JP2009521909A5 - - Google Patents

Download PDF

Info

Publication number
JP2009521909A5
JP2009521909A5 JP2008547875A JP2008547875A JP2009521909A5 JP 2009521909 A5 JP2009521909 A5 JP 2009521909A5 JP 2008547875 A JP2008547875 A JP 2008547875A JP 2008547875 A JP2008547875 A JP 2008547875A JP 2009521909 A5 JP2009521909 A5 JP 2009521909A5
Authority
JP
Japan
Prior art keywords
seq
antibody
light chain
heavy chain
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547875A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009521909A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2006/012236 external-priority patent/WO2007076927A1/en
Publication of JP2009521909A publication Critical patent/JP2009521909A/ja
Publication of JP2009521909A5 publication Critical patent/JP2009521909A5/ja
Pending legal-status Critical Current

Links

JP2008547875A 2005-12-30 2006-12-19 IL−6とIL−6Rαの複合体のgp130への結合を阻害する抗IL−6抗体 Pending JP2009521909A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75538305P 2005-12-30 2005-12-30
PCT/EP2006/012236 WO2007076927A1 (en) 2005-12-30 2006-12-19 Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130

Publications (2)

Publication Number Publication Date
JP2009521909A JP2009521909A (ja) 2009-06-11
JP2009521909A5 true JP2009521909A5 (https=) 2010-02-18

Family

ID=37950573

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547875A Pending JP2009521909A (ja) 2005-12-30 2006-12-19 IL−6とIL−6Rαの複合体のgp130への結合を阻害する抗IL−6抗体

Country Status (16)

Country Link
US (2) US7820155B2 (https=)
EP (1) EP1966244B1 (https=)
JP (1) JP2009521909A (https=)
KR (1) KR20080090484A (https=)
CN (1) CN101346395A (https=)
AT (1) ATE550353T1 (https=)
AU (1) AU2006332216A1 (https=)
BR (1) BRPI0620797A2 (https=)
CA (1) CA2635615A1 (https=)
DK (1) DK1966244T3 (https=)
EA (1) EA200870130A1 (https=)
ES (1) ES2382164T3 (https=)
PL (1) PL1966244T3 (https=)
PT (1) PT1966244E (https=)
WO (1) WO2007076927A1 (https=)
ZA (1) ZA200806610B (https=)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
US20050202538A1 (en) * 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
HUP0204475A2 (en) 2000-02-11 2003-04-28 Merck Patent Gmbh Enhancing the circulating half-life of antibody-based fusion proteins
AU2002248571B2 (en) 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
PT1383785E (pt) 2001-05-03 2011-06-28 Merck Patent Gmbh Anticorpo recombinante específico de tumores e utilização deste
PT1454138E (pt) 2001-12-04 2012-03-28 Merck Patent Gmbh Imunocitoquinas com seletividade modulada
CA2551915C (en) * 2003-12-30 2015-06-23 Merck Patent Gesellschaft Mit Beschraenkter Haftung Il-7 fusion proteins
JP2008504008A (ja) * 2003-12-31 2008-02-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 改良された薬物動態を有するFc−エリスロポエチン融合タンパク質
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
US20070104689A1 (en) * 2005-09-27 2007-05-10 Merck Patent Gmbh Compositions and methods for treating tumors presenting survivin antigens
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
WO2007076927A1 (en) 2005-12-30 2007-07-12 Merck Patent Gmbh Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130
EP2025346B1 (en) 2006-04-07 2016-08-10 Osaka University Muscle regeneration promoter
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US8153128B2 (en) * 2006-11-30 2012-04-10 Medimmune Limited Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor
WO2008090901A1 (ja) 2007-01-23 2008-07-31 Shinshu University 慢性拒絶反応抑制剤
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
HUE032563T2 (en) 2007-05-21 2017-09-28 Alderbio Holdings Llc Antibodies to IL-6 and their use
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
WO2009109584A1 (en) * 2008-03-07 2009-09-11 Ferring International Center S. A. ANTIBODY BINDING ONLY TO IL6-sIL6R COMPLEX
WO2009140348A2 (en) 2008-05-13 2009-11-19 Novimmune Sa Anti-il-6/il-6r antibodies and methods of use thereof
TWI528973B (zh) 2008-06-05 2016-04-11 Chugai Pharmaceutical Co Ltd Nerve infiltration inhibitor
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
EA019512B1 (ru) * 2008-07-02 2014-04-30 Эмерджент Продакт Дивелопмент Сиэтл, Ллс Il-6-опосредованная иммунотерапия
AU2009296937B2 (en) * 2008-09-29 2015-02-12 Centocor Ortho Biotech Inc. Anti-CD147 antibodies, methods, and uses
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
CA2744400C (en) * 2008-11-25 2019-01-15 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
EP2421896A1 (en) 2009-04-22 2012-02-29 Merck Patent GmbH Antibody fusion proteins with modified fcrn binding sites
EP2998405B1 (en) 2009-05-13 2019-12-11 Genzyme Corporation Anti-human cd52 immunoglobulins
EP2464666B1 (en) * 2009-07-15 2018-03-21 Eva Kovacs-Benke Combination of a human interleukin-6 antagonist and a human interleukin-6 receptor antagonist in therapy of tumour diseases
AU2010278067B2 (en) * 2009-07-31 2016-10-27 Shin Maeda Cancer metastasis inhibitor
ES2622487T3 (es) * 2009-08-19 2017-07-06 Merck Patent Gmbh Anticuerpos para la detección de complejos de integrina en material FFPE
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
WO2011066374A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US20130052195A1 (en) 2009-12-23 2013-02-28 Emergent Product Development Seattle,LLC Compositions Comprising TNF-alpha and IL-6 Antagonists and Methods of Use Thereof
JP6051049B2 (ja) 2010-05-28 2016-12-21 中外製薬株式会社 抗腫瘍t細胞応答増強剤
US9304134B2 (en) 2010-11-23 2016-04-05 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of anemia
US20140255405A1 (en) 2011-05-27 2014-09-11 Dutalys Removal of Monomeric Targets
EP2723380B1 (en) 2011-06-24 2019-08-21 Stephen D. Gillies Light chain immunoglobulin fusion proteins and methods of use thereof
US20140315956A1 (en) * 2011-07-29 2014-10-23 Nationwide Children's Hospital Small molecule inhibitors of il-6 and uses thereof
WO2013059548A1 (en) * 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
BR112015010360A8 (pt) * 2012-11-08 2018-01-16 Eleven Biotherapeutics Inc antagonistas de il-6 e utilização dos mesmos.
US9816989B2 (en) 2013-03-12 2017-11-14 Institute of Arthritis Research, LLC Immunologically active polypeptide
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
ES2915378T3 (es) 2013-09-13 2022-06-22 Hoffmann La Roche Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares
EP4331605A3 (en) 2013-09-13 2024-05-22 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
CN103897061B (zh) * 2014-03-25 2017-06-16 宝船生物医药科技(上海)有限公司 阻断西妥昔单抗和egfr结合的抗体、其试剂盒及杂交瘤细胞
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
PT3215530T (pt) * 2014-11-07 2019-11-21 Sesen Bio Inc Anticorpos de il-6 melhorados
LT3226888T (lt) * 2014-12-01 2021-05-25 Ferring B.V. Selektyvaus il-6-trans-signalinio inhibitoriaus skyrimas
RS65665B1 (sr) * 2014-12-01 2024-07-31 Ferring Bv Selektivne kompozicije inhibitora il-6-trans-signalizacije
TWI763630B (zh) 2015-07-02 2022-05-11 瑞士商赫孚孟拉羅股份公司 雙環內醯胺及其使用方法
EP3419599A4 (en) 2016-02-23 2019-09-11 Sesen Bio, Inc. IL-6 ANTAGONIST FORMULATIONS AND USE THEREOF
EP3526219B1 (en) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclic pyridone lactams and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
KR20200012823A (ko) 2017-02-01 2020-02-05 예일 유니버시티 이뇨제 내성의 치료
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
EP3698808B1 (en) 2017-10-20 2025-01-01 Hyogo College Of Medicine Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
CA3087699A1 (en) 2018-01-05 2019-07-11 Corvidia Therapeutics, Inc. Methods for treating il-6 mediated inflammation without immunosuppression
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Il-6阻害剤を含有する喘息の治療剤
WO2019204537A1 (en) 2018-04-20 2019-10-24 Genentech, Inc. N-[4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol e-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
IL287220B2 (en) 2019-04-17 2026-03-01 Univ Hiroshima A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor
US20200405883A1 (en) 2019-06-20 2020-12-31 Baxalta Incorporated Method of treatment with viral-based gene therapy
CN111057152B (zh) * 2019-12-11 2022-03-11 中国人民解放军第四军医大学 一种抗人IL-6Ra单克隆抗体及其应用
JP2023042974A (ja) * 2021-09-15 2023-03-28 シスメックス株式会社 抗サイトカイン抗体の抗原に対する親和性を向上させる方法、抗サイトカイン抗体の製造方法及び抗サイトカイン抗体
CN119080929B (zh) * 2023-06-05 2025-08-12 东莞市朋志生物科技有限公司 抗白介素6抗体、检测白介素6的试剂和试剂盒

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0800829B2 (en) * 1994-12-29 2012-07-25 Chugai Seiyaku Kabushiki Kaisha Use of a pm-1 antibody or of a mh 166 antibody for enhancing the anti-tumor effect of cisplatin or carboplatin
US7083950B2 (en) * 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
AU2002248571B2 (en) 2001-03-07 2007-01-18 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
PT1383785E (pt) * 2001-05-03 2011-06-28 Merck Patent Gmbh Anticorpo recombinante específico de tumores e utilização deste
BRPI0214168B8 (pt) * 2001-11-14 2021-05-25 Centocor Inc anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos
EP1572103A4 (en) 2002-11-15 2008-02-13 Centocor Inc ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS
WO2004071404A2 (en) 2003-02-04 2004-08-26 Centocor Inc. Use of il-6 antagonists in combination with steroids to enhance apoptosis
PE20061324A1 (es) * 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
WO2007076927A1 (en) 2005-12-30 2007-07-12 Merck Patent Gmbh Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130

Similar Documents

Publication Publication Date Title
JP2009521909A5 (https=)
JP7453206B2 (ja) 改良された血清アルブミン結合剤
ES2661032T3 (es) Proteínas de unión a interleucina-13
ES2965207T3 (es) Anticuerpos frente a CSF-1R
JP2013537418A5 (https=)
JP2014076062A5 (https=)
US10858425B2 (en) Pan-ELR+ CXC chemokine antibodies
JP6105146B2 (ja) Pan−ELR+CXCケモカイン抗体
BR112014009925B1 (pt) Construtores de polipeptídeos e seus usos
JP2018512157A5 (https=)
CN116987189A (zh) 单链可变片段cd3结合蛋白质
JP2014526898A5 (https=)
CN108290943A (zh) 改进的血清白蛋白结合免疫球蛋白可变结构域
CN102655880A (zh) Il-1结合蛋白
JP2013519364A5 (https=)
KR20130130825A (ko) 골관절염 및 통증의 치료 방법
JP2010535012A5 (https=)
JP2007526880A5 (https=)
ME00519B (me) Antitijela visokog afiniteta prema humanom il-6 receptoru
JP2007536932A5 (https=)
JP2009502171A5 (https=)
JP2014508511A5 (https=)
US20150125397A1 (en) Dual specific binding proteins directed against immune cell receptors and autoantigens
JP2012510814A5 (https=)
CN117860786B (zh) 基因修饰间充质干细胞在多种疾病中的制药用途和诊断用途