CA2512798A1 - Fluorescence based t-type channel assay - Google Patents

Fluorescence based t-type channel assay Download PDF

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Publication number
CA2512798A1
CA2512798A1 CA002512798A CA2512798A CA2512798A1 CA 2512798 A1 CA2512798 A1 CA 2512798A1 CA 002512798 A CA002512798 A CA 002512798A CA 2512798 A CA2512798 A CA 2512798A CA 2512798 A1 CA2512798 A1 CA 2512798A1
Authority
CA
Canada
Prior art keywords
cells
channel
calcium ion
type
channels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002512798A
Other languages
English (en)
French (fr)
Inventor
Francesco Belardetti
Diana Janke
David Parker
Terrance P. Snutch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taro Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2512798A1 publication Critical patent/CA2512798A1/en
Abandoned legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA002512798A 2003-01-07 2004-01-07 Fluorescence based t-type channel assay Abandoned CA2512798A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43861603P 2003-01-07 2003-01-07
US60/438,616 2003-01-07
US45740503P 2003-03-24 2003-03-24
US60/457,405 2003-03-24
PCT/CA2004/000023 WO2004060917A2 (en) 2003-01-07 2004-01-07 Fluorescence based t-type channel assay

Publications (1)

Publication Number Publication Date
CA2512798A1 true CA2512798A1 (en) 2004-07-22

Family

ID=32717990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002512798A Abandoned CA2512798A1 (en) 2003-01-07 2004-01-07 Fluorescence based t-type channel assay

Country Status (5)

Country Link
US (1) US7270949B2 (enExample)
EP (1) EP1581558A2 (enExample)
JP (1) JP2006526389A (enExample)
CA (1) CA2512798A1 (enExample)
WO (1) WO2004060917A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
WO2006105670A1 (en) * 2005-04-08 2006-10-12 Neuromed Pharmaceuticals Ltd. Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
KR100958291B1 (ko) 2008-01-23 2010-05-19 한국과학기술연구원 T―타입 칼슘채널을 억제하여 불안 장애를 치료하는 방법
DE102008001322A1 (de) 2008-04-22 2009-10-29 Linos Photonics Gmbh & Co. Kg System zur optischen Analyse von Probenarrays
US8816095B2 (en) * 2008-08-15 2014-08-26 Georgetown University Na channels, disease, and related assays and compositions
EP2654726A4 (en) 2011-03-08 2013-10-30 Zalicus Pharmaceuticals Ltd SOLID DISPERSION FORMULATIONS AND METHODS OF USE
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
KR101286424B1 (ko) * 2011-04-27 2013-07-23 경상대학교산학협력단 양극성 장애 치료제의 스크리닝 방법
CN104884632B (zh) 2012-12-27 2018-01-02 索尼公司 细胞分析系统及细胞分析方法
JP6942925B2 (ja) 2013-11-08 2021-09-29 ソニーグループ株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
CN116656770A (zh) * 2023-04-21 2023-08-29 中国药科大学 一种细胞失水模型及其建立方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US20020009772A1 (en) 1997-02-28 2002-01-24 Terry P. Snutch Novel human calcium channels and related probes, cell lines and mehtods
US6309858B1 (en) 1998-09-29 2001-10-30 Syntex (U.S.A.) Llc T-type calcium channel variants; compositions thereof; and uses
US6017537A (en) * 1998-12-18 2000-01-25 Connaught Laboratories, Inc. Formyl methionyl peptide vaccine adjuvant
EP1180142A2 (en) * 1999-05-27 2002-02-20 PHARMACIA & UPJOHN COMPANY Methods and compositions for measuring ion channel conductance
US6693172B1 (en) * 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
EP1780278A3 (en) 1999-07-02 2007-06-27 Neuromed Technologies, Inc. Mammalian calcium channels and related probes, cell lines and methods
US6358706B1 (en) 1999-10-26 2002-03-19 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human alpha1G-C T-Type calcium channel
WO2001062741A1 (en) * 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Tetrahydronaphtalene derivatives and their use
US7399599B2 (en) * 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
GB0120589D0 (en) * 2001-08-24 2001-10-17 Glaxo Group Ltd Assay
US20060014206A1 (en) * 2002-10-10 2006-01-19 Menghang Xia Assay methods for state-dependent calcium channel agonists/antagonists

Also Published As

Publication number Publication date
WO2004060917A2 (en) 2004-07-22
WO2004060917A3 (en) 2004-12-16
US20040180323A1 (en) 2004-09-16
EP1581558A2 (en) 2005-10-05
US7270949B2 (en) 2007-09-18
JP2006526389A (ja) 2006-11-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued