AU2007258511A1 - Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products - Google Patents

Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products Download PDF

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Publication number
AU2007258511A1
AU2007258511A1 AU2007258511A AU2007258511A AU2007258511A1 AU 2007258511 A1 AU2007258511 A1 AU 2007258511A1 AU 2007258511 A AU2007258511 A AU 2007258511A AU 2007258511 A AU2007258511 A AU 2007258511A AU 2007258511 A1 AU2007258511 A1 AU 2007258511A1
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AU
Australia
Prior art keywords
taste
cell
cells
gene
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007258511A
Other languages
English (en)
Inventor
Fernando Echeverri
Na Gao
Peter Hevezi
Dalia Kalabat
Min Lu
Bryan Moyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich Inc
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of AU2007258511A1 publication Critical patent/AU2007258511A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2007258511A 2006-06-08 2007-06-08 Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products Abandoned AU2007258511A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US81176306P 2006-06-08 2006-06-08
US60/811,763 2006-06-08
US83119906P 2006-07-17 2006-07-17
US60/831,199 2006-07-17
US84899506P 2006-10-04 2006-10-04
US60/848,995 2006-10-04
US86617806P 2006-11-16 2006-11-16
US60/866,178 2006-11-16
PCT/US2007/013502 WO2007146120A2 (en) 2006-06-08 2007-06-08 Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products

Publications (1)

Publication Number Publication Date
AU2007258511A1 true AU2007258511A1 (en) 2007-12-21

Family

ID=38832404

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007258511A Abandoned AU2007258511A1 (en) 2006-06-08 2007-06-08 Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products

Country Status (10)

Country Link
US (1) US20080261824A1 (enExample)
EP (1) EP2024518A4 (enExample)
JP (1) JP2009539377A (enExample)
AU (1) AU2007258511A1 (enExample)
CA (1) CA2654552A1 (enExample)
IL (1) IL195205A0 (enExample)
MX (1) MX2008015314A (enExample)
NO (1) NO20084993L (enExample)
TW (1) TW200813232A (enExample)
WO (1) WO2007146120A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10078087B2 (en) 2001-05-01 2018-09-18 Senomyx, Inc. Assays and enhancers of the human delta ENaC sodium channel
CA2530497A1 (en) 2003-07-10 2005-02-17 Senomyx, Inc. Improved electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes
CA2666962C (en) * 2006-10-19 2015-12-08 Monell Chemical Senses Center Human salty taste receptor and methods of modulating salty taste perception
US20090210953A1 (en) * 2007-06-08 2009-08-20 Bryan Moyer Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
EP2164976A4 (en) 2007-06-08 2010-06-30 Senomyx Inc THEORETICAL BASIS, METHODS AND TESTS FOR IDENTIFYING FLAVOR SPECIES OF HUMAN AND NON-MUSCLE PRIMATES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING TESTS
WO2010065863A2 (en) * 2008-12-05 2010-06-10 Senomyx, Inc. Assays for identifying genes encoding salty taste receptors and modulators
WO2010144773A1 (en) * 2009-06-12 2010-12-16 Monell Chemical Senses Center Stg promoter and its use as a marker for taste and oocyte cells
JP5206882B2 (ja) 2009-09-29 2013-06-12 味の素株式会社 塩味調節物質のスクリーニング方法
JP5627479B2 (ja) * 2011-01-24 2014-11-19 日清食品ホールディングス株式会社 Ｓｋｎ−１ａ／ｉノックアウトマウスを用いた味蕾細胞マーカー分子の探索方法
EP3285795B1 (en) * 2015-04-22 2022-11-16 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity
JP7357282B2 (ja) * 2017-12-28 2023-10-06 日清食品ホールディングス株式会社 塩味受容体を用いた塩味増強剤のスクリーニング方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US7041448B2 (en) * 2000-08-18 2006-05-09 The ML4 Foundation Gene encoding a new TRP channel is mutated in mucolipidosis IV
US20020164645A1 (en) * 2000-12-29 2002-11-07 The Regents Of The University Of California Assays for taste receptor cell specific ion channel
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
AU2002320294B2 (en) * 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
DE10155130A1 (de) * 2001-11-12 2003-05-22 Max Delbrueck Centrum Verfahren zur Isolierung von Neuronen
US20050266442A1 (en) * 2004-03-25 2005-12-01 Rachel Squillace Immortalized human Tuberous Sclerosis null angiomyolipoma cell and method of use thereof

Also Published As

Publication number Publication date
IL195205A0 (en) 2009-08-03
NO20084993L (no) 2008-11-28
WO2007146120A3 (en) 2008-12-04
US20080261824A1 (en) 2008-10-23
MX2008015314A (es) 2008-12-12
TW200813232A (en) 2008-03-16
EP2024518A4 (en) 2010-05-26
CA2654552A1 (en) 2007-12-21
EP2024518A2 (en) 2009-02-18
WO2007146120A2 (en) 2007-12-21
JP2009539377A (ja) 2009-11-19

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MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period