JP2009522579A5 - - Google Patents

Info

Publication number

JP2009522579A5

JP2009522579A5 JP2008549576A JP2008549576A JP2009522579A5 JP 2009522579 A5 JP2009522579 A5 JP 2009522579A5 JP 2008549576 A JP2008549576 A JP 2008549576A JP 2008549576 A JP2008549576 A JP 2008549576A JP 2009522579 A5 JP2009522579 A5 JP 2009522579A5

Authority

JP

Japan

Prior art keywords

polypeptide

cell

orai

test agent

nfat regulatory

Prior art date

2007-01-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 45
• 102000004196 processed proteins & peptides Human genes 0.000 claims 45
• 108090000765 processed proteins & peptides Proteins 0.000 claims 45
• 210000004027 cell Anatomy 0.000 claims 44
• 238000000034 method Methods 0.000 claims 34
• 239000003795 chemical substances by application Substances 0.000 claims 28
• 101100114828 Drosophila melanogaster Orai gene Proteins 0.000 claims 23
• 230000001105 regulatory effect Effects 0.000 claims 18
• 230000000694 effects Effects 0.000 claims 9
• 102000034356 gene-regulatory proteins Human genes 0.000 claims 8
• 108091006104 gene-regulatory proteins Proteins 0.000 claims 8
• 102100039319 Calcium release-activated calcium channel protein 1 Human genes 0.000 claims 7
• 101001122471 Homo sapiens Protein orai-3 Proteins 0.000 claims 7
• 108700027851 ORAI1 Proteins 0.000 claims 7
• 102000049665 ORAI2 Human genes 0.000 claims 7
• 108700027852 ORAI2 Proteins 0.000 claims 7
• 101150002636 ORAI2 gene Proteins 0.000 claims 7
• 102100027135 Protein orai-3 Human genes 0.000 claims 7
• 150000001768 cations Chemical class 0.000 claims 7
• 230000004941 influx Effects 0.000 claims 7
• 101150060735 orai1 gene Proteins 0.000 claims 7
• 101150079867 Orai gene Proteins 0.000 claims 6
• 108700005075 Regulator Genes Proteins 0.000 claims 6
• 230000027455 binding Effects 0.000 claims 6
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 5
• 108091006146 Channels Proteins 0.000 claims 5
• 229910052791 calcium Inorganic materials 0.000 claims 5
• 239000011575 calcium Substances 0.000 claims 5
• 230000014509 gene expression Effects 0.000 claims 5
• 238000012216 screening Methods 0.000 claims 5
• 241000238631 Hexapoda Species 0.000 claims 4
• 241000283984 Rodentia Species 0.000 claims 4
• 101150101888 Stim gene Proteins 0.000 claims 4
• 241000269370 Xenopus <genus> Species 0.000 claims 4
• 210000005260 human cell Anatomy 0.000 claims 4
• 210000004962 mammalian cell Anatomy 0.000 claims 4
• 101100043696 Drosophila melanogaster Stim gene Proteins 0.000 claims 3
• 230000009460 calcium influx Effects 0.000 claims 3
• 230000001413 cellular effect Effects 0.000 claims 3
• 230000004907 flux Effects 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 210000000170 cell membrane Anatomy 0.000 claims 2
• 230000003993 interaction Effects 0.000 claims 2
• 150000002500 ions Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1