CN101365686A - 作为离子通道调节剂的杂环衍生物 - Google Patents

作为离子通道调节剂的杂环衍生物 Download PDF

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Publication number
CN101365686A
CN101365686A CNA2006800525107A CN200680052510A CN101365686A CN 101365686 A CN101365686 A CN 101365686A CN A2006800525107 A CNA2006800525107 A CN A2006800525107A CN 200680052510 A CN200680052510 A CN 200680052510A CN 101365686 A CN101365686 A CN 101365686A
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China
Prior art keywords
compound
pain
aliphatic series
substituting group
halogen
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Pending
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CNA2006800525107A
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English (en)
Chinese (zh)
Inventor
D·威尔森
L·T·D·范宁
U·谢斯
E·马丁伯拉夫
A·特敏
T·纽伯特
N·齐默尔曼
T·诺尔
T·惠特尼
A·卡瓦特卡尔
D·莱斯坦
D·斯塔莫斯
周竞兰
V·阿勒穆加姆
C·古铁雷斯
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN101365686A publication Critical patent/CN101365686A/zh
Pending legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CNA2006800525107A 2005-12-21 2006-12-21 作为离子通道调节剂的杂环衍生物 Pending CN101365686A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US75292605P 2005-12-21 2005-12-21
US60/752,926 2005-12-21
US79118106P 2006-04-11 2006-04-11
US60/791,181 2006-04-11
US79979706P 2006-05-12 2006-05-12
US60/799,797 2006-05-12
US83944406P 2006-08-23 2006-08-23
US60/839,444 2006-08-23
PCT/US2006/048802 WO2007075895A2 (en) 2005-12-21 2006-12-21 Heterocyclic derivatives as modulators of ion channels

Publications (1)

Publication Number Publication Date
CN101365686A true CN101365686A (zh) 2009-02-11

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CNA2006800525107A Pending CN101365686A (zh) 2005-12-21 2006-12-21 作为离子通道调节剂的杂环衍生物

Country Status (15)

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US (4) US7799822B2 (enExample)
EP (3) EP1963281A2 (enExample)
JP (1) JP2009524591A (enExample)
KR (1) KR20080081178A (enExample)
CN (1) CN101365686A (enExample)
AU (1) AU2006331608B2 (enExample)
CA (1) CA2633653A1 (enExample)
IL (1) IL192184A0 (enExample)
NO (1) NO20083220L (enExample)
NZ (2) NZ569694A (enExample)
RU (1) RU2008129821A (enExample)
SG (1) SG181209A1 (enExample)
TW (1) TW200740803A (enExample)
WO (1) WO2007075895A2 (enExample)
ZA (1) ZA200805338B (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015077905A1 (en) * 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
WO2016177340A1 (zh) * 2015-05-05 2016-11-10 上海海雁医药科技有限公司 双环取代的苯磺酰胺衍生物、其制法与医药上的用途
CN108368092A (zh) * 2015-10-08 2018-08-03 格吕伦塔尔有限公司 吡唑基取代的四氢吡喃砜
CN109526219A (zh) * 2016-05-20 2019-03-26 泽农医药公司 苯磺酰胺及其作为治疗剂的用途
CN110896634A (zh) * 2017-07-03 2020-03-20 葛兰素史密斯克莱知识产权发展有限公司 作为atf4抑制剂用于治疗癌症和其它疾病的2-(4-氯苯氧基)-n-((1-(2-(4-氯苯氧基)乙炔氮杂环丁烷-3-基)甲基)乙酰胺衍生物和相关化合物
CN116406361A (zh) * 2020-09-14 2023-07-07 健赞公司 用于治疗镰状细胞病的作为二磷酸甘油酸变位酶调节剂的化合物
CN117384091A (zh) * 2023-12-08 2024-01-12 四川大学华西第二医院 一类酰胺衍生物、合成方法及用途

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615563B2 (en) * 2003-08-08 2009-11-10 Gonzalez Iii Jesus E Compositions useful as inhibitors of voltage-gated sodium channels
RU2007145434A (ru) * 2005-05-10 2009-06-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бициклические производные в качестве модуляторов ионных каналов
US7745629B2 (en) * 2005-05-16 2010-06-29 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
CN101300253B (zh) * 2005-09-09 2012-08-22 沃泰克斯药物股份有限公司 作为电压门控离子通道调控剂的二环衍生物
AU2006306367A1 (en) * 2005-10-21 2007-05-03 Vertex Pharmaceuticals Incorporated Derivatives for modulation of ion channels
CA2687764A1 (en) 2007-05-25 2008-12-04 Vertex Pharmaceuticals Incorporated Ion channel modulators and methods of use
UA101809C2 (uk) 2007-08-22 2013-05-13 Астразенека Аб Похідні циклопропіламіду
US7994174B2 (en) * 2007-09-19 2011-08-09 Vertex Pharmaceuticals Incorporated Pyridyl sulfonamides as modulators of ion channels
RU2010123876A (ru) * 2007-11-13 2011-12-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероциклические производные в качестве модуляторов ионных каналов
WO2009064747A2 (en) 2007-11-13 2009-05-22 Vertex Pharmaceuticals Incorporated 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain
CN101456860B (zh) * 2007-12-10 2011-02-16 中国科学院上海药物研究所 4-[9-(6-氨基嘌呤基)]-2(s)-羟基丁酸甲酯的制备方法
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2009089277A2 (en) * 2008-01-08 2009-07-16 The Trustees Of The University Of Pennsylvania Rel inhibitors and methods of use thereof
DE102008020785B4 (de) 2008-04-25 2021-11-04 Skw Stickstoffwerke Piesteritz Gmbh Verwendung von einfachen Derivaten von 5-Amino-1,2,4-thiadiazol zur Hemmung bzw. Steuerung der Nitrifikation
WO2009133641A1 (ja) * 2008-04-30 2009-11-05 シャープ株式会社 照明装置、及び表示装置
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