JP2009510170A5 - - Google Patents

Download PDF

Info

Publication number
JP2009510170A5
JP2009510170A5 JP2008534664A JP2008534664A JP2009510170A5 JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5 JP 2008534664 A JP2008534664 A JP 2008534664A JP 2008534664 A JP2008534664 A JP 2008534664A JP 2009510170 A5 JP2009510170 A5 JP 2009510170A5
Authority
JP
Japan
Prior art keywords
phenyl
pyrimidine
carboxylic acid
benzylamide
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008534664A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009510170A (ja
JP5452925B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/038841 external-priority patent/WO2007041634A1/en
Publication of JP2009510170A publication Critical patent/JP2009510170A/ja
Publication of JP2009510170A5 publication Critical patent/JP2009510170A5/ja
Application granted granted Critical
Publication of JP5452925B2 publication Critical patent/JP5452925B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008534664A 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物 Active JP5452925B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04
US60/723,570 2005-10-04
PCT/US2006/038841 WO2007041634A1 (en) 2005-10-04 2006-10-04 Pyrimidine amide compounds as pgds inhibitors

Publications (3)

Publication Number Publication Date
JP2009510170A JP2009510170A (ja) 2009-03-12
JP2009510170A5 true JP2009510170A5 (https=) 2009-11-19
JP5452925B2 JP5452925B2 (ja) 2014-03-26

Family

ID=37635758

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008534664A Active JP5452925B2 (ja) 2005-10-04 2006-10-04 Ｐｇｄｓ阻害剤としてのピリミジンアミド化合物

Country Status (27)

Country Link
US (1) US8202863B2 (https=)
EP (1) EP1937652B1 (https=)
JP (1) JP5452925B2 (https=)
KR (1) KR101457966B1 (https=)
CN (2) CN101538246B (https=)
AR (1) AR056871A1 (https=)
AU (1) AU2006299428B2 (https=)
BR (1) BRPI0616815A2 (https=)
CA (1) CA2624749C (https=)
CR (1) CR9832A (https=)
DO (1) DOP2006000210A (https=)
EC (1) ECSP088335A (https=)
ES (1) ES2514471T3 (https=)
IL (1) IL190411A (https=)
MA (1) MA29925B1 (https=)
MY (1) MY151172A (https=)
NO (1) NO20082000L (https=)
NZ (1) NZ567208A (https=)
PE (2) PE20070589A1 (https=)
RU (1) RU2420519C2 (https=)
SG (1) SG166121A1 (https=)
TN (1) TNSN08104A1 (https=)
TW (1) TWI415839B (https=)
UA (1) UA93213C2 (https=)
UY (1) UY29840A1 (https=)
WO (1) WO2007041634A1 (https=)
ZA (1) ZA200802222B (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759350B2 (en) * 2005-09-15 2010-07-20 Orchid Research Laboratories Ltd. Pyrimidine carboxamides
DOP2006000210A (es) 2005-10-04 2007-06-15 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
EP2004596A2 (en) 2006-04-11 2008-12-24 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of voltage-gated sodium channels
CA2672373C (en) 2006-12-19 2011-08-30 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
EP2132196A1 (en) 2007-02-26 2009-12-16 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
KR101669432B1 (ko) 2007-08-27 2016-10-26 다트 뉴로사이언스 (케이만) 엘티디. 치료적 이속사졸 화합물
AU2008310660A1 (en) * 2007-10-11 2009-04-16 Vertex Pharmaceuticals Incorporated Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
KR20100075631A (ko) 2007-10-11 2010-07-02 버텍스 파마슈티칼스 인코포레이티드 전압­개폐 나트륨 채널의 억제제로서 유용한 아릴 아미드
WO2009049181A1 (en) 2007-10-11 2009-04-16 Vertex Pharmaceuticals Incorporated Amides useful as inhibitors of voltage-gated sodium channels
WO2009064449A1 (en) * 2007-11-13 2009-05-22 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP2261210B1 (en) * 2008-02-06 2014-10-22 Msd K.K. 3-substituted sulfonyl piperazine derivative
WO2009140364A2 (en) * 2008-05-13 2009-11-19 Cayman Chemical Company Methods for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin d synthase
CA2725481A1 (en) 2008-06-18 2009-12-23 Pfizer Limited Nicotinamide derivatives
TW201010997A (en) 2008-06-18 2010-03-16 Pfizer Ltd Nicotinamide derivatives
US8536185B2 (en) 2008-09-22 2013-09-17 Cayman Chemical Company, Incorporated Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
WO2010056044A2 (ko) * 2008-11-11 2010-05-20 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물
KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
KR101252335B1 (ko) 2009-07-16 2013-04-08 (주)아모레퍼시픽 피부 노화 방지용 조성물
ES2564454T3 (es) 2009-03-09 2016-03-22 Taiho Pharmaceutical Co., Ltd. Compuesto de piperazina que puede inhibir la prostaglandina D sintasa
NZ599099A (en) * 2009-10-08 2013-05-31 Sanofi Sa Phenyloxadiazole derivatives as pgds inhibitors
WO2011090062A1 (ja) 2010-01-22 2011-07-28 大鵬薬品工業株式会社 Pgds阻害作用を有するピペラジン化合物
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
AU2011261164A1 (en) * 2010-06-01 2012-12-13 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
WO2012033069A1 (ja) 2010-09-07 2012-03-15 大鵬薬品工業株式会社 プロスタグランジンd合成酵素を阻害するピペリジン化合物
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
CN104159587A (zh) * 2012-01-06 2014-11-19 南佛罗里达大学 组合物、使用方法、以及治疗方法
CN104926808B (zh) * 2012-08-24 2018-09-14 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN108430992A (zh) 2015-12-17 2018-08-21 阿斯特克斯医疗公司 作为h-pgds抑制剂的喹啉-3-甲酰胺
WO2017160832A1 (en) * 2016-03-14 2017-09-21 Emory University Amide-sulfamide derivatives, compositions, and uses related to cxcr4 inhibition
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
TW201908311A (zh) 2017-06-13 2019-03-01 英商葛蘭素史克智慧財產發展有限公司 化合物
WO2019084529A1 (en) * 2017-10-29 2019-05-02 China Medical University ADAM9 INHIBITORS AND USES THEREOF
JP2021506811A (ja) 2017-12-13 2021-02-22 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｈ−ｐｇｄｓの阻害剤として作用する縮合ピリジン
MX2020009887A (es) * 2018-03-23 2020-10-12 Step Pharma S A S Derivados de aminopiridina como inhibidores de ctps1.
CN112969698A (zh) 2018-11-08 2021-06-15 葛兰素史密斯克莱知识产权发展有限公司 化学化合物
BR112022023025A2 (pt) * 2020-05-13 2023-03-28 Chdi Foundation Inc Moduladores de htt para tratar doença de huntington
CN115667259B (zh) 2020-06-19 2025-06-17 佐藤制药株式会社 抑制h-pgds的稠环化合物
US12331046B2 (en) * 2020-10-23 2025-06-17 Nimbus Clotho, Inc. CTPS1 inhibitors and uses thereof
CN113004208A (zh) * 2021-03-08 2021-06-22 沈阳药科大学 一种抑制黄嘌呤氧化酶活性的化合物及制备方法和应用
US12281116B2 (en) 2021-11-17 2025-04-22 Chdi Foundation, Inc. HTT modulators for treating Huntington's disease
WO2023113023A1 (ja) 2021-12-17 2023-06-22 佐藤製薬株式会社 Ｈ－ｐｇｄｓを阻害するアザインドール誘導体
CA3245288A1 (en) * 2022-02-28 2025-06-13 Shionogi & Co., Ltd. INDAZOLE COMPOUND AND ITS PHARMACEUTICAL USE

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2934543A1 (de) * 1979-08-27 1981-04-02 Basf Ag, 6700 Ludwigshafen Substituierte n-benzoylanthranilsaeurederivate und deren anydroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als herbizide
JPH03112985A (ja) * 1989-09-28 1991-05-14 Morishita Pharmaceut Co Ltd Ｎ―（１ｈ―テトラゾール―５―イル）―２―フェニル―５―ピリミジンカルボキシアミド類及びその合成用中間体
GB9405347D0 (en) * 1994-03-18 1994-05-04 Agrevo Uk Ltd Fungicides
JP2000226372A (ja) * 1999-02-01 2000-08-15 Nippon Soda Co Ltd アミド化合物、その製造方法及び農園芸用殺虫剤
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
EP1218336A2 (en) * 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
MY138097A (en) * 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
JP2003112985A (ja) 2001-10-01 2003-04-18 Nre Happiness Kk 食品残渣肥、飼料原料化システムおよびそれに使用する破砕貯留処理ユニット並びに乾燥冷却処理ユニット
JPWO2004011430A1 (ja) * 2002-07-25 2005-11-24 アステラス製薬株式会社 ナトリウムチャネル阻害剤
JP4595542B2 (ja) * 2002-07-30 2010-12-08 萬有製薬株式会社 ベンズイミダゾール誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤
EP1606289B1 (en) * 2003-02-14 2009-12-02 Glaxo Group Limited Carboxamide derivatives
PT1471057E (pt) * 2003-04-25 2006-05-31 Actimis Pharmaceuticals Inc Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2
MXPA06003949A (es) * 2003-10-07 2006-06-27 Renovis Inc Compuestos amida como ligandos del canal de ion y su uso.
CA2553968A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments of inflammatory and neuropathic pain
DOP2006000210A (es) 2005-10-04 2007-06-15 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds

Similar Documents

Publication Publication Date Title
JP2009510170A5 (https=)
CA2624749A1 (en) Pyrimidine amide compounds as pgds inhibitors
KR101247840B1 (ko) 아밀로이드 베타 조절제
KR101135310B1 (ko) Ｌ-ｃｐｔ1 억제제로서의 헤테로아릴 치환된 피페리딘유도체
JP2006500348A5 (https=)
JP2006511608A5 (https=)
CA2550596A1 (en) 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
JP5378532B2 (ja) 複素環γ−セクレターゼモジュレーター
JP2008503497A5 (https=)
JP2009537545A5 (https=)
CN1520296A (zh) 作为葡糖激酶(glk)调制剂的氨基烟酸盐衍生物
HRP20120589T1 (hr) Aktivatori glukokinaze pirolidinona
JP2010514677A5 (https=)
CA2588517A1 (en) 5-carboxamido substituted thiazole derivatives that interact with ion channels, in particular with ion channels from the kv family
JP2013517273A5 (https=)
WO2004103980A1 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i
RU2011115111A (ru) Замещенные пирролидин-2-карбоксамиды
JP2006528942A5 (https=)
JP2015509510A5 (https=)
ME02198B (me) Derivati ciklopentilakrilamida
RU2019122999A (ru) Новое соединение и его фармакологически приемлемая соль
JP2006500369A5 (https=)
KR20070083939A (ko) 아릴옥시 치환된 벤즈이미다졸 유도체
TW201300380A (zh) 抑制β－分泌酶活性之噁二唑化合物及其使用方法
RU2007129779A (ru) Новые соединения пиридина