NO20084993L - Forklaring, metoder, og prover for identifisering av nye smakscelle-gener og saltsmak-reseptor mal og prover som anvender disse identifiserte genene eller gen-produktene - Google Patents

Forklaring, metoder, og prover for identifisering av nye smakscelle-gener og saltsmak-reseptor mal og prover som anvender disse identifiserte genene eller gen-produktene

Info

Publication number
NO20084993L
NO20084993L NO20084993A NO20084993A NO20084993L NO 20084993 L NO20084993 L NO 20084993L NO 20084993 A NO20084993 A NO 20084993A NO 20084993 A NO20084993 A NO 20084993A NO 20084993 L NO20084993 L NO 20084993L
Authority
NO
Norway
Prior art keywords
taste
genes
methods
umami
bitter
Prior art date
Application number
NO20084993A
Other languages
English (en)
Inventor
Bryan Moyer
Min Lu
Fernando Echeverri
Dalia Kalabat
Na Gao
Peter Hevezi
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of NO20084993L publication Critical patent/NO20084993L/no

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Denne metoden gjelder nye prinsipper og fremgangsmåter for identifisering av smaksspesifikke gener, herunder gener involvert i oppfatningen av saltsmak, spesielt oppfatningen av saltsmak hos mennesker, men også gener involvert i oppfatningen av søt, bitter, umami og sursmak, og gener involvert i andre smakscelle- eller smaksreseptorrelaterte aktiviteter, som f.eks. fordøyelsesfunksjon og fordøyelsesrelaterte sykdommer, smakscelleomsetning, immunregulering i munnhule og fordøyelseskanal og stoffskifteregulering som f.eks. ved diabetes og sykelig overvekt, gener som identifiseres ved disse metodene og analyser for identifisering av smaksmodulatorer (forsterkere eller blokkerere) og potensielle terapeutiske midler basert på disse genene. Disse forbindelsene kan potensielt anvendes i modulering (forsterking eller blokkering) av smaksoppfatning, spesielt oppfatningen av saltsmak og som potensielle terapeutiske midler. I tillegg gjelder denne oppfinnelsen nye metoder for identifisering av smaksspesifikke gener som kan brukes som markører for forskjellige smakscelletyper, herunder celler for søt, bitter, umami, sur, saltsmak og andre smaker hos pattedyr samt analyser som måler aktiviteten i den søte, bitre, umami eller sure reseptoren i nærvær av disse genene for å identifisere modulatorer av søt, bitter, umami og sur smak og for å identifisere terapeutiske midler spesifikt for behandling av fordøyelses- eller metabolismerelaterte sykdommer, smakstap og munninfeksjoner. Oppfinnelsen gir også spesifikke metoder for rensing, anrikning, isolering eller merking av ønskede smakscellesubtyper eller -avstamninger som f.eks. søt, umami, bitter, salt, sur, fet eller stamceller osv, f.eks. ved bruk av FACS, magnetiske perler eller andre seleksjonsmetoder som renser, anriker, merker eller eliminerer som f.eks. ved bruk av merkede cytotoksinceller som uttrykker eller ikke uttrykker ett eller flere smaksspesifikke gener. 1
NO20084993A 2006-06-08 2008-11-28 Forklaring, metoder, og prover for identifisering av nye smakscelle-gener og saltsmak-reseptor mal og prover som anvender disse identifiserte genene eller gen-produktene NO20084993L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81176306P 2006-06-08 2006-06-08
US83119906P 2006-07-17 2006-07-17
US84899506P 2006-10-04 2006-10-04
US86617806P 2006-11-16 2006-11-16
PCT/US2007/013502 WO2007146120A2 (en) 2006-06-08 2007-06-08 Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products

Publications (1)

Publication Number Publication Date
NO20084993L true NO20084993L (no) 2008-11-28

Family

ID=38832404

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084993A NO20084993L (no) 2006-06-08 2008-11-28 Forklaring, metoder, og prover for identifisering av nye smakscelle-gener og saltsmak-reseptor mal og prover som anvender disse identifiserte genene eller gen-produktene

Country Status (10)

Country Link
US (1) US20080261824A1 (no)
EP (1) EP2024518A4 (no)
JP (1) JP2009539377A (no)
AU (1) AU2007258511A1 (no)
CA (1) CA2654552A1 (no)
IL (1) IL195205A0 (no)
MX (1) MX2008015314A (no)
NO (1) NO20084993L (no)
TW (1) TW200813232A (no)
WO (1) WO2007146120A2 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10078087B2 (en) 2001-05-01 2018-09-18 Senomyx, Inc. Assays and enhancers of the human delta ENaC sodium channel
AU2004263845A1 (en) 2003-07-10 2005-02-17 Senomyx, Inc. Improved electrophysiological assays using oocytes that express human ENaC and the use of phenamil to improve the effect of ENaC enhancers in assays using membrane potential reporting dyes
EP2557087A1 (en) * 2006-10-19 2013-02-13 Monell Chemical Senses Center Human salty taste receptor and methods of modulating salty taste perception
TW200904981A (en) 2007-06-08 2009-02-01 Senomyx Inc Identification of TRPML3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
US20090210953A1 (en) * 2007-06-08 2009-08-20 Bryan Moyer Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
WO2010065863A2 (en) * 2008-12-05 2010-06-10 Senomyx, Inc. Assays for identifying genes encoding salty taste receptors and modulators
WO2010144773A1 (en) * 2009-06-12 2010-12-16 Monell Chemical Senses Center Stg promoter and its use as a marker for taste and oocyte cells
SG175260A1 (en) * 2009-09-29 2011-11-28 Ajinomoto Kk Method for screening for salty taste control substance
JP5627479B2 (ja) * 2011-01-24 2014-11-19 日清食品ホールディングス株式会社 Ｓｋｎ−１ａ／ｉノックアウトマウスを用いた味蕾細胞マーカー分子の探索方法
EP4194001A1 (en) * 2015-04-22 2023-06-14 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity
JP7357282B2 (ja) * 2017-12-28 2023-10-06 日清食品ホールディングス株式会社 塩味受容体を用いた塩味増強剤のスクリーニング方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US7041448B2 (en) * 2000-08-18 2006-05-09 The ML4 Foundation Gene encoding a new TRP channel is mutated in mucolipidosis IV
US20020164645A1 (en) * 2000-12-29 2002-11-07 The Regents Of The University Of California Assays for taste receptor cell specific ion channel
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
MXPA03009580A (es) * 2001-04-20 2004-12-06 Sinai School Medicine Tir3, un receptor de sabor novedoso.
WO2003004992A2 (en) * 2001-07-03 2003-01-16 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
DE10155130A1 (de) * 2001-11-12 2003-05-22 Max Delbrueck Centrum Verfahren zur Isolierung von Neuronen
US20050266442A1 (en) * 2004-03-25 2005-12-01 Rachel Squillace Immortalized human Tuberous Sclerosis null angiomyolipoma cell and method of use thereof

Also Published As

Publication number Publication date
IL195205A0 (en) 2009-08-03
CA2654552A1 (en) 2007-12-21
MX2008015314A (es) 2008-12-12
EP2024518A2 (en) 2009-02-18
EP2024518A4 (en) 2010-05-26
WO2007146120A3 (en) 2008-12-04
US20080261824A1 (en) 2008-10-23
TW200813232A (en) 2008-03-16
AU2007258511A1 (en) 2007-12-21
JP2009539377A (ja) 2009-11-19
WO2007146120A2 (en) 2007-12-21

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