JP2006526389A5 - - Google Patents
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- Publication number
- JP2006526389A5 JP2006526389A5 JP2006500430A JP2006500430A JP2006526389A5 JP 2006526389 A5 JP2006526389 A5 JP 2006526389A5 JP 2006500430 A JP2006500430 A JP 2006500430A JP 2006500430 A JP2006500430 A JP 2006500430A JP 2006526389 A5 JP2006526389 A5 JP 2006526389A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- ion channel
- calcium ion
- channel
- test compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 13
- 108090000312 Calcium Channels Proteins 0.000 claims 10
- 102000003922 Calcium Channels Human genes 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 6
- 229910001424 calcium ion Inorganic materials 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 4
- 230000005284 excitation Effects 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 108010026389 Gramicidin Proteins 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 3
- 229960004905 gramicidin Drugs 0.000 claims 3
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 claims 3
- 108020001213 potassium channel Proteins 0.000 claims 3
- 229910001414 potassium ion Inorganic materials 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 102000003691 T-Type Calcium Channels Human genes 0.000 claims 2
- 108090000030 T-Type Calcium Channels Proteins 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- 108091006146 Channels Proteins 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 101000974745 Homo sapiens Potassium channel subfamily K member 10 Proteins 0.000 claims 1
- 101001050878 Homo sapiens Potassium channel subfamily K member 9 Proteins 0.000 claims 1
- 102100033114 Inward rectifier potassium channel 2 Human genes 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 108090000862 Ion Channels Proteins 0.000 claims 1
- 101710124951 Phospholipase C Proteins 0.000 claims 1
- 102100022798 Potassium channel subfamily K member 10 Human genes 0.000 claims 1
- 102100023204 Potassium channel subfamily K member 2 Human genes 0.000 claims 1
- 102100023205 Potassium channel subfamily K member 4 Human genes 0.000 claims 1
- 101710185483 Potassium channel subfamily K member 4 Proteins 0.000 claims 1
- 102100024986 Potassium channel subfamily K member 9 Human genes 0.000 claims 1
- -1 TASK-1 Proteins 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 108010057232 inward rectifier potassium channel 2 Proteins 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108010083945 potassium channel protein TREK-1 Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229910001415 sodium ion Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43861603P | 2003-01-07 | 2003-01-07 | |
| US45740503P | 2003-03-24 | 2003-03-24 | |
| PCT/CA2004/000023 WO2004060917A2 (en) | 2003-01-07 | 2004-01-07 | Fluorescence based t-type channel assay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006526389A JP2006526389A (ja) | 2006-11-24 |
| JP2006526389A5 true JP2006526389A5 (enExample) | 2007-02-15 |
Family
ID=32717990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500430A Withdrawn JP2006526389A (ja) | 2003-01-07 | 2004-01-07 | 蛍光ｔ型チャネルアッセイ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7270949B2 (enExample) |
| EP (1) | EP1581558A2 (enExample) |
| JP (1) | JP2006526389A (enExample) |
| CA (1) | CA2512798A1 (enExample) |
| WO (1) | WO2004060917A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040259866A1 (en) * | 1998-06-30 | 2004-12-23 | Snutch Terrance P. | Calcium channel blockers comprising two benzhydril moieties |
| WO2006105670A1 (en) * | 2005-04-08 | 2006-10-12 | Neuromed Pharmaceuticals Ltd. | Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain |
| WO2007133481A2 (en) * | 2006-05-11 | 2007-11-22 | Neuromed Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
| KR100958291B1 (ko) | 2008-01-23 | 2010-05-19 | 한국과학기술연구원 | Ｔ―타입 칼슘채널을 억제하여 불안 장애를 치료하는 방법 |
| DE102008001322A1 (de) | 2008-04-22 | 2009-10-29 | Linos Photonics Gmbh & Co. Kg | System zur optischen Analyse von Probenarrays |
| US8816095B2 (en) * | 2008-08-15 | 2014-08-26 | Georgetown University | Na channels, disease, and related assays and compositions |
| EP2654726A4 (en) | 2011-03-08 | 2013-10-30 | Zalicus Pharmaceuticals Ltd | SOLID DISPERSION FORMULATIONS AND METHODS OF USE |
| US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| KR101286424B1 (ko) * | 2011-04-27 | 2013-07-23 | 경상대학교산학협력단 | 양극성 장애 치료제의 스크리닝 방법 |
| CN104884632B (zh) | 2012-12-27 | 2018-01-02 | 索尼公司 | 细胞分析系统及细胞分析方法 |
| JP6942925B2 (ja) | 2013-11-08 | 2021-09-29 | ソニーグループ株式会社 | 細胞分析システム、細胞分析プログラム及び細胞分析方法 |
| CN116656770A (zh) * | 2023-04-21 | 2023-08-29 | 中国药科大学 | 一种细胞失水模型及其建立方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670113A (en) * | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| US20020009772A1 (en) | 1997-02-28 | 2002-01-24 | Terry P. Snutch | Novel human calcium channels and related probes, cell lines and mehtods |
| US6309858B1 (en) | 1998-09-29 | 2001-10-30 | Syntex (U.S.A.) Llc | T-type calcium channel variants; compositions thereof; and uses |
| US6017537A (en) * | 1998-12-18 | 2000-01-25 | Connaught Laboratories, Inc. | Formyl methionyl peptide vaccine adjuvant |
| EP1180142A2 (en) * | 1999-05-27 | 2002-02-20 | PHARMACIA & UPJOHN COMPANY | Methods and compositions for measuring ion channel conductance |
| US6693172B1 (en) * | 1999-05-27 | 2004-02-17 | Pharmacia And Upjohn Company | Double mutant alpha-7 nicotinic acetylcholine receptor |
| EP1780278A3 (en) | 1999-07-02 | 2007-06-27 | Neuromed Technologies, Inc. | Mammalian calcium channels and related probes, cell lines and methods |
| US6358706B1 (en) | 1999-10-26 | 2002-03-19 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human alpha1G-C T-Type calcium channel |
| WO2001062741A1 (en) * | 2000-02-25 | 2001-08-30 | South Alabama Medical Science Foundation | Tetrahydronaphtalene derivatives and their use |
| US7399599B2 (en) * | 2000-07-10 | 2008-07-15 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| GB0120589D0 (en) * | 2001-08-24 | 2001-10-17 | Glaxo Group Ltd | Assay |
| US20060014206A1 (en) * | 2002-10-10 | 2006-01-19 | Menghang Xia | Assay methods for state-dependent calcium channel agonists/antagonists |
-
2004
- 2004-01-07 US US10/754,085 patent/US7270949B2/en not_active Expired - Fee Related
- 2004-01-07 CA CA002512798A patent/CA2512798A1/en not_active Abandoned
- 2004-01-07 JP JP2006500430A patent/JP2006526389A/ja not_active Withdrawn
- 2004-01-07 WO PCT/CA2004/000023 patent/WO2004060917A2/en not_active Ceased
- 2004-01-07 EP EP04700421A patent/EP1581558A2/en not_active Withdrawn
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