JP2009508949A5 - - Google Patents
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- Publication number
- JP2009508949A5 JP2009508949A5 JP2008532213A JP2008532213A JP2009508949A5 JP 2009508949 A5 JP2009508949 A5 JP 2009508949A5 JP 2008532213 A JP2008532213 A JP 2008532213A JP 2008532213 A JP2008532213 A JP 2008532213A JP 2009508949 A5 JP2009508949 A5 JP 2009508949A5
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- JP
- Japan
- Prior art keywords
- group
- substituted
- groups
- compound
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C[C@]1(Cc(cc(*C2=CC=C*(*)C=C2)cc2)c2OC)N(**)CCC1 Chemical compound C[C@]1(Cc(cc(*C2=CC=C*(*)C=C2)cc2)c2OC)N(**)CCC1 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71901605P | 2005-09-21 | 2005-09-21 | |
| US60/719,016 | 2005-09-21 | ||
| PCT/US2006/024393 WO2007040682A1 (en) | 2005-09-21 | 2006-06-23 | Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009508949A JP2009508949A (ja) | 2009-03-05 |
| JP2009508949A5 true JP2009508949A5 (https=) | 2009-08-13 |
| JP5133889B2 JP5133889B2 (ja) | 2013-01-30 |
Family
ID=37205825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008532213A Expired - Fee Related JP5133889B2 (ja) | 2005-09-21 | 2006-06-23 | 炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20070078263A1 (https=) |
| EP (1) | EP1926708B1 (https=) |
| JP (1) | JP5133889B2 (https=) |
| KR (1) | KR101328306B1 (https=) |
| CN (1) | CN101312948B (https=) |
| AU (1) | AU2006297798B2 (https=) |
| BR (1) | BRPI0616187A2 (https=) |
| CA (1) | CA2623348A1 (https=) |
| EA (1) | EA017618B1 (https=) |
| IL (1) | IL190372A0 (https=) |
| NO (1) | NO20081829L (https=) |
| NZ (1) | NZ566788A (https=) |
| SG (1) | SG166769A1 (https=) |
| UA (1) | UA101943C2 (https=) |
| WO (2) | WO2007040681A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1963261A1 (en) * | 2005-12-21 | 2008-09-03 | Decode Genetics EHF | Biaryl substituted nitrogen containing heterocycle inhibitors of lta4h for treating inflammation |
| LT1976828T (lt) * | 2005-12-29 | 2017-04-25 | Celtaxsys, Inc. | Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai |
| KR101130380B1 (ko) * | 2006-06-13 | 2012-04-23 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도 |
| US8115005B2 (en) | 2006-08-04 | 2012-02-14 | Decode Genetics Ehf. | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation |
| CA2694362A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
| AR069126A1 (es) | 2007-10-31 | 2009-12-30 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa |
| US20090312558A1 (en) * | 2008-06-13 | 2009-12-17 | Reliance Life Sciences Pvt. Ltd. | Process for the preparation of arylcyclopropoane carboxylic carbonitriles, and compounds derived therefrom |
| WO2010045633A2 (en) * | 2008-10-17 | 2010-04-22 | National Jewish Health | Measurement and analysis of leukotrienes |
| US8399465B2 (en) * | 2009-05-14 | 2013-03-19 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase |
| WO2011011598A1 (en) | 2009-07-24 | 2011-01-27 | Decode Genetics Ehf | Process for preparing 4- { (s) -2- (4-(4-chlorophenoxy) phenoxymethyl) pyrrolidin-1-yl) } butyric acid and salts thereof |
| CN102666490A (zh) | 2009-12-25 | 2012-09-12 | 宇部兴产株式会社 | 氨基吡啶化合物 |
| US9617197B2 (en) | 2010-08-04 | 2017-04-11 | University Of Virginia Patent Foundation | Compositions and methods for treating inflammatory diseases |
| CN103415513B (zh) | 2011-03-14 | 2016-01-20 | 勃林格殷格翰国际有限公司 | 白三烯产物的苯并二氧杂环己烷抑制剂 |
| WO2013012844A1 (en) * | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| JP6080227B2 (ja) | 2012-03-06 | 2017-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成を阻害するためのベンゾジオキサン |
| US9662339B2 (en) | 2012-03-06 | 2017-05-30 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production for combination therapy |
| AU2013254657B2 (en) * | 2012-04-27 | 2015-12-24 | Glaxo Group Limited | Novel compounds |
| AR091786A1 (es) * | 2012-07-17 | 2015-02-25 | Boehringer Ingelheim Int | Inhibidores de la produccion de leucotrienos |
| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
| CA2906035A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| BR112015022864A8 (pt) | 2013-03-14 | 2019-11-26 | Celtaxsys Inc | composto, composição farmacêutica e uso dos mesmos |
| WO2015009609A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| WO2015009611A1 (en) * | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| US10080748B2 (en) | 2014-02-04 | 2018-09-25 | Bioscience Pharma Partners, Llc | Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system |
| CA3217238A1 (en) | 2015-07-20 | 2017-01-26 | Genzyme Corporation | Colony stimulating factor-1 receptor (csf-1r) inhibitors |
| WO2020039094A1 (en) * | 2018-08-24 | 2020-02-27 | Xeniopro GmbH | Phenoxy(hetero)aryl ethers of antiproliferative activity |
| CN108640864A (zh) * | 2018-03-27 | 2018-10-12 | 深圳大学 | 一种查尔酮基荧光探针及其制备方法与应用 |
| ES3014615T3 (en) | 2018-05-31 | 2025-04-23 | Celltaxis Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN112513026B (zh) * | 2018-07-31 | 2025-02-25 | 诺华股份有限公司 | Lta4h抑制剂的晶型 |
| CN111100063B (zh) * | 2018-10-25 | 2022-05-17 | 南京药石科技股份有限公司 | 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法 |
| CN111620942B (zh) * | 2020-06-12 | 2021-10-15 | 中国科学院昆明动物研究所 | 布氏鼠耳蝠白三烯A4水解酶抑制剂Motistin的成熟肽及其应用 |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0360246B1 (en) * | 1988-09-21 | 1994-03-30 | G.D. Searle & Co. | 3-Oxiranyl benzoic acids and derivatives thereof |
| IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
| US5149704A (en) * | 1991-05-03 | 1992-09-22 | Abbott Laboratories | Platelet activating antagonists |
| GB9226111D0 (en) | 1992-12-15 | 1993-02-10 | Smithkline Beecham Plc | Madicaments |
| GB9411045D0 (en) | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| US5925654A (en) | 1997-03-12 | 1999-07-20 | G.D. Searle & Co. | LTA4 , hydrolase inhibitors |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| CA2298651A1 (en) * | 1997-08-07 | 1999-02-18 | Jeffrey Alan Dodge | 1-¬4-(substituted alkoxy)benzyl|naphthalene compounds having estrogen inhibitory activity |
| DK1482931T3 (da) * | 2002-03-05 | 2011-12-19 | Transtech Pharma Inc | Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE |
| US6982259B2 (en) * | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| ATE403654T1 (de) * | 2003-07-28 | 2008-08-15 | Janssen Pharmaceutica Nv | Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren |
| WO2006038594A1 (ja) * | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
-
2006
- 2006-06-23 JP JP2008532213A patent/JP5133889B2/ja not_active Expired - Fee Related
- 2006-06-23 WO PCT/US2006/024392 patent/WO2007040681A1/en not_active Ceased
- 2006-06-23 CN CN200680043305.4A patent/CN101312948B/zh not_active Expired - Fee Related
- 2006-06-23 UA UAA200804989A patent/UA101943C2/ru unknown
- 2006-06-23 CA CA002623348A patent/CA2623348A1/en not_active Abandoned
- 2006-06-23 EA EA200800865A patent/EA017618B1/ru not_active IP Right Cessation
- 2006-06-23 BR BRPI0616187-1A patent/BRPI0616187A2/pt not_active IP Right Cessation
- 2006-06-23 EP EP06773804.7A patent/EP1926708B1/en active Active
- 2006-06-23 KR KR1020087009260A patent/KR101328306B1/ko not_active Expired - Fee Related
- 2006-06-23 US US11/426,284 patent/US20070078263A1/en not_active Abandoned
- 2006-06-23 SG SG201006851-8A patent/SG166769A1/en unknown
- 2006-06-23 US US11/426,287 patent/US7402684B2/en not_active Expired - Fee Related
- 2006-06-23 NZ NZ566788A patent/NZ566788A/xx not_active IP Right Cessation
- 2006-06-23 AU AU2006297798A patent/AU2006297798B2/en not_active Ceased
- 2006-06-23 WO PCT/US2006/024393 patent/WO2007040682A1/en not_active Ceased
-
2008
- 2008-03-23 IL IL190372A patent/IL190372A0/en unknown
- 2008-04-15 NO NO20081829A patent/NO20081829L/no not_active Application Discontinuation
- 2008-06-11 US US12/136,874 patent/US8598359B2/en not_active Expired - Fee Related
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