JP2006526389A - 蛍光ｔ型チャネルアッセイ - Google Patents

蛍光ｔ型チャネルアッセイ Download PDF

Info

Publication number
JP2006526389A
JP2006526389A JP2006500430A JP2006500430A JP2006526389A JP 2006526389 A JP2006526389 A JP 2006526389A JP 2006500430 A JP2006500430 A JP 2006500430A JP 2006500430 A JP2006500430 A JP 2006500430A JP 2006526389 A JP2006526389 A JP 2006526389A
Authority
JP
Japan
Prior art keywords
channel
type
calcium ion
cell
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006500430A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006526389A5 (enExample
Inventor
ベラルデッティ、フランチェスコ
ジャンク、ダイアナ
パーカー、デビッド
スナッチ、テランス、ピー．
Original Assignee
ニューロームド テクノロジーズ、インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニューロームド テクノロジーズ、インク． filed Critical ニューロームド テクノロジーズ、インク．
Publication of JP2006526389A publication Critical patent/JP2006526389A/ja
Publication of JP2006526389A5 publication Critical patent/JP2006526389A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2006500430A 2003-01-07 2004-01-07 蛍光ｔ型チャネルアッセイ Withdrawn JP2006526389A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43861603P 2003-01-07 2003-01-07
US45740503P 2003-03-24 2003-03-24
PCT/CA2004/000023 WO2004060917A2 (en) 2003-01-07 2004-01-07 Fluorescence based t-type channel assay

Publications (2)

Publication Number Publication Date
JP2006526389A true JP2006526389A (ja) 2006-11-24
JP2006526389A5 JP2006526389A5 (enExample) 2007-02-15

Family

ID=32717990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006500430A Withdrawn JP2006526389A (ja) 2003-01-07 2004-01-07 蛍光ｔ型チャネルアッセイ

Country Status (5)

Country Link
US (1) US7270949B2 (enExample)
EP (1) EP1581558A2 (enExample)
JP (1) JP2006526389A (enExample)
CA (1) CA2512798A1 (enExample)
WO (1) WO2004060917A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015068329A1 (ja) 2013-11-08 2015-05-14 ソニー株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
US10209236B2 (en) 2012-12-27 2019-02-19 Sony Corporation Cell analyzer system, cell analyzer program, and cell analyzing method

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
WO2006105670A1 (en) * 2005-04-08 2006-10-12 Neuromed Pharmaceuticals Ltd. Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
KR100958291B1 (ko) 2008-01-23 2010-05-19 한국과학기술연구원 Ｔ―타입 칼슘채널을 억제하여 불안 장애를 치료하는 방법
DE102008001322A1 (de) 2008-04-22 2009-10-29 Linos Photonics Gmbh & Co. Kg System zur optischen Analyse von Probenarrays
US8816095B2 (en) * 2008-08-15 2014-08-26 Georgetown University Na channels, disease, and related assays and compositions
EP2654726A4 (en) 2011-03-08 2013-10-30 Zalicus Pharmaceuticals Ltd SOLID DISPERSION FORMULATIONS AND METHODS OF USE
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
KR101286424B1 (ko) * 2011-04-27 2013-07-23 경상대학교산학협력단 양극성 장애 치료제의 스크리닝 방법
CN116656770A (zh) * 2023-04-21 2023-08-29 中国药科大学 一种细胞失水模型及其建立方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US20020009772A1 (en) 1997-02-28 2002-01-24 Terry P. Snutch Novel human calcium channels and related probes, cell lines and mehtods
US6309858B1 (en) 1998-09-29 2001-10-30 Syntex (U.S.A.) Llc T-type calcium channel variants; compositions thereof; and uses
US6017537A (en) * 1998-12-18 2000-01-25 Connaught Laboratories, Inc. Formyl methionyl peptide vaccine adjuvant
EP1180142A2 (en) * 1999-05-27 2002-02-20 PHARMACIA & UPJOHN COMPANY Methods and compositions for measuring ion channel conductance
US6693172B1 (en) * 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
EP1780278A3 (en) 1999-07-02 2007-06-27 Neuromed Technologies, Inc. Mammalian calcium channels and related probes, cell lines and methods
US6358706B1 (en) 1999-10-26 2002-03-19 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human alpha1G-C T-Type calcium channel
WO2001062741A1 (en) * 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Tetrahydronaphtalene derivatives and their use
US7399599B2 (en) * 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
GB0120589D0 (en) * 2001-08-24 2001-10-17 Glaxo Group Ltd Assay
US20060014206A1 (en) * 2002-10-10 2006-01-19 Menghang Xia Assay methods for state-dependent calcium channel agonists/antagonists

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10209236B2 (en) 2012-12-27 2019-02-19 Sony Corporation Cell analyzer system, cell analyzer program, and cell analyzing method
WO2015068329A1 (ja) 2013-11-08 2015-05-14 ソニー株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
US10163203B2 (en) 2013-11-08 2018-12-25 Sony Corporation Cell analysis system, cell analysis program and cell analysis method
US10482598B2 (en) 2013-11-08 2019-11-19 Sony Corporation Cell analysis system, cell analysis program and cell analysis method
US10861154B2 (en) 2013-11-08 2020-12-08 Sony Corporation Cell analysis system, cell analysis program and cell analysis method

Also Published As

Publication number Publication date
WO2004060917A2 (en) 2004-07-22
WO2004060917A3 (en) 2004-12-16
US20040180323A1 (en) 2004-09-16
CA2512798A1 (en) 2004-07-22
EP1581558A2 (en) 2005-10-05
US7270949B2 (en) 2007-09-18

Similar Documents

Publication Publication Date Title
Khoshbouei et al. Amphetamine-induced dopamine efflux: a voltage-sensitive and intracellular Na+-dependent mechanism
Yu et al. Detection of Calcium Transients in DrosophilaMushroom Body Neurons with Camgaroo Reporters
Sippy et al. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1
Benton et al. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo
JP2006526389A (ja) 蛍光ｔ型チャネルアッセイ
Frøkjær‐Jensen et al. Effects of voltage‐gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons
Bianchi Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans
Marcotti et al. The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI
Hirano et al. Vesicular release of GABA by mammalian horizontal cells mediates inhibitory output to photoreceptors
CN101971024A (zh) 用于测量铊流入和流出的组合物和方法
Yang et al. A force-sensitive adhesion GPCR is required for equilibrioception
BRPI0618247A2 (pt) ensaio de triagem de alto rendimento para canal iÈnico trpm5
Park et al. A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis elegans
Kang et al. Optical consequences of a genetically-encoded voltage indicator with a pH sensitive fluorescent protein
Biedermann et al. GABAA receptors in Müller glial cells of the human retina
JP2011529564A (ja) ナトリウム／カルシウム交換体（ｎｃｘ）「リバースモード」調節化合物を検出するための蛍光ベースのアッセイ
JP2006525011A (ja) 白内障形成リスクに関するスクリーニング法
Koulen et al. Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans
CN101960306A (zh) 嗅觉灵敏度抑制剂的筛选方法
JP6422665B2 (ja) 腋臭抑制剤の探索方法
JP5884222B2 (ja) イオンチャネルに作用する化合物のスクリーニング用材料及びその利用
US20240142474A1 (en) Opsins as Chemosensory Receptors and Related Methods
Bourgeois-Jaarsma et al. Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength
Xenias et al. Pathogenic LRRK2 R1441C mutation is associated with striatal alterations
Mijanović et al. The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061219

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061219

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090115