100731A patent/AR059597A1/es not_active Application Discontinuation
- 2007-02-21 ES ES07722883.1T patent/ES2540089T3/es active Active
- 2007-02-21 CN CN2007800064548A patent/CN101389633B/zh not_active Expired - Fee Related
-
2008
- 2008-06-19 ZA ZA200805331A patent/ZA200805331B/xx unknown
- 2008-07-21 IL IL192928A patent/IL192928A0/en unknown
- 2008-08-15 NO NO20083558A patent/NO20083558L/no not_active Application Discontinuation