JP2009519339A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009519339A5 JP2009519339A5 JP2008545718A JP2008545718A JP2009519339A5 JP 2009519339 A5 JP2009519339 A5 JP 2009519339A5 JP 2008545718 A JP2008545718 A JP 2008545718A JP 2008545718 A JP2008545718 A JP 2008545718A JP 2009519339 A5 JP2009519339 A5 JP 2009519339A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- mirna
- pharmaceutical composition
- gene
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700011259 MicroRNAs Proteins 0.000 description 14
- 239000002679 microRNA Substances 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 210000000663 muscle cell Anatomy 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 102000004446 Serum Response Factor Human genes 0.000 description 4
- 108010042291 Serum Response Factor Proteins 0.000 description 4
- 230000004663 cell proliferation Effects 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108010033040 Histones Proteins 0.000 description 2
- 108091092539 MiR-208 Proteins 0.000 description 2
- 108091060568 Mir-133 microRNA precursor family Proteins 0.000 description 2
- 108091027766 Mir-143 Proteins 0.000 description 2
- 108091062170 Mir-22 Proteins 0.000 description 2
- 208000029549 Muscle injury Diseases 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 108091028606 miR-1 stem-loop Proteins 0.000 description 2
- 108091070946 miR-128 stem-loop Proteins 0.000 description 2
- 108091023685 miR-133 stem-loop Proteins 0.000 description 2
- 108091063796 miR-206 stem-loop Proteins 0.000 description 2
- 108091046553 miR-26 stem-loop Proteins 0.000 description 2
- 108091023821 miR-26-1 stem-loop Proteins 0.000 description 2
- 108091045094 miR-26-2 stem-loop Proteins 0.000 description 2
- 108091007431 miR-29 Proteins 0.000 description 2
- -1 miR-30 Proteins 0.000 description 2
- 210000000107 myocyte Anatomy 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108091028684 Mir-145 Proteins 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74954405P | 2005-12-12 | 2005-12-12 | |
| PCT/US2006/047255 WO2007070483A2 (en) | 2005-12-12 | 2006-12-12 | Micrornas that regulate muscle cell proliferation and differentiation |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013027633A Division JP5796027B2 (ja) | 2005-12-12 | 2013-02-15 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
| JP2013253829A Division JP5740460B2 (ja) | 2005-12-12 | 2013-12-09 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009519339A JP2009519339A (ja) | 2009-05-14 |
| JP2009519339A5 true JP2009519339A5 (https=) | 2010-01-14 |
Family
ID=38163464
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545718A Pending JP2009519339A (ja) | 2005-12-12 | 2006-12-12 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
| JP2013027633A Expired - Fee Related JP5796027B2 (ja) | 2005-12-12 | 2013-02-15 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
| JP2013253829A Expired - Fee Related JP5740460B2 (ja) | 2005-12-12 | 2013-12-09 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013027633A Expired - Fee Related JP5796027B2 (ja) | 2005-12-12 | 2013-02-15 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
| JP2013253829A Expired - Fee Related JP5740460B2 (ja) | 2005-12-12 | 2013-12-09 | 筋細胞増殖及び分化を調節するマイクロｒｎａ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8431542B2 (https=) |
| EP (3) | EP2671949A1 (https=) |
| JP (3) | JP2009519339A (https=) |
| KR (2) | KR20140130562A (https=) |
| CN (2) | CN104027818A (https=) |
| AU (1) | AU2006326517B2 (https=) |
| BR (1) | BRPI0619755A2 (https=) |
| CA (2) | CA2634046A1 (https=) |
| DK (1) | DK1969125T3 (https=) |
| ES (1) | ES2387250T3 (https=) |
| NZ (3) | NZ593688A (https=) |
| PL (1) | PL1969125T3 (https=) |
| PT (1) | PT1969125E (https=) |
| WO (1) | WO2007070483A2 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006107826A2 (en) * | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| PL1969125T3 (pl) | 2005-12-12 | 2012-11-30 | Univ North Carolina Chapel Hill | Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych |
| KR101485495B1 (ko) | 2006-08-01 | 2015-01-22 | 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 베타-마이오신 중사슬의 발현을 활성화하는 마이크로-ｒｎａ의 동정 |
| GB2440782A (en) * | 2006-08-04 | 2008-02-13 | Cesare Peschle | Uses and compositions comprising miRNAs |
| EP3342415B1 (en) | 2006-08-08 | 2022-01-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
| CN102149826A (zh) | 2007-06-29 | 2011-08-10 | 波士顿生物医药公司 | 通过微小rna装置进行细菌介导的基因调节 |
| AU2008283795B2 (en) * | 2007-07-31 | 2013-11-21 | Board Of Regents, The University Of Texas System | A micro-RNA family that modulates fibrosis and uses thereof |
| WO2009018492A2 (en) | 2007-07-31 | 2009-02-05 | The Board Of Regents Of The University Of Texas System | Micro-rnas that control myosin expression and myofiber identity |
| WO2009105759A2 (en) * | 2008-02-21 | 2009-08-27 | The Board Of Regents Of The University Of Texas System | Micro-rnas that modulate smooth muscle proliferation and differentiation and uses thereof |
| CA2718520C (en) * | 2008-03-17 | 2020-01-07 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| AU2009257663B2 (en) | 2008-06-09 | 2014-06-26 | New York Medical College | Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium |
| GB0811715D0 (en) * | 2008-06-26 | 2008-07-30 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| CN102356162A (zh) | 2009-02-04 | 2012-02-15 | 得克萨斯系统大学董事会 | Mir-208和mir-499在治疗心脏病症中的双重靶向 |
| JP5883381B2 (ja) | 2009-05-05 | 2016-03-15 | ミラゲン セラピューティクス，インコーポレイテッド | 親油性ポリヌクレオチド接合体 |
| US20120059159A1 (en) * | 2009-05-25 | 2012-03-08 | Carola Ponzetto | Differentiation therapy for sarcomas |
| EP2540829B1 (en) * | 2010-02-26 | 2015-11-25 | Lsip, Llc | Marker for detection of myogenic diseases, and method for detection of the diseases using same |
| US8975021B2 (en) * | 2010-04-08 | 2015-03-10 | Kyoto Prefectural Public University Corporation | Method for detecting rhabdomyosarcoma using sample derived from body fluid |
| CA2804791C (en) | 2010-07-08 | 2019-07-30 | Duke University | Direct reprogramming of cells to cardiac myocyte fate |
| KR101235256B1 (ko) * | 2010-09-13 | 2013-02-21 | 서울대학교산학협력단 | ｍｉＲＮＡ를 타겟으로 한 신경퇴행성 질환 치료 |
| WO2012061810A1 (en) * | 2010-11-05 | 2012-05-10 | Miragen Therapeutics | Base modified oligonucleotides |
| EP2638158A4 (en) * | 2010-11-11 | 2015-07-15 | Univ Miami | COMPOSITIONS, CELLS, KITS AND METHODS FOR AUTOLOGOUS STEM CELL THERAPY |
| EA201370139A1 (ru) | 2010-12-15 | 2013-10-30 | Мираген Терапеутикс | Ингибиторы микро-рнк, содержащие закрытые нуклеотиды |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| EP2707485B1 (en) * | 2011-05-09 | 2016-12-14 | The University Court of The University Of Glasgow | Methods of modulating micrornas in the treatment of pulmonary arterial hypertension |
| US20140221464A1 (en) * | 2011-07-01 | 2014-08-07 | Board Of Regents, The University Of Texas System | Compositions and Methods for Treating Skeletal Myopathy |
| US20140259192A1 (en) * | 2011-07-12 | 2014-09-11 | Sanofi | Transgenic animal comprising a deletion or functional deletion of the 3'utr of an endogenous gene |
| EP2755663A4 (en) | 2011-09-13 | 2015-10-07 | Ottawa Hospital Res Inst | MicroRNA Inhibitors |
| WO2013052965A2 (en) | 2011-10-06 | 2013-04-11 | Miragen Therapeutics | Control of whole body energy homeostasis by microrna regulation |
| US9388408B2 (en) | 2012-06-21 | 2016-07-12 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| CN105188715B (zh) | 2013-03-15 | 2018-12-25 | 米拉根医疗股份有限公司 | Mir-145的锁定核酸抑制剂及其用途 |
| CA2902571A1 (en) | 2013-03-15 | 2014-09-18 | MiRagen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| WO2014201254A1 (en) * | 2013-06-12 | 2014-12-18 | University Of Washington Through Its Center For Commercialization | Methods for maturing cardiomyocytes and uses thereof |
| CN103710387B (zh) * | 2013-12-25 | 2015-10-14 | 天津农学院 | 一种促进牛骨骼肌卫星细胞体外增殖的方法 |
| JP6566536B2 (ja) * | 2014-06-16 | 2019-08-28 | 国立大学法人山口大学 | フォワードプライマー |
| CN104498497A (zh) * | 2014-12-10 | 2015-04-08 | 山东农业大学 | 一种与奶山羊乳腺上皮细胞凋亡相关的miRNA及其在奶山羊育种中的应用 |
| EP3246398B1 (en) * | 2015-01-14 | 2021-06-16 | Kyoto University | Method for selecting skeletal muscle progenitor cell |
| US9885042B2 (en) | 2015-01-20 | 2018-02-06 | MiRagen Therapeutics, Inc. | miR-92 inhibitors and uses thereof |
| CN104877960B (zh) * | 2015-06-01 | 2017-09-19 | 东北农业大学 | miR‑2400显著促进牛骨骼肌卫星细胞增殖的生物功能 |
| DK3426781T3 (da) * | 2016-03-07 | 2024-09-30 | Us Health | Mikro-rna'er og fremgangsmåder til anvendelse deraf |
| CN105713972A (zh) * | 2016-03-16 | 2016-06-29 | 上海中医药大学 | miRNA在制备药物性心脏病生物标志物中的用途 |
| CN106399473B (zh) * | 2016-08-23 | 2019-12-06 | 南京大学 | 检测和评价力量训练效果的miRNA标志物或其组合及其应用 |
| US10934543B2 (en) | 2016-10-13 | 2021-03-02 | National Center Of Neurology And Psychiatry | Inducer of muscle differentiation |
| WO2018080658A1 (en) | 2016-10-27 | 2018-05-03 | Aalborg University | Therapeutic targeting of a microrna to treat duchenne muscular dystrophy |
| CN108324946B (zh) * | 2017-01-20 | 2022-02-18 | 上海市东方医院 | miRNA708、和/或301簇的微小RNA在改善心脏功能方面的应用 |
| CN107096030A (zh) * | 2017-03-20 | 2017-08-29 | 天津农学院 | 一种利用miR‑143抑制剂延缓小鼠失神经后肌肉萎缩的方法 |
| US11365412B2 (en) | 2017-04-05 | 2022-06-21 | University Of Cincinnati | Promotion of cardiomyocyte proliferation and regenerative treatment of the heart by inhibition of microRNA-128 |
| KR102177130B1 (ko) | 2017-08-18 | 2020-11-10 | (주)큐라미스 | 근육 질환 및 신경근육 질환 예방, 치료 또는 진단을 위한 miR-18b의 용도 |
| WO2019035690A1 (ko) * | 2017-08-18 | 2019-02-21 | 서울대학교병원 | 근육 질환 및 신경근육 질환 예방, 치료 또는 진단을 위한 miR-18b의 용도 |
| KR20200096610A (ko) * | 2017-12-08 | 2020-08-12 | 유니버시티 오브 워싱톤 | 카르디올리핀 리모델링 및 심근세포 성숙을 검출 및 촉진하기 위한 방법 및 조성물 및 미토콘드리아 기능장애를 치료하는 관련 방법 |
| BR112020018705A2 (pt) * | 2018-03-14 | 2021-01-05 | Beth Israel Deaconess Medical Center | Inibidores de microrna 22 |
| CN108690846A (zh) * | 2018-04-17 | 2018-10-23 | 上海大学 | 抑制MiR-29b基因表达的应用 |
| CN108823209B (zh) * | 2018-07-18 | 2021-04-09 | 华中农业大学 | 骨骼肌特异性启动子及应用 |
| CA3111076A1 (en) | 2018-08-30 | 2020-03-05 | Tenaya Therapeutics, Inc. | Cardiac cell reprogramming with myocardin and ascl1 |
| CN111041052B (zh) * | 2019-12-30 | 2021-05-28 | 嘉兴学院 | mir-206在抑制猪脂肪细胞内的甘油三酯生成以及瘦肉猪育种中的应用 |
| US20230103731A1 (en) * | 2020-03-02 | 2023-04-06 | Tenaya Therapeutics, Inc. | Gene vector control by cardiomyocyte-expressed micrornas |
| CA3174286A1 (en) | 2020-04-02 | 2021-10-07 | Robert PLACE | Targeted inhibition using engineered oligonucleotides |
| CN112266912A (zh) * | 2020-10-22 | 2021-01-26 | 上海大学 | 靶向miR-29b的gRNA、AAV8-CRISPR/Cas9系统及其应用 |
| WO2023034966A1 (en) * | 2021-09-03 | 2023-03-09 | The University Of North Carolina At Chapel Hill | Compositions and methods of using the same for treating disorders associated with thymosin βeta 4 |
| CN114480672B (zh) * | 2022-02-22 | 2023-08-15 | 青岛农业大学 | 一种通过miR-145筛选高产肉率碱地黑牛的方法 |
| CN114748497B (zh) * | 2022-04-27 | 2024-10-18 | 广州市妇女儿童医疗中心 | 一种调控子宫肌收缩的miRNA分子miR-206及其应用 |
| CN115181722B (zh) * | 2022-08-30 | 2024-06-11 | 江苏农牧科技职业学院 | 一种鹅骨骼肌卫星细胞的体外分离和培养方法 |
| CN117511884B (zh) * | 2023-12-06 | 2024-06-11 | 中国农业科学院兰州畜牧与兽药研究所 | Rtl1在抑制牦牛成肌细胞分化中的应用 |
| KR20250173053A (ko) * | 2024-05-31 | 2025-12-10 | 충남대학교산학협력단 | 전구체 miRNA를 포함하는 근육 감소 또는 근육 위축 예방, 개선 또는 치료용 조성물 |
| KR20250173054A (ko) * | 2024-05-31 | 2025-12-10 | 충남대학교산학협력단 | 전구체 miRNA를 포함하는 근육 감소 또는 근육 위축 진단용 바이오마커 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803782B2 (en) * | 2003-05-28 | 2010-09-28 | Roche Madison Inc. | Intravenous delivery of polynucleotides to cells in mammalian limb |
| US20050124566A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
| EP2390331B1 (en) * | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US7781415B2 (en) * | 2003-02-07 | 2010-08-24 | Roche Madison Inc. | Process for delivering sirna to cardiac muscle tissue |
| JP2006519008A (ja) * | 2003-02-10 | 2006-08-24 | 独立行政法人産業技術総合研究所 | 哺乳動物細胞の調節 |
| SE0300500L (sv) * | 2003-02-26 | 2003-11-18 | Scania Cv Publ | Kraftöverföring med från en huvudväxel skild rangeväxel |
| CA2857881A1 (en) * | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2006107826A2 (en) * | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| US7338670B2 (en) | 2005-04-14 | 2008-03-04 | Duke University | Use of an agent that restores tissue perfusion and oxygenation |
| PL1969125T3 (pl) | 2005-12-12 | 2012-11-30 | Univ North Carolina Chapel Hill | Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych |
-
2006
- 2006-12-12 PL PL06845222T patent/PL1969125T3/pl unknown
- 2006-12-12 ES ES06845222T patent/ES2387250T3/es active Active
- 2006-12-12 NZ NZ593688A patent/NZ593688A/xx not_active IP Right Cessation
- 2006-12-12 AU AU2006326517A patent/AU2006326517B2/en not_active Ceased
- 2006-12-12 JP JP2008545718A patent/JP2009519339A/ja active Pending
- 2006-12-12 DK DK06845222.6T patent/DK1969125T3/da active
- 2006-12-12 EP EP13177425.9A patent/EP2671949A1/en not_active Withdrawn
- 2006-12-12 KR KR1020147028814A patent/KR20140130562A/ko not_active Ceased
- 2006-12-12 CA CA002634046A patent/CA2634046A1/en not_active Abandoned
- 2006-12-12 BR BRPI0619755-8A patent/BRPI0619755A2/pt not_active IP Right Cessation
- 2006-12-12 KR KR1020087017004A patent/KR101485071B1/ko not_active Expired - Fee Related
- 2006-12-12 CA CA2903764A patent/CA2903764A1/en not_active Abandoned
- 2006-12-12 EP EP06845222A patent/EP1969125B1/en active Active
- 2006-12-12 CN CN201410112733.4A patent/CN104027818A/zh active Pending
- 2006-12-12 EP EP12166173A patent/EP2497827A1/en not_active Withdrawn
- 2006-12-12 US US12/086,109 patent/US8431542B2/en not_active Expired - Fee Related
- 2006-12-12 PT PT06845222T patent/PT1969125E/pt unknown
- 2006-12-12 NZ NZ602571A patent/NZ602571A/en not_active IP Right Cessation
- 2006-12-12 CN CN200680052681.XA patent/CN101448942B/zh not_active Expired - Fee Related
- 2006-12-12 WO PCT/US2006/047255 patent/WO2007070483A2/en not_active Ceased
- 2006-12-12 NZ NZ569738A patent/NZ569738A/en not_active IP Right Cessation
-
2013
- 2013-02-15 JP JP2013027633A patent/JP5796027B2/ja not_active Expired - Fee Related
- 2013-03-08 US US13/791,309 patent/US9072764B2/en not_active Expired - Fee Related
- 2013-03-08 US US13/791,736 patent/US20130225658A1/en not_active Abandoned
- 2013-12-09 JP JP2013253829A patent/JP5740460B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009519339A5 (https=) | ||
| Liu et al. | The pivotal role of chemical modifications in mRNA therapeutics | |
| US8691965B2 (en) | Oligonucleotides for modulating target RNA activity | |
| JP7093728B2 (ja) | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 | |
| JP6700227B2 (ja) | タンパク質又はペプチドの発現を改善するための人工核酸分子 | |
| CN112022870B (zh) | 用于治疗缺血性损伤的化合物 | |
| JP2021531022A5 (https=) | ||
| JP7068821B2 (ja) | 化学修飾を有するガイドｒｎａ | |
| Tang et al. | Identification of novel non‐coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus | |
| JP2012519484A5 (https=) | ||
| JP2014527401A5 (https=) | ||
| CA3081346A1 (en) | Novel crispr-associated transposon systems and components | |
| Mizuno et al. | Regulation of gene expression by a small RNA transcript (micRNA) in Escherichia coli K-12 | |
| JP2002272489A5 (https=) | ||
| JP2013510561A5 (https=) | ||
| JP2019527563A5 (https=) | ||
| EP2838912A1 (en) | Peptides for the binding of nucleotide targets | |
| Philippen et al. | Antisense MicroRNA therapeutics in cardiovascular disease: quo vadis? | |
| JP2013507934A5 (https=) | ||
| CN110431230A (zh) | 慢病毒和非整合型慢病毒作为病毒载体实施crispr治疗 | |
| Naraba et al. | Assessment of the microRNA system in salt-sensitive hypertension | |
| WO2013013165A2 (en) | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus | |
| CN101402945A (zh) | 表达抗传染性法氏囊病病毒微小rna重组禽腺联病毒的制备方法 | |
| CN106103714B (zh) | 体内感染微生物、寄生微生物、共生微生物的非编码性rna及其鉴定和应用 | |
| KR102679172B1 (ko) | 질환 세포-특이적인 miRNA에 의해 세포 생리 활성 조절 물질의 활성을 조절하는 복합체 및 이를 CRISPR/Cas 시스템에 적용한 질환 특이적 유전자 조작용 복합체 |