JP2009508949A5 - - Google Patents

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Publication number
JP2009508949A5
JP2009508949A5 JP2008532213A JP2008532213A JP2009508949A5 JP 2009508949 A5 JP2009508949 A5 JP 2009508949A5 JP 2008532213 A JP2008532213 A JP 2008532213A JP 2008532213 A JP2008532213 A JP 2008532213A JP 2009508949 A5 JP2009508949 A5 JP 2009508949A5
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Japan
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groups
compound
het
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JP2008532213A
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Japanese (ja)
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JP2009508949A (ja
JP5133889B2 (ja
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Priority claimed from PCT/US2006/024393 external-priority patent/WO2007040682A1/en
Publication of JP2009508949A publication Critical patent/JP2009508949A/ja
Publication of JP2009508949A5 publication Critical patent/JP2009508949A5/ja
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Publication of JP5133889B2 publication Critical patent/JP5133889B2/ja
Expired - Fee Related legal-status Critical Current
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JP2008532213A 2005-09-21 2006-06-23 炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤 Expired - Fee Related JP5133889B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71901605P 2005-09-21 2005-09-21
US60/719,016 2005-09-21
PCT/US2006/024393 WO2007040682A1 (en) 2005-09-21 2006-06-23 Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation

Publications (3)

Publication Number Publication Date
JP2009508949A JP2009508949A (ja) 2009-03-05
JP2009508949A5 true JP2009508949A5 (https=) 2009-08-13
JP5133889B2 JP5133889B2 (ja) 2013-01-30

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ID=37205825

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008532213A Expired - Fee Related JP5133889B2 (ja) 2005-09-21 2006-06-23 炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤

Country Status (15)

Country Link
US (3) US20070078263A1 (https=)
EP (1) EP1926708B1 (https=)
JP (1) JP5133889B2 (https=)
KR (1) KR101328306B1 (https=)
CN (1) CN101312948B (https=)
AU (1) AU2006297798B2 (https=)
BR (1) BRPI0616187A2 (https=)
CA (1) CA2623348A1 (https=)
EA (1) EA017618B1 (https=)
IL (1) IL190372A0 (https=)
NO (1) NO20081829L (https=)
NZ (1) NZ566788A (https=)
SG (1) SG166769A1 (https=)
UA (1) UA101943C2 (https=)
WO (2) WO2007040681A1 (https=)

Families Citing this family (33)

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AU2006327245A1 (en) * 2005-12-21 2007-06-28 Decode Genetics Ehf Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation
WO2007079078A1 (en) * 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
KR101130380B1 (ko) * 2006-06-13 2012-04-23 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도
US8115005B2 (en) 2006-08-04 2012-02-14 Decode Genetics Ehf. Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation
CA2694362A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
AR069126A1 (es) 2007-10-31 2009-12-30 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
US20090312558A1 (en) * 2008-06-13 2009-12-17 Reliance Life Sciences Pvt. Ltd. Process for the preparation of arylcyclopropoane carboxylic carbonitriles, and compounds derived therefrom
US20100112606A1 (en) * 2008-10-17 2010-05-06 Michael Armstrong Measurement and analysis of leukotrienes
CN102459251B (zh) * 2009-05-14 2015-05-20 詹森药业有限公司 作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物
WO2011011598A1 (en) 2009-07-24 2011-01-27 Decode Genetics Ehf Process for preparing 4- { (s) -2- (4-(4-chlorophenoxy) phenoxymethyl) pyrrolidin-1-yl) } butyric acid and salts thereof
EP2520570A4 (en) 2009-12-25 2013-07-17 Ube Industries aminopyridine compound
US9617197B2 (en) 2010-08-04 2017-04-11 University Of Virginia Patent Foundation Compositions and methods for treating inflammatory diseases
CA2835617C (en) 2011-03-14 2020-07-21 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
TW201350474A (zh) 2012-03-06 2013-12-16 Boehringer Ingelheim Int 白三烯素生成之苯并二噁烷抑制劑
NZ628587A (en) 2012-03-06 2016-07-29 Boehringer Ingelheim Int Benzodioxanes in combination with other actives for inhibiting leukotriene production
CA2871534A1 (en) * 2012-04-27 2013-10-31 Glaxo Group Limited Novel compounds
US9403830B2 (en) 2012-07-17 2016-08-02 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
WO2014152536A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
RU2678196C2 (ru) 2013-03-14 2019-01-24 Селтакссис, Инк. Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
MX2015011677A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
JP6353899B2 (ja) 2013-07-15 2018-07-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
JP2016523982A (ja) * 2013-07-15 2016-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
US10080748B2 (en) 2014-02-04 2018-09-25 Bioscience Pharma Partners, Llc Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system
AR105392A1 (es) 2015-07-20 2017-09-27 Genzyme Corp Inhibidores del receptor del factor estimulador de colonias 1 (csf-1r)
CN108640864A (zh) * 2018-03-27 2018-10-12 深圳大学 一种查尔酮基荧光探针及其制备方法与应用
EP3801559B1 (en) 2018-05-31 2025-01-01 Celltaxis, LLC Method of reducing pulmonary exacerbations in respiratory disease patients
ES2984584T3 (es) * 2018-07-31 2024-10-30 Novartis Ag Formas cristalinas de un inhibidor de LTA4H
US20230141913A2 (en) * 2018-08-24 2023-05-11 Xeniopro GmbH Phenoxy(hetero)aryl ethers of antiproliferactive activity
CN111100063B (zh) * 2018-10-25 2022-05-17 南京药石科技股份有限公司 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法
CN111620942B (zh) * 2020-06-12 2021-10-15 中国科学院昆明动物研究所 布氏鼠耳蝠白三烯A4水解酶抑制剂Motistin的成熟肽及其应用
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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EP0360246B1 (en) * 1988-09-21 1994-03-30 G.D. Searle & Co. 3-Oxiranyl benzoic acids and derivatives thereof
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
US5149704A (en) * 1991-05-03 1992-09-22 Abbott Laboratories Platelet activating antagonists
GB9226111D0 (en) 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
GB9411045D0 (en) * 1994-06-02 1994-07-20 Smithkline Beecham Plc Compounds and use
US5925654A (en) 1997-03-12 1999-07-20 G.D. Searle & Co. LTA4 , hydrolase inhibitors
US6110944A (en) * 1997-03-12 2000-08-29 G. D. Searle & Co. LTA4, hydrolase inhibitors
JP2001513501A (ja) * 1997-08-07 2001-09-04 イーライ・リリー・アンド・カンパニー エストロゲン阻害活性を有する１−［４−（置換アルコキシ）ベンジル］ナフタレン化合物
JP4481011B2 (ja) * 2002-03-05 2010-06-16 トランス テック ファーマ，インコーポレイテッド リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体
US6982259B2 (en) * 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
SE0202463D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
CN1856490A (zh) * 2003-07-28 2006-11-01 詹森药业有限公司 苯并咪唑、苯并噻唑和苯并噁唑衍生物及其作为lta4h调节剂的应用
WO2006038594A1 (ja) * 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬

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