JP2008506632A5 - - Google Patents

Download PDF

Info

Publication number
JP2008506632A5
JP2008506632A5 JP2006554374A JP2006554374A JP2008506632A5 JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5 JP 2006554374 A JP2006554374 A JP 2006554374A JP 2006554374 A JP2006554374 A JP 2006554374A JP 2008506632 A5 JP2008506632 A5 JP 2008506632A5
Authority
JP
Japan
Prior art keywords
trp
azagly
asn
tyr
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006554374A
Other languages
English (en)
Other versions
JP2008506632A (ja
JP4346650B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2005/012021 external-priority patent/WO2006001499A2/en
Publication of JP2008506632A publication Critical patent/JP2008506632A/ja
Publication of JP2008506632A5 publication Critical patent/JP2008506632A5/ja
Application granted granted Critical
Publication of JP4346650B2 publication Critical patent/JP4346650B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Claims (2)

  1. Ac-D-Tyr-D-Trp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH2 （化合物番号550）またはその塩。
  2. Ac-D-Tyr-D-Trp-Asn-Thr-Phe-AzaGly-Leu-Arg(Me)-Trp-NH 2 （化合物番号550）またはその塩を含有してなる医薬組成物。
JP2006554374A 2004-06-25 2005-06-23 メタスチン誘導体およびその用途 Expired - Fee Related JP4346650B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004187671 2004-06-25
JP2004363311 2004-12-15
PCT/JP2005/012021 WO2006001499A2 (en) 2004-06-25 2005-06-23 Metastin derivatives and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008245073A Division JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途

Publications (3)

Publication Number Publication Date
JP2008506632A JP2008506632A (ja) 2008-03-06
JP2008506632A5 true JP2008506632A5 (ja) 2008-11-13
JP4346650B2 JP4346650B2 (ja) 2009-10-21

Family

ID=34971534

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2006554374A Expired - Fee Related JP4346650B2 (ja) 2004-06-25 2005-06-23 メタスチン誘導体およびその用途
JP2008245073A Active JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008245073A Active JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Country Status (20)

Country Link
US (2) US7625869B2 (ja)
EP (2) EP2113513B1 (ja)
JP (3) JP4346650B2 (ja)
CN (2) CN101863971A (ja)
AR (1) AR049938A1 (ja)
AU (1) AU2005257484A1 (ja)
BR (1) BRPI0512397A (ja)
CA (1) CA2571420A1 (ja)
CL (1) CL2008003730A1 (ja)
CR (1) CR8828A (ja)
IL (1) IL179640A0 (ja)
MA (1) MA28903B1 (ja)
MX (1) MXPA06014206A (ja)
NO (1) NO20065957L (ja)
NZ (1) NZ552029A (ja)
PE (2) PE20091567A1 (ja)
RU (1) RU2006145886A (ja)
SG (1) SG153865A1 (ja)
TW (1) TW200607816A (ja)
WO (1) WO2006001499A2 (ja)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
CN1761680A (zh) 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
EP1737573A2 (en) 2004-04-08 2007-01-03 Biomatrica, Inc. Integration of sample storage and sample management for life science
AU2005257484A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
PL1791542T3 (pl) 2004-08-23 2015-11-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
AU2006290870B2 (en) 2005-09-14 2013-02-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
EP2497484A3 (en) 2006-02-22 2012-11-07 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8183212B2 (en) * 2006-04-26 2012-05-22 Kyoto University Compound having GPR54 agonistic activity
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
TWI404726B (zh) * 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
UA94774C2 (en) * 2006-10-25 2011-06-10 Такеда Фармасьютикал Компани Лимитед Metastin derivatives and use thereof
WO2009131191A1 (ja) 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2009139298A1 (ja) 2008-04-30 2009-11-19 国立大学法人京都大学 メタスチン誘導体およびその用途
DK2570147T3 (da) 2008-06-13 2018-01-29 Mannkind Corp Tørpulverinhalator og system til lægemiddelindgivelse
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
PT2314609T (pt) 2008-07-30 2017-03-06 Takeda Pharmaceuticals Co Derivado de metastina e sua utilização
NZ593381A (en) * 2008-12-29 2013-01-25 Takeda Pharmaceutical Prophylactic/therapeutic agent for cancer comprising a metastin derivative
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010137022A1 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
MX2012006441A (es) 2009-12-22 2012-06-28 Takeda Pharmaceutical Formulacion de liberacion sostenida.
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
MY180552A (en) 2011-04-01 2020-12-02 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013017631A1 (en) 2011-08-04 2013-02-07 Msd Oss B.V. Kisspeptide-pentasaccharide conjugates
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
US9382293B2 (en) 2012-03-14 2016-07-05 Yeda Research And Development Co. Ltd. Modified kisspeptin peptides and uses thereof
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2014119753A1 (ja) * 2013-01-31 2014-08-07 学校法人 東京薬科大学 マイオスタチン阻害ペプチド
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
WO2015112703A1 (en) * 2014-01-22 2015-07-30 The Johns Hopkins University Compositions and methods for treating diabetes
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
JP6661554B2 (ja) 2014-06-10 2020-03-11 バイオマトリカ，インク． 周囲温度における血小板の安定化
SG11201804776SA (en) 2015-12-08 2018-07-30 Biomatrica Inc Reduction of erythrocyte sedimentation rate
AU2017336338B2 (en) 2016-09-30 2022-11-10 Myovant Sciences Gmbh Methods of treating female infertility
CN116813705A (zh) 2017-07-05 2023-09-29 凯惠科技发展(上海)有限公司 一种肽类化合物、其应用及含其的组合物
CN108752233B (zh) * 2018-07-18 2020-10-16 河北师范大学 小分子凝胶因子、凝胶材料及制备方法和应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
EP0876349B1 (en) 1995-10-19 2002-09-11 Takeda Chemical Industries, Ltd. Quinoline derivatives as gnrh antagonists
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
WO1998039448A2 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
MXPA01013367A (es) 1999-06-28 2002-07-02 Basf Ag Metodo para la prevencion del crecimiento tumoral.
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
JP2001231581A (ja) * 1999-12-17 2001-08-28 Takeda Chem Ind Ltd ＫｉＳＳ−１ペプチドの製造法
KR20020065510A (ko) 1999-12-17 2002-08-13 다케다 야쿠힌 고교 가부시키가이샤 ＫｉＳＳ-1 펩티드의 제조 방법
PL366626A1 (en) 2000-03-29 2005-02-07 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
WO2001075104A1 (fr) 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Nouvelle proteine, adn codant pour celle-ci, et son procede de production
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ
WO2002085399A1 (en) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Peptide-containing preparations
US20040185525A1 (en) * 2001-05-17 2004-09-23 Osamu Nishimura Process for producing peptide
WO2003027149A1 (fr) 2001-09-19 2003-04-03 Takeda Chemical Industries, Ltd. Anticorps et utilisation de ce dernier
EP1466976A4 (en) * 2002-01-11 2005-11-09 Takeda Pharmaceutical PROCESS FOR PREPARING KISS-1 PEPTIDES
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
JPWO2004035089A1 (ja) * 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
MXPA05004380A (es) 2002-10-25 2005-11-23 Paradigm Therapeutics Ltd Mamiferos gpr54 knock out y metodos de investigacion que los utilizan.
CN1761680A (zh) * 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
JP4804714B2 (ja) 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Ｌｋ8 단백질을 유효성분으로 포함하는 항암제
CA2518541C (en) * 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
EP1464652A1 (en) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
WO2004096855A2 (en) 2003-04-28 2004-11-11 Wyeth Methods utilising g-protein coupled receptor 54
WO2004101747A2 (en) 2003-05-07 2004-11-25 The General Hospital Corporation Identification and use of gpr54 and its ligands for reproductive disorders and contraception
EP1975153A3 (en) 2003-05-30 2010-03-31 Prozymex A/S Protease inhibitors
NZ547274A (en) 2003-11-03 2009-02-28 Sunbio Biotech Pharmaceuticals A recombinant protein with cancer suppression action, its encoding gene and use
RU2333221C2 (ru) 2003-11-03 2008-09-10 Бейцзин Санбио Байотек Ко., Лтд. Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение
WO2005095973A2 (en) 2004-03-25 2005-10-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54)
EP1750513A4 (en) 2004-04-23 2009-07-22 Serono Lab USE OF GPCR54 LIGANDS FOR THE TREATMENT OF INFERTILITY
AU2005257484A1 (en) * 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
WO2007084211A2 (en) 2005-11-11 2007-07-26 The General Hospital Corporation Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception
TWI386417B (zh) * 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
RU2008141280A (ru) 2006-03-20 2010-04-27 Мерк энд Ко., Инк. (US) Агонисты рецептора нейромедина u и их применение
AU2007231553B2 (en) * 2006-03-28 2012-10-25 Molecular Discovery Systems Agent for the treatment of hormone-dependent disorders and uses thereof
TWI404726B (zh) 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
CA2701612A1 (en) * 2007-10-05 2009-04-09 Takeda Pharmaceutical Company Limited Neuromedin u derivative
WO2009131191A1 (ja) 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2010033224A1 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of kiss1 peptides

Similar Documents

Publication Publication Date Title
JP2008506632A5 (ja)
JP2009520682A5 (ja)
NL301202I2 (nl) Linzagolix, of een farmaceutisch aanvaardbaar zout daarvan, zoals linzagolix choline
JP2010501534A5 (ja)
JP2006526031A5 (ja)
JP2007522220A5 (ja)
JP2005518413A5 (ja)
NL300703I2 (nl) Simeprevir, of een farmaceutisch aanvaardbaar zout daarvan, waaronder simeprevirnatrium.
EP1975149A4 (en) COMPOUND OF 1,3-BIS (SUBSTITUTED PHENYL) -3-HYDROXYPROPAN-1-ONE OR 2-PROPEN-1-ONE AND ITS SALT
JP2008514563A5 (ja)
JP2010500116A5 (ja)
HRP20120323T1 (en) Diarylhydantoin compounds
JP2006524283A5 (ja)
JP2007119504A5 (ja)
NO20052884D0 (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
NO20053762D0 (no) Kondensert furanforbindelse.
ATE531717T1 (de) Neue kristalline form eines pyridazinoä4,5- büindolderivats
JP2007520206A5 (ja)
JP2004149545A5 (ja)
NL1030010A1 (nl) 4-Amino-gesubstitueerde-2-gesubstitueerde-1,2,3,4- tetrahydrochinolineverbindingen.
JP2003160581A5 (ja)
JP2007523200A5 (ja)
BRPI0614413A2 (pt) composto, e, composição farmacêutica
BRPI0614412A2 (pt) composto, e, composição farmacêutica
JP2009215399A5 (ja)