JP2009520682A5 - - Google Patents

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Publication number
JP2009520682A5
JP2009520682A5 JP2008529406A JP2008529406A JP2009520682A5 JP 2009520682 A5 JP2009520682 A5 JP 2009520682A5 JP 2008529406 A JP2008529406 A JP 2008529406A JP 2008529406 A JP2008529406 A JP 2008529406A JP 2009520682 A5 JP2009520682 A5 JP 2009520682A5
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JP
Japan
Prior art keywords
tyr
compound
azagly
asn
trp
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JP2008529406A
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English (en)
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JP2009520682A (ja
JP4653840B2 (ja
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Priority claimed from PCT/JP2006/326176 external-priority patent/WO2007072997A1/en
Publication of JP2009520682A publication Critical patent/JP2009520682A/ja
Publication of JP2009520682A5 publication Critical patent/JP2009520682A5/ja
Application granted granted Critical
Publication of JP4653840B2 publication Critical patent/JP4653840B2/ja
Active legal-status Critical Current
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Claims (12)

  1. Ac-D-Tyr-Hyp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号723）、
    Ac-D-Tyr-Lys-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号745）、
    Ac-D-Tyr-Glu-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号746）、
    Ac-D-Tyr-Glu-Asn-Thr-Phe(3F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号757）、
    Ac-D-Tyr-Hyp-Asn-Thr-Phe(3F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号765）、
    Ac-D-Tyr-Hyp-Asn-Thr-Phe(4Cl)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号767）、
    Ac-D-Tyr-Tyr(PO3H2)-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号775）、
    Glycoloyl-D-Tyr-Hyp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号776）、
    Ac-D-Tyr-Hyp(Bzl)-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号781）及び
    Ac-D-Tyr-Hyp-Asn-Thr-Phe(4F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号787）
    から選ばれる化合物またはその塩。
  2. Ac-D-Tyr-Hyp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号723）またはそ
    の塩。
  3. Ac-D-Tyr-Lys-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号745）またはその塩。
  4. Ac-D-Tyr-Glu-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号746）またはその塩。
  5. Ac-D-Tyr-Glu-Asn-Thr-Phe(3F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号757）またはその塩。
  6. Ac-D-Tyr-Hyp-Asn-Thr-Phe(3F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号765）またはその塩。
  7. Ac-D-Tyr-Hyp-Asn-Thr-Phe(4Cl)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号767）またはその塩。
  8. Ac-D-Tyr-Tyr(PO3H2)-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号775）またはその塩。
  9. Glycoloyl-D-Tyr-Hyp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号776）またはその塩。
  10. Ac-D-Tyr-Hyp(Bzl)-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号781）またはその塩。
  11. Ac-D-Tyr-Hyp-Asn-Thr-Phe(4F)-AzaGly-Leu-Arg(Me)-Trp-NH2（化合物番号787）またはその塩。
  12. 請求項１記載の化合物またはその塩を含有してなる医薬。
JP2008529406A 2005-12-22 2006-12-21 メタスチン誘導体およびその用途 Active JP4653840B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005370388 2005-12-22
JP2006275843 2006-10-06
PCT/JP2006/326176 WO2007072997A1 (en) 2005-12-22 2006-12-21 Metastin derivatives and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010182482A Division JP5298087B2 (ja) 2005-12-22 2010-08-17 メタスチン誘導体およびその用途

Publications (3)

Publication Number Publication Date
JP2009520682A JP2009520682A (ja) 2009-05-28
JP2009520682A5 true JP2009520682A5 (ja) 2010-10-07
JP4653840B2 JP4653840B2 (ja) 2011-03-16

Family

ID=37846230

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008529406A Active JP4653840B2 (ja) 2005-12-22 2006-12-21 メタスチン誘導体およびその用途
JP2010182482A Active JP5298087B2 (ja) 2005-12-22 2010-08-17 メタスチン誘導体およびその用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010182482A Active JP5298087B2 (ja) 2005-12-22 2010-08-17 メタスチン誘導体およびその用途

Country Status (30)

Country Link
US (1) US7960348B2 (ja)
EP (1) EP1963362B1 (ja)
JP (2) JP4653840B2 (ja)
KR (1) KR101368607B1 (ja)
AR (1) AR058584A1 (ja)
AU (1) AU2006328333B2 (ja)
BR (1) BRPI0619399B8 (ja)
CA (1) CA2634647C (ja)
CR (1) CR10019A (ja)
CY (1) CY1112353T1 (ja)
DK (1) DK1963362T3 (ja)
ES (1) ES2375038T3 (ja)
GE (1) GEP20115356B (ja)
HK (1) HK1120809A1 (ja)
HR (1) HRP20110851T1 (ja)
IL (1) IL190888A (ja)
JO (1) JO2799B1 (ja)
MA (1) MA30060B1 (ja)
ME (1) ME01015B (ja)
MY (1) MY151967A (ja)
NO (1) NO341879B1 (ja)
NZ (1) NZ568322A (ja)
PE (1) PE20071141A1 (ja)
PL (1) PL1963362T3 (ja)
PT (1) PT1963362E (ja)
RS (1) RS52007B (ja)
RU (1) RU2430107C2 (ja)
SI (1) SI1963362T1 (ja)
TW (1) TWI386417B (ja)
WO (1) WO2007072997A1 (ja)

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CN1761680A (zh) 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
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US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
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WO2009131191A1 (ja) 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
PT2314609T (pt) 2008-07-30 2017-03-06 Takeda Pharmaceuticals Co Derivado de metastina e sua utilização
NZ593381A (en) * 2008-12-29 2013-01-25 Takeda Pharmaceutical Prophylactic/therapeutic agent for cancer comprising a metastin derivative
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CN110312512B (zh) 2016-09-30 2023-05-09 梦欧文科学有限责任公司 用于治疗子宫肌瘤和子宫内膜异位症的方法
AU2017336338B2 (en) * 2016-09-30 2022-11-10 Myovant Sciences Gmbh Methods of treating female infertility
CN116813705A (zh) * 2017-07-05 2023-09-29 凯惠科技发展(上海)有限公司 一种肽类化合物、其应用及含其的组合物

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