JP2009539377A5 - - Google Patents
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- Publication number
- JP2009539377A5 JP2009539377A5 JP2009514392A JP2009514392A JP2009539377A5 JP 2009539377 A5 JP2009539377 A5 JP 2009539377A5 JP 2009514392 A JP2009514392 A JP 2009514392A JP 2009514392 A JP2009514392 A JP 2009514392A JP 2009539377 A5 JP2009539377 A5 JP 2009539377A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- genes
- taste
- cells
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 238000000034 method Methods 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 24
- 235000019640 taste Nutrition 0.000 claims 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 13
- 229910052708 sodium Inorganic materials 0.000 claims 13
- 239000011734 sodium Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 7
- 102000005962 receptors Human genes 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 101000844521 Homo sapiens Transient receptor potential cation channel subfamily M member 5 Proteins 0.000 claims 6
- 102000004310 Ion Channels Human genes 0.000 claims 6
- 108090000862 Ion Channels Proteins 0.000 claims 6
- 102000003609 TRPM5 Human genes 0.000 claims 6
- 239000003623 enhancer Substances 0.000 claims 6
- 101000605625 Homo sapiens Polycystic kidney disease 2-like 1 protein Proteins 0.000 claims 5
- 101000730587 Homo sapiens Polycystic kidney disease protein 1-like 3 Proteins 0.000 claims 5
- 102100038330 Polycystic kidney disease 2-like 1 protein Human genes 0.000 claims 5
- 102100032598 Polycystic kidney disease protein 1-like 3 Human genes 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 4
- 235000019658 bitter taste Nutrition 0.000 claims 4
- 235000019583 umami taste Nutrition 0.000 claims 4
- 108010078791 Carrier Proteins Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 230000006870 function Effects 0.000 claims 3
- 235000019600 saltiness Nutrition 0.000 claims 3
- 108091005708 gustatory receptors Proteins 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 238000000370 laser capture micro-dissection Methods 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 235000019608 salt taste sensations Nutrition 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 235000019614 sour taste Nutrition 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 235000019607 umami taste sensations Nutrition 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 108091006146 Channels Proteins 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000000984 immunochemical effect Effects 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 210000002243 primary neuron Anatomy 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000019605 sweet taste sensations Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81176306P | 2006-06-08 | 2006-06-08 | |
| US83119906P | 2006-07-17 | 2006-07-17 | |
| US84899506P | 2006-10-04 | 2006-10-04 | |
| US86617806P | 2006-11-16 | 2006-11-16 | |
| PCT/US2007/013502 WO2007146120A2 (en) | 2006-06-08 | 2007-06-08 | Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009539377A JP2009539377A (ja) | 2009-11-19 |
| JP2009539377A5 true JP2009539377A5 (enExample) | 2010-07-29 |
Family
ID=38832404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514392A Abandoned JP2009539377A (ja) | 2006-06-08 | 2007-06-08 | 新規味細胞遺伝子および塩味受容体標的を同定するための理論的根拠、方法、およびアッセイならびにこれらの同定された遺伝子または遺伝子産物を使用するアッセイ |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080261824A1 (enExample) |
| EP (1) | EP2024518A4 (enExample) |
| JP (1) | JP2009539377A (enExample) |
| AU (1) | AU2007258511A1 (enExample) |
| CA (1) | CA2654552A1 (enExample) |
| IL (1) | IL195205A0 (enExample) |
| MX (1) | MX2008015314A (enExample) |
| NO (1) | NO20084993L (enExample) |
| TW (1) | TW200813232A (enExample) |
| WO (1) | WO2007146120A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10078087B2 (en) | 2001-05-01 | 2018-09-18 | Senomyx, Inc. | Assays and enhancers of the human delta ENaC sodium channel |
| CA2530497A1 (en) | 2003-07-10 | 2005-02-17 | Senomyx, Inc. | Improved electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes |
| CA2666962C (en) * | 2006-10-19 | 2015-12-08 | Monell Chemical Senses Center | Human salty taste receptor and methods of modulating salty taste perception |
| US20090210953A1 (en) * | 2007-06-08 | 2009-08-20 | Bryan Moyer | Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release |
| EP2164976A4 (en) | 2007-06-08 | 2010-06-30 | Senomyx Inc | THEORETICAL BASIS, METHODS AND TESTS FOR IDENTIFYING FLAVOR SPECIES OF HUMAN AND NON-MUSCLE PRIMATES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING TESTS |
| WO2010065863A2 (en) * | 2008-12-05 | 2010-06-10 | Senomyx, Inc. | Assays for identifying genes encoding salty taste receptors and modulators |
| WO2010144773A1 (en) * | 2009-06-12 | 2010-12-16 | Monell Chemical Senses Center | Stg promoter and its use as a marker for taste and oocyte cells |
| JP5206882B2 (ja) | 2009-09-29 | 2013-06-12 | 味の素株式会社 | 塩味調節物質のスクリーニング方法 |
| JP5627479B2 (ja) * | 2011-01-24 | 2014-11-19 | 日清食品ホールディングス株式会社 | Ｓｋｎ−１ａ／ｉノックアウトマウスを用いた味蕾細胞マーカー分子の探索方法 |
| EP3285795B1 (en) * | 2015-04-22 | 2022-11-16 | Cedars-Sinai Medical Center | Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity |
| JP7357282B2 (ja) * | 2017-12-28 | 2023-10-06 | 日清食品ホールディングス株式会社 | 塩味受容体を用いた塩味増強剤のスクリーニング方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750339A (en) * | 1994-11-30 | 1998-05-12 | Thomas Jefferson University | Methods for identifying fetal cells |
| US7041448B2 (en) * | 2000-08-18 | 2006-05-09 | The ML4 Foundation | Gene encoding a new TRP channel is mutated in mucolipidosis IV |
| US20020164645A1 (en) * | 2000-12-29 | 2002-11-07 | The Regents Of The University Of California | Assays for taste receptor cell specific ion channel |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| WO2002086079A2 (en) * | 2001-04-20 | 2002-10-31 | Mount Sinai School Of Medicine | T1r3 a novel taste receptor |
| AU2002320294B2 (en) * | 2001-07-03 | 2009-01-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mammalian sweet and amino acid heterodimeric taste receptors |
| DE10155130A1 (de) * | 2001-11-12 | 2003-05-22 | Max Delbrueck Centrum | Verfahren zur Isolierung von Neuronen |
| US20050266442A1 (en) * | 2004-03-25 | 2005-12-01 | Rachel Squillace | Immortalized human Tuberous Sclerosis null angiomyolipoma cell and method of use thereof |
-
2007
- 2007-06-08 WO PCT/US2007/013502 patent/WO2007146120A2/en not_active Ceased
- 2007-06-08 JP JP2009514392A patent/JP2009539377A/ja not_active Abandoned
- 2007-06-08 EP EP07809397A patent/EP2024518A4/en not_active Withdrawn
- 2007-06-08 US US11/808,356 patent/US20080261824A1/en not_active Abandoned
- 2007-06-08 AU AU2007258511A patent/AU2007258511A1/en not_active Abandoned
- 2007-06-08 CA CA002654552A patent/CA2654552A1/en not_active Abandoned
- 2007-06-08 MX MX2008015314A patent/MX2008015314A/es unknown
- 2007-06-08 TW TW096120717A patent/TW200813232A/zh unknown
-
2008
- 2008-11-10 IL IL195205A patent/IL195205A0/en unknown
- 2008-11-28 NO NO20084993A patent/NO20084993L/no not_active Application Discontinuation
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