JP2009523139A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009523139A5 JP2009523139A5 JP2008549780A JP2008549780A JP2009523139A5 JP 2009523139 A5 JP2009523139 A5 JP 2009523139A5 JP 2008549780 A JP2008549780 A JP 2008549780A JP 2008549780 A JP2008549780 A JP 2008549780A JP 2009523139 A5 JP2009523139 A5 JP 2009523139A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- aryl
- halogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 claims 33
- -1 Amino, hydroxyl Chemical group 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 17
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims 14
- 125000005914 C6-C14 aryloxy group Chemical group 0.000 claims 14
- 125000003282 alkyl amino group Chemical group 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 2
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 2
- GFICWFZTBXUVIG-UHFFFAOYSA-N 6-n,6-n,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Chemical compound CC1N=C(N)NC(N(C)C)=N1 GFICWFZTBXUVIG-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
- 229940122199 Insulin secretagogue Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 238000003419 tautomerization reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0600342A FR2896157B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline. |
| FR06/00342 | 2006-01-13 | ||
| PCT/EP2006/012182 WO2007079914A2 (en) | 2006-01-13 | 2006-12-18 | Combination of triazine derivatives and insulin secretion stimulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523139A JP2009523139A (ja) | 2009-06-18 |
| JP2009523139A5 true JP2009523139A5 (enExample) | 2010-02-12 |
| JP5702911B2 JP5702911B2 (ja) | 2015-04-15 |
Family
ID=36648317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008549780A Active JP5702911B2 (ja) | 2006-01-13 | 2006-12-18 | トリアジン誘導体およびインスリン分泌促進剤の組合せ |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8227465B2 (enExample) |
| EP (1) | EP1971339B1 (enExample) |
| JP (1) | JP5702911B2 (enExample) |
| KR (1) | KR20080091366A (enExample) |
| CN (1) | CN101355949A (enExample) |
| AR (1) | AR059030A1 (enExample) |
| AT (1) | ATE540682T1 (enExample) |
| AU (1) | AU2006334731B2 (enExample) |
| BR (1) | BRPI0620923A2 (enExample) |
| CA (1) | CA2636837C (enExample) |
| CY (1) | CY1112674T1 (enExample) |
| DK (1) | DK1971339T3 (enExample) |
| EA (1) | EA016649B1 (enExample) |
| ES (1) | ES2378469T3 (enExample) |
| FR (1) | FR2896157B1 (enExample) |
| IL (1) | IL192596A (enExample) |
| PL (1) | PL1971339T3 (enExample) |
| PT (1) | PT1971339E (enExample) |
| SI (1) | SI1971339T1 (enExample) |
| WO (1) | WO2007079914A2 (enExample) |
| ZA (1) | ZA200806938B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG171986A1 (en) | 2008-12-12 | 2011-07-28 | Merck Patent Gmbh | Combination of insulin with triazine derivatives and its use for treating diabetes |
| FR2948028B1 (fr) * | 2009-07-17 | 2011-12-02 | Merck Sante Sas | Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine |
| RU2550798C2 (ru) * | 2011-05-12 | 2015-05-10 | Василий Иосифович Зоря | Способ стимуляции секреции инсулина |
| FR2987268B1 (fr) * | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
| TWI748945B (zh) * | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| CN111163782A (zh) | 2017-10-02 | 2020-05-15 | 普克塞尔公司 | 治疗射血分数保留型心力衰竭的方法 |
| SG11202007172YA (en) | 2018-06-06 | 2020-08-28 | Metavant Sciences Gmbh | Methods of treating subjects having diabetes with chronic kidney disease |
| CA3103324A1 (en) * | 2018-06-14 | 2019-12-19 | Poxel | Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes |
| USD945167S1 (en) | 2018-10-31 | 2022-03-08 | Kimberly-Clark Worldwide, Inc. | Paper sheet |
| KR20220113942A (ko) * | 2019-12-13 | 2022-08-17 | 스미토모 파마 가부시키가이샤 | 제조성 및 용출성이 우수한 소형 정제 |
| US12280125B2 (en) | 2022-09-09 | 2025-04-22 | Imam Abdulrahman Bin Faisal University | Method for delivering insulin |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| IT1276130B1 (it) | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
| FR2781152B1 (fr) | 1998-07-20 | 2001-07-06 | Permatec Tech Ag | Utilisation d'un polymere de type acrylique en tant qu'agent de desagregation |
| ATE372782T1 (de) * | 1999-06-21 | 2007-09-15 | Lilly Co Eli | Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin- abhängigen diabetes |
| US6559188B1 (en) * | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| EP1741445B1 (en) * | 2000-01-21 | 2013-08-14 | Novartis AG | Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents |
| FR2804113B1 (fr) * | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
| ITFI20010126A1 (it) | 2001-07-09 | 2003-01-09 | Molteni & C | Composizioni farmaceutiche per uso orale,contenenti,in combinazione,metformina e gliclazide |
| ATE361065T1 (de) * | 2002-01-25 | 2007-05-15 | Silanes Sa De Cv Lab | Pharmazeutische zusammensetzung zur kontrolle des blutzuckers bei patienten mit typ 2 diabetes |
| US7985422B2 (en) * | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| US20040147564A1 (en) * | 2003-01-29 | 2004-07-29 | Rao Vinay U. | Combinations of glimepiride and the thiazolidinedione for treatment of diabetes |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| MXPA06002127A (es) * | 2003-09-02 | 2006-05-31 | Prosidion Ltd | Terapia combinada para control glucemico. |
-
2006
- 2006-01-13 FR FR0600342A patent/FR2896157B1/fr not_active Expired - Fee Related
- 2006-12-18 AU AU2006334731A patent/AU2006334731B2/en not_active Ceased
- 2006-12-18 BR BRPI0620923-8A patent/BRPI0620923A2/pt not_active Application Discontinuation
- 2006-12-18 EP EP06829703A patent/EP1971339B1/en not_active Not-in-force
- 2006-12-18 ES ES06829703T patent/ES2378469T3/es active Active
- 2006-12-18 SI SI200631268T patent/SI1971339T1/sl unknown
- 2006-12-18 WO PCT/EP2006/012182 patent/WO2007079914A2/en not_active Ceased
- 2006-12-18 EA EA200801665A patent/EA016649B1/ru not_active IP Right Cessation
- 2006-12-18 CN CNA2006800507984A patent/CN101355949A/zh active Pending
- 2006-12-18 JP JP2008549780A patent/JP5702911B2/ja active Active
- 2006-12-18 KR KR1020087019388A patent/KR20080091366A/ko not_active Ceased
- 2006-12-18 PL PL06829703T patent/PL1971339T3/pl unknown
- 2006-12-18 CA CA2636837A patent/CA2636837C/en not_active Expired - Fee Related
- 2006-12-18 PT PT06829703T patent/PT1971339E/pt unknown
- 2006-12-18 DK DK06829703.5T patent/DK1971339T3/da active
- 2006-12-18 US US12/160,637 patent/US8227465B2/en not_active Expired - Fee Related
- 2006-12-18 AT AT06829703T patent/ATE540682T1/de active
-
2007
- 2007-01-12 AR ARP070100136A patent/AR059030A1/es unknown
-
2008
- 2008-07-02 IL IL192596A patent/IL192596A/en active IP Right Grant
- 2008-08-12 ZA ZA200806938A patent/ZA200806938B/xx unknown
-
2012
- 2012-02-08 CY CY20121100133T patent/CY1112674T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2397168C2 (ru) | Производные тиофена в качестве ингибиторов снк 1 | |
| JP2004516314A5 (enExample) | ||
| JP2008509166A5 (enExample) | ||
| JP2009523139A5 (enExample) | ||
| JP2006515858A5 (enExample) | ||
| RU2009102535A (ru) | Производные карбамидов тропана, их получение и их применение в терапии | |
| AR064304A1 (es) | Formulaciones de ansamicina y sus metodos de uso | |
| CA2445190A1 (en) | Indole, azaindole and related heterocyclic amidopiperazine derivatives | |
| JP2008528447A5 (enExample) | ||
| JP2009535307A5 (enExample) | ||
| WO2008142720A4 (en) | Quinazolin-oxime derivatives as hsp90 inhibitors | |
| JP2016527277A5 (enExample) | ||
| JP2018511647A5 (enExample) | ||
| RU2009106934A (ru) | Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента | |
| RU2007125726A (ru) | Новое производное антраниловой кислоты или его соль | |
| JPWO2023099592A5 (enExample) | ||
| JP2013514980A5 (enExample) | ||
| JP2009523142A5 (enExample) | ||
| KR20170081228A (ko) | 티족사나이드, 그의 유사체 또는 염의 전구 약물을 이용한 치료 조성물 및 방법 | |
| RU2009144538A (ru) | Новые циклические пептидные соединения | |
| JP2010500962A5 (enExample) | ||
| JP2015535847A5 (enExample) | ||
| JP2019527724A5 (enExample) | ||
| MA33501B1 (fr) | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) | |
| NO20075617L (no) | 4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater for behandling av infertilitet |