JP2009525330A5 - - Google Patents
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- Publication number
- JP2009525330A5 JP2009525330A5 JP2008553277A JP2008553277A JP2009525330A5 JP 2009525330 A5 JP2009525330 A5 JP 2009525330A5 JP 2008553277 A JP2008553277 A JP 2008553277A JP 2008553277 A JP2008553277 A JP 2008553277A JP 2009525330 A5 JP2009525330 A5 JP 2009525330A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- kinase
- compound
- formula
- mediated condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 108091000080 Phosphotransferase Proteins 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 10
- 102000020233 phosphotransferase Human genes 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 208000020084 Bone disease Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 230000001066 destructive effect Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- -1 2-((3- (3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl) ureido) methyl) -4-fluorophenoxy Chemical group 0.000 claims 3
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- QDWJUBJKEHXSMT-UHFFFAOYSA-N boranylidynenickel Chemical compound [Ni]#B QDWJUBJKEHXSMT-UHFFFAOYSA-N 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000000865 phosphorylative effect Effects 0.000 claims 1
- 0 CC(C)(C)C(C=C1*C(N)O)=**1c1ccc(C)cc1 Chemical compound CC(C)(C)C(C=C1*C(N)O)=**1c1ccc(C)cc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76371206P | 2006-01-31 | 2006-01-31 | |
| US60/763,712 | 2006-01-31 | ||
| PCT/US2007/002272 WO2007089646A1 (en) | 2006-01-31 | 2007-01-26 | Kinase inhibitors and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525330A JP2009525330A (ja) | 2009-07-09 |
| JP2009525330A5 true JP2009525330A5 (https=) | 2010-03-04 |
| JP5131990B2 JP5131990B2 (ja) | 2013-01-30 |
Family
ID=38037453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553277A Active JP5131990B2 (ja) | 2006-01-31 | 2007-01-26 | キナーゼ阻害剤およびその使用方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8044083B2 (https=) |
| EP (1) | EP1981851B1 (https=) |
| JP (1) | JP5131990B2 (https=) |
| KR (1) | KR101357465B1 (https=) |
| CN (1) | CN101415685B (https=) |
| AT (1) | ATE542800T1 (https=) |
| AU (1) | AU2007210073B2 (https=) |
| BR (1) | BRPI0707401B8 (https=) |
| CA (1) | CA2635813C (https=) |
| CY (1) | CY1112770T1 (https=) |
| DK (1) | DK1981851T3 (https=) |
| ES (1) | ES2379656T3 (https=) |
| HR (1) | HRP20120256T1 (https=) |
| IL (3) | IL192949A (https=) |
| MY (1) | MY151835A (https=) |
| NZ (1) | NZ570846A (https=) |
| PL (1) | PL1981851T3 (https=) |
| PT (1) | PT1981851E (https=) |
| RS (1) | RS52298B (https=) |
| RU (1) | RU2442777C2 (https=) |
| SG (1) | SG175599A1 (https=) |
| SI (1) | SI1981851T1 (https=) |
| TW (1) | TWI388557B (https=) |
| UA (1) | UA94733C2 (https=) |
| WO (1) | WO2007089646A1 (https=) |
| ZA (1) | ZA200806507B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| RS52298B (sr) | 2006-01-31 | 2012-12-31 | Array Biopharma Inc. | Inhibitori kinaze i postupak njihove upotrebe |
| WO2009015000A1 (en) * | 2007-07-25 | 2009-01-29 | Array Biopharma Inc. | Pyrazole urea derivatives used as kinase inhibitors |
| EP2196461A1 (de) | 2008-12-15 | 2010-06-16 | Bayer CropScience AG | 4-Amino-1,2,3-benzoxathiazin-Derivate als Pestizide |
| CA2835835C (en) | 2011-05-13 | 2019-04-02 | Array Biopharma Inc. | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors |
| SI2819998T1 (sl) * | 2012-03-01 | 2022-07-29 | Array Biopharma Inc. | Kristalinske oblike 1-(3-tert-butil-1-P-tolil-1H-pirazol-5-il)-3- (5-fluoro-2-(1-(2-hidroksietil)-1H-indazol-5-iloksi)benzil)urea hidroklorida |
| WO2014134313A1 (en) | 2013-02-27 | 2014-09-04 | Array Biopharma Inc. | Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof |
| BR112020006677A2 (pt) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | uso de inibidores p38 para reduzir a expressão de dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019114792A1 (zh) * | 2017-12-13 | 2019-06-20 | 劲方医药科技(上海)有限公司 | 一种TGF-βRI抑制剂的晶型、盐型及其制备方法 |
| WO2023084459A1 (en) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Methods of treating sars-cov-2 |
| CN115850179B (zh) * | 2022-12-13 | 2025-03-25 | 北京科翔中升医药科技有限公司 | 一种氘代吲唑类mapk抑制剂药物及用途 |
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| EA002113B1 (ru) | 1996-09-04 | 2001-12-24 | Пфайзер Инк. | Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно) |
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| EA199900452A1 (ru) | 1996-11-08 | 2000-02-28 | Дюпон Фармасьютикалз Компани | 1-(3-аминоиндазол-5-ил)-3-фенилметилциклические мочевины, полезные в качестве ингибиторов вич-протеазы |
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| US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
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| EP1019394A1 (en) * | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
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| US6297239B1 (en) * | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
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| IL135714A0 (en) * | 1997-11-04 | 2001-05-20 | Pfizer Prod Inc | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
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| US7521447B2 (en) * | 2003-03-03 | 2009-04-21 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
| GB0320244D0 (en) | 2003-05-06 | 2003-10-01 | Aventis Pharma Inc | Pyrazoles as inhibitors of tumour necrosis factor |
| US7129252B2 (en) | 2003-06-16 | 2006-10-31 | Guoqing P Chen | Six membered amino-amide derivatives an angiogenisis inhibitors |
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| CN1894240A (zh) | 2003-12-22 | 2007-01-10 | 伊莱利利公司 | 阿片受体拮抗剂 |
| WO2006122230A1 (en) * | 2005-05-11 | 2006-11-16 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
| RS52298B (sr) | 2006-01-31 | 2012-12-31 | Array Biopharma Inc. | Inhibitori kinaze i postupak njihove upotrebe |
-
2007
- 2007-01-26 RS RS20120119A patent/RS52298B/sr unknown
- 2007-01-26 PL PL07762713T patent/PL1981851T3/pl unknown
- 2007-01-26 DK DK07762713.1T patent/DK1981851T3/da active
- 2007-01-26 CA CA2635813A patent/CA2635813C/en active Active
- 2007-01-26 US US12/161,412 patent/US8044083B2/en active Active
- 2007-01-26 PT PT07762713T patent/PT1981851E/pt unknown
- 2007-01-26 JP JP2008553277A patent/JP5131990B2/ja active Active
- 2007-01-26 AU AU2007210073A patent/AU2007210073B2/en active Active
- 2007-01-26 HR HR20120256T patent/HRP20120256T1/hr unknown
- 2007-01-26 RU RU2008135332/04A patent/RU2442777C2/ru active
- 2007-01-26 ES ES07762713T patent/ES2379656T3/es active Active
- 2007-01-26 BR BRPI0707401A patent/BRPI0707401B8/pt active IP Right Grant
- 2007-01-26 SI SI200730895T patent/SI1981851T1/sl unknown
- 2007-01-26 MY MYPI20082836 patent/MY151835A/en unknown
- 2007-01-26 CN CN2007800120196A patent/CN101415685B/zh active Active
- 2007-01-26 SG SG2011073152A patent/SG175599A1/en unknown
- 2007-01-26 EP EP07762713A patent/EP1981851B1/en active Active
- 2007-01-26 WO PCT/US2007/002272 patent/WO2007089646A1/en not_active Ceased
- 2007-01-26 NZ NZ570846A patent/NZ570846A/en unknown
- 2007-01-26 AT AT07762713T patent/ATE542800T1/de active
- 2007-01-26 UA UAA200810690A patent/UA94733C2/ru unknown
- 2007-01-26 KR KR1020087021184A patent/KR101357465B1/ko active Active
- 2007-01-30 TW TW096103341A patent/TWI388557B/zh active
-
2008
- 2008-07-22 IL IL192949A patent/IL192949A/en active IP Right Grant
- 2008-07-25 ZA ZA200806507A patent/ZA200806507B/xx unknown
-
2011
- 2011-02-03 US US13/020,578 patent/US8039639B2/en active Active
-
2012
- 2012-03-19 CY CY20121100291T patent/CY1112770T1/el unknown
- 2012-05-08 IL IL219643A patent/IL219643A/en active IP Right Grant
- 2012-05-08 IL IL219644A patent/IL219644A/en active IP Right Grant
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