JP2009524591A5 - - Google Patents

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Publication number
JP2009524591A5
JP2009524591A5 JP2008547549A JP2008547549A JP2009524591A5 JP 2009524591 A5 JP2009524591 A5 JP 2009524591A5 JP 2008547549 A JP2008547549 A JP 2008547549A JP 2008547549 A JP2008547549 A JP 2008547549A JP 2009524591 A5 JP2009524591 A5 JP 2009524591A5
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JP
Japan
Prior art keywords
aliphatic
compound
halo
independently selected
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547549A
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English (en)
Japanese (ja)
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JP2009524591A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/048802 external-priority patent/WO2007075895A2/en
Publication of JP2009524591A publication Critical patent/JP2009524591A/ja
Publication of JP2009524591A5 publication Critical patent/JP2009524591A5/ja
Pending legal-status Critical Current

Links

JP2008547549A 2005-12-21 2006-12-21 イオンチャネルのモジュレーターとしての複素環誘導体 Pending JP2009524591A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75292605P 2005-12-21 2005-12-21
US79118106P 2006-04-11 2006-04-11
US79979706P 2006-05-12 2006-05-12
US83944406P 2006-08-23 2006-08-23
PCT/US2006/048802 WO2007075895A2 (en) 2005-12-21 2006-12-21 Heterocyclic derivatives as modulators of ion channels

Publications (2)

Publication Number Publication Date
JP2009524591A JP2009524591A (ja) 2009-07-02
JP2009524591A5 true JP2009524591A5 (enExample) 2011-01-13

Family

ID=38050930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547549A Pending JP2009524591A (ja) 2005-12-21 2006-12-21 イオンチャネルのモジュレーターとしての複素環誘導体

Country Status (15)

Country Link
US (4) US7799822B2 (enExample)
EP (3) EP2316829A1 (enExample)
JP (1) JP2009524591A (enExample)
KR (1) KR20080081178A (enExample)
CN (1) CN101365686A (enExample)
AU (1) AU2006331608B2 (enExample)
CA (1) CA2633653A1 (enExample)
IL (1) IL192184A0 (enExample)
NO (1) NO20083220L (enExample)
NZ (2) NZ593074A (enExample)
RU (1) RU2008129821A (enExample)
SG (1) SG181209A1 (enExample)
TW (1) TW200740803A (enExample)
WO (1) WO2007075895A2 (enExample)
ZA (1) ZA200805338B (enExample)

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US7615563B2 (en) * 2003-08-08 2009-11-10 Gonzalez Iii Jesus E Compositions useful as inhibitors of voltage-gated sodium channels
US7786137B2 (en) 2005-05-10 2010-08-31 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
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WO2007030618A2 (en) * 2005-09-09 2007-03-15 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of voltage gated ion channels
EP1948597A1 (en) * 2005-10-21 2008-07-30 Vertex Pharmaceuticals Incorporated Derivatives for modulation of ion channels
NZ581309A (en) 2007-05-25 2012-02-24 Vertex Pharma Ion channel modulators and methods of use
CN101835750B (zh) 2007-08-22 2013-07-17 阿斯利康(瑞典)有限公司 环丙基酰胺衍生物
US7994174B2 (en) * 2007-09-19 2011-08-09 Vertex Pharmaceuticals Incorporated Pyridyl sulfonamides as modulators of ion channels
AU2008321137A1 (en) 2007-11-13 2009-05-22 Vertex Pharmaceuticals Incorporated 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain
AU2008321142A1 (en) * 2007-11-13 2009-05-22 Vertex Pharmaceuticals Incorporated Heterocyclic derivatives as modulators of ion channels
CN101456860B (zh) * 2007-12-10 2011-02-16 中国科学院上海药物研究所 4-[9-(6-氨基嘌呤基)]-2(s)-羟基丁酸甲酯的制备方法
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
EP2242367A4 (en) * 2008-01-08 2012-07-04 Univ Pennsylvania Rel inhibitors and methods of use thereof
DE102008020785B4 (de) 2008-04-25 2021-11-04 Skw Stickstoffwerke Piesteritz Gmbh Verwendung von einfachen Derivaten von 5-Amino-1,2,4-thiadiazol zur Hemmung bzw. Steuerung der Nitrifikation
WO2009133641A1 (ja) * 2008-04-30 2009-11-05 シャープ株式会社 照明装置、及び表示装置
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN102099356A (zh) * 2008-07-01 2011-06-15 沃泰克斯药物股份有限公司 用作离子通道调节剂的杂环衍生物
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
US20110201623A1 (en) 2010-02-18 2011-08-18 Uczynski Michael A Crystalline Form Of A Cyclopropyl Benzamide Derivative
MX2014005068A (es) 2011-10-28 2014-07-30 Merck Sharp & Dohme Compuestos de benzoxazolinona con actividad selectiva en canales de sodio activados por voltaje.
US9624208B2 (en) 2012-10-26 2017-04-18 Merck Sharp & Dohme Corp. Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
CA2922567A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5]decane derivatives and use thereof
WO2015077905A1 (en) 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
KR102412146B1 (ko) 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
CN106795149B (zh) * 2015-05-05 2019-09-24 上海海雁医药科技有限公司 双环取代的苯磺酰胺衍生物、其制法与医药上的用途
TW201718557A (zh) * 2015-10-08 2017-06-01 歌林達有限公司 經吡唑基取代之四氫吡喃基碸
KR102366077B1 (ko) * 2016-05-20 2022-02-21 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
EP3541373B1 (en) * 2016-11-17 2023-11-01 Merck Sharp & Dohme LLC Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
KR20190086772A (ko) 2016-12-09 2019-07-23 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
CA3068395A1 (en) * 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited 2-(4-chlorophenoxy)-n-((1-(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases
BR112020024729A2 (pt) 2018-06-13 2021-03-23 Xenon Pharmaceuticals, Inc. compostos de benzenossulfonamida e seu uso como agentes terapêuticos
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
GB201810581D0 (en) 2018-06-28 2018-08-15 Ctxt Pty Ltd Compounds
IL279810B2 (en) 2018-08-31 2025-03-01 Xenon Pharmaceuticals Inc Heteroaryl-modified sulfonamide compounds and their use as medicinal agents
CA3104913A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
PH12021553107A1 (en) 2019-06-18 2022-08-01 Ctxt Pty Ltd Benzisoxazole sulfonamide derivatives
KR20260058912A (ko) * 2020-09-14 2026-04-30 젠자임 코포레이션 겸상 적혈구 질환 치료를 위한 비스-포스포글리세레이트 뮤타제 조절제로서의 화합물
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer
WO2023028056A1 (en) * 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
KR20240149461A (ko) 2022-01-18 2024-10-14 메이즈 테라퓨틱스, 인코퍼레이티드 Apol1 저해제 및 사용 방법
WO2024249254A2 (en) * 2023-05-26 2024-12-05 Maze Therapeutics, Inc. Methods of using apol1 inhibitors
CN117326903B (zh) * 2023-09-27 2025-05-02 常州大学 一种高立体选择性合成n-烷基化吲哚衍生物的方法
AU2024371386A1 (en) * 2023-10-31 2026-05-07 Xenon Pharmaceuticals Inc. Substituted aryl sulfonamides for use as sodium channel inhibitors
CN117384091B (zh) * 2023-12-08 2024-02-20 四川大学华西第二医院 一类酰胺衍生物、合成方法及用途
WO2025245351A1 (en) * 2024-05-22 2025-11-27 Xenon Pharmaceuticals Inc. Substituted aryl sulfonamides and compositions and uses thereof

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US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
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HUP0003073A3 (en) 1997-07-11 2002-10-28 Smithkline Beecham Plc Benzenesulfonamide derivatives, process for producing them and their use as medicines
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
US7615563B2 (en) 2003-08-08 2009-11-10 Gonzalez Iii Jesus E Compositions useful as inhibitors of voltage-gated sodium channels
TW200524888A (en) * 2003-08-08 2005-08-01 Vertex Pharma Compositions useful as inhibitors of voltage-gated ion channels
SE0302570D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
JP4473764B2 (ja) * 2005-03-31 2010-06-02 タカラベルモント株式会社 椅子昇降用油圧装置
US7786137B2 (en) 2005-05-10 2010-08-31 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
KR20080021030A (ko) 2005-05-16 2008-03-06 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서의 바이사이클릭 유도체
WO2006133459A1 (en) 2005-06-09 2006-12-14 Vertex Pharmaceuticals Incorporated Indane derivatives as modulators of ion channels
WO2007030618A2 (en) 2005-09-09 2007-03-15 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of voltage gated ion channels
ES2383090T3 (es) 2005-10-12 2012-06-18 Vertex Pharmaceuticals, Inc. Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje
EP1948597A1 (en) 2005-10-21 2008-07-30 Vertex Pharmaceuticals Incorporated Derivatives for modulation of ion channels
US7994174B2 (en) 2007-09-19 2011-08-09 Vertex Pharmaceuticals Incorporated Pyridyl sulfonamides as modulators of ion channels

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